{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:55:15Z","timestamp":1767142515484,"version":"build-2238731810"},"reference-count":37,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":2934,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of nutrition, health and aging"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s12603-015-0660-3","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T20:10:21Z","timestamp":1452024621000},"page":"1003-1008","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Examining the association between vitamin B12 deficiency and dementia in high-risk hospitalized patients"],"prefix":"10.1016","volume":"19","author":[{"given":"O.","family":"Siswanto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Smeall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Donnelly-Vanderloo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Foley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Madill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1007\/s12603-015-0660-3_bib1","first-page":"1425","article-title":"Update on vitamin B12 deficiency","volume":"83","author":"Langan","year":"2011","journal-title":"Am Fam Physician"},{"issue":"4","key":"10.1007\/s12603-015-0660-3_bib2","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1017\/S0029665107005873","article-title":"Folate and vitamin B12: friendly or enemy nutrients for the elderly","volume":"66","author":"Cuskelly","year":"2007","journal-title":"Proc Nutr Soc"},{"key":"10.1007\/s12603-015-0660-3_bib3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1503\/cmaj.1031155","article-title":"Vitamin B12 (cobalamin) deficiency in elderly patients","volume":"3","author":"Andr\u00e8s","year":"2004","journal-title":"CMAJ171"},{"key":"10.1007\/s12603-015-0660-3_bib4","first-page":"CD004655","article-title":"Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency","volume":"3","author":"Vidal-Alaball","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1007\/s12603-015-0660-3_bib5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1056\/NEJMcp1113996","article-title":"Vitamin B12 deficiency","volume":"368","author":"Stabler","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1007\/s12603-015-0660-3_bib6","unstructured":"World Health Organization. 10 facts on dementia. http:\/\/www.who.int\/features\/factfiles\/dementia\/en\/. Accessed 2014 Aug 8"},{"key":"10.1007\/s12603-015-0660-3_bib7","unstructured":"Canadian Medical Association. Toward a dementia strategy for Canada. http:\/\/www.cma.ca\/multimedia\/CMA\/Content_Images\/Inside_cma\/Submissions\/2013\/CMArecommendations-NationalDementiaStrategy_en.pdf. Accessed 20 Dec 2013"},{"issue":"11","key":"10.1007\/s12603-015-0660-3_bib8","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archneur.55.11.1449","article-title":"Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease","volume":"55","author":"Clarke","year":"1998","journal-title":"Arch Neurol"},{"issue":"4","key":"10.1007\/s12603-015-0660-3_bib9","doi-asserted-by":"crossref","first-page":"909","DOI":"10.3233\/JAD-2011-110752","article-title":"Homocysteine, vitamin B12, and folic acid levels in Alzheimer\u2019s disease, mild cognitive impairment, and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle study","volume":"27","author":"Faux","year":"2011","journal-title":"J Alzheimers Dis"},{"issue":"9","key":"10.1007\/s12603-015-0660-3_bib10","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1515\/CCLM.2004.208","article-title":"Homocysteine, vitamin B12 and folate in vascular dementia and in Alzheimer disease","volume":"42","author":"Malaguarnera","year":"2004","journal-title":"Clin Chem Lab Med"},{"issue":"12","key":"10.1007\/s12603-015-0660-3_bib11","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.clinbiochem.2007.04.007","article-title":"Relations between homocysteine, folate and vitamin B12 in vascular dementia and in Alzheimer disease","volume":"40","author":"K\u00f6seoglu","year":"2007","journal-title":"Clin Biochem"},{"issue":"1","key":"10.1007\/s12603-015-0660-3_bib12","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/ajcn\/80.1.114","article-title":"Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia","volume":"80","author":"Quadri","year":"2004","journal-title":"Am