{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:00:51Z","timestamp":1781020851096,"version":"3.54.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171264"],"award-info":[{"award-number":["82171264"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171264"],"award-info":[{"award-number":["82171264"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171264"],"award-info":[{"award-number":["82171264"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171264"],"award-info":[{"award-number":["82171264"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["82271295"],"award-info":[{"award-number":["82271295"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["23ZR1409300"],"award-info":[{"award-number":["23ZR1409300"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100015359","name":"Shanghai Medical College, Fudan University","doi-asserted-by":"publisher","award":["FDYXYBJ-20222004"],"award-info":[{"award-number":["FDYXYBJ-20222004"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100015359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100018684","name":"National Health Commission of the People's Republic of China","doi-asserted-by":"publisher","award":["RCLX2315001"],"award-info":[{"award-number":["RCLX2315001"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100018684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202240315"],"award-info":[{"award-number":["202240315"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Can J Anesth\/J Can Anesth"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s12630-026-03125-3","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T15:12:33Z","timestamp":1780326753000},"page":"379-390","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of different weight-based scalars of remimazolam for anesthesia induction in patients with obesity: a randomized controlled trial","Comparaison de diff\u00e9rents scalaires pond\u00e9raux du r\u00e9mimazolam pour l\u2019induction anesth\u00e9sique de la patient\u00e8le ob\u00e8se : une \u00e9tude randomis\u00e9e contr\u00f4l\u00e9e"],"prefix":"10.1007","volume":"73","author":[{"given":"Wenwen","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2019e","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mannan","family":"Abdul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yirong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"3125_CR1","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/s0140-6736(25)00355-1","volume":"405","author":"GBD 2021 Adult BMI Collaborators","year":"2025","unstructured":"GBD 2021 Adult BMI Collaborators. Global, regional, and national prevalence of adult overweight and obesity, 1990-2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021. Lancet 2025; 405: 813\u201338. https:\/\/doi.org\/10.1016\/s0140-6736(25)00355-1","journal-title":"Lancet"},{"key":"3125_CR2","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1080\/17425255.2018.1440287","volume":"14","author":"C Smit","year":"2018","unstructured":"Smit C, De Hoogd S, Br\u00fcggemann RJ, Knibbe CA. Obesity and drug pharmacology: a review of the influence of obesity on pharmacokinetic and pharmacodynamic parameters. Expert Opin Drug Metab Toxicol 2018; 14: 275\u201385. https:\/\/doi.org\/10.1080\/17425255.2018.1440287","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"3125_CR3","doi-asserted-by":"publisher","first-page":"i16","DOI":"10.1093\/bja\/aeq312","volume":"105","author":"J Ingrande","year":"2010","unstructured":"Ingrande J, Lemmens HJ. Dose adjustment of anaesthetics in the morbidly obese. Br J Anaesth 2010; 105: i16\u201323. https:\/\/doi.org\/10.1093\/bja\/aeq312","journal-title":"Br J Anaesth"},{"key":"3125_CR4","doi-asserted-by":"publisher","first-page":"779","DOI":"10.3238\/arztebl.m2023.0216","volume":"120","author":"K Hardt","year":"2023","unstructured":"Hardt K, Wappler F. Anesthesia for morbidly obese patients. Dtsch Arztebl Int 2023; 120: 779\u201385. https:\/\/doi.org\/10.3238\/arztebl.m2023.0216","journal-title":"Dtsch Arztebl Int"},{"key":"3125_CR5","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1111\/j.1365-2125.2004.02157.x","volume":"58","author":"B Green","year":"2004","unstructured":"Green B, Duffull SB. What is the best size descriptor to