{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:08:25Z","timestamp":1773925705061,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":2934,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of nutrition, health and aging"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s12603-015-0661-2","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T20:10:21Z","timestamp":1452024621000},"page":"1009-1011","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Analysing time to event data in dementia prevention trials: The example of the guidage study of EGB761\u00ae"],"prefix":"10.1016","volume":"19","author":[{"given":"Bruno","family":"Scherrer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Andrieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.-J.","family":"Ousset","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Berrut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-F.","family":"Dartigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Dubois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Pasquier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Piette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Robert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Touchon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Garnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Mathiex-Fortunet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Vellas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s12603-015-0661-2_bib1","first-page":"2","article-title":"Consensus guidelines for the design and implementation of clinical trials in ALS","volume":"169","author":"Miller","year":"1999","journal-title":"World Federation of Neurology committee on Research. J Neurol Sci"},{"key":"10.1007\/s12603-015-0661-2_bib2","first-page":"1425","article-title":"Dose-ranging study of riluzole in amyotrophic lateral sclerosis","volume":"347","author":"Lacomblez","year":"1996","journal-title":"Amyotrophic Lateral Sclerosis\/Riluzole Study Group II. Lancet"},{"key":"10.1007\/s12603-015-0661-2_bib3","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1001\/jama.2014.3654","article-title":"Pharmacological treatment of Parkinson disease: a review","volume":"311","author":"Connolly","year":"2014","journal-title":"Jama"},{"key":"10.1007\/s12603-015-0661-2_bib4","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1212\/01.wnl.0000303814.13509.db","article-title":"A randomized placebocontrolled trial of Ginkgo biloba for the prevention of cognitive decline","volume":"70","author":"Dodge","year":"2008","journal-title":"Neurology"},{"key":"10.1007\/s12603-015-0661-2_bib5","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1001\/jama.291.24.2947","article-title":"Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women\u2019s Health Initiative Memory Study","volume":"291","author":"Shumaker","year":"2004","journal-title":"Jama"},{"key":"10.1007\/s12603-015-0661-2_bib6","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1212\/01.wnl.0000260269.93245.d2","article-title":"Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial","volume":"68","author":"Lyketsos","year":"2007","journal-title":"Neurology"},{"key":"10.1007\/s12603-015-0661-2_bib7","unstructured":"Gar\u00e8s V, Andrieu S, Dupuy JF, Savy N (in press) On the use of Fleming- Harrington\u2019s test in prevention trials. Biometrika."},{"key":"10.1007\/s12603-015-0661-2_bib8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1055\/s-0029-1242817","article-title":"Effectiveness of standardized ginkgo biloba extract on cognitive symptoms of dementia with a six-month treatment: a bivariate random effect meta-analysis","volume":"43","author":"Wang","year":"2010","journal-title":"Pharmacopsychiatry"},{"key":"10.1007\/s12603-015-0661-2_bib9","doi-asserted-by":"crossref","unstructured":"Weinmann S, Roll S, Schwarzbach C, Vauth C, Willich SN, Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. BMC Geriatr, 2010, 14","DOI":"10.1186\/1471-2318-10-14"},{"key":"10.1007\/s12603-015-0661-2_bib10","first-page":"1125","article-title":"Meta-analysis of Ginkgo biloba extract for the treatment of Alzheimer\u2019s disease","volume":"6","author":"Yang","year":"2011","journal-title":"Neural Regen Res"},{"key":"10.1007\/s12603-015-0661-2_bib11","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10354-010-0844-8","article-title":"Ginkgo biloba in Alzheimer\u2019s disease: a systematic review","volume":"160","author":"Janssen","year":"2011","journal-title":"Wien Med Wochenschr"},{"key":"10.1007\/s12603-015-0661-2_bib12","first-page":"73","article-title":"[Effect of Ginkgo-biloba extract on mental