{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:58:01Z","timestamp":1773320281746,"version":"3.50.1"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[2010,3,19]],"date-time":"2010-03-19T00:00:00Z","timestamp":1268956800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1007\/s12640-010-9168-0","type":"journal-article","created":{"date-parts":[[2010,3,18]],"date-time":"2010-03-18T16:10:32Z","timestamp":1268928632000},"page":"313-327","source":"Crossref","is-referenced-by-count":23,"title":["Physical Exercise Attenuates MPTP-Induced Deficits in Mice"],"prefix":"10.1007","volume":"18","author":[{"given":"Trevor","family":"Archer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Fredriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,3,19]]},"reference":[{"key":"9168_CR1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neulet.2008.11.065","volume":"450","author":"AO Ahmad","year":"2009","unstructured":"Ahmad AO, Park J-H, Stenho-Bittel L, Lau YS (2009) Effects of endurance exercise on ventral tegmental area neurons in the chronic 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine and probenecid-treated mice. Neurosci Lett 450:102\u2013105","journal-title":"Neurosci Lett"},{"key":"9168_CR2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.neulet.2008.09.029","volume":"452","author":"I Aksu","year":"2009","unstructured":"Aksu I, Topcu A, Camsari UM, Acikgoz O (2009) Effect of acute and chronic exercise on oxidant-antioxidant equilibrium in rat hippocampus, prefrontal cortex and striatum. Neurosci Lett 452:281\u2013285","journal-title":"Neurosci Lett"},{"key":"9168_CR3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neuroscience.2007.07.038","volume":"149","author":"M Al-Jarrah","year":"2007","unstructured":"Al-Jarrah M, Pothakos K, Novikova L, Smirnova IV, Kurz MJ, Stenho-Bittel L, Lau YS (2007) Endurance exercise promotes cardiorespiratory rehabilitation without neurorestoration in the chronic mouse model of Parkinsonism with severe neurodegeneration. Neuroscience 149:28\u201337","journal-title":"Neuroscience"},{"key":"9168_CR4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00702-002-0777-5","volume":"110","author":"T Archer","year":"2003","unstructured":"Archer T, Fredriksson A (2003) An antihypokinesic action of \u03b12-adrenoceptors upon MPTP-induced behavior deficits in mice. J Neural Transm 110:183\u2013200","journal-title":"J Neural Transm"},{"key":"9168_CR5","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s00702-005-0402-5","volume":"113","author":"T Archer","year":"2006","unstructured":"Archer T, Fredriksson A (2006) Influence of noradrenaline denervation upon MPTP-induced deficts in mice. J Neural Transm 113:1119\u20131129","journal-title":"J Neural Transm"},{"key":"9168_CR6","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s11064-007-9358-1","volume":"32","author":"T Archer","year":"2007","unstructured":"Archer T, Fredriksson A (2007) Functional consequences of iron overload in catecholaminergic interactions: the Youdim factor. Neurochem Res 32:1625\u20131639","journal-title":"Neurochem Res"},{"key":"9168_CR7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF00652230","volume":"88","author":"T Archer","year":"1986","unstructured":"Archer T, Fredriksson A, Jonsson G, Lewander T, Mohammed AK, Ross SB, S\u00f6derberg U (1986) Central noradrenaline depletion antagonizes aspects of d-amphetamineinduced hyperactivity in the rat. Psychopharmacology 88:141\u2013146","journal-title":"Psychopharmacology"},{"key":"9168_CR8","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.pbb.2009.06.009","volume":"93","author":"CH Balthazar","year":"2009","unstructured":"Balthazar CH, Leite LH, Rodrigues AG, Coimbra CC (2009) Performance-enhancing and thermoregulatory effects of intracerebroventricular dopamine in running rats. Pharmacol Biochem Behav 93:465\u2013469","journal-title":"Pharmacol Biochem Behav"},{"key":"9168_CR9","first-page":"45","volume-title":"Activity anorexia: