{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:28:11Z","timestamp":1791419291490,"version":"4.3.3"},"reference-count":44,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":3148,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of nutrition, health and aging"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1007\/s12603-014-0576-3","type":"journal-article","created":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T18:44:57Z","timestamp":1420224297000},"page":"555-561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["The effects of substance P on tendinopathy are dose-dependent: An in vitro and in vivo model study"],"prefix":"10.1016","volume":"19","author":[{"given":"Y.","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanglai","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s12603-014-0576-3_bib1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/nm1630","article-title":"Identification of tendon stem\/progenitor cells and the role of the extracellular matrix in their niche","volume":"13","author":"Bi","year":"2007","journal-title":"Nature medicine"},{"key":"10.1007\/s12603-014-0576-3_bib2","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1089\/ten.tea.2009.0529","article-title":"Isolation and characterization of multipotent rat tendon-derived stem cells","volume":"16","author":"Rui","year":"2010","journal-title":"Tissue Engineering Part A"},{"key":"10.1007\/s12603-014-0576-3_bib3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2474-11-10","article-title":"Characterization of differential properties of rabbit tendon stem cells and tenocytes","volume":"11","author":"Zhang","year":"2010","journal-title":"BMC musculoskeletal disorders"},{"key":"10.1007\/s12603-014-0576-3_bib4","first-page":"e710","article-title":"The Effects of Mechanical Loading on Tendons-An In Vivo and In Vitro Model Study","volume":"8","author":"Zhang","year":"2013","journal-title":"PloS one"},{"key":"10.1007\/s12603-014-0576-3_bib5","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/jor.22290","article-title":"BMP-2 stimulated nontenogenic differentiation and promoted proteoglycan deposition of tendon-derived stem cells (TDSCs) in vitro","volume":"31","author":"Rui","year":"2013","journal-title":"Journal of Orthopaedic Research"},{"key":"10.1007\/s12603-014-0576-3_bib6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s12603-014-0026-2","article-title":"An overview of structure, mechanical properties, and treatment for age-related tendinopathy","volume":"18","author":"Zhou","year":"2014","journal-title":"The journal of nutrition, health & aging"},{"key":"10.1007\/s12603-014-0576-3_bib7","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/ard.2005.044016","article-title":"Dupuytren's contracture is associated with sprouting of substance P positive nerve fibres and infiltration by mast cells","volume":"65","author":"Schubert","year":"2006","journal-title":"Annals of the rheumatic diseases"},{"key":"10.1007\/s12603-014-0576-3_bib8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1172\/JCI117557","article-title":"Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P","volume":"94","author":"Ziche","year":"1994","journal-title":"Journal of Clinical Investigation"},{"key":"10.1007\/s12603-014-0576-3_bib9","first-page":"1","article-title":"Increased substance P expression in the trochanteric bursa of patients with greater trochanteric pain syndrome","author":"Fearon","year":"2014","journal-title":"Rheumatology international"},{"key":"10.1007\/s12603-014-0576-3_bib10","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/jor.1100160515","article-title":"Increased substance P in subacromial bursa and shoulder pain in rotator cuff diseases","volume":"16","author":"Gotoh","year":"1998","journal-title":"Journal of orthopaedic research"},{"key":"10.1007\/s12603-014-0576-3_bib11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1136\/ard.51.3.313","article-title":"Localisation and characterisation of substance P binding to human synovial tissue in rheumatoid arthritis","volume":"51","author":"Walsh","year":"1992","journal-title":"Annals of the rheumatic diseases"},{"key":"10.1007\/s12603-014-0576-3_bib12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.regpep.2008.02.005","article-title":"Presence of substance P and the neurokinin-1 receptor in tenocytes of the human Achilles tendon","volume":"150","author":"Andersson","year":"2008","journal-title":"Regulatory peptides"},{"key":"10.1007\/s12603-014-0576-3_bib13","first-page":"349","article-title":"The effects of substance P on pluripotent tendon cells: an in vitro and in vivo study","volume":"14","author":"Zhou","year":"2014","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"10.1007\/s12603-014-0576-3_bib14","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1136\/ard.2004.029876","article-title":"Achilles tendinosis is associated with sprouting of substance P positive nerve fibres","volume":"64","author":"Schubert","year":"2005","journal-title":"Annals of the rheumatic diseases"},{"key":"10.1007\/s12603-014-0576-3_bib15","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1227\/NEU.0b013e3181fa7032","article-title":"Changes in tissue substance P levels in patients with carpal tunnel