{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:01:42Z","timestamp":1777471302339,"version":"3.51.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,12,18]],"date-time":"2009-12-18T00:00:00Z","timestamp":1261094400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1007\/s12640-009-9144-8","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T21:49:49Z","timestamp":1261086589000},"page":"102-114","source":"Crossref","is-referenced-by-count":15,"title":["Differential Effects of Tityus bahiensis Scorpion Venom on Tetrodotoxin-Sensitive and Tetrodotoxin-Resistant Sodium Currents"],"prefix":"10.1007","volume":"19","author":[{"given":"Eder R.","family":"Moraes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evanguedes","family":"Kalapothakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edgia A.","family":"Naves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Kushmerick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,12,18]]},"reference":[{"key":"9144_CR1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0041-0101(01)00197-0","volume":"40","author":"LM Alvarenga","year":"2002","unstructured":"Alvarenga LM, Diniz CR, Granier C, Ch\u00e1vez-Ol\u00f3rtegui C (2002) Induction of neutralizing antibodies against Tityus serrulatus scorpion toxins by immunization with a mixture of defined synthetic epitopes. Toxicon 40:89\u201395","journal-title":"Toxicon"},{"key":"9144_CR2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1085\/jgp.63.5.533","volume":"63","author":"CM Armstrong","year":"1974","unstructured":"Armstrong CM, Bezanilla F (1974) Charge movement associated with the opening and closing of the activation gates of the Na channels. J Gen Physiol 63:533\u2013552","journal-title":"J Gen Physiol"},{"issue":"Pt 3","key":"9144_CR3","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1042\/bj3130753","volume":"313","author":"B Becerril","year":"1996","unstructured":"Becerril B, Corona M, Coronas FI, Zamudio F, Calderon-Aranda ES, Fletcher PL, Martin BM, Possani LD (1996) Toxic peptides and genes encoding toxin gamma of the Brazilian scorpions Tityus bahiensis and Tityus stigmurus. Biochem J 313(Pt 3):753\u2013760","journal-title":"Biochem J"},{"key":"9144_CR4","first-page":"1294","volume":"61","author":"L Bonilha","year":"2004","unstructured":"Bonilha L, Cendes F, Ghizoni E, Vieira RJ, Li LM (2004) Epilepsy due to a destructive brain lesion caused by a scorpion sting. Arch Neurol 61:1294\u20131296","journal-title":"Arch Neurol"},{"key":"9144_CR5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.toxicon.2007.08.006","volume":"51","author":"A Borges","year":"2008","unstructured":"Borges A, Sousa LD, Espinoza J, Melo MM, Santos RG, Kalapothakis E, Valadares D, Ch\u00e1vez-Ol\u00f3rtegui C (2008) Characterization of Tityus scorpion venoms using synaptosome binding assays and reactivity towards Venezuelan and Brazilian antivenoms. Toxicon 51:66\u201379","journal-title":"Toxicon"},{"key":"9144_CR6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"9144_CR7","first-page":"83","volume":"25","author":"W Bucherl","year":"1953","unstructured":"Bucherl W (1953) Scorpions and scorpionism in Brazil. 2. Effect of the venom of Tityus serrulatus and T. bahiensis on mice. Mem Inst Butantan 25:83\u2013108","journal-title":"Mem Inst Butantan"},{"key":"9144_CR8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1113\/jphysiol.1975.sp010810","volume":"244","author":"MD Cahalan","year":"1975","unstructured":"Cahalan MD (1975) Modification of sodium channel gating in frog myelinated nerve fibres by Centruroides sculpturatus scorpion venom. J Physiol 244:511\u2013534","journal-title":"J Physiol"},{"key":"9144_CR9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.toxicon.2004.01.012","volume":"43","author":"FV Campos","year":"2004","unstructured":"Campos FV, Moreira TH, Beir\u00e3o PSL, Cruz JS (2004) Veratridine modifies the TTX-resistant Na+ channels in rat vagal afferent neurons. Toxicon 43:401\u2013406","journal-title":"Toxicon"},{"key":"9144_CR10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1085\/jgp.200609719","volume":"130","author":"FV Campos","year":"2007","unstructured":"Campos FV, Chanda B, Beir\u00e3o PSL, Bezanilla F (2007) beta-Scorpion toxin modifies gating transitions in all four voltage sensors of the sodium channel. J Gen Physiol 130:257\u2013268","journal-title":"J Gen Physiol"},{"key":"9144_CR11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev.pa.20.040180.000311","volume":"20","author":"WA Catterall","year":"1980","unstructured":"Catterall WA (1980) Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Annu Rev Pharmacol Toxicol 20:15\u201343","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"9144_CR12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)81133-2","volume":"26","author":"WA