{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:25:56Z","timestamp":1790623556926,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Can J Anesth\/J Can Anesth"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s12630-025-03025-y","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T22:39:27Z","timestamp":1754347167000},"page":"1291-1304","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of sevoflurane, propofol, remifentanil, and fentanyl on the endothelial proinflammatory response: an in vitro exploratory study","Effets du s\u00e9voflurane, du propofol, du r\u00e9mifentanil et du fentanyl sur la r\u00e9ponse pro-inflammatoire endoth\u00e9liale : une \u00e9tude exploratoire in vitro"],"prefix":"10.1007","volume":"72","author":[{"given":"Rozemarijn S.","family":"Tuinhout","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne M.","family":"Jongman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gertrude J.","family":"Nieuwenhuijs-Moeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayel H.","family":"Abdulahad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel M. R. F.","family":"Struys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matijs","family":"van Meurs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8275-5321","authenticated-orcid":false,"given":"Dirk J.","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"3025_CR1","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1097\/ta.0b013e3182516a97","volume":"72","author":"RD Becher","year":"2012","unstructured":"Becher RD, Hoth JJ, Miller PR, Meredith JW, Chang MC. Systemic inflammation worsens outcomes in emergency surgical patients. J Trauma Acute Care Surg 2012; 72: 1140\u20139. https:\/\/doi.org\/10.1097\/ta.0b013e3182516a97","journal-title":"J Trauma Acute Care Surg"},{"key":"3025_CR2","doi-asserted-by":"publisher","unstructured":"Fathima P, Chausse JM. Monitoring the post surgery inflammatory host response. J Emerg Crit Care Med 2019; 3. https:\/\/doi.org\/10.21037\/jeccm.2019.08.06","DOI":"10.21037\/jeccm.2019.08.06"},{"key":"3025_CR3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/1756-8722-6-61","volume":"6","author":"J Mai","year":"2013","unstructured":"Mai J, Virtue A, Shen J, Wang H, Yang XF. An evolving new paradigm: endothelial cells\u2014conditional innate immune cells. J Hematol Oncol 2013; 6: 61. https:\/\/doi.org\/10.1186\/1756-8722-6-61","journal-title":"J Hematol Oncol"},{"key":"3025_CR4","doi-asserted-by":"publisher","first-page":"4150","DOI":"10.1182\/blood-2003-10-3685","volume":"103","author":"U Fiedler","year":"2004","unstructured":"Fiedler U, Scharpfenecker M, Koidl S, et al. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies.\u00a0Blood 2004; 103: 4150\u20136. https:\/\/doi.org\/10.1182\/blood-2003-10-3685","journal-title":"Blood"},{"key":"3025_CR5","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1177\/021849230501300422","volume":"13","author":"SG Raja","year":"2005","unstructured":"Raja SG, Dreyfus GD. Modulation of systemic inflammatory response after cardiac surgery. Asian Cardiovasc Thorac Ann 2005; 13: 382\u201395. https:\/\/doi.org\/10.1177\/021849230501300422","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"3025_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228580","volume":"15","author":"AM Alhayyan","year":"2020","unstructured":"Alhayyan AM, McSorley ST, Kearns RJ, Horgan PG, Roxburgh CS, McMillan DC. The relationship between anaesthetic technique, clinicopathological characteristics and the magnitude of the postoperative systemic inflammatory response in patients undergoing elective surgery for colon cancer. PLoS One 2020; 15: e0228580. https:\/\/doi.org\/10.1371\/journal.pone.0228580","journal-title":"PLoS One"},{"key":"3025_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.sopen.2019.06.001","volume":"2","author":"A Alhayyan","year":"2019","unstructured":"Alhayyan A, McSorley S, Roxburgh C, Kearns R, Horgan P, McMillan D. The effect of anesthesia on the postoperative systemic inflammatory response in patients undergoing surgery: a systematic review and meta-analysis. Surg Open Sci 2019; 2: 1\u201321. https:\/\/doi.org\/10.1016\/j.sopen.2019.06.001","journal-title":"Surg Open Sci"},{"key":"3025_CR8","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1213\/ane.0000000000002484","volume":"126","author":"J Rossaint","year":"2018","unstructured":"Rossaint J, Zarbock A. Perioperative inflammation and its modulation by anesthetics. Anesth Analg 2018; 126: 1058\u201367. https:\/\/doi.org\/10.1213\/ane.0000000000002484","journal-title":"Anesth