theory, research, and treatment","author":"W Belke","year":"1996","unstructured":"Belke W (1996) Investigating the reinforcing properties of running. In: Epling WF, Pierce WD (eds) Activity anorexia: theory, research, and treatment. Erlbaum, Mahwah, pp 45\u201355"},{"key":"9168_CR10","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/ptj\/36.3.176","volume":"36","author":"DS Bilowit","year":"1956","unstructured":"Bilowit DS (1956) Establishing physical objectives in rehabilitation of patients with Parkinson\u2019s disease. Phys Ther Rev 36:176\u2013178","journal-title":"Phys Ther Rev"},{"key":"9168_CR11","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0014-2999(91)90502-H","volume":"199","author":"L Bj\u00f6rk","year":"1991","unstructured":"Bj\u00f6rk L, Lindgren S, Hacksell U, Lewander T (1991) (S)-UH-301 antagonizes (R)-8-OH-DPAT-induced cardiovascular effects in the rat. Eur J Pharmacol 199:367\u2013370","journal-title":"Eur J Pharmacol"},{"key":"9168_CR12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0031-9384(00)00241-9","volume":"70","author":"T Cambras","year":"2000","unstructured":"Cambras T, Vilaplana J, Campuzano A, Canal-Corretger MM, Carulla M, Diez-Noguera A (2000) Entrainment of the rat motor activity rhythm: effects of light-dark cycle and physical exercise. Physiol Behav 70:227\u2013232","journal-title":"Physiol Behav"},{"key":"9168_CR13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3940(96)12715-4","volume":"211","author":"E Challet","year":"1996","unstructured":"Challet E, Malan A, P\u00e9vet P (1996) Daily hypocaloric feeding entrains circadian rhythms of wheel-running and body temperature in rats kept at constant darkness. Neurosci Lett 211:1\u20134","journal-title":"Neurosci Lett"},{"issue":"Suppl. 2","key":"9168_CR14","doi-asserted-by":"crossref","first-page":"S172","DOI":"10.1016\/j.parkreldis.2008.04.027","volume":"14","author":"MR Ciucci","year":"2008","unstructured":"Ciucci MR, Ma ST, Kane JR, Ahrens AM, Schallert T (2008) Limb use and complex ultrasonic vocalization in a rat model of Parkinson\u2019s disease: deficit-targeted training. Parkinsonism Relat Disord 14(Suppl. 2):S172\u2013S175","journal-title":"Parkinsonism Relat Disord"},{"key":"9168_CR15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1471-4159.2003.01657.x","volume":"85","author":"AD Cohen","year":"2003","unstructured":"Cohen AD, Tillerson JL, Smith AD, Schallert T, Zigmond MJ (2003) Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF. J Neurochem 85:299\u2013305","journal-title":"J Neurochem"},{"key":"9168_CR16","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0166-2236(02)02143-4","volume":"25","author":"CW Cotman","year":"2002","unstructured":"Cotman CW, Berchtold NC (2002) Exercise: a behavioural intervention to enhance brain health and plasticity. Trends Neurosci 25:295\u2013301","journal-title":"Trends Neurosci"},{"key":"9168_CR17","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bbr.2004.12.004","volume":"160","author":"L Visser de","year":"2005","unstructured":"de Visser L, van der Bos R, Spruijt BM (2005) Automated home cage observations as a tool to measure the effects of wheel running on cage floor locomotion. Behav Brain Res 160:382\u2013388","journal-title":"Behav Brain Res"},{"key":"9168_CR18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.bbr.2006.11.019","volume":"177","author":"L Visser de","year":"2007","unstructured":"de Visser L, van der Bos R, Stoker AK, Kas MJH, Spruijt BM (2007) Effects of genetic background and environmental novelty on wheel running as a rewarding behaviour in mice. Behav Brain Res 177:290\u2013297","journal-title":"Behav Brain Res"},{"key":"9168_CR19","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/j.1460-9568.2004.03586.x","volume":"20","author":"E Decamp","year":"2004","unstructured":"Decamp E, Schneider JS (2004) Attention and executive function deficits in chronic low-dose MPTP-treated non-human primates. Eur J Neurosci 20:1371\u20131378","journal-title":"Eur