{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:15:31Z","timestamp":1791270931758,"version":"4.1.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T00:00:00Z","timestamp":1247702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1007\/s12640-009-9086-1","type":"journal-article","created":{"date-parts":[[2009,7,20]],"date-time":"2009-07-20T17:11:49Z","timestamp":1248109909000},"page":"167-178","source":"Crossref","is-referenced-by-count":68,"title":["Bortezomib Induces the Formation of Nuclear poly(A) RNA Granules Enriched in Sam68 and PABPN1 in Sensory Ganglia Neurons"],"prefix":"10.1007","volume":"17","author":[{"given":"I\u00f1igo","family":"Casafont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T.","family":"Berciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Lafarga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,7,16]]},"reference":[{"key":"9086_CR1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1535-6108(04)00120-5","volume":"5","author":"J Adams","year":"2004","unstructured":"Adams J (2004) The development of proteasome inhibitors as anticancer drugs. Cancer Cell 5:417\u2013421","journal-title":"Cancer Cell"},{"key":"9086_CR2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0166-2236(98)01276-4","volume":"21","author":"A Alves-Rodrigues","year":"1998","unstructured":"Alves-Rodrigues A, Gregory L, Figueiredo-Pereira ME (1998) Ubiquitin, cellular inclusions and their role in neurodegeneration. Trends Neurosci 21:517\u2013520","journal-title":"Trends Neurosci"},{"key":"9086_CR3","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1083\/jcb.200512082","volume":"172","author":"P Anderson","year":"2006","unstructured":"Anderson P, Kedersha N (2006) RNA granules. J Cell Biol 172:803\u2013808","journal-title":"J Cell Biol"},{"key":"9086_CR4","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/hmg\/ddh101","volume":"13","author":"MT Berciano","year":"2004","unstructured":"Berciano MT, Villagra NT, Ojeda JL, Navascues J, Gomes A, Lafarga M, Carmo-Fonseca M (2004) Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus. Hum Mol Genet 13:829\u2013838","journal-title":"Hum Mol Genet"},{"key":"9086_CR5","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jsb.2006.12.008","volume":"158","author":"MT Berciano","year":"2007","unstructured":"Berciano MT, Novell M, Villagra NT, Casafont I, Bengoechea R, Val-Bernal JF, Lafarga M (2007) Cajal body number and nucleolar size correlate with the cell body mass in human sensory ganglia neurons. J Struct Biol 158:410\u2013420","journal-title":"J Struct Biol"},{"key":"9086_CR6","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrm1405","volume":"5","author":"G Biamonti","year":"2004","unstructured":"Biamonti G (2004) Nuclear stress bodies: a heterochromatin affair? Nat Rev Mol Cell Biol 5:493\u2013498","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9086_CR7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1177\/002215549804600313","volume":"46","author":"M Biggiogera","year":"1998","unstructured":"Biggiogera M, Fakan S (1998) Fine structural specific visualization of RNA on ultrathin sections. J Histochem Cytochem 46:389\u2013395","journal-title":"J Histochem Cytochem"},{"key":"9086_CR8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1432-0436.2007.00211.x","volume":"76","author":"M Biggiogera","year":"2008","unstructured":"Biggiogera M, Cisterna B, Spedito A, Vecchio L, Malatesta M (2008) Perichromatin fibrils as early markers of transcriptional alterations. Differentiation 76:57\u201365","journal-title":"Differentiation"},{"key":"9086_CR9","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/BF00685380","volume":"57","author":"L Bigotte","year":"1982","unstructured":"Bigotte L, Arvidson B, Olsson Y (1982) Cytofluorescence localization of adriamycin in the nervous system. II. Distribution of the drug in the somatic and autonomic peripheral nervous systems of normal adult mice after intravenous injection. Acta Neuropathol 57:130\u2013136","journal-title":"Acta Neuropathol"},{"key":"9086_CR10","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1152\/ajplegacy.1926.76.2.380","volume":"76","author":"GG Carman","year":"1926","unstructured":"Carman GG, Mitchell HH (1926) Estimation of the surface area of the white rat. Am J Physiol 76:380\u2013384","journal-title":"Am J