{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:39:55Z","timestamp":1757543995118},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,8,22]],"date-time":"2009-08-22T00:00:00Z","timestamp":1250899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1007\/s12640-009-9100-7","type":"journal-article","created":{"date-parts":[[2009,8,21]],"date-time":"2009-08-21T16:00:47Z","timestamp":1250870447000},"page":"268-278","source":"Crossref","is-referenced-by-count":6,"title":["Genetic Susceptibility in Solvent Induced Neurobehavioral Effects"],"prefix":"10.1007","volume":"17","author":[{"given":"L.","family":"Godderis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Maertens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"de Gelder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"De Lamper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"De Ruyck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Vernimmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bulterys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Moens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Thierens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. K.","family":"Viaene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,8,22]]},"reference":[{"key":"9100_CR1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1191\/0748233702th152oa","volume":"18","author":"A Ahmadi","year":"2002","unstructured":"Ahmadi A, Jonsson P, Flodin U, Soderkvist P (2002) Interaction between smoking and glutathione S-transferase polymorphisms in solvent-induced chronic toxic encephalopathy. Toxicol Ind Health 18:289\u2013296","journal-title":"Toxicol Ind Health"},{"key":"9100_CR2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1006\/abio.1996.0153","volume":"236","author":"M Arand","year":"1996","unstructured":"Arand M, M\u00fchlbauer R, Hengstler J, J\u00e4ger E, Fuchs J, Winkler L, Oesch F (1996) A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms. Anal Biochem 236:184\u2013186","journal-title":"Anal Biochem"},{"key":"9100_CR3","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/hmg\/6.4.577","volume":"6","author":"T Arinami","year":"1997","unstructured":"Arinami T, Gao M, Hamaguchi H, Toru M (1997) A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum Mol Genet 6:577\u2013582","journal-title":"Hum Mol Genet"},{"key":"9100_CR4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1196\/annals.1417.013","volume":"1129","author":"MA Bellgrove","year":"2008","unstructured":"Bellgrove MA, Mattingley JB (2008) Molecular genetics of attention. Ann N Y Acad Sci 1129:200\u2013212","journal-title":"Ann N Y Acad Sci"},{"key":"9100_CR5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s002590050374","volume":"26","author":"J Booij","year":"1999","unstructured":"Booij J, Tissingh G, Winogrodzka A, van Royen EA (1999) Imaging of the dopaminergic neurotransmission system using single-photon emission tomography and positron emission tomography in patients with parkinsonism. Eur J Nucl Med 26:171\u2013182","journal-title":"Eur J Nucl Med"},{"key":"9100_CR6","unstructured":"Brebels R, Viaene MK (2008) Chronic toxic encephalopathy by solvents: 10\u00a0years experience with a difficult diagnosis (in Dutch). Patient Care Neuropsychiatrie 5\u20139"},{"key":"9100_CR7","unstructured":"Bulterys S, Viaene MK (1994) The development of a screening test for the neuropsycho-logical evaluation of solvent-exposed workers [abstract]. Abstract book 5th international symposium on neurobehavioral methods and effects in occupational and environmental health. Cairo"},{"key":"9100_CR8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0924-9338(02)00625-9","volume":"17","author":"JP Connor","year":"2002","unstructured":"Connor JP, Young RM, Lawford BR, Ritchie TL, Noble EP (2002) D(2) dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence. Eur Psychiatry 17:17\u201323","journal-title":"Eur Psychiatry"},{"key":"9100_CR9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1136\/oem.2005.022400","volume":"63","author":"FD Dick","year":"2006","unstructured":"Dick FD (2006) Solvent neurotoxicity. Occup Environ Med 63:221\u2013226","journal-title":"Occup Environ Med"},{"key":"9100_CR10","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/qjmed\/95.6.379","volume":"95","author":"F Dick","year":"2002","unstructured":"Dick F, Semple S, Osborne A, Soutar A, Seaton A, Cherrie JW, Walker LG, Haites N (2002) Organic solvent exposure, genes, and risk of neuropsychological impairment. QJM 95:379\u2013387","journal-title":"QJM"},{"key":"9100_CR11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1136\/oem.2006.032078","volume":"64","author":"FD