Analg"},{"key":"3025_CR9","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.bbrc.2015.03.126","volume":"460","author":"S Li","year":"2015","unstructured":"Li S, Xu J, Yao W, et al. Sevoflurane pretreatment attenuates TNF-\u03b1-induced human endothelial cell dysfunction through activating eNOS\/NO pathway. Biochem Biophys Res Commun 2015; 460: 879\u201386. https:\/\/doi.org\/10.1016\/j.bbrc.2015.03.126","journal-title":"Biochem Biophys Res Commun"},{"key":"3025_CR10","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1097\/aln.0000000000004141","volume":"136","author":"DJ Bosch","year":"2022","unstructured":"Bosch DJ, Nieuwenhuijs-Moeke GJ, van Meurs M, Abdulahad WH, Struys MM. Immune modulatory effects of nonsteroidal anti-inflammatory drugs in the perioperative period and their consequence on postoperative outcome. Anesthesiology 2022; 136: 843\u201360. https:\/\/doi.org\/10.1097\/aln.0000000000004141","journal-title":"Anesthesiology"},{"key":"3025_CR11","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1093\/bja\/aex057","volume":"118","author":"GJ Nieuwenhuijs-Moeke","year":"2017","unstructured":"Nieuwenhuijs-Moeke GJ, Nieuwenhuijs VB, Seelen MA, et al. Propofol-based anaesthesia versus sevoflurane-based anaesthesia for living donor kidney transplantation: results of the VAPOR-1 randomized controlled trial. Br J Anaesth 2017; 118: 720\u201332. https:\/\/doi.org\/10.1093\/bja\/aex057","journal-title":"Br J Anaesth"},{"key":"3025_CR12","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1111\/anae.15125","volume":"75","author":"L Van Hese","year":"2020","unstructured":"Van Hese L, Theys T, Absalom AR, Rex S, Cuypers E. Comparison of predicted and real propofol and remifentanil concentrations in plasma and brain tissue during target-controlled infusion: a prospective observational study.\u00a0Anaesthesia 2020; 75: 1626\u201334. https:\/\/doi.org\/10.1111\/anae.15125","journal-title":"Anaesthesia"},{"key":"3025_CR13","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1093\/bja\/aep053","volume":"102","author":"M Grossherr","year":"2009","unstructured":"Grossherr M, Hengstenberg A, Meier T, et al. Propofol concentration in exhaled air and arterial plasma in mechanically ventilated patients undergoing cardiac surgery.\u00a0Br J Anaesth 2009; 102: 608\u201313. https:\/\/doi.org\/10.1093\/bja\/aep053","journal-title":"Br J Anaesth"},{"key":"3025_CR14","doi-asserted-by":"publisher","unstructured":"Duthie DJ, McLaren AD, Nimmo WS. Pharmacokinetics of fentanyl during constant rate i.v. infusion for the relief of pain after surgery.\u00a0Br J Anaesth 1986; 58: 950\u20136. https:\/\/doi.org\/10.1093\/bja\/58.9.950","DOI":"10.1093\/bja\/58.9.950"},{"key":"3025_CR15","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.bja.2020.05.051","volume":"125","author":"DJ Eleveld","year":"2020","unstructured":"Eleveld DJ, Colin P, Absalom AR, Struys MM. Target-controlled-infusion models for remifentanil dosing consistent with approved recommendations.\u00a0Br J Anaesth 2020; 125: 483\u201391. https:\/\/doi.org\/10.1016\/j.bja.2020.05.051","journal-title":"Br J Anaesth"},{"key":"3025_CR16","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1097\/00000542-200409000-00008","volume":"101","author":"K Shibutani","year":"2004","unstructured":"Shibutani K, Inchiosa MA Jr, Sawada K, Bairamian M. Accuracy of pharmacokinetic models for predicting plasma fentanyl concentrations in lean and obese surgical patients: derivation of dosing weight (\u201cpharmacokinetic mass\u201d).\u00a0Anesthesiology 2004; 101: 603\u201313. https:\/\/doi.org\/10.1097\/00000542-200409000-00008","journal-title":"Anesthesiology"},{"key":"3025_CR17","doi-asserted-by":"publisher","first-page":"7614","DOI":"10.1074\/jbc.m009705200","volume":"276","author":"I Kim","year":"2001","unstructured":"Kim I, Moon SO, Kim SH, Kim HJ, Koh YS, Koh GY. Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells.\u00a0J Biol Chem 2001; 276: 7614\u201320. https:\/\/doi.org\/10.1074\/jbc.m009705200","journal-title":"J Biol Chem"},{"key":"3025_CR18","doi-asserted-by":"publisher","first-page":"4070","DOI":"10.1096\/fj.201701536r","volume":"32","author":"L Zhong","year":"2018","unstructured":"Zhong L, Simard MJ, Huot J. Endothelial microRNAs regulating the NF-\u03baB pathway and cell adhesion molecules during inflammation.\u00a0FASEB J 2018; 32: 4070\u201384. https:\/\/doi.org\/10.1096\/fj.201701536r","journal-title":"FASEB J"},{"key":"3025_CR19","doi-asserted-by":"publisher","first-page":"C1229","DOI":"10.1152\/ajpcell.00620.2004","volume":"289","author":"JM Kuldo","year":"2005","unstructured":"Kuldo JM, Westra J, Asgeirsd\u00f3ttir SA, et al. Differential effects of NF-\u03baB and p38 MAPK inhibitors and combinations thereof on TNF-\u03b1- and IL-1\u03b2-induced proinflammatory status of endothelial cells in vitro.