Physiol"},{"key":"9086_CR11","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1083\/jcb.115.5.1191","volume":"115","author":"KC Carter","year":"1991","unstructured":"Carter KC, Taneja KL, Lawrence JB (1991) Discrete nuclear domains of poly(A) RNA and their relationship to the functional organization of the nucleus. J Cell Biol 115:1191\u20131202","journal-title":"J Cell Biol"},{"key":"9086_CR12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.neuroscience.2006.02.030","volume":"140","author":"I Casafont","year":"2006","unstructured":"Casafont I, Navascues J, Pena E, Lafarga M, Berciano MT (2006) Nuclear organization and dynamics of transcription sites in rat sensory ganglia neurons detected by incorporation of 5\u2032-fluorouridina into nascent RNA. Neuroscience 140:453\u2013462","journal-title":"Neuroscience"},{"key":"9086_CR13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.expneurol.2006.11.010","volume":"204","author":"G Cavaletti","year":"2007","unstructured":"Cavaletti G, Gilardini A, Canta A, Rigamonti L, Rodriguez-Menendez V, Ceresa C, Marmiroli P, Bossi M, Oggioni N, D\u2032Incalci M, De Coster R (2007) Bortezomib-induced peripheral neurotoxicity: a neurophysiological and pathological study in the rat. Exp Neurol 204:317\u2013325","journal-title":"Exp Neurol"},{"key":"9086_CR14","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1091\/mbc.10.9.3015","volume":"10","author":"T Chen","year":"1999","unstructured":"Chen T, Boisvert FM, Bazzet-Jones DP, Richard S (1999) A role for the GSG domain in localizing Sam68 to novel nuclear structures in cancer cells. Mol Biol Cell 10:3015\u20133033","journal-title":"Mol Biol Cell"},{"key":"9086_CR15","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1242\/jcs.113.22.4043","volume":"113","author":"I Chiodi","year":"2000","unstructured":"Chiodi I, Biggiogera M, Denegri M, Corioni M, Weighardt F, Cobianchi F, Riva S, Biamonti G (2000) Structure and dynamics of hnRNP-labelled nuclear bodies induced by stress treatments. J Cell Sci 113:4043\u20134053","journal-title":"J Cell Sci"},{"key":"9086_CR16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1073\/pnas.88.1.139","volume":"88","author":"A Ciechanover","year":"1991","unstructured":"Ciechanover A, DiGiuseppe JA, Bercovich B, Orian A, Richter JD (1991) Degradation of nuclear oncoproteins by the ubiquitin system in vitro. Proc Natl Acad Sci USA 88:139\u2013143","journal-title":"Proc Natl Acad Sci USA"},{"key":"9086_CR17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.cellbio.20.010403.103738","volume":"21","author":"M Cioce","year":"2005","unstructured":"Cioce M, Lamond AI (2005) Cajal Bodies: A long history of discovery. Annu Rev Cell Dev Biol 21:105\u2013131","journal-title":"Annu Rev Cell Dev Biol"},{"key":"9086_CR18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.gde.2006.02.009","volume":"16","author":"GA Collins","year":"2006","unstructured":"Collins GA, Tansey WP (2006) The proteasome: a utility tool for transcription? Curr Opin Genet Dev 16:197\u2013202","journal-title":"Curr Opin Genet Dev"},{"key":"9086_CR19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrm760","volume":"3","author":"G Dreyfuss","year":"2002","unstructured":"Dreyfuss G, Kim VN, Kataoka N (2002) Messenger-RNA-binding proteins and the messages they carry. Nat Rev Mol Cell Biol 3:195\u2013205","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9086_CR20","first-page":"125","volume-title":"Basal metabolism in health and disease","author":"E Dubois","year":"1936","unstructured":"Dubois E (1936) Basal metabolism in health and disease. Lea & Febiger, Philadelphia, pp 125\u2013144"},{"key":"9086_CR21","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jns.2007.05.023","volume":"263","author":"M Filosto","year":"2007","unstructured":"Filosto M, Rossi G, Pelizzari AM, Buzio S, Tentorio M, Broglio L, Mancuso M, Rinaldi M, Scarpelli M, Padovani A (2007) A high-dose bortezomib neuropathy with sensory ataxia and myelin involvement. J Neurol Sci 263:40\u201343","journal-title":"J Neurol Sci"},{"key":"9086_CR22","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1242\/jcs.00927","volume":"117","author":"NB Fredj","year":"2004","unstructured":"Fredj NB, Grange J, Sadoul R, Richard S, Goldberg Y, Boyer V (2004) Depolarization-induced translocation of the RNA-binding protein Sam68 to the dendrites of hippocampal neurons. J Cell