{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:52:49Z","timestamp":1773028369168,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2014,6,7]],"date-time":"2014-06-07T00:00:00Z","timestamp":1402099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,6,7]],"date-time":"2014-06-07T00:00:00Z","timestamp":1402099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Can J Anesth\/J Can Anesth"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s12630-014-0190-1","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T16:48:25Z","timestamp":1402073305000},"page":"808-818","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Comparative efficacy of uterotonic agents: in vitro contractions in isolated myometrial strips of labouring and non-labouring women","Efficacit\u00e9 compar\u00e9e des ut\u00e9rotoniques: contractions in vitro d\u2019\u00e9chantillons de myom\u00e8tre isol\u00e9s de femmes en travail d\u2019accouchement ou non"],"prefix":"10.1007","volume":"61","author":[{"given":"Mrinalini","family":"Balki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda","family":"Erik-Soussi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kingdom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose C. A.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,6,7]]},"reference":[{"key":"190_CR1","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/S0140-6736(06)68397-9","volume":"367","author":"KS Khan","year":"2006","unstructured":"Khan KS, Wojdyla D, Say L, Gulmezoglu AM, Van Look PF. WHO analysis of causes of maternal death: a systematic review. Lancet 2006; 367: 1066-74.","journal-title":"Lancet"},{"key":"190_CR2","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S1701-2163(16)34329-8","volume":"31","author":"D Leduc","year":"2009","unstructured":"Leduc D, Senikas V, Lalonde AB, et al. Active management of the third stage of labour: prevention and treatment of postpartum hemorrhage. J Obstet Gynaecol Can 2009; 31: 980-93.","journal-title":"J Obstet Gynaecol Can"},{"key":"190_CR3","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1097\/00006250-200610000-00046","volume":"108","author":"American College of Obstetricians and Gynecologists","year":"2006","unstructured":"American College of Obstetricians and Gynecologists. ACOG Practice Bulletin: Clinical management guidelines for obstetrician-gynecologists number 76, October 2006: postpartum hemorrhage. Obstet Gynecol 2006; 108: 1039-47.","journal-title":"Obstet Gynecol"},{"key":"190_CR4","unstructured":"Royal College of Obstetricians and Gynaecologists. Prevention and Management of Postpartum Haemorrhage. Green-top Guideline No. 52; May 2009. Available from URL: http:\/\/www.rcog.org.uk\/files\/rcog-corp\/GT52PostpartumHaemorrhage0411.pdf (accessed May 2014)."},{"key":"190_CR5","first-page":"CD005456","volume":"2","author":"T Liabsuetrakul","year":"2007","unstructured":"Liabsuetrakul T, Choobun T, Peeyananjarassri K, Islam QM. Prophylactic use of ergot alkaloids in the third stage of labour. Cochrane Database Syst Rev 2007; 2: CD005456.","journal-title":"Cochrane Database Syst Rev"},{"key":"190_CR6","first-page":"CD000494","volume":"3","author":"AM Gulmezoglu","year":"2007","unstructured":"Gulmezoglu AM, Forna F, Villar J, Hofmeyr GJ. Prostaglandins for preventing postpartum haemorrhage. Cochrane Database Syst Rev 2007; 3: CD000494.","journal-title":"Cochrane Database Syst Rev"},{"key":"190_CR7","first-page":"CD003249","volume":"1","author":"HA Mousa","year":"2007","unstructured":"Mousa HA, Alfirevic Z. Treatment for primary postpartum haemorrhage. Cochrane Database Syst Rev 2007; 1: CD003249.","journal-title":"Cochrane Database Syst Rev"},{"key":"190_CR8","first-page":"CD001808","volume":"10","author":"G Westhoff","year":"2013","unstructured":"Westhoff G, Cotter AM, Tolosa JE. Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage. Cochrane Database Syst Rev 2013; 10: CD001808.","journal-title":"Cochrane Database Syst Rev"},{"key":"190_CR9","first-page":"CD000201","volume":"1","author":"S McDonald","year":"2004","unstructured":"McDonald S, Abbott JM, Higgins SP. Prophylactic ergometrine-oxytocin versus oxytocin for the third stage of labour. Cochrane Database Syst Rev 2004; 1: CD000201.","journal-title":"Cochrane Database Syst Rev"},{"key":"190_CR10","doi-asserted-by":"crossref","unstructured":"Grotegut CA, Paglia MJ, Johnson LN, Thames B, James AH. Oxytocin exposure during labour among women with postpartum hemorrhage secondary to uterine atony. Am J Obstet Gynecol 2011; 204: 56.e1-6.","DOI":"10.1016\/j.ajog.2010.08.023"},{"key":"190_CR11","doi-asserted-by":"publisher","first-page":"e000514","DOI":"10.1136\/bmjopen-2011-000514","volume":"1","author":"J Belghiti","year":"2011","unstructured":"Belghiti J, Kayem G, Dupont C, Rudigoz RC, Bouvier-Colle MH, Deneux-Tharaux C. Oxytocin during labour and risk of severe postpartum haemorrhage: a population-based, cohort-nested case-control study. BMJ Open 2011; 1: e000514.","journal-title":"BMJ Open"},{"key":"190_CR12","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1067\/mob.2003.22","volume":"188","author":"C Robinson","year":"2003","unstructured":"Robinson C, Schumann R, Zhang P, Young RC. Oxytocin-induced desensitization of the oxytocin receptor. Am J Obstet Gynecol 2003; 188: 497-502.","journal-title":"Am J Obstet Gynecol"},{"key":"190_CR13","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1677\/joe.0.1540007","volume":"154","author":"S Phaneuf","year":"1997","unstructured":"Phaneuf S, Asboth G, Carrasco MP, et al. The desensitization of oxytocin receptors in human myometrial cells is accompanied by down-regulation of oxytocin receptor messenger RNA. J Endocrinol 1997; 154: 7-18.","journal-title":"J Endocrinol"},{"key":"190_CR14","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1093\/humupd\/4.5.625","volume":"4","author":"S Phaneuf","year":"1998","unstructured":"Phaneuf S, Asboth G, Carrasco MP, et al. Desensitization of oxytocin receptors in human myometrium. Hum Reprod Update 1998; 4: 625-33.","journal-title":"Hum Reprod Update"},{"key":"190_CR15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1530\/reprod\/120.1.91","volume":"120","author":"S Phaneuf","year":"2000","unstructured":"Phaneuf S, Rodriguez Linares B, TambyRaja RL, MacKenzie IZ, Lopez Bernal A. Loss of myometrial oxytocin receptors during oxytocin-induced and oxytocin-augmented labour. J Reprod Fertil 2000; 120: 91-7.","journal-title":"J Reprod Fertil"},{"key":"190_CR16","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1177\/1933719112438971","volume":"19","author":"M Balki","year":"2012","unstructured":"Balki M, Kanwal N, Erik-Soussi M, Kingdom J, Carvalho JC. Contractile efficacy of various prostaglandins in pregnant rat myometrium pretreated with oxytocin. Reprod Sci 2012; 19: 968-75.","journal-title":"Reprod Sci"},{"key":"190_CR17","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1177\/1933719108329954","volume":"16","author":"JK Magalhaes","year":"2009","unstructured":"Magalhaes JK, Carvalho JC, Parkes RK, Kingdom J, Li Y, Balki M. Oxytocin pretreatment decreases oxytocin-induced myometrial contractions in pregnant rats in a concentration-dependent but not time-dependent manner. Reprod Sci 2009; 16: 501-8.","journal-title":"Reprod Sci"},{"key":"190_CR18","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1177\/1933719109351934","volume":"17","author":"M Balki","year":"2010","unstructured":"Balki M, Cristian AL, Kingdom J, Carvalho JC. Oxytocin pretreatment of pregnant rat myometrium reduces the efficacy of oxytocin but not of ergonovine maleate or prostaglandin F 2 alpha. Reprod Sci 2010; 17: 269-77.","journal-title":"Reprod Sci"},{"key":"190_CR19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/physrev.2001.81.2.629","volume":"81","author":"G Gimpl","year":"2001","unstructured":"Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev 2001; 81: 629-83.","journal-title":"Physiol Rev"},{"key":"190_CR20","doi-asserted-by":"publisher","first-page":"523","DOI":"10.2165\/00003495-199856040-00002","volume":"56","author":"AN de Groot","year":"1998","unstructured":"de Groot AN, van Dongen PW, Vree TB, Hekster YA, van Roosmalen J. Ergot alkaloids. Current status and review of clinical pharmacology and therapeutic use compared with other oxytocics in obstetrics and gynaecology. Drugs 1998; 56: 523-35.","journal-title":"Drugs"},{"key":"190_CR21","first-page":"421","volume":"395","author":"MA Mirando","year":"1995","unstructured":"Mirando MA, Prince BC, Tysseling KA, et al. A proposed role for oxytocin in regulation of endometrial prostaglandin F2 alpha secretion