syndrome","volume":"67","author":"\u00d6zt\u00fcrk","year":"2010","journal-title":"Neurosurgery"},{"key":"10.1007\/s12603-014-0576-3_bib16","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1136\/bjsm.2010.082750","article-title":"Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model","volume":"45","author":"Andersson","year":"2011","journal-title":"British journal of sports medicine"},{"key":"10.1007\/s12603-014-0576-3_bib17","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1600-0838.2009.01080.x","article-title":"Substance P injections enhance tissue proliferation and regulate sensory nerve ingrowth in rat tendon repair","volume":"21","author":"Carlsson","year":"2011","journal-title":"Scandinavian journal of medicine & science in sports"},{"key":"10.1007\/s12603-014-0576-3_bib18","first-page":"3","article-title":"Qualitative analysis of substance P, NK1-receptor and nerve ingrowth in substance P-treated ruptured rat Achilles tendon","volume":"76","author":"Steyaert","year":"2010","journal-title":"Acta Orthop\u00e6dica Belgica"},{"key":"10.1007\/s12603-014-0576-3_bib19","doi-asserted-by":"crossref","first-page":"e272","DOI":"10.1371\/journal.pone.0027209","article-title":"Substance P is a mechanoresponsive, autocrine regulator of human tenocyte proliferation","volume":"6","author":"Backman","year":"2011","journal-title":"PloS one"},{"key":"10.1007\/s12603-014-0576-3_bib20","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1177\/147323001204000418","article-title":"Autologous platelet-rich clot releasate stimulates proliferation and inhibits differentiation of adult rat tendon stem cells towards nontenocyte lineages","volume":"40","author":"Chen","year":"2012","journal-title":"Journal of International Medical Research"},{"key":"10.1007\/s12603-014-0576-3_bib21","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.bbrc.2012.11.083","article-title":"Phosphoinositide 3-kinase\/Akt signaling is essential for prostaglandin E2-induced osteogenic differentiation of rat tendon stem cells","volume":"435","author":"Liu","year":"2013","journal-title":"Biochemical and biophysical research communications"},{"key":"10.1007\/s12603-014-0576-3_bib22","first-page":"e854","article-title":"Insulin-Like Growth Factor-1 and Bone Morphogenetic Protein-2 Jointly Mediate Prostaglandin E2-Induced Adipogenic Differentiation of Rat Tendon Stem Cells","volume":"9","author":"Liu","year":"2014","journal-title":"PloS one"},{"key":"10.1007\/s12603-014-0576-3_bib23","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/jor.21046","article-title":"Mechanobiological response of tendon stem cells: implications of tendon homeostasis and pathogenesis of tendinopathy","volume":"28","author":"Zhang","year":"2010","journal-title":"Journal of Orthopaedic Research"},{"key":"10.1007\/s12603-014-0576-3_bib24","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1136\/bjsm.2007.040931","article-title":"Circulating substance P levels and shoulder joint contracture after arthroscopic repair of the rotator cuff","volume":"42","author":"Franceschi","year":"2008","journal-title":"British Journal of Sports Medicine"},{"key":"10.1007\/s12603-014-0576-3_bib25","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/s00167-007-0364-2","article-title":"Nerve-related characteristics of ventral paratendinous tissue in chronic Achilles tendinosis","volume":"15","author":"Andersson","year":"2007","journal-title":"Knee Surgery, Sports Traumatology, Arthroscopy"},{"key":"10.1007\/s12603-014-0576-3_bib26","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1357-2725(01)00031-0","volume":"33","author":"Harrison","year":"2001","journal-title":"Substance p. The international journal of biochemistry & cell biology"},{"key":"10.1007\/s12603-014-0576-3_bib27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1136\/bjsm.2009.068122","article-title":"Tenocyte hypercellularity and vascular proliferation in a rabbit model of tendinopathy: contralateral effects suggest the involvement of central neuronal mechanisms","volume":"45","author":"Andersson","year":"2011","journal-title":"British journal of sports medicine"},{"key":"10.1007\/s12603-014-0576-3_bib28","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0736-0266(01)00159-0","article-title":"Early nerve regeneration after Achilles tendon rupture\u2014a prerequisite for healing?","volume":"20","author":"Ackermann","year":"2002","journal-title":"A study in the rat. Journal of orthopaedic research"},{"key":"10.1007\/s12603-014-0576-3_bib29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/jor.22191","article-title":"Substance P enhances collagen remodeling and MMP-3 expression by human tenocytes","volume":"31","author":"Fong","year":"2013","journal-title":"Journal of Orthopaedic Research"},{"key":"10.1007\/s12603-014-0576-3_bib30","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.orthres.2004.08.017","article-title":"Increase in sensory neuropeptides surrounding the Achilles tendon in rats with adjuvant arthritis","volume":"23","author":"Bring","year":"2005","journal-title":"Journal of orthopaedic research"},{"key":"10.1007\/s12603-014-0576-3_bib31","first-page":"133","article-title":"Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy-peptidergic elevation preceding tendinosis-like tissue changes","volume":"11","author":"Backman","year":"2011","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"10.1007\/s12603-014-0576-3_bib32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/jcpt.12011","article-title":"Effect