Catterall","year":"2000","unstructured":"Catterall WA (2000) From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26:13\u201325","journal-title":"Neuron"},{"key":"9144_CR13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1124\/pr.55.4.7","volume":"55","author":"WA Catterall","year":"2003","unstructured":"Catterall WA, Goldin AL, Waxman SG (2003) International Union of Pharmacology. XXXIX. Compendium of voltage-gated ion channels: sodium channels. Pharmacol Rev 55:575\u2013578","journal-title":"Pharmacol Rev"},{"key":"9144_CR14","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0300-9084(00)01174-3","volume":"82","author":"S Cest\u00e8le","year":"2000","unstructured":"Cest\u00e8le S, Catterall WA (2000) Molecular mechanisms of neurotoxin action on voltage-gated sodium channels. Biochimie 82:883\u2013892","journal-title":"Biochimie"},{"key":"9144_CR15","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0896-6273(00)80606-6","volume":"21","author":"S Cest\u00e8le","year":"1998","unstructured":"Cest\u00e8le S, Qu Y, Rogers JC, Rochat H, Scheuer T, Catterall WA (1998) Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3\u2013S4 loop in domain II. Neuron 21:919\u2013931","journal-title":"Neuron"},{"key":"9144_CR16","doi-asserted-by":"crossref","first-page":"21332","DOI":"10.1074\/jbc.M603814200","volume":"281","author":"S Cest\u00e8le","year":"2006","unstructured":"Cest\u00e8le S, Yarov-Yarovoy V, Qu Y, Sampieri F, Scheuer T, Catterall WA (2006) Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin. J Biol Chem 281:21332\u201321344","journal-title":"J Biol Chem"},{"key":"9144_CR17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1152\/jn.00854.2005","volume":"96","author":"J-S Choi","year":"2006","unstructured":"Choi J-S, Hudmon A, Waxman SG, Dib-Hajj SD (2006) Calmodulin regulates current density and frequency-dependent inhibition of sodium channel Nav1.8 in DRG neurons. J Neurophysiol 96:97\u2013108","journal-title":"J Neurophysiol"},{"key":"9144_CR18","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0022-3565(25)28128-9","volume":"164","author":"AP Corrado","year":"1968","unstructured":"Corrado AP, Antonio A, Diniz CR (1968) Brazilian scorpion venom (Tityus serrulatus), an unusual sympathetic postganglionic stimulant. J Pharmacol Exp Ther 164:253\u2013258","journal-title":"J Pharmacol Exp Ther"},{"key":"9144_CR19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mcn.2004.01.015","volume":"26","author":"B Coste","year":"2004","unstructured":"Coste B, Osorio N, Padilla F, Crest M, Delmas P (2004) Gating and modulation of presumptive NaV1.9 channels in enteric and spinal sensory neurons. Mol Cell Neurosci 26:123\u2013134","journal-title":"Mol Cell Neurosci"},{"key":"9144_CR20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1085\/jgp.200609665","volume":"129","author":"B Coste","year":"2007","unstructured":"Coste B, Crest M, Delmas P (2007) Pharmacological dissection and distribution of NaN\/Nav1.9, T-type Ca2+ currents, and mechanically activated cation currents in different populations of DRG neurons. J Gen Physiol 129:57\u201377","journal-title":"J Gen Physiol"},{"key":"9144_CR21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.toxicon.2006.09.016","volume":"49","author":"RCR Vega de la","year":"2007","unstructured":"de la Vega RCR, Possani LD (2007) Novel paradigms on scorpion toxins that affects the activating mechanism of sodium channels. Toxicon 49:171\u2013180","journal-title":"Toxicon"},{"key":"9144_CR22","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1016\/S0006-3495(02)75270-3","volume":"83","author":"MAL Eriksson","year":"2002","unstructured":"Eriksson MAL, Roux B (2002) Modeling the structure of agitoxin in complex with the Shaker K+ channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cycles. Biophys J 83:2595\u20132609","journal-title":"Biophys J"},{"key":"9144_CR23","first-page":"899","volume":"33","author":"MV Gomez","year":"1966","unstructured":"Gomez MV, Diniz CR (1966) Separation of toxic components from the Brazilian scorpion Tityus serrulatus venom. Mem Inst Butantan 33:899\u2013902","journal-title":"Mem Inst Butantan"},{"key":"9144_CR24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/15563659209038636","volume":"30","author":"M Gueron","year":"1992","unstructured":"Gueron M, Ilia R, Sofer S (1992) The cardiovascular system after scorpion envenomation. A review. J Toxicol Clin Toxicol 30:245\u2013258","journal-title":"J Toxicol Clin Toxicol"},{"key":"9144_CR51","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","volume":"391","author":"OP Hamill","year":"1981","unstructured":"Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391:85\u2013100","journal-title":"Pflugers