during luteolysis in swine. Adv Exp Med Biol 1995; 395: 421-33.","journal-title":"Adv Exp Med Biol"},{"key":"190_CR22","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1111\/j.1471-0528.2005.00658.x","volume":"112","author":"AM Friel","year":"2005","unstructured":"Friel AM, O\u2019Reilly MW, Sexton DJ, Morrison JJ. Specific PGF(2alpha) receptor (FP) antagonism and human uterine contractility in vitro. BJOG 2005; 112: 1034-42.","journal-title":"BJOG"},{"key":"190_CR23","first-page":"426","volume":"58","author":"RH Hayashi","year":"1981","unstructured":"Hayashi RH, Castillo MS, Noah ML. Management of severe postpartum hemorrhage due to uterine atony using an analogue of prostaglandin F2 alpha. Obstet Gynecol 1981; 58: 426-9.","journal-title":"Obstet Gynecol"},{"key":"190_CR24","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0010-7824(76)80042-X","volume":"13","author":"N Takaki","year":"1976","unstructured":"Takaki N, Tredway D, Toomer P, Murray W, Daane T. Therapeutic abortion of early human gestation with intramuscular 15-methyl prostaglandin F2 alpha. Contraception 1976; 13: 319-32.","journal-title":"Contraception"},{"issue":"Suppl 2","key":"190_CR25","doi-asserted-by":"publisher","first-page":"S160","DOI":"10.1016\/j.ijgo.2007.09.004","volume":"99","author":"OS Tang","year":"2007","unstructured":"Tang OS, Gemzell-Danielsson K, Ho PC. Misoprostol: pharmacokinetic profiles, effects on the uterus and side-effects. Int J Gynaecol Obstet 2007; 99(Suppl 2): S160-7.","journal-title":"Int J Gynaecol Obstet"},{"key":"190_CR26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0031-6997(25)06784-5","volume":"46","author":"RA Coleman","year":"1994","unstructured":"Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 1994; 46: 205-29.","journal-title":"Pharmacol Rev"},{"key":"190_CR27","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1054\/ijoa.2002.0970","volume":"11","author":"AJ Pinder","year":"2002","unstructured":"Pinder AJ, Dresner M, Calow C, Shorten GD, O\u2019Riordan J, Johnson R. Haemodynamic changes caused by oxytocin during caesarean section under spinal anaesthesia. Int J Obstet Anesth 2002; 11: 156-9.","journal-title":"Int J Obstet Anesth"},{"key":"190_CR28","doi-asserted-by":"crossref","first-page":"C81","DOI":"10.1152\/ajpcell.1980.238.3.C81","volume":"238","author":"RE Garfield","year":"1980","unstructured":"Garfield RE, Kannan MS, Daniel EE. Gap junction formation in myometrium: control by estrogens, progesterone, and prostaglandins. Am J Physiol 1980; 238: C81-9.","journal-title":"Am J Physiol"},{"key":"190_CR29","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/0002-9378(84)90677-X","volume":"150","author":"AR Fuchs","year":"1984","unstructured":"Fuchs AR, Fuchs F, Husslein P, Soloff MS. Oxytocin receptors in the human uterus during pregnancy and parturition. Am J Obstet Gynecol 1984; 150: 734-41.","journal-title":"Am J Obstet Gynecol"},{"key":"190_CR30","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1097\/ALN.0b013e318297d347","volume":"119","author":"M Balki","year":"2013","unstructured":"Balki M, Erik-Soussi M, Kingdom J, Carvalho JC. Oxytocin pretreatment attenuates oxytocin-induced contractions in human myometrium in vitro. Anesthesiology 2013; 119: 552-61.","journal-title":"Anesthesiology"},{"key":"190_CR31","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1097\/01.AOG.0000191529.52596.c0","volume":"107","author":"M Balki","year":"2006","unstructured":"Balki M, Ronayne M, Davies S, et al. Minimum oxytocin dose requirement after cesarean delivery for labor arrest. Obstet Gynecol 2006; 107: 45-50.","journal-title":"Obstet Gynecol"},{"key":"190_CR32","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1097\/01.AOG.0000142709.04450.bd","volume":"104","author":"JC Carvalho","year":"2004","unstructured":"Carvalho JC, Balki M, Kingdom J, Windrim R. Oxytocin requirements at elective cesarean delivery: a dose-finding study. Obstet Gynecol 2004; 104: 1005-10.","journal-title":"Obstet Gynecol"},{"key":"190_CR33","first-page":"1215","volume":"20","author":"JM Crane","year":"1998","unstructured":"Crane JM, Young DC. Meta-analysis of low-dose versus high-dose oxytocin for labour induction. J Soc Obstet Gynaecol Can 1998; 20: 1215-23.","journal-title":"J Soc Obstet Gynaecol