of pilocarpine on substance P and calcitonin gene-related peptide releases correlate with salivary secretion in human saliva and plasma","volume":"38","author":"Sato","year":"2013","journal-title":"Journal of clinical pharmacy and therapeutics"},{"key":"10.1007\/s12603-014-0576-3_bib33","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1177\/0363546509355402","article-title":"Expression of sensory neuropeptides in tendon is associated with failed healing and activity-related tendon pain in collagenase-induced tendon injury","volume":"38","author":"Lui","year":"2010","journal-title":"The American journal of sports medicine"},{"key":"10.1007\/s12603-014-0576-3_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2474-15-126","article-title":"Inhibitors of endopeptidase and angiotensin-converting enzyme lead to an amplification of the morphological changes and an upregulation of the substance P system in a muscle overuse model","volume":"15","author":"Song","year":"2014","journal-title":"BMC musculoskeletal disorders"},{"key":"10.1007\/s12603-014-0576-3_bib35","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1136\/ard.48.11.928","article-title":"Inhibition of carrageenan induced inflammation in the rat knee joint by substance P antagonist","volume":"48","author":"Lam","year":"1989","journal-title":"Annals of the rheumatic diseases"},{"key":"10.1007\/s12603-014-0576-3_bib36","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1524-475X.2011.00755.x","article-title":"Residual substance P levels after capsaicin treatment correlate with tendon repair","volume":"20","author":"Bring","year":"2012","journal-title":"Wound Repair and Regeneration"},{"key":"10.1007\/s12603-014-0576-3_bib37","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2165\/00007256-199927060-00004","article-title":"Histopathology of common tendinopathies","author":"Khan","year":"1999","journal-title":"Sports Medicine 27"},{"key":"10.1007\/s12603-014-0576-3_bib38","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.12059","article-title":"Akt-mediated anti-apoptotic effects of substance P in Anti-Fas-induced apoptosis of human tenocytes","author":"Backman","year":"2013","journal-title":"Journal of cellular and molecular medicine"},{"key":"10.1007\/s12603-014-0576-3_bib39","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/jor.20984","article-title":"Exposuredependent increases in IL-1\u00df, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper extremity repetitive strain injury","volume":"28","author":"Fedorczyk","year":"2010","journal-title":"Journal of Orthopaedic Research"},{"key":"10.1007\/s12603-014-0576-3_bib40","article-title":"Substance P reduces TNF-a-induced apoptosis in human tenocytes through NK-1 receptor stimulation","author":"Backman","year":"2013","journal-title":"British journal of sports medicine: bjsports-2013-0924-8"},{"key":"10.1007\/s12603-014-0576-3_bib41","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1136\/annrheumdis-2012-202846","article-title":"Neuropeptides activate TRPV1 in rheumatoid arthritis fibroblast-like synoviocytes and foster IL-6 and IL-8 production","volume":"72","author":"Terenzi","year":"2013","journal-title":"Annals of the rheumatic diseases"},{"key":"10.1007\/s12603-014-0576-3_bib42","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0736-0266(03)00183-9","article-title":"Neurokinin 1-receptors and sensory neuropeptides in tendon insertions at the medial and lateral epicondyles of the humerus Studies on tennis elbow and medial epicondylalgia","volume":"22","author":"Ljung","year":"2004","journal-title":"Journal of orthopaedic research"},{"key":"10.1007\/s12603-014-0576-3_bib43","first-page":"e876","article-title":"Prostaglandin E2 (PGE2) Exerts Biphasic Effects on Human Tendon Stem Cells","volume":"9","author":"Zhang","year":"2014","journal-title":"PloS one"},{"key":"10.1007\/s12603-014-0576-3_bib44","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1136\/ard.51.8.1014","article-title":"Role of substance P in inflammatory arthritis","volume":"51","author":"Garrett","year":"1992","journal-title":"Annals of the rheumatic diseases"}],"container-title":["The Journal of nutrition, health and aging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-014-0576-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12603-014-0576-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770723013696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770723013696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-014-0576-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:55:50Z","timestamp":1761137750000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1279770723013696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S1279770723013696"],"URL":"https:\/\/doi.org\/10.1007\/s12603-014-0576-3","relation":{},"ISSN":["1279-7707"],"issn-type":[{"value":"1279-7707","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of substance P on tendinopathy are dose-dependent: An in vitro and in vivo model study","name":"articletitle","label":"Article Title"},{"value":"The Journal of nutrition, health and aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12603-014-0576-3","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 SERDI Publisher.","name":"copyright","label":"Copyright"}]}}