Arch"},{"key":"9144_CR25","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1152\/jn.2001.86.3.1351","volume":"86","author":"RI Herzog","year":"2001","unstructured":"Herzog RI, Cummins TR, Waxman SG (2001) Persistent TTX-resistant Na+ current affects resting potential and response to depolarization in simulated spinal sensory neurons. J Neurophysiol 86:1351\u20131364","journal-title":"J Neurophysiol"},{"key":"9144_CR26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1113\/jphysiol.1987.sp016656","volume":"389","author":"SR Ikeda","year":"1987","unstructured":"Ikeda SR, Schofield GG (1987) Tetrodotoxin-resistant sodium current of rat nodose neurones: monovalent cation selectivity and divalent cation block. J Physiol 389:255\u2013270","journal-title":"J Physiol"},{"key":"9144_CR27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1085\/jgp.200409054","volume":"124","author":"C-C Kuo","year":"2004","unstructured":"Kuo C-C, Chen W-Y, Yang Y-C (2004) Block of tetrodotoxin-resistant Na+ channel pore by multivalent cations: gating modification and Na+ flow dependence. J Gen Physiol 124:27\u201342","journal-title":"J Gen Physiol"},{"key":"9144_CR28","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0028-3908(99)00267-1","volume":"39","author":"RM Le\u00e3o","year":"2000","unstructured":"Le\u00e3o RM, Cruz JS, Diniz CR, Cordeiro MN, Beir\u00e3o PS (2000) Inhibition of neuronal high-voltage activated calcium channels by the omega-phoneutria nigriventer Tx3-3 peptide toxin. Neuropharmacology 39:1756\u20131767","journal-title":"Neuropharmacology"},{"key":"9144_CR29","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0006-291X(86)80112-7","volume":"139","author":"MED Lima","year":"1986","unstructured":"Lima MED, Martin MF, Diniz CR, Rochat H (1986) Tityus serrulatus toxin VII bears pharmacological properties of both beta-toxin and insect toxin from scorpion venoms. Biochem Biophys Res Commun 139:296\u2013302","journal-title":"Biochem Biophys Res Commun"},{"key":"9144_CR30","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1073\/pnas.2627986100","volume":"100","author":"SKG Maier","year":"2003","unstructured":"Maier SKG, Westenbroek RE, Yamanushi TT, Dobrzynski H, Boyett MR, Catterall WA, Scheuer T (2003) An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node. Proc Natl Acad Sci USA 100:3507\u20133512","journal-title":"Proc Natl Acad Sci USA"},{"key":"9144_CR31","doi-asserted-by":"crossref","first-page":"C381","DOI":"10.1152\/ajpcell.1983.245.5.C381","volume":"245","author":"N Matsuki","year":"1983","unstructured":"Matsuki N, Hermsmeyer K (1983) Tetrodotoxin-sensitive Na+ channels in isolated single cultured rat myocardial cells. Am J Physiol 245:C381\u2013C387","journal-title":"Am J Physiol"},{"key":"9144_CR32","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0041-008X(02)00036-4","volume":"187","author":"MBS Mesquita","year":"2003","unstructured":"Mesquita MBS, Moraes-Santos T, Moraes MFD (2003) Centrally injected tityustoxin produces the systemic manifestations observed in severe scorpion poisoning. Toxicol Appl Pharmacol 187:58\u201366","journal-title":"Toxicol Appl Pharmacol"},{"key":"9144_CR33","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.toxicon.2004.12.020","volume":"45","author":"EB Nascimento","year":"2005","unstructured":"Nascimento EB, Costa KA, Bertollo CM, Oliveira ACP, Rocha LTS, Souza ALS, Gl\u00f3ria MBA, Moraes-Santos T, Coelho MM (2005) Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus. Toxicon 45:585\u2013593","journal-title":"Toxicon"},{"key":"9144_CR34","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.toxicon.2006.01.015","volume":"47","author":"DG Nascimento","year":"2006","unstructured":"Nascimento DG, Rates B, Santos DM, Verano-Braga T, Barbosa-Silva A, Dutra AAA, Biondi I, Martin-Eauclaire MF, Lima MED, Pimenta AMC (2006) Moving pieces in a taxonomic puzzle: venom 2D-LC\/MS and data clustering analyses to infer phylogenetic relationships in some scorpions from the Buthidae family (Scorpiones). Toxicon 47:628\u2013639","journal-title":"Toxicon"},{"key":"9144_CR35","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/0041-0101(94)90377-8","volume":"32","author":"AK Nishikawa","year":"1994","unstructured":"Nishikawa AK, Caricati CP, Lima ML, Santos MCD, Kipnis TL, Eickstedt VR, Knysak I, Silva MHD, Higashi HG, Silva WDD (1994) Antigenic cross-reactivity among the venoms from several species of Brazilian scorpions. Toxicon 32:989\u2013998","journal-title":"Toxicon"},{"key":"9144_CR36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0024-3205(03)00264-9","volume":"73","author":"EA Nunan","year":"2003","unstructured":"Nunan