J Neurosci"},{"key":"9168_CR20","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/35104055","volume":"2","author":"MD D\u00f6br\u00f6ssy","year":"2001","unstructured":"D\u00f6br\u00f6ssy MD, Dunnett SB (2001) The influence of environment and experience on neural grafts. Nat Rev Neurosci 2:871\u2013879","journal-title":"Nat Rev Neurosci"},{"key":"9168_CR21","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0014-4886(03)00028-1","volume":"184","author":"MD D\u00f6br\u00f6ssy","year":"2003","unstructured":"D\u00f6br\u00f6ssy MD, Dunnett SB (2003) Motor training effects on recovery of function after striatal lesions and striatal grafts. Exp Neurol 184:274\u2013284","journal-title":"Exp Neurol"},{"key":"9168_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.amepre.2004.09.003","volume":"28","author":"AL Dunn","year":"2005","unstructured":"Dunn AL, Trivedi MH, Kampert JB, Clark CG, Chambliss HO (2005) Exercise treatment for depression: efficacy and dose response. Am J Prev Med 28:1\u20138","journal-title":"Am J Prev Med"},{"key":"9168_CR23","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/jnr.20162","volume":"77","author":"BE Fisher","year":"2004","unstructured":"Fisher BE, Petzinger GM, Nixon K, Hogg E, Bremmer S, Meshul CK, Jakowec MW (2004) Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-lesioned mouse basal ganglia. J Neurosci Res 77:378\u2013390","journal-title":"J Neurosci Res"},{"key":"9168_CR24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12017-008-8032-3","volume":"10","author":"TE Foley","year":"2008","unstructured":"Foley TE, Fleshner M (2008) Neuroplasticity of dopamine circuits after exercise: implications for central fatigue. Neuromol Med 10:67\u201380","journal-title":"Neuromol Med"},{"key":"9168_CR25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1055\/s-2006-955118","volume":"27","author":"CM Fox","year":"2006","unstructured":"Fox CM, Ramig LO, Ciucci MR, Sapir S, McFarland DH, Farley BG (2006) The science and practice of LSVT\/LOUD: neural plasticity approach to treating individuals with Parkinson\u2019s disease and other neurological disorders. Semin Speech Lang 27:283\u2013299","journal-title":"Semin Speech Lang"},{"key":"9168_CR26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF02260967","volume":"7","author":"A Fredriksson","year":"1994","unstructured":"Fredriksson A, Archer T (1994) MPTP-induced behavioural and biochemical deficits: a parametric analysis. J Neural Transm Dis Dement Sect 7:123\u2013132","journal-title":"J Neural Transm Dis Dement Sect"},{"key":"9168_CR27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0166-4328(02)00035-9","volume":"139","author":"A Fredriksson","year":"2003","unstructured":"Fredriksson A, Archer T (2003) Effect of postnatal iron administration on MPTP-induced behavioural deficits and neurotoxicity: behavioural enhancement by L-Dopa-MK-801 co-administration. Behav Brain Res 139:31\u201346","journal-title":"Behav Brain Res"},{"key":"9168_CR28","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00702-006-0522-6","volume":"114","author":"A Fredriksson","year":"2007","unstructured":"Fredriksson A, Archer T (2007) Postnatal iron overload destroys NA-DA functional interactions. J Neural Transm 114:195\u2013203","journal-title":"J Neural Transm"},{"key":"9168_CR90","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF02336141","volume":"97","author":"A Fredriksson","year":"1994","unstructured":"Fredriksson A, Gentsch C, Archer T (1994) Synergistic interactions between NMDA-antagonists and L-Dopa on activity in MPTP-treated mice. J Neural Transm [Gen Sect] 97:197\u2013209","journal-title":"J Neural Transm [Gen Sect]"},{"key":"9168_CR29","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1600-0773.1990.tb00833.x","volume":"67","author":"A Fredriksson","year":"1990","unstructured":"Fredriksson A, Plaznik A, Sundstr\u00f6m E, Jonsson G, Archer T (1990) MPTP-induced hypoactivity in mice: reversal by L-Dopa. Pharmacol Toxicol 