performance","volume":"110","author":"Grassel","year":"1992","journal-title":"Doubleblind study using computerized measurement conditions in patients with cerebral insufficiency]. Fortschr Med"},{"key":"10.1007\/s12603-015-0661-2_bib13","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4236\/nm.2011.21007","article-title":"Effects of Ginkgo Biloba special extract EGb 761\u00ae in very mild cognitive impairment (vMCI)","volume":"2","author":"Grass-Kapanke","year":"2011","journal-title":"Neuroscience & Medicine"},{"key":"10.1007\/s12603-015-0661-2_bib14","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/gerona\/58.4.M372","article-title":"Association of Alzheimer\u2019s disease onset with ginkgo biloba and other symptomatic cognitive treatments in a population of women aged 75 years and older from the EPIDOS study","volume":"58","author":"Andrieu","year":"2003","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1007\/s12603-015-0661-2_bib15","doi-asserted-by":"crossref","first-page":"e52755","DOI":"10.1371\/journal.pone.0052755","article-title":"Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study","volume":"8","author":"Amieva","year":"2013","journal-title":"Plos One"},{"key":"10.1007\/s12603-015-0661-2_bib16","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S1474-4422(12)70206-5","article-title":"Long-term use of standardised ginkgo biloba extract for the prevention of Alzheimer\u2019s disease (GuidAge): a randomised placebo-controlled trial","volume":"11","author":"Vellas","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1007\/s12603-015-0661-2_bib17","first-page":"S6","article-title":"The GuidAge study: methodological issues","volume":"67","author":"Vellas","year":"2006","journal-title":"A 5-year double-blind randomized trial of the efficacy of EGb 761 for prevention of Alzheimer disease in patients over 70 with a memory complaint. Neurology"},{"key":"10.1007\/s12603-015-0661-2_bib18","unstructured":"American Psychiatric Association. Diagnostic and Statistical Manual for Mental Disorders. Washington DC, USA: American Psychiatric Association, 1994."},{"key":"10.1007\/s12603-015-0661-2_bib19","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1007\/s12603-015-0661-2_bib20","unstructured":"Alzheimer\u2019s Disease International. World Alzheimer Report, 2009."},{"key":"10.1007\/s12603-015-0661-2_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1517\/14656566.7.1.1","article-title":"Pharmacological strategies for the prevention of Alzheimer\u2019s disease","volume":"7","author":"Doraiswamy","year":"2006","journal-title":"Expert Opin Pharmacother"},{"key":"10.1007\/s12603-015-0661-2_bib22","doi-asserted-by":"crossref","unstructured":"Williams JW, Plassman BL, Burke J, Benjamin S, Preventing Alzheimer\u2019s disease and cognitive decline. Evid Rep Technol Assess (Full Rep), 2010, 1\u2013727","DOI":"10.1037\/e554772010-001"},{"key":"10.1007\/s12603-015-0661-2_bib23","first-page":"841","article-title":"A comparison of the constant piecewise weighted logrank and Fleming-Harrington tests","volume":"8","author":"Gar\u00e8s","year":"2015","journal-title":"Electronic J Stat"},{"key":"10.1007\/s12603-015-0661-2_bib24","doi-asserted-by":"crossref","unstructured":"Gares V, Andrieu S, Dupuy JF, Savy N.An omnibus test for several hazard alternatives in prevention randomized controlled clinical trials. Stat Med 2015;34:541\u2013557.","DOI":"10.1002\/sim.6366"}],"container-title":["The Journal of nutrition, health and aging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-015-0661-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12603-015-0661-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770723016330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770723016330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-015-0661-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:57:30Z","timestamp":1761137850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1279770723016330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":24,"aliases":["10.1007\/s12603-015-0582-0"],"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S1279770723016330"],"URL":"https:\/\/doi.org\/10.1007\/s12603-015-0661-2","relation":{},"ISSN":["1279-7707"],"issn-type":[{"value":"1279-7707","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysing time to event data in dementia prevention trials: The example of the guidage study of EGB761\u00ae","name":"articletitle","label":"Article Title"},{"value":"The Journal of nutrition, health and aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12603-015-0661-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 SERDI Publisher.","name":"copyright","label":"Copyright"}]}}