Dick","year":"2007","unstructured":"Dick FD, De Palma G, Ahmadi A, Osborne A, Scott NW, Prescott GJ, Bennett J, Semple S, Dick S, Mozzoni P, Haites N, Wettinger SB, Mutti A, Otelea M, Seaton A, Soderkvist P, Felice A (2007) Gene-environment interactions in parkinsonism and Parkinson\u2019s disease: the Geoparkinson study. Occup Environ Med 64:673\u2013680","journal-title":"Occup Environ Med"},{"key":"9100_CR12","first-page":"659","volume":"21","author":"EW Dryson","year":"2000","unstructured":"Dryson EW, Ogden JA (2000) Organic solvent induced chronic toxic encephalopathy: extent of recovery, and associated factors, following cessation of exposure. Neurotoxicology 21:659\u2013665","journal-title":"Neurotoxicology"},{"key":"9100_CR13","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s004200050204","volume":"70","author":"C Edling","year":"1997","unstructured":"Edling C, Hellman B, Arvidson B, Andersson J, Hartvig P, Lilja A, Valind S, L\u00e5ngstr\u00f6m B (1997) Do organic solvents induce changes in the dopaminergic system? Positron emission tomography studies of occupationally exposed subjects. Int Arch Occup Environ Health 70:180\u2013186","journal-title":"Int Arch Occup Environ Health"},{"key":"9100_CR14","doi-asserted-by":"crossref","unstructured":"Frank MJ, Hutchison K (2009) Genetic contributions to avoidance-based decisions: striatal D2 receptor polymorphisms. Neuroscience [Epub ahead of print]","DOI":"10.1016\/j.neuroscience.2009.04.048"},{"key":"9100_CR15","first-page":"1","volume":"25","author":"S Garte","year":"1997","unstructured":"Garte S, Zocchetti C, Taioli E (1997) Gene\u2013environment interactions in the application of biomarkers of cancer susceptibility in epidemiology. IARC Sci Publ 25:1\u2013264","journal-title":"IARC Sci Publ"},{"key":"9100_CR16","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/em.20069","volume":"44","author":"L Godderis","year":"2004","unstructured":"Godderis L, De Boeck M, Haufroid V, Emmery M, Mateuca R, Gardinal S, Kirsch-Volders M, Veulemans H, Lison D (2004) Influence of genetic polymorphisms on biomarkers of exposure and genotoxic effects in styrene-exposed workers. Environ Mol Mutagen 44:293\u2013303","journal-title":"Environ Mol Mutagen"},{"key":"9100_CR17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ijheh.2005.09.005","volume":"209","author":"L Godderis","year":"2006","unstructured":"Godderis L, Braeckman L, Vanhoorne M, Viaene M (2006a) Neurobehavioral and clinical effects in workers exposed to CS(2). Int J Hyg Environ Health 209:139\u2013150","journal-title":"Int J Hyg Environ Health"},{"key":"9100_CR18","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.tox.2005.11.021","volume":"219","author":"L Godderis","year":"2006","unstructured":"Godderis L, Aka P, Mateuca R, Kirsch-Volders M, Lison D, Veulemans H (2006b) Dose-dependent influence of genetic polymorphisms on DNA damage induced by styrene oxide, ethylene oxide and gamma-radiation. Toxicology 219:220\u2013229","journal-title":"Toxicology"},{"issue":"3","key":"9100_CR19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1023\/A:1022191012698","volume":"33","author":"VE Golimbet","year":"2003","unstructured":"Golimbet VE, Aksenova MG, Nosikov VV, Orlova VA, Kaleda VG (2003) Analysis of the linkage of the Taq1A and Taq1B loci of the dopamine D2 receptor gene with schizophrenia in patients and their siblings. Neurosci Behav Physiol 33(3):223\u2013225","journal-title":"Neurosci Behav Physiol"},{"key":"9100_CR20","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s004150050334","volume":"246","author":"G Hageman","year":"1999","unstructured":"Hageman G, van der Hoek J, van Hout M, van der Laan G, Steur EJ, de Bruin W, Herholz K (1999) Parkinsonism, pyramidal signs, polyneuropathy, and cognitive decline after long-term occupational solvent exposure. J Neurol 246:198\u2013206","journal-title":"J Neurol"},{"key":"9100_CR21","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/00008571-200212000-00003","volume":"12","author":"V Haufroid","year":"2002","unstructured":"Haufroid V, Jakubowski M, Janasik B, Ligocka D, Buchet JP, Bergamaschi E, Manini P, Mutti A, Ghittori S, Arand M, Hangen N, Oesch F, Hirvonen A, Lison D (2002) Interest of genotyping and phenotyping of drug-metabolizing enzymes for the interpretation of biological monitoring of exposure to styrene. Pharmacogenetics 12:691\u2013702","journal-title":"Pharmacogenetics"},{"key":"9100_CR22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF03033483","volume":"11","author":"J Hoenicka","year":"2007","unstructured":"Hoenicka J, Aragues M, Ponce