67:295\u2013301","journal-title":"Pharmacol Toxicol"},{"key":"9168_CR30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s007020050158","volume":"106","author":"A Fredriksson","year":"1999","unstructured":"Fredriksson A, Palomo T, Chase TN, Archer T (1999) Tolerance to a suprathreshold dose of L-Dopa in MPTP mice: effects of glutamate antagonists. J Neural Transm 106:283\u2013300","journal-title":"J Neural Transm"},{"key":"9168_CR31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1353-8020(00)00028-6","volume":"7","author":"A Fredriksson","year":"2001","unstructured":"Fredriksson A, Schr\u00f6der N, Eriksson P, Izquierdo I, Archer T (2001) Neonatal iron potentiates adult MPTP-induced neurodegenerative and functional deficits. Parkinsonism Relat Dis 7:97\u2013105","journal-title":"Parkinsonism Relat Dis"},{"key":"9168_CR32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/neur.1996.0041","volume":"5","author":"DC German","year":"1996","unstructured":"German DC, Nelson EL, Liang CL, Speciale SG, Sinton CM, Sonsalla PK (1996) The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration 5:299\u2013312","journal-title":"Neurodegeneration"},{"key":"9168_CR33","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1152\/jn.00152.2002","volume":"88","author":"F Gomez-Pinilla","year":"2002","unstructured":"Gomez-Pinilla F, Ying Z, Roy RR, Molteni R, Edgerton VR (2002) Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. J Neurophysiol 88:2187\u20132195","journal-title":"J Neurophysiol"},{"key":"9168_CR34","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/mds.21922","volume":"23","author":"VA Goodwin","year":"2008","unstructured":"Goodwin VA, Richards SH, Taylor RS, Taylor AH, Campbell JL (2008) The effectiveness of exercise interventions for people with Parkinson\u2019s disease: a systematic review and meta-analysis. Mov Dis 23:631\u2013640","journal-title":"Mov Dis"},{"key":"9168_CR35","first-page":"401","volume":"49","author":"M Harri","year":"1999","unstructured":"Harri M, Lindblom J, Malinen H, Hyttinen M, Lapvetelainen T, Escola S, Helminen HJ (1999) Effect of access to a running wheel on behaviour of C57Bl\/6\u00a0J mice. Lab Anim Sci 49:401\u2013405","journal-title":"Lab Anim Sci"},{"key":"9168_CR36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF03159727","volume":"10","author":"RE Heikkila","year":"1989","unstructured":"Heikkila RE, Sieber B-A, Manzino L, Sonsalla PK (1989) Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrohydropyridine (MPTP) in the mouse. Mol Chem Neuropathol 10:171\u2013183","journal-title":"Mol Chem Neuropathol"},{"key":"9168_CR37","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/01376517-198906000-00008","volume":"21","author":"A Hurwitz","year":"1989","unstructured":"Hurwitz A (1989) The benefit of a home exercise regime for ambulatory Parkinson\u2019s disease patients. J Neurosci Nurs 21:180\u2013184","journal-title":"J Neurosci Nurs"},{"key":"9168_CR38","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/1055-8330(95)90015-2","volume":"4","author":"V Jackson-Lewis","year":"1995","unstructured":"Jackson-Lewis V, Jakowec M, Burke RE, Przedborski S (1995) Time course and morphology of dopaminergic neuronal death cauesed by the neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine. Neurodegeneration 4:257\u2013269","journal-title":"Neurodegeneration"},{"key":"9168_CR39","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/brain\/118.4.913","volume":"118","author":"M Jahanshahi","year":"1995","unstructured":"Jahanshahi M, Jenkins IH, Brown RG, Marsden CD, Passingham RE, Brooks DJ (1995) Self-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson\u2019s disease subjects. Brain 118:913\u2013933","journal-title":"Brain"},{"key":"9168_CR40","volume-title":"Experimental design: procedures for the behavioral sciences","author":"R Kirk","year":"1995","unstructured":"Kirk R (1995) Experimental design: procedures for the behavioral