Sci 117:1079\u20131090","journal-title":"J Cell Sci"},{"key":"9086_CR23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev.cellbio.16.1.273","volume":"16","author":"JC Gall","year":"2000","unstructured":"Gall JC (2000) Cajal bodies: the first 100\u00a0years. Annu Rev Cell Dev Biol 16:273\u2013300","journal-title":"Annu Rev Cell Dev Biol"},{"key":"9086_CR24","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/jnr.20003","volume":"75","author":"J Grange","year":"2004","unstructured":"Grange J, Boyer V, Fabian-Fine R, Fredj NB, Sadoul R, Goldberg Y (2004) Somatodendritic localization and mRNA association of the splicing regulatory protein Sam68 in the hippocampus and cortex. J Neurosci Res 75:654\u2013666","journal-title":"J Neurosci Res"},{"key":"9086_CR25","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1091\/mbc.10.11.3909","volume":"10","author":"AM Hartmann","year":"1999","unstructured":"Hartmann AM, Nayler O, Schwaiger FW, Obermeier A, Stamm S (1999) The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59fyn. Mol Biol Cell 10:3909\u20133926","journal-title":"Mol Biol Cell"},{"key":"9086_CR26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.molcel.2008.11.024","volume":"33","author":"J Henao-Mejia","year":"2009","unstructured":"Henao-Mejia J, Liu Y, Park YW, Zhang J, Sanford J, He JJ (2009) Supression of HIV-1 nef translation by Sam68 mutant-induced stress granules and nef mRNA sequestration. Mol Cell 33:87\u201396","journal-title":"Mol Cell"},{"key":"9086_CR27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1365-2141.2004.05188.x","volume":"127","author":"S Jagannath","year":"2004","unstructured":"Jagannath S, Barlogie B, Berenson J, Siegel D, Irwin D, Richardson PG, Niesvizky R, Alexanian R, Limentani SA, Alsina M, Adams J, Kauffman M, Esseltine DL, Schenkein D, Anderson KC (2004) A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. Br J Haematol 127:165\u2013172","journal-title":"Br J Haematol"},{"key":"9086_CR28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/excr.1994.1235","volume":"214","author":"S Krause","year":"1994","unstructured":"Krause S, Fakan S, Weis K, Wahle E (1994) Immunodetection of poly (A)-binding protein II in the cell nucleus. Exp Cell Res 214:75\u201382","journal-title":"Exp Cell Res"},{"key":"9086_CR29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbaexp.2004.03.008","volume":"1678","author":"U K\u00fchn","year":"2004","unstructured":"K\u00fchn U, Wahle E (2004) Structure and function of poly(A) binding proteins. Biochim Biophys Acta 1678:67\u201384","journal-title":"Biochim Biophys Acta"},{"key":"9086_CR30","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1091\/mbc.e02-03-0122","volume":"13","author":"M Lafarga","year":"2002","unstructured":"Lafarga M, Berciano MT, Pena E, Mayo I, Castano JG, Bohmann D, Rodrigues JP, Tavanez JP, Carmo-Fonseca M (2002) Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. Mol Biol Cell 13:2771\u20132782","journal-title":"Mol Biol Cell"},{"key":"9086_CR31","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nrm1172","volume":"4","author":"AI Lamond","year":"2003","unstructured":"Lamond AI, Spector DL (2003) Nuclear speckles: a model for nuclear organelles. Nat Rev Mol Cell Biol 4:605\u2013612","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9086_CR32","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1158\/0008-5472.CAN-04-3684","volume":"65","author":"TH Landowski","year":"2005","unstructured":"Landowski TH, Megli CJ, Nullmeyer KD, Lynch RM, Dorr RT (2005) Mitochondrial-mediated disregulation of Ca2+ is a critical determinant of Velcade (PS-341\/bortezomib) cytotoxicity in myeloma cells lines. Cancer Res 65:3828\u20133836","journal-title":"Cancer Res"},{"key":"9086_CR33","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1126\/science.284.5413.499","volume":"284","author":"G Laroia","year":"1999","unstructured":"Laroia G, Cuesta R, Brewer G, Scheneider RJ (1999) Control of mRNA decay by heat shock-ubiquitin-proteasome pathway. Science 284:499\u2013502","journal-title":"Science"},{"key":"9086_CR34","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1073\/pnas.042575699","volume":"99","author":"G Laroia","year":"2002","unstructured":"Laroia G, Sarkar B, Scheneider RJ (2002) Ubiquitin-dependent mechanisms regulates rapid turnover of AU-rich cytokine mRNAs. Proc Natl Acad Sci