G, Rodriguez-Jimenez R, Jimenez-Arriero MA, Palomo T (2007) From dopaminergic genes to psychiatric disorders. Neurotox Res 11:61\u201372","journal-title":"Neurotox Res"},{"key":"9100_CR23","first-page":"249","volume-title":"Developments in occupational medicine","author":"C Hogstedt","year":"1980","unstructured":"Hogstedt C, Hane M, Axelson O (1980) Diagnostic and health care aspects of workers exposed to solvents. In: Zenz C (ed) Developments in occupational medicine. Year Book Medical Publisher Inc., Chicago, London, pp 249\u2013258"},{"key":"9100_CR24","volume-title":"Development of cut-off scores for the Neurotoxicity Symptom Checklist (NSC-60)","author":"J Hooisma","year":"1992","unstructured":"Hooisma J, Emmen HH (1992) Development of cut-off scores for the Neurotoxicity Symptom Checklist (NSC-60). Stichting Arbouw, Amsterdam"},{"issue":"suppl 1","key":"9100_CR25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5271\/sjweh.1826","volume":"16","author":"A Iregren","year":"1990","unstructured":"Iregren A, Gamberale F (1990) Human behavioral toxicology. Central nervous effects of low-dose exposure to neurotoxic substances in the work environment. Scand J Work Environ Health 16(suppl 1):17\u201325","journal-title":"Scand J Work Environ Health"},{"key":"9100_CR26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2486\/indhealth.32.145","volume":"32","author":"M Kanada","year":"1994","unstructured":"Kanada M, Miyagawa M, Sato M, Hasegawa H, Honma T (1994) Neurochemical profile of effects of 28 neurotoxic chemicals on the central nervous system in rats. Effects of oral administration on brain contents of biogenic amines and metabolites. Ind Health 32:145\u2013164","journal-title":"Ind Health"},{"key":"9100_CR27","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1177\/0748233706070287","volume":"22","author":"S Kezic","year":"2006","unstructured":"Kezic S, Calkoen F, Wenker MA, Jacobs JJ, Verberk MM (2006) Genetic polymorphism of metabolic enzymes modifies the risk of chronic solvent-induced encephalopathy. Toxicol Ind Health 22:281\u2013289","journal-title":"Toxicol Ind Health"},{"key":"9100_CR28","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1158\/1055-9965.EPI-05-0487","volume":"15","author":"M Kirsch-Volders","year":"2006","unstructured":"Kirsch-Volders M, Mateuca RA, Roelants M, Tremp A, Zeiger E, Bonassi S, Holland N, Chang WP, Aka PV, Deboeck M, Godderis L, Haufroid V, Ishikawa H, Laffon B, Marcos R, Migliore L, Norppa H, Teixeira JP, Zijno A, Fenech M (2006) The effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo. Cancer Epidemiol Biomarkers Prev 15:1038\u20131042","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"9100_CR29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0300-483X(02)00729-1","volume":"186","author":"B Laffon","year":"2003","unstructured":"Laffon B, Perez-Cadahia B, Pasaro E, Mendez J (2003) Individual sensitivity to DNA damage induced by styrene in vitro: influence of cytochrome p450, epoxide hydrolase and glutathione S-transferase genotypes. Toxicology 186:131\u2013141","journal-title":"Toxicology"},{"key":"9100_CR30","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/sj.npp.1300861","volume":"31","author":"C Lerman","year":"2006","unstructured":"Lerman C, Jepson C, Wileyto EP, Epstein LH, Rukstalis M, Patterson F, Kaufmann V, Restine S, Hawk L, Niaura R, Berrettini W (2006) Role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials. Neuropsychopharmacology 31:231\u2013242","journal-title":"Neuropsychopharmacology"},{"key":"9100_CR31","first-page":"195","volume":"90","author":"R Letz","year":"1991","unstructured":"Letz R (1991) Use of computerized test batteries for quantifying neurobehavioral outcomes. Environ Health Perspect 90:195\u2013198","journal-title":"Environ Health Perspect"},{"issue":"4\u20135","key":"9100_CR32","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0161-813X(03)00044-5","volume":"24","author":"R Letz","year":"2003","unstructured":"Letz R, DiIorio CK, Shafer PO, Yeager KA, Schomer DL, Henry TR (2003) Further standardization of some NES3 tests. Neurotoxicology 24(4\u20135):491\u2013501","journal-title":"Neurotoxicology"},{"key":"9100_CR33","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/sj.mp.4001938","volume":"12","author":"MR Munafo","year":"2007","unstructured":"Munafo MR, Matheson IJ, Flint J (2007) Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case\u2013control studies and evidence of publication bias. Mol Psychiatry 12:454\u2013461","journal-title":"Mol Psychiatry"},{"key":"9100_CR34","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1517\/14622416.1.3.309","volume":"1","author":"EP