sciences. Brooks\/Cole, Belmont"},{"key":"9168_CR41","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neulet.2007.09.060","volume":"429","author":"MJ Kurz","year":"2007","unstructured":"Kurz MJ, Pothakos K, Jamaluddon S, Scott-Pandorf M, Arellano C, Lau Y-S (2007) A chronic mouse model of Parkinson\u2019s disease has a reduced gait pattern certainty. Neurosci Lett 429:39\u201342","journal-title":"Neurosci Lett"},{"key":"9168_CR42","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0024-3205(85)90059-1","volume":"36","author":"JW Langston","year":"1985","unstructured":"Langston JW (1985) MPTP neurotoxicity: an overview and characterization of phases of toxicity. Life Sci 36:201\u2013206","journal-title":"Life Sci"},{"key":"9168_CR43","first-page":"109","volume-title":"Parkinson\u2019s disease","author":"YS Lau","year":"2005","unstructured":"Lau YS (2005) Progressive neurodegeneration in the chronic MPTP\/probenecid model of Parkinson\u2019s disease. In: Ebadi M, Pfeiffer R (eds) Parkinson\u2019s disease. CRC Press, Boca Raton, pp 109\u2013115"},{"key":"9168_CR44","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1001\/archneur.58.3.498","volume":"58","author":"D Laurin","year":"2001","unstructured":"Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K (2001) Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol 58:498\u2013504","journal-title":"Arch Neurol"},{"key":"9168_CR45","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/appe.1999.0274","volume":"34","author":"BT Lett","year":"2000","unstructured":"Lett BT, Grant VL, Byrne MJ, Koh MT (2000) Pairings of a distinctive chamber with the after effect of wheel running produce conditioned place preference. Appetite 34:87\u201394","journal-title":"Appetite"},{"key":"9168_CR46","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1152\/physiolgenomics.00125.2004","volume":"19","author":"JT Lightfoot","year":"2004","unstructured":"Lightfoot JT, Turner MJ, Daves M, Vordermark A, Kleeberger SR (2004) Genetic influence on daily wheel running activity level. Physiol Genomics 19:270\u2013276","journal-title":"Physiol Genomics"},{"key":"9168_CR47","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1021\/jm00001a020","volume":"38","author":"Y Liu","year":"1995","unstructured":"Liu Y, Yu H, Mohell N, Nordvall G, Lewander T, Hacksell U (1995) Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists. J Med Chem 38:150\u2013160","journal-title":"J Med Chem"},{"key":"9168_CR48","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1242\/jeb.028886","volume":"212","author":"TH Meek","year":"2009","unstructured":"Meek TH, Lonquich BP, Hannon RM, Garland T (2009) Endurance capacity of mice selectively bred for high voluntary wheel running. J Exp Biol 212:2908\u20132917","journal-title":"J Exp Biol"},{"key":"9168_CR49","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1053\/apmr.2000.4439","volume":"81","author":"I Miyai","year":"2000","unstructured":"Miyai I, Fujimoto Y, Ueda Y, Yamamoto H, Nozaki S, Saito T, Kang J (2000) Treadmill training with body weight support: its effect on Parkinson\u2019s disease. Arch Phys Med Rehabil 81:849\u2013852","journal-title":"Arch Phys Med Rehabil"},{"key":"9168_CR50","volume-title":"Optimizing exercise and physical activity in older adults","author":"M Morris","year":"2004","unstructured":"Morris M, Schoo A (2004) Optimizing exercise and physical activity in older adults. Butterworth Heinemann, Edinburgh"},{"key":"9168_CR51","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/mds.21346","volume":"22","author":"S Muhlack","year":"2007","unstructured":"Muhlack S, Welnic J, Woitalla D, M\u00fcller T (2007) Exercise improves efficacy of levodopa in patients with Parkinson\u2019s disease. Mov Dis 22:427\u2013430","journal-title":"Mov Dis"},{"key":"9168_CR52","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuroscience.2006.02.007","volume":"140","author":"L Novikova","year":"2006","unstructured":"Novikova L, Garris BL, Garris DR, Lau YS (2006) Early signs of neuronal