{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T03:15:28Z","timestamp":1778987728586,"version":"3.51.4"},"reference-count":13,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":5003,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of nutrition, health and aging"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1007\/s12603-010-0066-1","type":"journal-article","created":{"date-parts":[[2010,4,30]],"date-time":"2010-04-30T22:49:49Z","timestamp":1272667789000},"page":"295-298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["The potential and limits for clinical trials for early Alzheimer's disease and some recommendations"],"prefix":"10.1016","volume":"14","author":[{"given":"L.S.","family":"Schneider","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s12603-010-0066-1_bib1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the MNCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1007\/s12603-010-0066-1_bib2","series-title":"Animal and Translational Models of Behavioural Disorders, volume 2: Neurological Disorders","article-title":"Issues in design and conductance of clinical trials for cognitiveenhancing drugs","author":"Schneider","year":"2008"},{"key":"10.1007\/s12603-010-0066-1_bib3","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/archneur.63.5.674","article-title":"Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia","volume":"63","author":"Jicha","year":"2006","journal-title":"Arch Neurol"},{"key":"10.1007\/s12603-010-0066-1_bib4","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1056\/NEJMoa050151","article-title":"Vitamin E and donepezil for the treatment of mild cognitive impairment","volume":"352","author":"Petersen","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1007\/s12603-010-0066-1_bib5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-Mental-Test: a practical method for grading the cognitive state of patient for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1007\/s12603-010-0066-1_bib6","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S1474-4422(07)70178-3","article-title":"Research criteria for the diagnosis of Alzheimer\u2019s disease: revising the NINCDS-ADRDA criteria","volume":"6","author":"Dubois","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1007\/s12603-010-0066-1_bib7","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1212\/01.wnl.0000238517.59286.c5","article-title":"Ten-year risk of dementia in subjects with mild cognitive impairment","volume":"67","author":"Visser","year":"2006","journal-title":"Neurology"},{"issue":"5","key":"10.1007\/s12603-010-0066-1_bib8","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jalz.2009.07.038","article-title":"Current Alzheimer Disease Clinical Trials: Methods and Placebo Outcomes","volume":"5","author":"Schneider","year":"2009","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"3","key":"10.1007\/s12603-010-0066-1_bib9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/WAD.0b013e31819cb760","article-title":"Characteristics and performance of a modified version of the ADCS-CGIC CIBIC+ for mild cognitive impairment clinical trials","volume":"23","author":"Schneider","year":"2009","journal-title":"Alzheimer\u2019s Disease and Associated Disorders"},{"issue":"4Suppl.3","key":"10.1007\/s12603-010-0066-1_bib10","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1097\/01.wad.0000213873.25053.2b","article-title":"ADCS prevention instrument project: assessment of instrumental activities of daily living for community-dwelling elderly individuals in dementia prevention clinical trials","volume":"20","author":"Galasko","year":"2006","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1007\/s12603-010-0066-1_bib11","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1212\/01.wnl.0000260269.93245.d2","article-title":"Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial","volume":"68","year":"2007","journal-title":"Neurology"},{"issue":"19","key":"10.1007\/s12603-010-0066-1_bib12","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1001\/jama.2008.683","article-title":"Ginkgo Evaluation of Memory (GEM) Study Investigators. Ginkgo biloba for prevention of dementia: a randomized controlled trial","volume":"300","author":"DeKosky","year":"2008","journal-title":"JAMA"},{"issue":"4","key":"10.1007\/s12603-010-0066-1_bib13","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2174\/156720508785132271","article-title":"GuidAge study; a 5-year double blind, randomised trial of EGb 761 for the prevention of Alzheimer\u2019s disease in elderly subjects with memory complaints. i. rationale, design and baseline data","volume":"5","author":"Andrieu","year":"2008","journal-title":"Current Alzheimer Research"}],"container-title":["The Journal of nutrition, health and aging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-010-0066-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12603-010-0066-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S127977072301919X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S127977072301919X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-010-0066-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T13:01:56Z","timestamp":1761138116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S127977072301919X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":13,"aliases":["10.1007\/s12603-009-0234-3"],"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S127977072301919X"],"URL":"https:\/\/doi.org\/10.1007\/s12603-010-0066-1","relation":{},"ISSN":["1279-7707"],"issn-type":[{"value":"1279-7707","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The potential and limits for clinical trials for early Alzheimer's disease and some recommendations","name":"articletitle","label":"Article Title"},{"value":"The Journal of nutrition, health and aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12603-010-0066-1","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2010 SERDI Publisher.","name":"copyright","label":"Copyright"}]}}