{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:31:27Z","timestamp":1790188287940,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Can J Anesth\/J Can Anesth"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s12630-022-02339-5","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T21:02:50Z","timestamp":1665608570000},"page":"1459-1470","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Association of intraoperative dexmedetomidine use with postoperative hypotension in unilateral hip and knee arthroplasties: a historical cohort study","Association entre l\u2019utilisation perop\u00e9ratoire de dexm\u00e9d\u00e9tomidine et l\u2019hypotension postop\u00e9ratoire dans les arthroplasties unilat\u00e9rales de la hanche et du genou\u00a0: une \u00e9tude de cohorte historique"],"prefix":"10.1007","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3859-5110","authenticated-orcid":false,"given":"Stephen Su","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Gelinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Yim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy M. J.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Kardash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jed","family":"Lipes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"2339_CR1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.bja.2019.05.042","volume":"123","author":"SG Memtsoudis","year":"2019","unstructured":"Memtsoudis SG, Cozowicz C, Bekeris J, et al. Anaesthetic care of patients undergoing primary hip and knee arthroplasty: consensus recommendations from the International Consensus on Anaesthesia-Related Outcomes after Surgery group (ICAROS) based on a systematic review and meta-analysis. Br J Anaesth 2019; 123: 269\u201387. https:\/\/doi.org\/10.1016\/j.bja.2019.05.042","journal-title":"Br J Anaesth"},{"key":"2339_CR2","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1097\/aln.0b013e318286061d","volume":"118","author":"SG Memtsoudis","year":"2013","unstructured":"Memtsoudis SG, Sun X, Chiu YL, et al. Perioperative comparative effectiveness of anesthetic technique in orthopedic patients. Anesthesiology 2013; 118: 1046\u201358. https:\/\/doi.org\/10.1097\/aln.0b013e318286061d","journal-title":"Anesthesiology"},{"key":"2339_CR3","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1213\/ane.0000000000003315","volume":"129","author":"HJ Shin","year":"2019","unstructured":"Shin HJ, Do SH, Lee JS, Kim TK, Na HS. Comparison of intraoperative sedation with dexmedetomidine versus propofol on acute postoperative pain in total knee arthroplasty under spinal anesthesia: a randomized trial. Anesth Analg 2019; 129: 1512\u20138. https:\/\/doi.org\/10.1213\/ane.0000000000003315","journal-title":"Anesth Analg"},{"key":"2339_CR4","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s12630-016-0597-y","volume":"63","author":"IA Chan","year":"2016","unstructured":"Chan IA, Maslany JG, Gorman KJ, O'Brien JM, McKay WP. Dexmedetomidine during total knee arthroplasty performed under spinal anesthesia decreases opioid use: a randomized-controlled trial. Can J Anesth 2016; 63: 569\u201376. https:\/\/doi.org\/10.1007\/s12630-016-0597-y","journal-title":"Can J Anesth"},{"key":"2339_CR5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3928\/01477447-20181023-04","volume":"41","author":"C Lee","year":"2018","unstructured":"Lee C, Lee J, Lee G, Lee H, Koh E, Hwang J. Pregabalin and dexmedetomidine combined for pain after total knee arthroplasty or total hip arthroplasty performed under spinal anesthesia. Orthopedics 2018; 41: 365\u201370. https:\/\/doi.org\/10.3928\/01477447-20181023-04","journal-title":"Orthopedics"},{"key":"2339_CR6","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1097\/ajp.0000000000000605","volume":"34","author":"B Mei","year":"2018","unstructured":"Mei B, Meng G, Xu G, et al. Intraoperative sedation with dexmedetomidine is superior to propofol for elderly patients undergoing hip arthroplasty: a prospective randomized controlled study. Clin J Pain 2018; 34: 811\u20137. https:\/\/doi.org\/10.1097\/ajp.0000000000000605","journal-title":"Clin J Pain"},{"key":"2339_CR7","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1213\/ane.0000000000005843","volume":"134","author":"JC Sin","year":"2022","unstructured":"Sin JC, Tabah A, Campher MJ, Laupland KB, Eley VA. The effect of dexmedetomidine on postanesthesia care unit discharge and recovery: a systematic review and meta-analysis. Anesth Analg 2022; 134: 1229\u201344. https:\/\/doi.org\/10.1213\/ane.0000000000005843","journal-title":"Anesth Analg"},{"key":"2339_CR8","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s40262-017-0507-7","volume":"56","author":"MA Weerink","year":"2017","unstructured":"Weerink MA, Struys M, Hannivoort LN, Barends CR, Absalom AR, Colin P. Clinical pharmacokinetics and pharmacodynamics of dexmedetomidine. Clin Pharmacokinet 2017; 56: 893\u2013913. https:\/\/doi.org\/10.1007\/s40262-017-0507-7","journal-title":"Clin Pharmacokinet"},{"key":"2339_CR9","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1016\/s0140-6736(08)60601-7","volume":"371","author":"PJ Devereaux","year":"2008","unstructured":"POISE Study Group, Devereaux PJ, Yang H, et al. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet 2008; 371: 1839\u201347. https:\/\/doi.org\/10.1016\/s0140-6736(08)60601-7","journal-title":"Lancet"},{"key":"2339_CR10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/aln.0000000000001404","volume":"126","author":"PS Roshanov","year":"2017","unstructured":"Roshanov PS, Rochwerg B, Patel A, et al. Withholding versus continuing angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers before noncardiac surgery: an analysis of the vascular events in noncardiac surgery patients cohort evaluation prospective cohort. Anesthesiology 2017; 126: 16\u201327. https:\/\/doi.org\/10.1097\/aln.0000000000001404","journal-title":"Anesthesiology"},{"key":"2339_CR11","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/s0140-6736(07)61602-x","volume":"370","author":"E von Elm","year":"2007","unstructured":"von Elm E, Altman DG, Egger M, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 2007; 370: 1453\u20137. https:\/\/doi.org\/10.1016\/s0140-6736(07)61602-x","journal-title":"Lancet"},{"key":"2339_CR12","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jclinepi.2014.11.010","volume":"68","author":"GS Collins","year":"2015","unstructured":"Collins GS, Reitsma JB, Altman DG, Moons KG. Transparent reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD): the TRIPOD statement. J Clin Epidemiol 2015; 68: 134\u201343. https:\/\/doi.org\/10.1016\/j.jclinepi.2014.11.010","journal-title":"J Clin Epidemiol"},{"key":"2339_CR13","doi-asserted-by":"publisher","first-page":"276","DOI":"10.11613\/BM.2012.031","volume":"22","author":"ML McHugh","year":"2012","unstructured":"McHugh ML. Interrater reliability: the kappa statistic. Biochem Med (Zagreb) 2012; 22: 276\u201382.","journal-title":"Biochem Med (Zagreb)"},{"key":"2339_CR14","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1016\/j.csda.2010.04.005","volume":"54","author":"IR White","year":"2010","unstructured":"White IR, Daniel R, Royston P. Avoiding bias due to perfect prediction in multiple imputation of incomplete categorical variables. Comput Stat Data Anal 2010; 54: 2267\u201375. https:\/\/doi.org\/10.1016\/j.csda.2010.04.005","journal-title":"Comput Stat Data Anal"},{"key":"2339_CR15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/0049124197026001001","volume":"26","author":"LR Landerman","year":"1997","unstructured":"Landerman LR, Land KC, Pieper CF. An empirical evaluation of the predictive mean matching method for imputing missing values. Sociol Methods Res 1997; 26: 3\u201333.","journal-title":"Sociol Methods Res"},{"key":"2339_CR16","doi-asserted-by":"publisher","first-page":"b604","DOI":"10.1136\/bmj.b604","volume":"338","author":"P Royston","year":"2009","unstructured":"Royston P, Moons KG, Altman DG, Vergouwe Y. Prognosis and prognostic research: developing a prognostic model. BMJ 2009; 338: b604. https:\/\/doi.org\/10.1136\/bmj.b604","journal-title":"BMJ"},{"key":"2339_CR17","doi-asserted-by":"publisher","first-page":"575","DOI":"10.4097\/kjae.2015.68.6.575","volume":"68","author":"KH Ko","year":"2015","unstructured":"Ko KH, Jun IJ, Lee S, Lim Y, Yoo B, Kim KM. Effective dose of dexmedetomidine to induce adequate sedation in elderly patients under spinal anesthesia. Korean J Anesthesiol 2015; 68: 575\u201380. https:\/\/doi.org\/10.4097\/kjae.2015.68.6.575","journal-title":"Korean J Anesthesiol"},{"key":"2339_CR18","doi-asserted-by":"publisher","first-page":"h2622","DOI":"10.1136\/bmj.h2622","volume":"350","author":"JM Bland","year":"2015","unstructured":"Bland JM, Altman DG. Statistics notes: bootstrap resampling methods. BMJ 2015; 350: h2622. https:\/\/doi.org\/10.1136\/bmj.h2622","journal-title":"BMJ"},{"key":"2339_CR19","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-19425-7","volume-title":"Regression Modeling Strategies: With Applications to Linear Models, Logistic and Ordinal Regression, and Survival Analysis","author":"FE Harrell Jr","year":"2015","unstructured":"Harrell FE Jr. Regression Modeling Strategies: With Applications to Linear Models, Logistic and Ordinal Regression, and