EA, Moraes MFD, Cardoso VN, Moraes-Santos T (2003) Effect of age on body distribution of Tityustoxin from Tityus serrulatus scorpion venom in rats. Life Sci 73:319\u2013325","journal-title":"Life Sci"},{"key":"9144_CR37","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0006-3495(88)83017-0","volume":"54","author":"C Oliva","year":"1988","unstructured":"Oliva C, Cohen IS, Mathias RT (1988) Calculation of time constants for intracellular diffusion in whole cell patch clamp configuration. Biophys J 54:791\u2013799","journal-title":"Biophys J"},{"key":"9144_CR38","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0041-0101(00)00240-3","volume":"39","author":"AM Pimenta","year":"2001","unstructured":"Pimenta AM, Martin-Eauclaire M, Rochat H, Figueiredo SG, Kalapothakis E, Afonso LC, Lima MED (2001) Purification, amino-acid sequence and partial characterization of two toxins with anti-insect activity from the venom of the South American scorpion Tityus bahiensis (Buthidae). Toxicon 39:1009\u20131019","journal-title":"Toxicon"},{"key":"9144_CR39","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0300-9084(00)01167-6","volume":"82","author":"LD Possani","year":"2000","unstructured":"Possani LD, Merino E, Corona M, Bolivar F, Becerril B (2000) Peptides and genes coding for scorpion toxins that affect ion-channels. Biochimie 82:861\u2013868","journal-title":"Biochimie"},{"key":"9144_CR40","doi-asserted-by":"crossref","first-page":"15950","DOI":"10.1074\/jbc.271.27.15950","volume":"271","author":"JC Rogers","year":"1996","unstructured":"Rogers JC, Qu Y, Tanada TN, Scheuer T, Catterall WA (1996) Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3\u2013S4 extracellular loop in domain IV of the Na+ channel alpha subunit. J Biol Chem 271:15950\u201315962","journal-title":"J Biol Chem"},{"key":"9144_CR41","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1523\/JNEUROSCI.23-07-02715.2003","volume":"23","author":"F Rugiero","year":"2003","unstructured":"Rugiero F, Mistry M, Sage D, Black JA, Waxman SG, Crest M, Clerc N, Delmas P, Gola M (2003) Selective expression of a persistent tetrodotoxin-resistant Na+ current and NaV1.9 subunit in myenteric sensory neurons. J Neurosci 23:2715\u20132725","journal-title":"J Neurosci"},{"key":"9144_CR42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.2006.121483","volume":"579","author":"AM Rush","year":"2007","unstructured":"Rush AM, Cummins TR, Waxman SG (2007) Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons. J Physiol 579:1\u201314","journal-title":"J Physiol"},{"key":"9144_CR43","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0304-3940(02)00860-1","volume":"331","author":"CY Saab","year":"2002","unstructured":"Saab CY, Cummins TR, Dib-Hajj SD, Waxman SG (2002) Molecular determinant of Na(v)1.8 sodium channel resistance to the venom from the scorpion Leiurus quinquestriatus hebraeus. Neurosci Lett 331:79\u201382","journal-title":"Neurosci Lett"},{"key":"9144_CR44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0300-9629(95)00096-P","volume":"112","author":"C Trequattrini","year":"1995","unstructured":"Trequattrini C, Zamudio FZ, Petris A, Prestipino G, Possani LD, Franciolini F (1995) Tityus bahiensis toxin IV-5b selectively affects Na channel inactivation in chick dorsal root ganglion neurons. Comp Biochem Physiol A Physiol 112:21\u201328","journal-title":"Comp Biochem Physiol A Physiol"},{"key":"9144_CR45","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.neures.2009.04.003","volume":"64","author":"J Wang","year":"2009","unstructured":"Wang J, Ou S-W, Wang Y-J, Kameyama M, Kameyama A, Zong Z-H (2009) Analysis of four novel variants of Nav1.5\/SCN5A cloned from the brain. Neurosci Res 64:339\u2013347","journal-title":"Neurosci Res"},{"key":"9144_CR46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1529\/biophysj.103.039156","volume":"87","author":"Y Wu","year":"2004","unstructured":"Wu Y, Cao Z, Yi H, Jiang D, Mao X, Liu H, Li W (2004) Simulation of the interaction between ScyTx and small conductance calcium-activated potassium channel by docking and MM-PBSA. Biophys J 87:105\u2013112","journal-title":"Biophys J"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-009-9144-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12640-009-9144-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-009-9144-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T22:15:02Z","timestamp":1739484902000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12640-009-9144-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,18]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["9144"],"URL":"https:\/\/doi.org\/10.1007\/s12640-009-9144-8","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,18]]}}}