USA 99:1842\u20131846","journal-title":"Proc Natl Acad Sci USA"},{"key":"9086_CR35","doi-asserted-by":"crossref","first-page":"8374","DOI":"10.1128\/JVI.76.16.8374-8382.2002","volume":"76","author":"J Li","year":"2002","unstructured":"Li J, Liu Y, Kim BO, He JJ (2002) Direct participation of Sam68, the 68-kilodalton Src-associated protein in mitosis, in the CRM1-mediated Rev nuclear export pathway. J Virol 76:8374\u20138382","journal-title":"J Virol"},{"key":"9086_CR36","first-page":"73","volume":"1653","author":"KE Lukong","year":"2003","unstructured":"Lukong KE, Richard S (2003) Sam68, the KH domain-containing superSTAR. Biochim Biophys Acta 1653:73\u201386","journal-title":"Biochim Biophys Acta"},{"key":"9086_CR37","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nature01153","volume":"420","author":"N Matter","year":"2002","unstructured":"Matter N, Herrlich P, K\u00f6nig H (2002) Signal-dependent regulation of splicing via phosphorylation of SAM68. Nature 420:691\u2013695","journal-title":"Nature"},{"key":"9086_CR38","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1091\/mbc.e06-12-1079","volume":"18","author":"R Mazroui","year":"2007","unstructured":"Mazroui R, Di Marco S, Kaufman RJ, Gallouzi IE (2007) Inhibition of the ubiquitin-proteasome system induces stress granule formation. Mol Biol Cell 18:2603\u20132618","journal-title":"Mol Biol Cell"},{"key":"9086_CR39","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.drup.2008.08.002","volume":"11","author":"DJ McConkey","year":"2008","unstructured":"McConkey DJ, Zhu K (2008) Mechanisms of proteasome inhibitor action and resistance in cancer. Drug Resist Updat 11:164\u2013179","journal-title":"Drug Resist Updat"},{"key":"9086_CR40","doi-asserted-by":"crossref","first-page":"6331","DOI":"10.1523\/JNEUROSCI.16-20-06331.1996","volume":"16","author":"E Mengual","year":"1996","unstructured":"Mengual E, Arizti P, Rodrigo J, Gim\u00e9nez-Amaya JM, Casta\u00f1o JG (1996) Immunohistochemical distribution and electron microscopic subcellular localization of the proteasome in the rat CNS. J Neurosci 16:6331\u20136341","journal-title":"J Neurosci"},{"key":"9086_CR41","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/nar\/gki231","volume":"33","author":"S Modem","year":"2005","unstructured":"Modem S, Badri KR, Holland TC, Reddy TR (2005) Sam68 is absolutely required for Rev function and HIV-1 production. Nucleic Acids Res 33:873\u2013879","journal-title":"Nucleic Acids Res"},{"key":"9086_CR42","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF02705243","volume":"31","author":"D Nandi","year":"2006","unstructured":"Nandi D, Tahiliani P, Kumar A, Chandu D (2006) The ubiquitin-proteasome system. J Biosci 31:137\u2013155","journal-title":"J Biosci"},{"key":"9086_CR43","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1083\/jcb.200811138","volume":"185","author":"MP Paronetto","year":"2009","unstructured":"Paronetto MP, Messina V, Bianchi E, Barchi M, Vogel G, Moretti C, Palombi F, Stefanini M, Geremia R, Richard S, Sette C (2009) Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis. J Cell Biol 185:235\u2013249","journal-title":"J Cell Biol"},{"key":"9086_CR44","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/excr.2000.4814","volume":"10","author":"E Pena","year":"2000","unstructured":"Pena E, Berciano MT, Fernandez R, Crespo P, Lafarga M (2000) Stress-induced activation of c-Jun N-terminal kinase in sensory ganglion neurons: accumulation in nuclear domains enriched in splicing factors and distribution in perichromatin fibrils. Exp Cell Res 10:179\u2013191","journal-title":"Exp Cell Res"},{"key":"9086_CR45","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/1096-9861(20010205)430:2<250::AID-CNE1029>3.0.CO;2-L","volume":"430","author":"E Pena","year":"2001","unstructured":"Pena E, Berciano MT, Fernandez R, Ojeda JL, Lafarga M (2001) Neuronal body size correlates with the number of nucleoli and Cajal bodies, and with the organization of the splicing machinery in rat trigeminal ganglion neurons. J Comp Neurol 430:250\u2013263","journal-title":"J Comp Neurol"},{"key":"9086_CR46","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1042\/BST0360505","volume":"36","author":"P Rajan","year":"2008","unstructured":"Rajan P, Gaughant L, Dalgliesh C, El-Sherif A, Robson CN, Leung HY, Elliott DJ (2008) Regulation of gene expression