Survival Analysis, 2nd ed. New York: Springer; 2015.","edition":"2"},{"key":"2339_CR20","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s12630-021-02167-z","volume":"69","author":"L Leung","year":"2022","unstructured":"Leung L, Lee LH, Lee B, Chau A, Wang EH. The safety of high-dose dexmedetomidine after cardiac surgery: a historical cohort study. Can J Anesth 2022; 69: 323\u201332. https:\/\/doi.org\/10.1007\/s12630-021-02167-z","journal-title":"Can J Anesth"},{"key":"2339_CR21","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2344\/0003-3006-62.1.31","volume":"62","author":"JA Giovannitti Jr","year":"2015","unstructured":"Giovannitti JA Jr, Thoms SM, Crawford JJ. Alpha-2 adrenergic receptor agonists: a review of current clinical applications. Anesth Prog 2015; 62: 31\u20139. https:\/\/doi.org\/10.2344\/0003-3006-62.1.31","journal-title":"Anesth Prog"},{"key":"2339_CR22","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.artd.2021.05.020","volume":"11","author":"CL Herndon","year":"2021","unstructured":"Herndon CL, Levitsky MM, Ezuma C, Sarpong NO, Shah RP, Cooper HJ. Lower dosing of bupivacaine spinal anesthesia is not associated with improved perioperative outcomes after total joint arthroplasty. Arthroplast Today 2021; 11: 6\u20139. https:\/\/doi.org\/10.1016\/j.artd.2021.05.020","journal-title":"Arthroplast Today"},{"key":"2339_CR23","volume-title":"Advanced Trauma Life Support (Student Manual)","author":"American College of Surgeons Committee on Trauma","year":"2018","unstructured":"American College of Surgeons Committee on Trauma. Advanced Trauma Life Support (Student Manual). Chicago: American College of Surgeons; 2018."},{"key":"2339_CR24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.4103\/2229-516x.136788","volume":"4","author":"SV Reddy","year":"2014","unstructured":"Reddy SV, Balaji D, Ahmed SN. Dexmedetomidine versus esmolol to attenuate the hemodynamic response to laryngoscopy and tracheal intubation: a randomized double-blind clinical study. Int J Appl Basic Med Res 2014; 4: 95\u2013100. https:\/\/doi.org\/10.4103\/2229-516x.136788","journal-title":"Int J Appl Basic Med Res"},{"key":"2339_CR25","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1097\/aln.0000000000003725","volume":"134","author":"H Beloeil","year":"2021","unstructured":"Beloeil H, Garot M, Lebuffe G, et al. Balanced opioid-free anesthesia with dexmedetomidine versus balanced anesthesia with remifentanil for major or intermediate noncardiac surgery. Anesthesiology 2021; 134: 541\u201351. https:\/\/doi.org\/10.1097\/aln.0000000000003725","journal-title":"Anesthesiology"},{"key":"2339_CR26","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1345\/aph.1p726","volume":"45","author":"GM Jones","year":"2011","unstructured":"Jones GM, Murphy CV, Gerlach AT, Goodman EM, Pell LJ. High-dose dexmedetomidine for sedation in the intensive care unit: an evaluation of clinical efficacy and safety. Ann Pharmacother 2011; 45: 740\u20137. https:\/\/doi.org\/10.1345\/aph.1p726","journal-title":"Ann Pharmacother"},{"key":"2339_CR27","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.bja.2019.07.029","volume":"123","author":"M Demiri","year":"2019","unstructured":"Demiri M, Antunes T, Fletcher D, Martinez V. Perioperative adverse events attributed to \u03b12-adrenoceptor agonists in patients not at risk of cardiovascular events: systematic review and meta-analysis. Br J Anaesth 2019; 123: 795\u2013807. https:\/\/doi.org\/10.1016\/j.bja.2019.07.029","journal-title":"Br J Anaesth"},{"key":"2339_CR28","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s12576-019-00727-z","volume":"69","author":"Q Fu","year":"2019","unstructured":"Fu Q, Ogoh S. Sex differences in baroreflex function in health and disease. J Physiol Sci 2019; 69: 851\u20139. https:\/\/doi.org\/10.1007\/s12576-019-00727-z","journal-title":"J Physiol Sci"},{"key":"2339_CR29","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1161\/hypertensionaha.116.06602","volume":"68","author":"EE Gillis","year":"2016","unstructured":"Gillis EE, Sullivan JC. Sex Differences in hypertension: recent advances. Hypertension 2016; 68: 1322\u20137. https:\/\/doi.org\/10.1161\/hypertensionaha.116.06602","journal-title":"Hypertension"},{"key":"2339_CR30","doi-asserted-by":"publisher","first-page":"CD007858","DOI":"10.1002\/14651858.cd007858.pub2","volume":"7","author":"TP Zonneveld","year":"2018","unstructured":"Zonneveld TP, Richard E, Vergouwen MD, et al. Blood pressure-lowering treatment for preventing recurrent stroke, major vascular events, and dementia in patients with a history of stroke or transient ischaemic attack. Cochrane Database Syst Rev 2018; 7: CD007858. https:\/\/doi.org\/10.1002\/14651858.cd007858.