\u00a0Am J Physiol Cell Physiol 2005; 289: C1229\u201339. https:\/\/doi.org\/10.1152\/ajpcell.00620.2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"3025_CR20","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.imbio.2019.07.004","volume":"224","author":"X Yu","year":"2019","unstructured":"Yu X, Zhang F, Shi J. Effect of sevoflurane treatment on microglia activation, NF-kB and MAPK activities. Immunobiology 2019; 224: 638-44. https:\/\/doi.org\/10.1016\/j.imbio.2019.07.004","journal-title":"NF-kB and MAPK activities. Immunobiology"},{"key":"3025_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.717745","volume":"13","author":"X Huang","year":"2021","unstructured":"Huang X, Ying J, Yang D, et al. The mechanisms of sevoflurane-induced neuroinflammation. Front Aging Neurosci 2021; 13: 717745. https:\/\/doi.org\/10.3389\/fnagi.2021.717745","journal-title":"Front Aging Neurosci"},{"key":"3025_CR22","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1161\/01.atv.0000194074.59584.42","volume":"26","author":"C De Palma","year":"2006","unstructured":"De Palma C, Meacci E, Perrotta C, Bruni P, Clementi E. Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium.\u00a0Arterioscler Thromb Vasc Biol 2006; 26: 99\u2013105. https:\/\/doi.org\/10.1161\/01.atv.0000194074.59584.42","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"3025_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2024.106821","volume":"172","author":"W Ni","year":"2024","unstructured":"Ni W, Zou Z, Jiang P, Wang S. Sevoflurane alleviates inflammation, apoptosis and permeability damage of human umbilical vein endothelial cells induced by lipopolysaccharide by inhibiting endoplasmic reticulum stress via upregulating ROR\u03b1.\u00a0Prostaglandins Other Lipid Mediat 2024; 172: 106821. https:\/\/doi.org\/10.1016\/j.prostaglandins.2024.106821","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"3025_CR24","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1093\/abbs\/gmz105","volume":"51","author":"J Qi","year":"2019","unstructured":"Qi J, Wu Q, Zhu X, et al. Propofol attenuates the adhesion of tumor and endothelial cells through inhibiting glycolysis in human umbilical vein endothelial cells. Acta Biochim Biophys Sin (Shanghai) 2019; 51: 1114\u201322. https:\/\/doi.org\/10.1093\/abbs\/gmz105","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"3025_CR25","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1097\/01.ccm.0000198530.68343.21","volume":"34","author":"HP Yu","year":"2006","unstructured":"Yu HP, Lui PW, Hwang TL, Yen CH, Lau YT. Propofol improves endothelial dysfunction and attenuates vascular superoxide production in septic rats. Crit Care Med 2006; 34: 453\u201360. https:\/\/doi.org\/10.1097\/01.ccm.0000198530.68343.21","journal-title":"Crit Care Med"},{"key":"3025_CR26","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s12871-021-01487-3","volume":"21","author":"D Yuan","year":"2021","unstructured":"Yuan D, Zou Z, Li X, et al. A new side-effect of sufentanil: increased monocyte-endothelial adhesion. BMC Anesthesiol 2021; 21: 267. https:\/\/doi.org\/10.1186\/s12871-021-01487-3","journal-title":"BMC Anesthesiol"},{"key":"3025_CR27","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1097\/shk.0b013e318145a7c1","volume":"29","author":"M van Meurs","year":"2008","unstructured":"van Meurs M, Wulfert FM, Knol AJ, et al. Early organ-specific endothelial activation during hemorrhagic shock and resuscitation.\u00a0Shock 2008; 29: 291\u20139. https:\/\/doi.org\/10.1097\/shk.0b013e318145a7c1","journal-title":"Shock"}],"container-title":["Canadian Journal of Anesthesia\/Journal canadien d'anesth\u00e9sie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12630-025-03025-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12630-025-03025-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12630-025-03025-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T14:47:50Z","timestamp":1755096470000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12630-025-03025-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["3025"],"URL":"https:\/\/doi.org\/10.1007\/s12630-025-03025-y","relation":{},"ISSN":["0832-610X","1496-8975"],"issn-type":[{"value":"0832-610X","type":"print"},{"value":"1496-8975","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"8 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}