{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:05:25Z","timestamp":1781003125878,"version":"3.54.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000241","name":"Physicians' Services Incorporated Foundation","doi-asserted-by":"publisher","award":["r13-49"],"award-info":[{"award-number":["r13-49"]}],"id":[{"id":"10.13039\/501100000241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Can J Anesth\/J Can Anesth"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s12630-017-0814-3","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T20:49:23Z","timestamp":1486154963000},"page":"385-395","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["A randomized-controlled trial of nabilone for the prevention of acute postoperative nausea and vomiting in elective surgery","Une \u00e9tude randomis\u00e9e contr\u00f4l\u00e9e pour \u00e9valuer l\u2019efficacit\u00e9 du nabilone pour la pr\u00e9vention des naus\u00e9es et vomissements postop\u00e9ratoires aigus lors de chirurgie non urgente"],"prefix":"10.1007","volume":"64","clinical-trial-number":[{"clinical-trial-number":"nct02115529","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"David Neville","family":"Levin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Dulberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Wen","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M. T.","family":"Hare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. David","family":"Mazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,3]]},"reference":[{"key":"814_CR1","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1001\/jama.287.10.1233","volume":"287","author":"TJ Gan","year":"2002","unstructured":"Gan TJ. Postoperative nausea and vomiting\u2013can it be eliminated? JAMA 2002; 287: 1233-6.","journal-title":"JAMA"},{"key":"814_CR2","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1097\/00000542-199909000-00022","volume":"91","author":"CC Apfel","year":"1999","unstructured":"Apfel CC, Laara E, Koivuranta M, Greim CA, Roewer N. A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. Anesthesiology 1999; 91: 693-700.","journal-title":"Anesthesiology"},{"key":"814_CR3","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1007\/BF03012088","volume":"45","author":"J Fortier","year":"1998","unstructured":"Fortier J, Chung F, Su J. Unanticipated admission after ambulatory surgery\u2013a prospective study. Can J Anaesth 1998; 45: 612-9.","journal-title":"Can J Anaesth"},{"key":"814_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/MJT.0b013e3181e7a512","volume":"19","author":"R Dzwonczyk","year":"2012","unstructured":"Dzwonczyk R, Weaver TE, Puente EG, Bergese SD. Postoperative nausea and vomiting prophylaxis from an economic point of view. Am J Ther 2012; 19: 11-5.","journal-title":"Am J Ther"},{"key":"814_CR5","first-page":"493","volume":"22","author":"D Gupta","year":"2014","unstructured":"Gupta D, Haber H. Emetogenicity-risk procedures in same day surgery center of an academic university hospital in United States: a retrospective cost-audit of postoperative nausea vomiting management. Middle East J Anaesthesiol 2014; 22: 493-502.","journal-title":"Middle East J Anaesthesiol"},{"key":"814_CR6","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1007\/s12630-011-9660-x","volume":"59","author":"I Parra-Sanchez","year":"2012","unstructured":"Parra-Sanchez I, Abdallah R, You J, et al. A time-motion economic analysis of postoperative nausea and vomiting in ambulatory surgery. Can J Anesth 2012; 59: 366-75.","journal-title":"Can J Anesth"},{"key":"814_CR7","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1517\/14740338.2013.780026","volume":"12","author":"SA Doggrell","year":"2013","unstructured":"Doggrell SA, Hancox JC. Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia. Expert Opin Drug Saf 2013; 12: 421-31.","journal-title":"Expert Opin Drug Saf"},{"key":"814_CR8","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1111\/j.1526-4637.2012.01406.x","volume":"13","author":"C Spevak","year":"2012","unstructured":"Spevak C, Hamsher C, Brown CQ, Wedam EF, Haigney MC. The clinical significance of QT interval prolongation in anesthesia and pain management: what you should and should not worry about. Pain Med 2012; 13: 1072-80.","journal-title":"Pain Med"},{"key":"814_CR9","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1007\/s12630-016-0598-x","volume":"63","author":"P Beaulieu","year":"2016","unstructured":"Beaulieu P, Boulanger A, Desroches J, Clark AJ. Medical cannabis: considerations for the anesthesiologist and pain physician. Can J Anesth 2016; 63: 608-24.","journal-title":"Can J Anesth"},{"key":"814_CR10","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.ejphar.2013.09.068","volume":"722","author":"KA Sharkey","year":"2014","unstructured":"Sharkey KA, Darmani NA, Parker LA. Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system. Eur J Pharmacol 2014; 722: 134-46.","journal-title":"Eur J Pharmacol"},{"key":"814_CR11","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1136\/bmj.323.7303.16","volume":"323","author":"MR Tramer","year":"2001","unstructured":"Tramer MR, Carroll D, Campbell FA, Reynolds DJ, Moore RA, McQuay HJ. Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. BMJ 2001; 323: 16-21.","journal-title":"BMJ"},{"key":"814_CR12","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2147\/TCRM.S1132","volume":"4","author":"MA Ware","year":"2008","unstructured":"Ware MA, Daeninck P, Maida V. A review of nabilone in the treatment of chemotherapy-induced nausea and vomiting. Ther Clin Risk Manag 2008; 4: 99-107.","journal-title":"Ther Clin Risk Manag"},{"key":"814_CR13","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.2174\/092986710790980050","volume":"17","author":"RG Pertwee","year":"2010","unstructured":"Pertwee RG. Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists. Curr Med Chem 2010; 17: 1360-81.","journal-title":"Curr Med Chem"},{"key":"814_CR14","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1097\/MJT.0b013e3181ea7821","volume":"17","author":"ES Hsu","year":"2010","unstructured":"Hsu ES. A review of granisetron, 5-hydroxytryptamine3 receptor antagonists, and other antiemetics. Am J Ther 2010; 17: 476-86.","journal-title":"Am J Ther"},{"key":"814_CR15","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1093\/bja\/aes276","volume":"109","author":"CC Apfel","year":"2012","unstructured":"Apfel CC, Heidrich FM, Jukar-Rao S, et al. Evidence-based analysis of risk factors for postoperative nausea and vomiting. Br J Anaesth 2012; 109: 742-53.","journal-title":"Br J Anaesth"},{"key":"814_CR16","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1001\/jama.1961.03040420001001","volume":"178","author":"RD Dripps","year":"1961","unstructured":"Dripps RD, Lamont A, Eckenhoff JE. The role of anesthesia in surgical mortality. JAMA 1961; 178: 261-6.","journal-title":"JAMA"},{"key":"814_CR17","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s12916-015-0371-y","volume":"13","author":"AC Tricco","year":"2015","unstructured":"Tricco AC, Soobiah C, Blondal E, et al. Comparative efficacy of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis. BMC Med 2015; 13: 136.","journal-title":"BMC Med"},{"key":"814_CR18","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s00520-006-0186-7","volume":"15","author":"K Jordan","year":"2007","unstructured":"Jordan K, Hinke A, Grothey A, et al. A meta-analysis comparing the efficacy of four 5-HT3-receptor antagonists for acute chemotherapy-induced emesis. Support Care Cancer 2007; 15: 1023-33.","journal-title":"Support Care Cancer"},{"key":"814_CR19","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1093\/bja\/aer505","volume":"108","author":"PS Myles","year":"2012","unstructured":"Myles PS, Wengritzky R. Simplified postoperative nausea and vomiting impact scale for audit and post-discharge review. Br J Anaesth 2012; 108: 423-9.","journal-title":"Br J Anaesth"},{"key":"814_CR20","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1097\/j.pain.0000000000000382","volume":"157","author":"JM Chauny","year":"2016","unstructured":"Chauny JM, Paquet J, Lavigne G, Marquis M, Daoust R. Evaluating acute pain intensity relief: challenges when using an 11-point numerical rating scale. Pain 2016; 157: 355-60.","journal-title":"Pain"},{"key":"814_CR21","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/S1089-9472(98)80044-0","volume":"13","author":"JA Aldrete","year":"1998","unstructured":"Aldrete JA. Modifications to the postanesthesia score for use in ambulatory surgery. Journal of perianesthesia nursing: official journal of the American Society of PeriAnesthesia Nurses \/ American Society of PeriAnesthesia Nurses 1998; 13: 148-55.","journal-title":"Journal of perianesthesia nursing: official journal of the American Society of PeriAnesthesia Nurses \/ American Society of PeriAnesthesia Nurses"},{"key":"814_CR22","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1056\/NEJMoa032196","volume":"350","author":"CC Apfel","year":"2004","unstructured":"Apfel CC, Korttila K, Abdalla M, et al. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med 2004; 350: 2441-51.","journal-title":"N Engl J Med"},{"key":"814_CR23","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1093\/bja\/73.2.244","volume":"73","author":"IH Lewis","year":"1994","unstructured":"Lewis IH, Campbell DN, Barrowcliffe MP. Effect of nabilone on nausea and vomiting after total abdominal hysterectomy. Br J Anaesth 1994; 73: 244-6.","journal-title":"Br J Anaesth"},{"key":"814_CR24","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.amjsurg.2005.07.040","volume":"191","author":"R Layeeque","year":"2006","unstructured":"Layeeque R, Siegel E, Kass R, et al. Prevention of nausea and vomiting following breast surgery. Am J Surg 2006; 191: 767-72.","journal-title":"Am J Surg"},{"key":"814_CR25","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1213\/ANE.0000000000000877","volume":"121","author":"M Kleine-Brueggeney","year":"2015","unstructured":"Kleine-Brueggeney M, Greif R, Brenneisen R, Urwyler N, Stueber F, Theiler LG. Intravenous delta-9-tetrahydrocannabinol to prevent postoperative nausea and vomiting: a randomized controlled trial. Anesth Analg 2015; 121: 1157-64.","journal-title":"Anesth Analg"},{"key":"814_CR26","doi-asserted-by":"crossref","unstructured":"Einhorn L. Nabilone: an effective antiemetic agent in patients receiving cancer chemotherapy. Cancer Treat Rev 1982; 9 Suppl B: 55-61.","DOI":"10.1016\/S0305-7372(82)80037-6"},{"key":"814_CR27","doi-asserted-by":"crossref","unstructured":"Jones SE, Durant JR, Greco FA, Robertone A. A multi-institutional phase III study of nabilone vs. placebo in chemotherapy-induced nausea and vomiting. Cancer Treat Rev 1982; 9 Suppl B: 45-8.","DOI":"10.1016\/S0305-7372(82)80035-2"},{"key":"814_CR28","doi-asserted-by":"crossref","unstructured":"Levitt M. Nabilone vs. placebo in the treatment of chemotherapy-induced nausea and vomiting in cancer patients. Cancer Treat Rev 1982; 9 Suppl B: 49-53.","DOI":"10.1016\/S0305-7372(82)80036-4"},{"key":"814_CR29","doi-asserted-by":"crossref","unstructured":"Wada JK, Bogdon DL, Gunnell JC, Hum GJ, Gota CH, Rieth TE. Double-blind, randomized, crossover trial of nabilone vs. placebo in cancer chemotherapy. Cancer Treat Rev 1982; 9 Suppl B: 39-44.","DOI":"10.1016\/S0305-7372(82)80034-0"},{"key":"814_CR30","unstructured":"Valeant Canada Limit\u00e9e\/Limited. Product monograph, Nabilone; submission control no: 124406. 2009. Available from URL: http:\/\/www.editorialmanager.com\/caan\/download.aspx?id=90945&guid={A1DB26F5-FE4C-49F7-AA37-99FB10C2E271}&scheme=1 (accessed November 2016)."},{"key":"814_CR31","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s12871-015-0100-2","volume":"15","author":"XX Wang","year":"2015","unstructured":"Wang XX, Zhou Q, Pan DB, et al. Dexamethasone versus ondansetron in the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery: a meta-analysis of randomized controlled trials. BMC Anesthesiol 2015; 15: 118.","journal-title":"BMC Anesthesiol"},{"key":"814_CR32","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/978-3-662-46450-2_7","volume":"227","author":"SG Woodhams","year":"2015","unstructured":"Woodhams SG, Sagar DR, Burston JJ, Chapman V. The role of the endocannabinoid system in pain. Hand Exp Pharmacol 2015; 227: 119-43.","journal-title":"Hand Exp Pharmacol"},{"key":"814_CR33","first-page":"13","volume":"323","author":"FA Campbell","year":"2001","unstructured":"Campbell FA, Tramer MR, Carroll D, Reynolds DJ, Moore RA, McQuay HJ. Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review. BMJ 2001; 323: 13-6.","journal-title":"A qualitative systematic review. BMJ"}],"container-title":["Canadian Journal of Anesthesia\/Journal canadien d'anesth\u00e9sie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12630-017-0814-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12630-017-0814-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12630-017-0814-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T16:45:24Z","timestamp":1628613924000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12630-017-0814-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,3]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["814"],"URL":"https:\/\/doi.org\/10.1007\/s12630-017-0814-3","relation":{},"ISSN":["0832-610X","1496-8975"],"issn-type":[{"value":"0832-610X","type":"print"},{"value":"1496-8975","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,3]]},"assertion":[{"value":"3 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}