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"2339_CR31","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1136\/emj.2002.004143","volume":"21","author":"YF Choi","year":"2004","unstructured":"Choi YF, Wong TW, Lau CC. Midazolam is more likely to cause hypotension than etomidate in emergency department rapid sequence intubation. Emerg Med J 2004; 21: 700\u20132. https:\/\/doi.org\/10.1136\/emj.2002.004143","journal-title":"Emerg Med J"},{"key":"2339_CR32","unstructured":"Guritzky RP, Arain SR, Ebert TJ. Mechanism of hypotension from midazolam: direct vascular versus indirect effects in humans. Available from URL: http:\/\/www.asaabstracts.com\/strands\/asaabstracts\/abstract.htm?year=2001&index=3&absnum=1808 (accessed June 2022)."},{"key":"2339_CR33","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.4103\/joacp.joacp_35_18","volume":"35","author":"AD Kaye","year":"2019","unstructured":"Kaye AD, Urman RD, Cornett EM, et al. Enhanced recovery pathways in orthopedic surgery. J Anaesthesiol Clin Pharmacol 2019; 35: S35\u20139. https:\/\/doi.org\/10.4103\/joacp.joacp_35_18","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"2339_CR34","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1097\/01.psy.0000127692.23278.a9","volume":"66","author":"MA Babyak","year":"2004","unstructured":"Babyak MA. What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. Psychosom Med 2004; 66: 411\u201321. https:\/\/doi.org\/10.1097\/01.psy.0000127692.23278.a9","journal-title":"Psychosom Med"},{"key":"2339_CR35","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1016\/s0895-4356(96)00236-3","volume":"49","author":"P Peduzzi","year":"1996","unstructured":"Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 1996; 49: 1373\u20139. https:\/\/doi.org\/10.1016\/s0895-4356(96)00236-3","journal-title":"J Clin Epidemiol"},{"key":"2339_CR36","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1161\/hypertensionaha.118.11688","volume":"72","author":"L Meng","year":"2018","unstructured":"Meng L, Yu W, Wang T, Zhang L, Heerdt PM, Gelb AW. Blood pressure targets in perioperative care. Hypertension 2018; 72: 806\u201317. https:\/\/doi.org\/10.1161\/hypertensionaha.118.11688","journal-title":"Hypertension"},{"key":"2339_CR37","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/01.anes.0000270724.40897.8e","volume":"107","author":"JB Bijker","year":"2007","unstructured":"Bijker JB, van Klei WA, Kappen TH, van Wolfswinkel L, Moons KG, Kalkman CJ. Incidence of intraoperative hypotension as a function of the chosen definition: literature definitions applied to a retrospective cohort using automated data collection. Anesthesiology 2007; 107: 213\u201320. https:\/\/doi.org\/10.1097\/01.anes.0000270724.40897.8e","journal-title":"Anesthesiology"},{"key":"2339_CR38","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1161\/hypertensionaha.117.10546","volume":"71","author":"V Tsimihodimos","year":"2018","unstructured":"Tsimihodimos V, Gonzalez-Villalpando C, Meigs JB, Ferrannini E. Hypertension and diabetes mellitus: coprediction and time trajectories. Hypertension 2018; 71: 422\u20138. https:\/\/doi.org\/10.1161\/hypertensionaha.117.10546","journal-title":"Hypertension"},{"key":"2339_CR39","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1213\/01.ane.0000180204.64588.ec","volume":"101","author":"GW Roberts","year":"2005","unstructured":"Roberts GW, Bekker TB, Carlsen HH, Moffatt CH, Slattery PJ, McClure AF. Postoperative nausea and vomiting are strongly influenced by postoperative opioid use in a dose-related manner. Anesth Analg 2005; 101: 1343\u20138. https:\/\/doi.org\/10.1213\/01.ane.0000180204.64588.ec","journal-title":"Anesth Analg"}],"container-title":["Canadian Journal of Anesthesia\/Journal canadien d'anesth\u00e9sie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12630-022-02339-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12630-022-02339-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12630-022-02339-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:03:31Z","timestamp":1697069011000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12630-022-02339-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,12]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["2339"],"URL":"https:\/\/doi.org\/10.1007\/s12630-022-02339-5","relation":{},"ISSN":["0832-610X","1496-8975"],"issn-type":[{"value":"0832-610X","type":"print"},{"value":"1496-8975","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,12]]},"assertion":[{"value":"28 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}