{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:39:28Z","timestamp":1762252768912,"version":"build-2065373602"},"reference-count":29,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"vor","delay-in-days":1830,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013077","name":"National Science and Technology Planning Project","doi-asserted-by":"publisher","award":["2012BAI37B05"],"award-info":[{"award-number":["2012BAI37B05"]}],"id":[{"id":"10.13039\/501100013077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1001700"],"award-info":[{"award-number":["2017YFC1001700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of nutrition, health and aging"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s12603-018-1062-0","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T22:58:06Z","timestamp":1529967486000},"page":"1189-1197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Metabolic Biomarkers of Aging and Aging-related Diseases in Chinese Middle-Aged and Elderly Men"],"prefix":"10.1016","volume":"22","author":[{"given":"W.","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meilin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s12603-018-1062-0_bib1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mad.2015.03.006","article-title":"MARK-AGE biomarkers of ageing","volume":"151","author":"Burkle","year":"2015","journal-title":"Mech Ageing Dev"},{"key":"10.1007\/s12603-018-1062-0_bib2","doi-asserted-by":"crossref","unstructured":"Wagner KH, Cameron-Smith D, Wessner B, Franzke B. Biomarkers of Aging: From Function to Molecular Biology. Nutrients 2016,8.","DOI":"10.3390\/nu8060338"},{"key":"10.1007\/s12603-018-1062-0_bib3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/ejhf.30","article-title":"Co-morbidities in patients with heart failure: an analysis of the European Heart Failure Pilot Survey","volume":"16","author":"van Deursen","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"10.1007\/s12603-018-1062-0_bib4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.brainres.2013.05.011","article-title":"Oral L-citrulline administration improves memory deficits following transient brain ischemia through cerebrovascular protection","volume":"1520","author":"Yabuki","year":"2013","journal-title":"Brain Res"},{"key":"10.1007\/s12603-018-1062-0_bib5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.neuroscience.2017.02.033","article-title":"Further studies of the effects of aging on arginine metabolites in the rat vestibular nucleus and cerebellum","volume":"348","author":"Liu","year":"2017","journal-title":"Neuroscience"},{"key":"10.1007\/s12603-018-1062-0_bib6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.nut.2012.07.002","article-title":"Citrulline: from metabolism to therapeutic use","volume":"29","author":"Bahri","year":"2013","journal-title":"Nutrition"},{"key":"10.1007\/s12603-018-1062-0_bib7","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.bbrc.2016.09.116","article-title":"Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction","volume":"479","author":"Consitt","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1007\/s12603-018-1062-0_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2016.03.005","article-title":"Mediumchain plasma acylcarnitines, ketone levels, cognition, and gray matter volumes in healthy elderly, mildly cognitively impaired, or Alzheimer\u2019s disease subjects","volume":"43","author":"Ciavardelli","year":"2016","journal-title":"Neurobiol Aging"},{"key":"10.1007\/s12603-018-1062-0_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cmet.2007.10.013","article-title":"Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance","volume":"7","author":"Koves","year":"2008","journal-title":"Cell Metab"},{"key":"10.1007\/s12603-018-1062-0_bib10","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","article-title":"A branchedchain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance","volume":"9","author":"Newgard","year":"2009","journal-title":"Cell Metab"},{"key":"10.1007\/s12603-018-1062-0_bib11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.atherosclerosis.2015.05.007","volume":"241","author":"Vlachopoulos","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1007\/s12603-018-1062-0_bib12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/07315724.1998.10720458","article-title":"Age-and sex-related differences of serum carnitine in a Japanese population","volume":"17","author":"Takiyama","year":"1998","journal-title":"J Am Coll Nutr"},{"key":"10.1007\/s12603-018-1062-0_bib13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1053\/j.jrn.2017.01.020","article-title":"The Association Between the Metabolic Syndrome and Metabolic Syndrome Score and Urine Microalbumin\/Urine Creatinine Ratio and Glomerular Filtration Rate in Korean Adults With Obesity","volume":"27","author":"Yoon","year":"2017","journal-title":"J Ren Nutr"},{"key":"10.1007\/s12603-018-1062-0_bib14","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1053\/j.ajkd.2017.05.006","article-title":"Associations of Early Kidney Disease With Brain Magnetic Resonance Imaging and Cognitive Function in African Americans With Type 2 Diabetes Mellitus","volume":"70","author":"Freedman","year":"2017","journal-title":"Am J Kidney Dis"},{"key":"10.1007\/s12603-018-1062-0_bib15","doi-asserted-by":"crossref","unstructured":"Burns, CM, Knopman, DS, Tupper, DE, Davey, CS, Slinin, YM, Lakshminarayan, K, et