Can"},{"key":"190_CR34","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1111\/j.1467-9280.2007.02010.x","volume":"18","author":"R Feldman","year":"2007","unstructured":"Feldman R, Weller A, Zagoory-Sharon O, Levine A. Evidence for a neuroendocrinological foundation of human affiliation: plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding. Psychol Sci 2007; 18: 965-70.","journal-title":"Psychol Sci"},{"key":"190_CR35","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0002-9378(84)90355-7","volume":"150","author":"J Seitchik","year":"1984","unstructured":"Seitchik J, Amico J, Robinson AG, Castillo M. Oxytocin augmentation of dysfunctional labor. IV. Oxytocin pharmacokinetics. Am J Obstet Gynecol 1984; 150: 225-8.","journal-title":"Am J Obstet Gynecol"},{"key":"190_CR36","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/BF00931436","volume":"241","author":"Y Kuwabara","year":"1987","unstructured":"Kuwabara Y, Takeda S, Mizuno M, Sakamoto S. Oxytocin levels in maternal and fetal plasma, amniotic fluid, and neonatal plasma and urine. Arch Gynecol Obstet 1987; 241: 13-23.","journal-title":"Arch Gynecol Obstet"},{"key":"190_CR37","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1034\/j.1600-0412.2002.811107.x","volume":"81","author":"VA Rahm","year":"2002","unstructured":"Rahm VA, Hallgren A, Hogberg H, Hurtig I, Odlind V. Plasma oxytocin levels in women during labor with or without epidural analgesia: a prospective study. Acta Obstet Gynecol Scand 2002; 81: 1033-9.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"190_CR38","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.ijoa.2011.03.004","volume":"20","author":"ET Yamaguchi","year":"2011","unstructured":"Yamaguchi ET, Cardoso MM, Torres ML, et al. Serum oxytocin concentrations in elective caesarean delivery: a randomized comparison of three infusion regimens. Int J Obstet Anesth 2011; 20: 224-8.","journal-title":"Int J Obstet Anesth"},{"key":"190_CR39","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0378-4347(00)84211-5","volume":"226","author":"PO Edlund","year":"1981","unstructured":"Edlund PO. Determination of ergot alkaloids in plasma by high-performance liquid chromatography and fluorescence detection. J Chromatogr 1981; 226: 107-15.","journal-title":"J Chromatogr"},{"key":"190_CR40","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1177\/0091270007309707","volume":"48","author":"BL Powers","year":"2008","unstructured":"Powers BL, Wing DA, Carr D, Ewert K, Di Spirito M. Pharmacokinetic profiles of controlled-release hydrogel polymer vaginal inserts containing misoprostol. J Clin Pharmacol 2008; 48: 26-34.","journal-title":"J Clin Pharmacol"},{"key":"190_CR41","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jsgi.2005.10.004","volume":"13","author":"WF Rayburn","year":"2006","unstructured":"Rayburn WF, Powers BL, Plasse TF, Carr D, Di Spirito M. Pharmacokinetics of a controlled-release misoprostol vaginal insert at term. J Soc Gynecol Investig 2006; 13: 112-7.","journal-title":"J Soc Gynecol Investig"},{"key":"190_CR42","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/S1521-6934(03)00043-9","volume":"17","author":"M Bygdeman","year":"2003","unstructured":"Bygdeman M. Pharmacokinetics of prostaglandins. Best Pract Res Clin Obstet Gynaecol 2003; 17: 707-16.","journal-title":"Best Pract Res Clin Obstet Gynaecol"}],"container-title":["Canadian Journal of Anesthesia\/Journal canadien d'anesth\u00e9sie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12630-014-0190-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12630-014-0190-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12630-014-0190-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12630-014-0190-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T07:42:08Z","timestamp":1746258128000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12630-014-0190-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,7]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["190"],"URL":"https:\/\/doi.org\/10.1007\/s12630-014-0190-1","relation":{},"ISSN":["0832-610X","1496-8975"],"issn-type":[{"value":"0832-610X","type":"print"},{"value":"1496-8975","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,7]]},"assertion":[{"value":"11 December 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}