by the RNA-binding protein SAM68 in cancer. Biochem Soc Trans 36:505\u2013507","journal-title":"Biochem Soc Trans"},{"key":"9086_CR47","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/1047-8477(90)90066-L","volume":"104","author":"I Raska","year":"1990","unstructured":"Raska I, Ochs RL, Andrade LEC, Chan EKL, Burlingame R, Peebles C, Gruol D, Tan EM (1990) Association between the nucleolus and the coiled body. J Struct Biol 104:120\u2013127","journal-title":"J Struct Biol"},{"key":"9086_CR48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev.med.57.042905.122625","volume":"57","author":"PG Richardson","year":"2006","unstructured":"Richardson PG, Mitsiades C, Hideshima T, Anderson KC (2006a) Bortezomib: proteasome inhibition as an effective anticancer therapy. Annu Rev Med 57:33\u201347","journal-title":"Annu Rev Med"},{"key":"9086_CR49","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1200\/JCO.2005.04.7779","volume":"24","author":"PG Richardson","year":"2006","unstructured":"Richardson PG, Briemberg H, Jagannath S, Wen PY, Barlogie B, Berenson J, Singhal S, Siegel DS, Irwin D, Schuster M, Srkalovic G, Alexanian R, Rajkumar SV, Limentani S, Alsina M, Orlowski RZ, Najarian K, Esseltine D, Anderson KC, Amato AA (2006b) Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib. J Clin Oncol 24:3113\u20133120","journal-title":"J Clin Oncol"},{"key":"9086_CR50","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/978-1-60327-461-6_22","volume-title":"The nucleus: volume 2","author":"J Rouquette","year":"2008","unstructured":"Rouquette J, Kalland KH, Fakan S (2008) Visualization of RNA by electron microscopic in situ hybridization. In: Hancock R (ed) The nucleus: volume 2. Humana Press, Totowa, NJ, pp 403\u2013413"},{"key":"9086_CR51","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.1158\/1078-0432.CCR-04-0422","volume":"10","author":"MH Shah","year":"2004","unstructured":"Shah MH, Young D, Kindler HL, Webb I, Kleiber B, Wright J, Grever M (2004) Phase II study of the proteasome inhibitor bortezomib (PS-341) in patients with metastatic neuroendocrine tumors. Clin Cancer Res 10:6111\u20136118","journal-title":"Clin Cancer Res"},{"key":"9086_CR52","first-page":"175","volume-title":"Handbook of biological data","author":"WS Spector","year":"1956","unstructured":"Spector WS (1956) Handbook of biological data. W.B. Sanders Co., Philadelphia, p 175"},{"key":"9086_CR53","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.cell.2006.10.045","volume":"127","author":"H Szutorisz","year":"2006","unstructured":"Szutorisz H, Georgiou A, Tora L, Dillon N (2006) The proteasome restricts permissive transcription at tissue-specific gene loci in embryonic stem cells. Cell 127:1375\u20131388","journal-title":"Cell"},{"key":"9086_CR54","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(94)90502-9","volume":"78","author":"M Treier","year":"1994","unstructured":"Treier M, Staszewski LM, Bohmann D (1994) Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell 78:787\u2013798","journal-title":"Cell"},{"key":"9086_CR55","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/j.bbamcr.2008.05.005","volume":"1783","author":"J Woulfe","year":"2008","unstructured":"Woulfe J (2008) Nuclear bodies in neurodegenerative disease. Biochim Biophys Acta 1783:2195\u20132206","journal-title":"Biochim Biophys Acta"},{"key":"9086_CR56","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1038\/sj.onc.1203606","volume":"19","author":"J Zimmermann","year":"2000","unstructured":"Zimmermann J, Erdmann D, Lalande I, Grossenbacher R, Noorani M, Furst P (2000) Proteasome inhibitor induced gene expression profiles reveal overexpression of transcriptional regulators ATF3, GADD153 and MAD1. Oncogene 19:2913\u20132920","journal-title":"Oncogene"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-009-9086-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12640-009-9086-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-009-9086-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T21:28:52Z","timestamp":1633728532000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12640-009-9086-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,16]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["9086"],"URL":"https:\/\/doi.org\/10.1007\/s12640-009-9086-1","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,16]]}}}