J Clin Nutr"},{"issue":"04","key":"10.1007\/s12603-015-0660-3_bib13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1017\/S1041610211002511","article-title":"Cognitive impairment and vitamin B12: a review","volume":"24","author":"Moore","year":"2012","journal-title":"Int Psychogeriatr"},{"key":"10.1007\/s12603-015-0660-3_bib14","unstructured":"Malouf R, Areosa Sastre A. Vitamin B12 for cognition. Cochrane Database Syst Rev 2009;1(CD004326)"},{"key":"10.1007\/s12603-015-0660-3_bib15","doi-asserted-by":"crossref","unstructured":"Vogiatzoglou A, Refsum H, Johnston C, Smith SM, Bradley KM, de Jager C, et al.Vitamin B12 status and rate of brain volume loss in community-dwelling elderly. Neurology 2008;71(11):826\u201332","DOI":"10.1212\/01.wnl.0000325581.26991.f2"},{"issue":"2","key":"10.1007\/s12603-015-0660-3_bib16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/jnnp.2008.149286","article-title":"Plasma vitamin B12 status and cerebral white-matter lesions","volume":"80","author":"de Lau","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry."},{"issue":"17","key":"10.1007\/s12603-015-0660-3_bib17","doi-asserted-by":"crossref","first-page":"14674","DOI":"10.1074\/jbc.M200997200","article-title":"Neurodegeneration in methylmalonic aciduria involves inhibition of complex II and the tricarboxylic acid cycle, and synergistically acting excitotoxicity","volume":"277","author":"Okun","year":"2002","journal-title":"J Biol Chem"},{"issue":"13","key":"10.1007\/s12603-015-0660-3_bib18","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1016\/j.febslet.2006.04.088","article-title":"Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia","volume":"580","author":"Obeid","year":"2006","journal-title":"FEBS Lett"},{"issue":"17","key":"10.1007\/s12603-015-0660-3_bib19","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1212\/WNL.0b013e3181f962c4","article-title":"Vitamins B12, B6, and folic acid for cognition in older men","volume":"75","author":"Ford","year":"2010","journal-title":"Neurology"},{"issue":"4","key":"10.1007\/s12603-015-0660-3_bib20","first-page":"254","article-title":"Prevalence of vitamin B12 deficiency among demented patients and cognitive recovery with cobalamin replacement","volume":"6","author":"Abyad","year":"2002","journal-title":"J Nutr Health Aging"},{"issue":"2","key":"10.1007\/s12603-015-0660-3_bib21","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1532-5415.1992.tb01939.x","article-title":"Time dependency of cognitive recovery with cobalamin replacement: report of a pilot study","volume":"40","author":"Martin","year":"1992","journal-title":"J Am Geriatr Soc"},{"issue":"4","key":"10.1007\/s12603-015-0660-3_bib22","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3945\/ajcn.111.020230","article-title":"Vitamin B12 and homocysteine status in a folate-replete population: results from the Canadian Health Measures Survey","volume":"94","author":"MacFarlane","year":"2011","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"10.1007\/s12603-015-0660-3_bib23","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1093\/ajcn\/86.3.718","article-title":"Trends in blood folate and vitamin B-12 concentrations in the United States, 1988-2004","volume":"86","author":"Pfeiffer","year":"2007","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"10.1007\/s12603-015-0660-3_bib24","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0009-9120(03)00061-4","article-title":"Persistence of vitamin B12 insufficiency among elderly women after folic acid food fortification","volume":"36","author":"Ray","year":"2003","journal-title":"Clin Biochem"},{"key":"10.1007\/s12603-015-0660-3_bib25","first-page":"743","article-title":"Vitamin B12 deficiency","volume":"50","author":"Gupta","year":"2004","journal-title":"Prevalence among South Asians at a Toronto clinic. Can Fam Physician M\u00e9decin Fam Can"},{"key":"10.1007\/s12603-015-0660-3_bib26","series-title":"American Psychiatric Association Practice Guidelines for the Treatment of Psychiatric Disorders","year":"2006"},{"key":"10.1007\/s12603-015-0660-3_bib27","unstructured":"The Guidelines and