{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T17:30:11Z","timestamp":1776015011911,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":518,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of nutrition, health and aging"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s12603-022-1815-7","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T05:02:36Z","timestamp":1655096556000},"page":"657-662","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modestly Increased Incidence of Ketosis in Caloric Restriction Does not Significantly Alter the Effects of Caloric Restriction"],"prefix":"10.1016","volume":"26","author":[{"given":"B.S.","family":"Ferguson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"McGrail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Francois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew S.","family":"Stratton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s12603-022-1815-7_bib1","first-page":"244e54","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann N Y Acad Sci June"},{"issue":"1","key":"10.1007\/s12603-022-1815-7_bib2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cell.2015.02.020","article-title":"Promoting health and longevity through diet: from model organisms to humans","volume":"161","author":"Fontana","year":"2015","journal-title":"Cell"},{"issue":"1","key":"10.1007\/s12603-022-1815-7_bib3","doi-asserted-by":"crossref","first-page":"E197","DOI":"10.1152\/ajpendo.00102.2007","article-title":"Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial","volume":"293","author":"Fontana","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"13","key":"10.1007\/s12603-022-1815-7_bib4","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1001\/jama.295.13.1539","article-title":"Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial","volume":"295","author":"Heilbronn","year":"2006","journal-title":"JAMA"},{"issue":"1","key":"10.1007\/s12603-022-1815-7_bib5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.atherosclerosis.2008.05.036","article-title":"Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals","volume":"203","author":"Lefevre","year":"2009","journal-title":"Atherosclerosis"},{"issue":"9","key":"10.1007\/s12603-022-1815-7_bib6","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/gerona\/61.9.943","article-title":"One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue","volume":"61","author":"Racette","year":"2006","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"3","key":"10.1007\/s12603-022-1815-7_bib7","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1210\/jc.2006-2184","article-title":"Effect of calorie restriction with or without exercise on body composition and fat distribution","volume":"92","author":"Redman","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1007\/s12603-022-1815-7_bib8","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/ajcn\/84.5.1033","article-title":"Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial","volume":"84","author":"Weiss","year":"2006","journal-title":"Am J Clin Nutr"},{"issue":"8","key":"10.1007\/s12603-022-1815-7_bib9","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0531-5565(01)00107-3","article-title":"Caloric restriction lowers plasma lipoprotein (a) in male but not female rhesus monkeys","volume":"36","author":"Edwards","year":"2001","journal-title":"Exp Gerontol"},{"issue":"4","key":"10.1007\/s12603-022-1815-7_bib10","doi-asserted-by":"crossref","first-page":"E757","DOI":"10.1152\/ajpendo.2001.281.4.E757","article-title":"Dietary restriction and glucose regulation in aging rhesus monkeys: a follow-up report at 8.5 yr","volume":"281","author":"Gresl","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"10.1007\/s12603-022-1815-7_bib11","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.exger.2009.02.008","article-title":"Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates","volume":"44","author":"Rezzi","year":"2009","journal-title":"Exp Gerontol"},{"issue":"11","key":"10.1007\/s12603-022-1815-7_bib12","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.exger.2013.08.002","article-title":"Long-term calorie restriction decreases metabolic cost of movement and prevents decrease of physical activity during aging in rhesus monkeys","volume":"48","author":"Yamada","year":"2013","journal-title":"Exp Gerontol"},{"key":"10.1007\/s12603-022-1815-7_bib13","doi-asserted-by":"crossref","first-page":"14063","DOI":"10.1038\/ncomms14063","article-title":"Caloric restriction improves health and survival of rhesus monkeys","volume":"8","author":"Mattison","year":"2017","journal-title":"Nat Commun"},{"issue":"7","key":"10.1007\/s12603-022-1815-7_bib14","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.18632\/aging.100994","article-title":"Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans","volume":"8","author":"Meydani","year":"2016","journal-title":"Aging (Albany NY)"},{"issue":"6","key":"10.1007\/s12603-022-1815-7_bib19","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/oby.22468","article-title":"Glucose and Lipid Homeostasis and Inflammation in Humans Following an Isocaloric Ketogenic Diet","volume":"27","author":"Rosenbaum","year":"2019","journal-title":"Obesity (Silver Spring)"},{"issue":"9","key":"10.1007\/s12603-022-1815-7_bib23","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/gerona\/glv057","article-title":"A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity","volume":"70","author":"Ravussin","year":"2015","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"4","key":"10.1007\/s12603-022-1815-7_bib24","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3945\/ajcn.116.137232","article-title":"Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans","volume":"105","author":"Das","year":"2017","journal-title":"Am