apoptosis in the substantia nigra pars compacta of the progressive neurodegenerative mouse 1.methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine\/probenecid model of Parkinson\u2019s disease. Neuroscience 140:67\u201376","journal-title":"Neuroscience"},{"key":"9168_CR53","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.neuroscience.2006.10.042","volume":"144","author":"SJ O\u2019Dell","year":"2007","unstructured":"O\u2019Dell SJ, Gross NB, Fricks AN, Casiano BD, Nguyen TB, Marshall JF (2007) Running wheel exercise enhances recovery from nigrostriatal dopamine injury without inducing neuroprotection. Neuroscience 144:1141\u20131151","journal-title":"Neuroscience"},{"key":"9168_CR54","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/0003-9993(86)90007-9","volume":"67","author":"SS Palmer","year":"1986","unstructured":"Palmer SS, Mortimer JA, Webster DD, Bistevins R, Dickinson GL (1986) Exercise therapy for Parkinson\u2019s disease. Arch Phys Med Rehab 67:741\u2013745","journal-title":"Arch Phys Med Rehab"},{"key":"9168_CR55","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0306-4522(01)00295-0","volume":"106","author":"E Petroske","year":"2001","unstructured":"Petroske E, Meredith GE, Callen S, Totterdell S, Lau YS (2001) Mouse model of Parkinsonism: a comparison between subacute MPTP and chronic MPTP\/probenecid treatment. Neuroscience 106:589\u2013601","journal-title":"Neuroscience"},{"key":"9168_CR56","doi-asserted-by":"crossref","first-page":"52291","DOI":"10.1523\/JNEUROSCI.1069-07.2007","volume":"27","author":"GM Petzinger","year":"2007","unstructured":"Petzinger GM, Walsh JP, Akopian G, Hogg E, Abernathy A, Arevalo P, Turnquist P, Vuckovic M, Fisher BE, Togasaki DM, Jakowec MW (2007) Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. J Neurosci 27:52291\u201352300","journal-title":"J Neurosci"},{"key":"9168_CR57","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1016\/S0003-9993(03)00433-7","volume":"84","author":"M Pohl","year":"2003","unstructured":"Pohl M, Rockstroh G, Ruckreim S, Mrass G, Mehrholz J (2003) Immediate effects of speed-dependent treadmill training on gait parameters in early Parkinson\u2019s disease. Arch Phys Med Rehabil 84:1760\u20131766","journal-title":"Arch Phys Med Rehabil"},{"key":"9168_CR58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2202-10-6","volume":"10","author":"K Pothakos","year":"2009","unstructured":"Pothakos K, Kurz MJ, Lau YS (2009) Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson\u2019s disease with severe neurodegeneration. BMC Neurosci 10:1\u201314","journal-title":"BMC Neurosci"},{"key":"9168_CR59","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1177\/1545968308328726","volume":"23","author":"AL Ridgel","year":"2009","unstructured":"Ridgel AL, Vitek JL, Alberts JL (2009) Forced, not voluntary, exercise improves motor function in Parkinson\u2019s disease patients. Neurorehabil Neural Repair 23:600\u2013608","journal-title":"Neurorehabil Neural Repair"},{"key":"9168_CR60","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/brain\/123.2.394","volume":"123","author":"U Sabatini","year":"2000","unstructured":"Sabatini U, Boulanouar K, Fabre N et al (2000) Cortical motor reorganisation in akinetic patients with Parkinson\u2019s disease: a functional MRI study. Brain 123:394\u2013403","journal-title":"Brain"},{"key":"9168_CR61","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0168-1591(97)00049-X","volume":"55","author":"CM Sherwin","year":"1998","unstructured":"Sherwin CM (1998a) The use and perceived importance of three resources which provide caged laboratory mice the opportunity for extended locomotion. Appl Anim Behav Sci 55:353\u2013367","journal-title":"Appl Anim Behav Sci"},{"key":"9168_CR62","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/anbe.1998.0836","volume":"56","author":"CM Sherwin","year":"1998","unstructured":"Sherwin CM (1998b) Voluntary wheel running: a review and novel interpretation. Anim Behav 