Protocols Advisory Committee of British Columbia; 2007. Cognitive impairment in the elderly\u2013recognition, diagnosis and management. http:\/\/www.bcguidelines.ca\/pdf\/cognitive_summary.pdf. Accessed 3 July 2014"},{"issue":"2","key":"10.1007\/s12603-015-0660-3_bib28","doi-asserted-by":"crossref","first-page":"E100","DOI":"10.1503\/cmaj.100568","article-title":"Folate status of the population in the Canadian Health Measures Survey","volume":"183","author":"Colapinto","year":"2011","journal-title":"CMAJ"},{"issue":"23","key":"10.1007\/s12603-015-0660-3_bib29","first-page":"1","article-title":"Vitamin B12 and cognitive function: an evidence-based analysis","volume":"13","year":"2013","journal-title":"Ont Health Technol Assess Ser"},{"issue":"9","key":"10.1007\/s12603-015-0660-3_bib30","doi-asserted-by":"crossref","first-page":"e12244","DOI":"10.1371\/journal.pone.0012244","article-title":"Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial","volume":"5","author":"Smith","year":"2010","journal-title":"PLoS ONE."},{"issue":"7","key":"10.1007\/s12603-015-0660-3_bib31","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMoa011613","article-title":"Plasma homocysteine as a risk factor for dementia and Alzheimer\u2019s disease","volume":"346","author":"Seshadri","year":"2002","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1007\/s12603-015-0660-3_bib32","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/ajcn\/82.3.636","article-title":"Homocysteine and folate as risk factors for dementia and Alzheimer disease","volume":"82","author":"Ravaglia","year":"2005","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"10.1007\/s12603-015-0660-3_bib33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1212\/01.wnl.0000341272.48617.b0","article-title":"Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline","volume":"72","author":"Tangney","year":"2009","journal-title":"Neurology"},{"key":"10.1007\/s12603-015-0660-3_bib34","unstructured":"Food and Nutrition Board, Institute of Medicine; 2010. Vitamin B12. http:\/\/ods.od.nih.gov\/factsheets\/VitaminB12-HealthProfessional\/. Accessed 20 October 2012"},{"key":"10.1007\/s12603-015-0660-3_bib35","unstructured":"Health Canada; 2010. Dietary Reference Intakes. http:\/\/www.hc-sc.gc.ca\/fn-an\/nutrition\/reference\/table\/ref_vitam_tbl-eng.php. Accessed 30 August 2013"},{"issue":"6","key":"10.1007\/s12603-015-0660-3_bib36","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.ypmed.2004.04.047","article-title":"Cobalamin: a critical vitamin in the elderly","volume":"39","author":"Wolters","year":"2004","journal-title":"Prev Med"},{"issue":"1","key":"10.1007\/s12603-015-0660-3_bib37","doi-asserted-by":"crossref","first-page":"313S","DOI":"10.3945\/ajcn.111.013243","article-title":"Biomarkers of vitamin B-12 status in NHANES: a roundtable summary","volume":"94","author":"Yetley","year":"2011","journal-title":"Am J Clin Nutr"}],"container-title":["The Journal of nutrition, health and aging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-015-0660-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12603-015-0660-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770723016329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770723016329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-015-0660-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:57:02Z","timestamp":1761137822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1279770723016329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":37,"aliases":["10.1007\/s12603-015-0531-y"],"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S1279770723016329"],"URL":"https:\/\/doi.org\/10.1007\/s12603-015-0660-3","relation":{},"ISSN":["1279-7707"],"issn-type":[{"value":"1279-7707","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Examining the association between vitamin B12 deficiency and dementia in high-risk hospitalized patients","name":"articletitle","label":"Article Title"},{"value":"The Journal of nutrition, health and aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12603-015-0660-3","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 SERDI Publisher.","name":"copyright","label":"Copyright"}]}}