Noble","year":"2000","unstructured":"Noble EP (2000) The DRD2 gene in psychiatric and neurological disorders and its phenotypes. Pharmacogenomics 1:309\u2013333","journal-title":"Pharmacogenomics"},{"key":"9100_CR35","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/00008571-200012000-00003","volume":"10","author":"J Sarmanova","year":"2000","unstructured":"Sarmanova J, Tynkova L, Susova S, Gut I, Soucek P (2000) Genetic polymorphisms of biotransformation enzymes: allele frequencies in the population of the Czech Republic. Pharmacogenetics 10:781\u2013788","journal-title":"Pharmacogenetics"},{"key":"9100_CR36","doi-asserted-by":"crossref","first-page":"360","DOI":"10.5271\/sjweh.154","volume":"22","author":"P S\u00f6derkvist","year":"1996","unstructured":"S\u00f6derkvist P, Ahmadi A, Akerback A, Axelson O, Flodin U (1996) Glutathione S-transferase M1 null genotype as a risk modifier for solvent-induced chronic toxic encephalopathy. Scand J Work Environ Health 22:360\u2013363","journal-title":"Scand J Work Environ Health"},{"issue":"5","key":"9100_CR37","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/mds.10406","volume":"18","author":"EK Tan","year":"2003","unstructured":"Tan EK, Tan Y, Chai A, Tan C, Shen H, Lum SY, Fook-Cheong SM, Teoh ML, Yih Y, Wong MC, Zhao Y (2003) Dopamine D2 receptor TaqIA and TaqIB polymorphisms in Parkinson\u2019s disease. Mov Disord 18(5):593\u2013595","journal-title":"Mov Disord"},{"key":"9100_CR38","first-page":"217","volume":"60","author":"MK Viaene","year":"2002","unstructured":"Viaene MK (2002) Overview of the neurotoxic effects in solvent-exposed workers. Arch Public Health 60:217\u2013232","journal-title":"Arch Public Health"},{"key":"9100_CR39","first-page":"7","volume":"20","author":"MK Viaene","year":"1999","unstructured":"Viaene MK, Roels HA, Leenders J, De Groof M, Swerts LJ, Lison D, Masschelein R (1999) Cadmium: a possible etiological factor in peripheral polyneuropathy. Neurotoxicology 20:7\u201316","journal-title":"Neurotoxicology"},{"issue":"2","key":"9100_CR40","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1136\/oem.58.2.103","volume":"58","author":"MK Viaene","year":"2001","unstructured":"Viaene MK, Roels HA, Leenders J, De Groof M, Swerts LJ, Lison D, Masschelein R (2001) Neurobehavioural changes and persistence of complaints in workers exposed to styrene in a polyester boat building plant: influence of exposure characteristics and microsomal epoxide hydrolase phenotype. Occup Environ Med 58(2):103\u2013112","journal-title":"Occup Environ Med"},{"key":"9100_CR41","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.21364","volume":"63","author":"I Visser","year":"2008","unstructured":"Visser I, Lavini C, Booij J, Reneman L, Majoie C, de Boer AG, Wekking EM, de Joode EA, van der Laan G, van Dijk FJ, Schene AH, Den Heeten GJ (2008) Cerebral impairment in chronic solvent-induced encephalopathy. Ann Neurol 63:572\u2013580","journal-title":"Ann Neurol"},{"key":"9100_CR42","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0140-6736(96)07218-2","volume":"349","author":"RF White","year":"1997","unstructured":"White RF, Proctor SP (1997) Solvents and neurotoxicity. Lancet 349:1239\u20131243","journal-title":"Lancet"},{"key":"9100_CR43","first-page":"20","volume":"5","author":"World Health Organization and Nordic Council of Ministers Working group","year":"1985","unstructured":"World Health Organization and Nordic Council of Ministers Working group (1985) Chronic effects of organic solvents on the central nervous system and diagnostic criteria. Environ Health 5:20\u201335","journal-title":"Environ Health"},{"issue":"51","key":"9100_CR44","doi-asserted-by":"crossref","first-page":"20552","DOI":"10.1073\/pnas.0707106104","volume":"104","author":"Y Zhang","year":"2007","unstructured":"Zhang Y, Bertolino A, Fazio L, Blasi G, Rampino A, Romano R, Lee M-LT, Xiao T, Papp A, Wang D, Sad\u00e9e W (2007) Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proc Natl Acad Sci USA 104(51):20552\u201320557","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-009-9100-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12640-009-9100-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-009-9100-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T13:31:13Z","timestamp":1559482273000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12640-009-9100-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,22]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["9100"],"URL":"https:\/\/doi.org\/10.1007\/s12640-009-9100-7","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,22]]}}}