al, Prevalence and Risk of Severe Cognitive Impairment in Advanced Chronic Kidney Disease, J Gerontol A Biol Sci Med Sci, 2017","DOI":"10.1093\/gerona\/glx241"},{"key":"10.1007\/s12603-018-1062-0_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.nut.2017.01.001","article-title":"Citrulline stimulates locomotor activity in aged rats: Implication of the dopaminergic pathway","volume":"38","author":"Moinard","year":"2017","journal-title":"Nutrition"},{"key":"10.1007\/s12603-018-1062-0_bib17","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1515\/cclm-2011-0846","article-title":"Age-related changes in serum amino acids concentrations in healthy individuals","volume":"50","author":"Kouchiwa","year":"2012","journal-title":"Clin Chem Lab Med"},{"key":"10.1007\/s12603-018-1062-0_bib18","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0140-6736(07)61778-4","article-title":"Blood cholesterol and vascular mortality by age, sex, and blood pressure: a metaanalysis of individual data from 61 prospective studies with 55,000 vascular deaths","volume":"370","author":"Prospective Studies","year":"2007","journal-title":"Lancet"},{"key":"10.1007\/s12603-018-1062-0_bib19","doi-asserted-by":"crossref","first-page":"b92","DOI":"10.1136\/bmj.b92","article-title":"Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis","volume":"338","author":"Briel","year":"2009","journal-title":"BMJ"},{"key":"10.1007\/s12603-018-1062-0_bib20","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.2337\/dc09-1231","article-title":"International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes: response to the International Expert Committee","volume":"32","author":"Kilpatrick","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1007\/s12603-018-1062-0_bib21","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.mad.2011.08.001","article-title":"Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study","volume":"132","author":"Martin-Ruiz","year":"2011","journal-title":"Mech Ageing Dev"},{"key":"10.1007\/s12603-018-1062-0_bib22","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1210\/jc.2005-0872","article-title":"Thyroid hormone concentrations, disease, physical function, and mortality in elderly men","volume":"90","author":"van den Beld","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1007\/s12603-018-1062-0_bib23","doi-asserted-by":"crossref","first-page":"vii","DOI":"10.1111\/j.1749-6632.2009.05394.x","article-title":"Introduction to Aging, Cancer, and Age-related Diseases","volume":"1197","author":"Perry","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1007\/s12603-018-1062-0_bib24","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1182\/blood-2015-01-619981","article-title":"Anemia and ischemia: how low can you go?","volume":"125","author":"Quinn","year":"2015","journal-title":"Blood"},{"key":"10.1007\/s12603-018-1062-0_bib25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000367973","article-title":"Moyamoya syndrome associated with hemoglobin Southampton (Casper)","volume":"49","author":"Delavari","year":"2013","journal-title":"Pediatr Neurosurg"},{"key":"10.1007\/s12603-018-1062-0_bib26","doi-asserted-by":"crossref","unstructured":"Yuan, XM, Ward, LJ, Forssell, C, Siraj, N, Li, W, Carotid Atheroma From Men Has Significantly Higher Levels of Inflammation and Iron Metabolism Enabled by Macrophages, Stroke, 2017","DOI":"10.1161\/STROKEAHA.117.018724"},{"key":"10.1007\/s12603-018-1062-0_bib27","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000431332","article-title":"Aortic stiffness and kidney disease in an elderly population","volume":"41","author":"Michener","year":"2015","journal-title":"Am J Nephrol"},{"key":"10.1007\/s12603-018-1062-0_bib28","first-page":"677","article-title":"Aortic stiffness and change in glomerular filtration rate and albuminuria in older people","volume":"32","author":"Huang","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"10.1007\/s12603-018-1062-0_bib29","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jcmg.2013.11.014","article-title":"Carotid intima-media thickness and plaque in cardiovascular risk assessment","volume":"7","author":"Naqvi","year":"2014","journal-title":"JACC Cardiovasc Imaging"}],"container-title":["The Journal of nutrition, health and aging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12603-018-1062-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-018-1062-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770723010540?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770723010540?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-018-1062-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:51:55Z","timestamp":1761137515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1279770723010540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S1279770723010540"],"URL":"https:\/\/doi.org\/10.1007\/s12603-018-1062-0","relation":{},"ISSN":["1279-7707"],"issn-type":[{"type":"print","value":"1279-7707"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic Biomarkers of Aging and Aging-related Diseases in Chinese Middle-Aged and Elderly Men","name":"articletitle","label":"Article Title"},{"value":"The Journal of nutrition, health and aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12603-018-1062-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 SERDI Publisher.","name":"copyright","label":"Copyright"}]}}