use for pharmacokinetic studies in the obese? Br J Clin Pharmacol 2004; 58: 119\u201333. https:\/\/doi.org\/10.1111\/j.1365-2125.2004.02157.x","journal-title":"Br J Clin Pharmacol"},{"key":"3125_CR6","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1097\/01.anes.0000267503.85085.c0","volume":"107","author":"GJ Kilpatrick","year":"2007","unstructured":"Kilpatrick GJ, McIntyre MS, Cox RF, et al. CNS 7056: a novel ultra-short-acting benzodiazepine. Anesthesiology 2007; 107: 60\u20136. https:\/\/doi.org\/10.1097\/01.anes.0000267503.85085.c0","journal-title":"Anesthesiology"},{"key":"3125_CR7","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1213\/ane.0b013e31825ef8d7","volume":"115","author":"KB Johnson","year":"2012","unstructured":"Johnson KB. New horizons in sedative hypnotic drug development: fast, clean, and soft. Anesth Analg 2012; 115: 220\u20132. https:\/\/doi.org\/10.1213\/ane.0b013e31825ef8d7","journal-title":"Anesth Analg"},{"key":"3125_CR8","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1213\/ane.0b013e3182a705ae","volume":"117","author":"MT Worthington","year":"2013","unstructured":"Worthington MT, Antonik LJ, Goldwater DR, et al. A phase Ib, dose-finding study of multiple doses of remimazolam (CNS 7056) in volunteers undergoing colonoscopy. Anesth Analg 2013; 117: 1093\u2013100. https:\/\/doi.org\/10.1213\/ane.0b013e3182a705ae","journal-title":"Anesth Analg"},{"key":"3125_CR9","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1097\/aln.0000000000003103","volume":"132","author":"J Sch\u00fcttler","year":"2020","unstructured":"Sch\u00fcttler J, Eisenried A, Lerch M, Fechner J, Jeleazcov C, Ihmsen H. Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy male volunteers: part I. Pharmacokinetics and clinical pharmacodynamics. Anesthesiology 2020; 132: 636\u201351. https:\/\/doi.org\/10.1097\/aln.0000000000003103.","journal-title":"Anesthesiology"},{"key":"3125_CR10","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1213\/ane.0b013e318241f68a","volume":"115","author":"HR Wiltshire","year":"2012","unstructured":"Wiltshire HR, Kilpatrick GJ, Tilbrook GS, Borkett KM. A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): part II. Population pharmacokinetic and pharmacodynamic modeling and simulation. Anesth Analg 2012; 115: 284\u201396. https:\/\/doi.org\/10.1213\/ane.0b013e318241f68a","journal-title":"Anesth Analg"},{"key":"3125_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s40981-021-00417-z","volume":"7","author":"A Yoshida","year":"2021","unstructured":"Yoshida A, Kurata S, Kida K, Tsubokawa T. Anesthetic management for the sleep-awake-sleep technique of awake craniotomy using a novel benzodiazepine remimazolam and its antagonist flumazenil. JA Clin Rep 2021; 7: 14. https:\/\/doi.org\/10.1186\/s40981-021-00417-z","journal-title":"JA Clin Rep"},{"key":"3125_CR12","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1007\/s12630-024-02736-y","volume":"71","author":"JR Renew","year":"2024","unstructured":"Renew JR. Is remimazolam the elusive anesthetic on\/off switch? Can J Anesth 2024; 71: 1057\u201361. https:\/\/doi.org\/10.1007\/s12630-024-02736-y","journal-title":"Can J Anesth"},{"key":"3125_CR13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s44254-023-00021-7","volume":"1","author":"JR Sneyd","year":"2023","unstructured":"Sneyd JR. Remimazolam\u2014current status, opportunities and challenges. APS 2023; 1: 25. https:\/\/doi.org\/10.1007\/s44254-023-00021-7","journal-title":"APS"},{"key":"3125_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-023-07739-6","volume":"24","author":"W Ni","year":"2023","unstructured":"Ni W, Yi X, Feng L, et al. Comparison of different weight-based scalars of remimazolam tosylate for anesthesia induction in obese patients: study protocol for a prospective, controlled trial. Trials 2023; 24: 719. https:\/\/doi.org\/10.1186\/s13063-023-07739-6","journal-title":"Trials"},{"key":"3125_CR15","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.2165\/00003088-200544100-00004","volume":"44","author":"S Janmahasatian","year":"2005","unstructured":"Janmahasatian S, Duffull SB, Ash S, Ward LC, Byrne NM, Green B. Quantification of lean bodyweight. Clin Pharmacokinet 2005; 44: 1051\u201365. https:\/\/doi.org\/10.2165\/00003088-200544100-00004","journal-title":"Clin Pharmacokinet"},{"key":"3125_CR16","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1200\/jco.2011.39.9436","volume":"30","author":"JJ Griggs","year":"2012","unstructured":"Griggs JJ, Mangu PB, Anderson H, et al. Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol 2012; 30: 1553\u201361. https:\/\/doi.org\/10.1200\/jco.2011.39.9436","journal-title":"J Clin Oncol"},{"key":"3125_CR17","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.anclin.2019.10.008","volume":"38","author":"S Sharma","year":"2020","unstructured":"Sharma S, Arora L. Anesthesia for the morbidly obese patient. Anesthesiol Clin 2020; 38: 197\u2013212. https:\/\/doi.org\/10.1016\/j.anclin.2019.10.008","journal-title":"Anesthesiol Clin"},{"key":"3125_CR18","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/00004714-199008000-00003","volume":"10","author":"DA Chernik","year":"1990","unstructured":"Chernik DA, Gillings D, Laine H, et al. Validity and reliability of the Observer\u2019s Assessment of Alertness\/Sedation Scale: study with intravenous midazolam. J Clin Psychopharmacol 1990; 10: 244\u201351.","journal-title":"J Clin Psychopharmacol"},{"key":"3125_CR19","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1093\/bja\/aep014","volume":"102","author":"UH Frey","year":"2009","unstructured":"Frey UH, Scharmann P, L\u00f6hlein C, Peters J. P6 acustimulation effectively decreases postoperative nausea and vomiting in high-risk patients. Br J Anaesth 2009; 102: 620\u20135. https:\/\/doi.org\/10.1093\/bja\/aep014","journal-title":"Br J Anaesth"},{"key":"3125_CR20","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1093\/bja\/42.6.535","volume":"42","author":"DD Brice","year":"1970","unstructured":"Brice DD, Hetherington RR, Utting JE. A simple study of awareness and dreaming during anaesthesia. Br J Anaesth 1970; 42: 535\u201342. https:\/\/doi.org\/10.1093\/bja\/42.6.535","journal-title":"Br J Anaesth"},{"key":"3125_CR21","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s00540-020-02788-6","volume":"34","author":"M Doi","year":"2020","unstructured":"Doi M, Morita K, Takeda J, Sakamoto A, Yamakage M, Suzuki T. Efficacy and safety of remimazolam versus propofol for general anesthesia: a multicenter, single-blind, randomized, parallel-group, phase IIb\/III trial. J Anesth 2020; 34: 543\u201353. https:\/\/doi.org\/10.1007\/s00540-020-02788-6","journal-title":"J Anesth"},{"key":"3125_CR22","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1097\/eja.0000000000001902","volume":"40","author":"S Kempenaers","year":"2023","unstructured":"Kempenaers S, Hansen TG, Van de Velde M. Remimazolam and serious adverse events: a scoping review. Eur J Anaesthesiol 2023; 40: 841\u201353. https:\/\/doi.org\/10.1097\/eja.0000000000001902","journal-title":"Eur J Anaesthesiol"},{"key":"3125_CR23","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1213\/ane.0000000000001564","volume":"124","author":"A Heard","year":"2017","unstructured":"Heard A, Toner AJ, Evans JR, Aranda Palacios AM, Lauer S. Apneic oxygenation during prolonged laryngoscopy in obese patients: a randomized, controlled trial of Buccal RAE tube oxygen administration. Anesth Analg 2017; 124: 1162\u20137. https:\/\/doi.org\/10.1213\/ane.0000000000001564","journal-title":"Anesth Analg"},{"key":"3125_CR24","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s12630-017-0852-x","volume":"64","author":"Y Subramani","year":"2017","unstructured":"Subramani Y, Riad W, Chung F, Wong J. Optimal propofol induction dose in morbidly obese patients: a randomized controlled trial comparing the bispectral index and lean body weight scalar. Can J Anesth 2017; 64: 471\u20139. https:\/\/doi.org\/10.1007\/s12630-017-0852-x","journal-title":"Can J Anesth"},{"key":"3125_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1411856","volume":"15","author":"M Chen","year":"2024","unstructured":"Chen M, Wang H, Sun J, et al. The dose of remimazolam combined with sufentanil for the induction of general anesthesia in obese patients undergoing bariatric surgery: an up-and-down sequential allocation trial. Front Pharmacol 2024; 15: 1411856. https:\/\/doi.org\/10.3389\/fphar.2024.1411856","journal-title":"Front