56:11\u201327","journal-title":"Anim Behav"},{"key":"9168_CR63","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.expneurol.2003.08.017","volume":"184","author":"AD Smith","year":"2003","unstructured":"Smith AD, Zigmond MJ (2003) Can the brain be protected through exercise? Lessons from an animal model of parkinsonism. Exp Neurol 184:31\u201339","journal-title":"Exp Neurol"},{"key":"9168_CR64","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0014-2999(86)90444-9","volume":"129","author":"PK Sonsalla","year":"1986","unstructured":"Sonsalla PK, Heikkila RE (1986) The influence of dose and dosing interval on MPTP-induced dopaminergic neurotoxicity in mice. Eur J Pharmacol 129:339\u2013345","journal-title":"Eur J Pharmacol"},{"key":"9168_CR65","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0006-8993(90)91656-2","volume":"528","author":"E Sundstr\u00f6m","year":"1990","unstructured":"Sundstr\u00f6m E, Fredriksson A, Archer T (1990) Chronic neurochemical and behavioural changes in MPTP-lesioned C57 BL\/6 mice: a model for Parkinson\u2019s disease. Brain Res 528:181\u2013188","journal-title":"Brain Res"},{"key":"9168_CR66","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1023\/A:1021479331779","volume":"28","author":"JG Swallow","year":"1998","unstructured":"Swallow JG, Carter PA, Garland T (1998a) Artificial selection for increased wheel-running behavior in house mice. Behav Genet 28:227\u2013237","journal-title":"Behav Genet"},{"key":"9168_CR67","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1152\/jappl.1998.84.1.69","volume":"84","author":"JG Swallow","year":"1998","unstructured":"Swallow JG, Carter PA, Zhan WZ, Sieck GC (1998b) Effects of voluntary activity and genetic selection on aerobic capacity in house mice (Mus domesticus). J Appl Physiol 84:69\u201376","journal-title":"J Appl Physiol"},{"key":"9168_CR68","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.pbb.2007.10.004","volume":"88","author":"AM Teixeira","year":"2008","unstructured":"Teixeira AM, Trevizol F, Colpo G, Garcia SC, Char\u00e3o M, Pereira RP, Fachinetto R, Rocha JB, B\u00fcrger ME (2008) Influence of chronic exercise on reserpine-induced oxidative stress in rats: behavioral and antioxidant evaluations. Pharmacol Biochem Behav 88:465\u2013472","journal-title":"Pharmacol Biochem Behav"},{"issue":"Suppl. 1","key":"9168_CR69","first-page":"308","volume":"36","author":"JW Tetrud","year":"1986","unstructured":"Tetrud JW, Langston JW, Redmond DE, Roth RH, Sladek JR, Angel RW (1986) MPTP-induced tremor in human and non-human primates. Neurology 36(Suppl. 1):308","journal-title":"Neurology"},{"key":"9168_CR70","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1523\/JNEUROSCI.21-12-04427.2001","volume":"21","author":"JL Tillerson","year":"2001","unstructured":"Tillerson JL, Cohen AD, Philpower J, Miller GW, Zigmond MJ, Schallert T (2001) Forced limb-use effects on the behavioral and neurochemical effects of 6-hydroxydopamine. J Neurosci 21:4427\u20134435","journal-title":"J Neurosci"},{"key":"9168_CR71","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1006\/exnr.2002.8021","volume":"178","author":"JL Tillerson","year":"2002","unstructured":"Tillerson JL, Caudle WM, Reveron ME, Miller GW (2002) Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine. Exp Neurol 178:80\u201390","journal-title":"Exp Neurol"},{"key":"9168_CR72","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0306-4522(03)00096-4","volume":"119","author":"JL Tillerson","year":"2003","unstructured":"Tillerson JL, Caudle WM, Reveron ME, Miller GW (2003) Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson\u2019s disease. Neuroscience 119:899\u2013911","journal-title":"Neuroscience"},{"key":"9168_CR73","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3233\/NRE-2005-20406","volume":"20","author":"T Toole","year":"2005","unstructured":"Toole T, Maitland CG, Warren E, Hubmann MF, Panton L (2005) The effects of loading and unloading treadmill walking on balance, gait, fall