J Clin Nutr"},{"issue":"9","key":"10.1007\/s12603-022-1815-7_bib25","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S2213-8587(19)30151-2","article-title":"2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial","volume":"7","author":"Kraus","year":"2019","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"11","key":"10.1007\/s12603-022-1815-7_bib26","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1249\/MSS.0000000000001353","article-title":"Effects of two years of calorie restriction on aerobic capacity and muscle strength","volume":"49","author":"Racette","year":"2017","journal-title":"Medicine and science in sports and exercise"},{"key":"10.1007\/s12603-022-1815-7_bib27","doi-asserted-by":"crossref","first-page":"101261","DOI":"10.1016\/j.eclinm.2021.101261","article-title":"Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE\u2122 a multicentre, phase 2, randomised controlled trial","volume":"43","author":"Huffman","year":"2022","journal-title":"EClinicalMedicine"},{"issue":"1","key":"10.1007\/s12603-022-1815-7_bib28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/mnfr.201500272","article-title":"The complex immunological and inflammatory network of adipose tissue in obesity","volume":"60","author":"Apostolopoulos","year":"2016","journal-title":"Molecular nutrition & food research"},{"key":"10.1007\/s12603-022-1815-7_bib29","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fcvm.2019.00140","article-title":"The Role of the TGF-\u03b2 Superfamily in Myocardial Infarction","volume":"6","author":"Hanna","year":"2019","journal-title":"Front Cardiovasc Med"},{"issue":"6","key":"10.1007\/s12603-022-1815-7_bib30","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s11357-019-00096-w","article-title":"The enigmatic role of growth hormone in age-related diseases, cognition, and longevity","volume":"41","author":"Colon","year":"2019","journal-title":"Geroscience"},{"key":"10.1007\/s12603-022-1815-7_bib31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2147\/IBPC.S152761","article-title":"White coat syndrome and its variations: differences and clinical impact","volume":"11","author":"Pioli","year":"2018","journal-title":"Integr Blood Press Control"},{"issue":"3","key":"10.1007\/s12603-022-1815-7_bib15","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.cmet.2017.08.005","article-title":"A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice","volume":"26","author":"Roberts","year":"2017","journal-title":"Cell Metab"},{"issue":"3","key":"10.1007\/s12603-022-1815-7_bib16","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.cmet.2017.08.004","article-title":"Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice","volume":"26","author":"Newman","year":"2017","journal-title":"Cell Metab"},{"issue":"2","key":"10.1007\/s12603-022-1815-7_bib17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12031-010-9336-y","article-title":"Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity","volume":"42","author":"Yang","year":"2010","journal-title":"J Mol Neurosci"},{"issue":"7","key":"10.1007\/s12603-022-1815-7_bib18","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1111\/epi.13038","article-title":"Ketogenic diet exhibits anti-inflammatory properties","volume":"56","author":"Dupuis","year":"2015","journal-title":"Epilepsia"},{"key":"10.1007\/s12603-022-1815-7_bib20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41394-018-0121-4","article-title":"Evaluation of a ketogenic diet for improvement of neurological recovery in individuals with acute spinal cord injury: a pilot, randomized safety and feasibility trial","volume":"4","author":"Yarar-Fisher","year":"2018","journal-title":"Spinal Cord Ser Cases"},{"key":"10.1007\/s12603-022-1815-7_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.semcancer.2017.12.011","article-title":"Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma","volume":"56","author":"Poff","year":"2019","journal-title":"Semin Cancer Biol"},{"key":"#cr-split#-10.1007\/s12603-022-1815-7_bib22.1","doi-asserted-by":"crossref","unstructured":"Mihaylova MM and Stratton MS (2019) Short chain fatty acids as epigenetic and metabolic regulators of neurocognitive health and disease. In: Ferguson BS","DOI":"10.1016\/B978-0-12-816843-1.00023-0"},{"key":"#cr-split#-10.1007\/s12603-022-1815-7_bib22.2","unstructured":"(ed) Nutritional Epigenomics, Vol 14 in Translational Epigenetics. 2019. Elsevier Inc, Chapter 23, pp 381-397."}],"container-title":["The Journal of nutrition, health and aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-022-1815-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12603-022-1815-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S127977072300831X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S127977072300831X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12603-022-1815-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:49:29Z","timestamp":1761137369000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S127977072300831X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S127977072300831X"],"URL":"https:\/\/doi.org\/10.1007\/s12603-022-1815-7","relation":{},"ISSN":["1279-7707"],"issn-type":[{"value":"1279-7707","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modestly Increased Incidence of Ketosis in Caloric Restriction Does not Significantly Alter the Effects of Caloric Restriction","name":"articletitle","label":"Article Title"},{"value":"The Journal of nutrition, health and aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12603-022-1815-7","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 SERDI Publisher.","name":"copyright","label":"Copyright"}]}}