Pharmacol"},{"key":"3125_CR26","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.bjae.2018.09.001","volume":"18","author":"CP Hebbes","year":"2018","unstructured":"Hebbes CP, Thompson JP. Pharmacokinetics of anaesthetic drugs at extremes of body weight. BJA Educ 2018; 18: 364\u201370. https:\/\/doi.org\/10.1016\/j.bjae.2018.09.001","journal-title":"BJA Educ"},{"key":"3125_CR27","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1213\/ane.0b013e3181f6d9c0","volume":"113","author":"J Ingrande","year":"2011","unstructured":"Ingrande J, Brodsky JB, Lemmens HJ. Lean body weight scalar for the anesthetic induction dose of propofol in morbidly obese subjects. Anesth Analg 2011; 113: 57\u201362. https:\/\/doi.org\/10.1213\/ane.0b013e3181f6d9c0","journal-title":"Anesth Analg"},{"key":"3125_CR28","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1111\/anae.13101","volume":"70","author":"CE Nightingale","year":"2015","unstructured":"Nightingale CE, Margarson MP, Shearer E, et al. Peri-operative management of the obese surgical patient 2015: Association of Anaesthetists of Great Britain and Ireland Society for Obesity and Bariatric Anaesthesia. Anaesthesia 2015; 70: 859\u201376. https:\/\/doi.org\/10.1111\/anae.13101","journal-title":"Anaesthesia"},{"key":"3125_CR29","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1213\/ane.0b013e31823f0c28","volume":"115","author":"LJ Antonik","year":"2012","unstructured":"Antonik LJ, Goldwater DR, Kilpatrick GJ, Tilbrook GS, Borkett KM. A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): part I. Safety, efficacy, and basic pharmacokinetics. Anesth Analg 2012; 115: 274\u201383. https:\/\/doi.org\/10.1213\/ane.0b013e31823f0c28","journal-title":"Anesth Analg"},{"key":"3125_CR30","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1097\/aln.0000000000005195","volume":"141","author":"JR Sneyd","year":"2024","unstructured":"Sneyd JR, Anderson BJ. Remimazolam and ciprofol: more research is needed but ask the right questions and perhaps aim higher. Anesthesiology 2024; 141: 1034\u20138. https:\/\/doi.org\/10.1097\/aln.0000000000005195","journal-title":"Anesthesiology"},{"key":"3125_CR31","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1111\/anae.16205","volume":"79","author":"J Fechner","year":"2024","unstructured":"Fechner J, El-Boghdadly K, Spahn DR, et al. Anaesthetic efficacy and postinduction hypotension with remimazolam compared with propofol: a multicentre randomised controlled trial. Anaesthesia 2024; 79: 410\u201322. https:\/\/doi.org\/10.1111\/anae.16205","journal-title":"Anaesthesia"},{"key":"3125_CR32","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1097\/aln.0000000000003102","volume":"132","author":"A Eisenried","year":"2020","unstructured":"Eisenried A, Sch\u00fcttler J, Lerch M, Ihmsen H, Jeleazcov C. Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy male volunteers: part II. Pharmacodynamics of electroencephalogram effects. Anesthesiology 2020; 132: 652\u201366. https:\/\/doi.org\/10.1097\/aln.0000000000003102","journal-title":"Anesthesiology"},{"key":"3125_CR33","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1213\/ane.0000000000002331","volume":"126","author":"BG Fahy","year":"2018","unstructured":"Fahy BG, Chau DF. The technology of processed electroencephalogram monitoring devices for assessment of depth of anesthesia. Anesth Analg 2018; 126: 111\u20137. https:\/\/doi.org\/10.1213\/ane.0000000000002331","journal-title":"Anesth Analg"}],"container-title":["Canadian Journal of Anesthesia\/Journal canadien d'anesth\u00e9sie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12630-026-03125-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12630-026-03125-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12630-026-03125-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:24:13Z","timestamp":1781018653000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12630-026-03125-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["3125"],"URL":"https:\/\/doi.org\/10.1007\/s12630-026-03125-3","relation":{},"ISSN":["0832-610X","1496-8975"],"issn-type":[{"value":"0832-610X","type":"print"},{"value":"1496-8975","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"25 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}