risk, and daily function in Parkinsonism. NeuroRehabilitation 20:307\u2013322","journal-title":"NeuroRehabilitation"},{"key":"9168_CR74","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1152\/physiolgenomics.00243.2004","volume":"22","author":"MJ Turner","year":"2005","unstructured":"Turner MJ, Kleeberger SR, Lightfoot JT (2005) Influence of genetic background on daily running-wheel activity differs with aging. Physiol Genomics 22:76\u201385","journal-title":"Physiol Genomics"},{"key":"9168_CR75","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1002\/mds.22293","volume":"23","author":"FJM Eijkeren Van","year":"2008","unstructured":"Van Eijkeren FJM, Reijmers RSJ, Kleinveld MJ, Minten A, ter Bruggen JP, Bloem BR (2008) Nordic walking improves mobility in Parkinson\u2019s disease. Mov Dis 23:2239\u20132243","journal-title":"Mov Dis"},{"key":"9168_CR76","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1212\/01.WNL.0000147474.29994.35","volume":"63","author":"BM Gelder Van","year":"2004","unstructured":"Van Gelder BM, Tijhuis MA, Kalmijn S, Giampeoli S, Nissinen A, Kromhout D (2004) Physical activity in relation to cognitive decline in elderly men: the FINE study. Neurology 63:2316\u20132321","journal-title":"Neurology"},{"key":"9168_CR77","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.neulet.2004.05.029","volume":"366","author":"H Vargas-Perez","year":"2004","unstructured":"Vargas-Perez H, Borelli E, Diaz J-L (2004) Wheel running use in dopamine D2L receptor knockout mice. Neurosci Lett 366:172\u2013175","journal-title":"Neurosci Lett"},{"key":"9168_CR78","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.nbd.2008.07.015","volume":"32","author":"MG Vuckovi\u0107","year":"2008","unstructured":"Vuckovi\u0107 MG, Wood RI, Holschneider DP, Abernathy A, Togasaki DM, Smith A, Petzinger GM, Jakowec MW (2008) Memory, mood, dopamine, and serotonin in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. Neurobiol Dis 32:319\u2013327","journal-title":"Neurobiol Dis"},{"key":"9168_CR79","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1046\/j.1460-9568.2000.00147.x","volume":"12","author":"M Werme","year":"2000","unstructured":"Werme M, Thoren P, Olson L, Brene S (2000) Running and cocaine both upregulate dynorphin mRNA in medial caudate putamen. Eur J Neurosci 12:2967\u20132974","journal-title":"Eur J Neurosci"},{"key":"9168_CR80","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0959-4388(96)80024-9","volume":"6","author":"T Wichmann","year":"1996","unstructured":"Wichmann T, DeLong MR (1996) Functional and pathophysiological models of the basal ganglia. Curr Opin Neurobiol 6:751\u2013758","journal-title":"Curr Opin Neurobiol"},{"key":"9168_CR81","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neulet.2007.06.031","volume":"423","author":"MC Yoon","year":"2007","unstructured":"Yoon MC, Shin MS, Kim TS, Kim BK, Ko IG, Sung YH, Kim SE, Lee HH, Kim YP, Kim CJ (2007) Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson\u2019s rats. Neurosci Lett 423:12\u201317","journal-title":"Neurosci Lett"},{"key":"9168_CR82","doi-asserted-by":"crossref","unstructured":"Yousefi B, Tadibi V, Khoei AF and Montazeri A (2009) Exercise therapy, quality of life, and activities of daily living in patients with Parkinson disease: a small scale quasi-randomised trial. Trials 10:67","DOI":"10.1186\/1745-6215-10-67"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-010-9168-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12640-010-9168-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-010-9168-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T04:09:32Z","timestamp":1591157372000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12640-010-9168-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,19]]},"references-count":83,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["9168"],"URL":"https:\/\/doi.org\/10.1007\/s12640-010-9168-0","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,19]]}}}