{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:03:30Z","timestamp":1776153810002,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,2,4]],"date-time":"2012-02-04T00:00:00Z","timestamp":1328313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1007\/s12640-012-9310-2","type":"journal-article","created":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T14:24:25Z","timestamp":1328279065000},"page":"79-90","source":"Crossref","is-referenced-by-count":21,"title":["Further Studies on the Hypothesis of PARP-1 Inhibition as a Strategy for Lessening the Long-Term Effects Produced by Perinatal Asphyxia: Effects of Nicotinamide and Theophylline on PARP-1 Activity in Brain and Peripheral Tissue"],"prefix":"10.1007","volume":"22","author":[{"given":"C.","family":"Allende-Castro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Espina-Marchant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Bustamante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Rojas-Mancilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Neira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Gutierrez-Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Esmar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Valdes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Gebicke-Haerter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Herrera-Marschitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,2,4]]},"reference":[{"key":"9310_CR1","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/bies.20085","volume":"26","author":"J-C Am\u00e9","year":"2004","unstructured":"Am\u00e9 J-C, Spenlehauer C, de Murcia G (2004) The PARP superfamily. BioEssays 26:882\u2013893","journal-title":"BioEssays"},{"key":"9310_CR2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2307\/3576299","volume":"1001","author":"NA Berger","year":"1985","unstructured":"Berger NA (1985) Poly (ADP-ribose) in the cellular response to DNA damage. Radiat Res 1001:4\u201315","journal-title":"Radiat Res"},{"key":"9310_CR3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00221-002-1304-5","volume":"148","author":"D Bustamante","year":"2003","unstructured":"Bustamante D, Goiny M, \u00c5str\u00f6m G, Gross J, Andersson K, Herrera-Marschitz M (2003) Nicotinamide prevents the long-term effects of perinatal asphyxia on basal ganglia monoamine systems in the rat. Exp Brain Res 148:227\u2013232","journal-title":"Exp Brain Res"},{"key":"9310_CR4","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s00221-006-0679-0","volume":"177","author":"D Bustamante","year":"2007","unstructured":"Bustamante D, Morales P, Torres-Pereyra J, Goiny M, Herrera-Marschitz M (2007) Nicotinamide prevents the effect of perinatal asphyxia on dopamine release evaluated with in vivo microdialysis 3\u00a0months after birth. Exp Brain Res 177:358\u2013369","journal-title":"Exp Brain Res"},{"key":"9310_CR5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0165-3806(97)00131-4","volume":"104","author":"Y Chen","year":"1997","unstructured":"Chen Y, Engidawork E, Loidl F, Dell\u2019Anna E, Goiny M, Lubec G, Andersson K, Herrera-Marschitz M (1997) Short- and long-term effects of perinatal asphyxia on monoamine, amino acid and glycolysis product levels measured in the basal ganglia of the rat. Dev Brain Res 104:19\u201330","journal-title":"Dev Brain Res"},{"key":"9310_CR6","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0024-3205(98)00377-4","volume":"63","author":"M Chiappe-Gutierrez","year":"1998","unstructured":"Chiappe-Gutierrez M, Kitzmueller E, Labudova O, Fuerst G, Hoeger H, Hardmeier R, Nohl H, Gille L, Lubec B (1998) mRNA levels of the hypoxia inducible factor (HIF-1) and DNA repair genes in perinatal asphyxia of the rat. Life Sci 63:1157\u20131167","journal-title":"Life Sci"},{"key":"9310_CR7","first-page":"556","volume":"28","author":"M Cohen-Armon","year":"2008","unstructured":"Cohen-Armon M (2008) PARP-1 activation in the ERK signaling pathway. TIPS 28:556\u2013560","journal-title":"TIPS"},{"key":"9310_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2009.06443.x","volume":"112","author":"SC Correia","year":"2010","unstructured":"Correia SC, Moreira PI (2010) Hypoxia-inducible factor 1: a new hope to counteract neurodegeneration? J Neurochem 112:1\u201312","journal-title":"J Neurochem"},{"key":"9310_CR10","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1046\/j.1471-4159.2000.0742504.x","volume":"74","author":"S Ducrocq","year":"2000","unstructured":"Ducrocq S, Benjelloun N, Plotkine M, Ben-Ari Y, Charriaut-Marlangue C (2000) Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain. J Neurochem 74:2504\u20132511","journal-title":"J Neurochem"},{"key":"9310_CR11","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1111\/j.1582-4934.2009.00875.x","volume":"13","author":"M F\u00e4hling","year":"2009","unstructured":"F\u00e4hling M (2009) Surviving hypoxia by modulation of mRNA translation rate. J Cell Mol Med 13:2770\u20132779","journal-title":"J Cell Mol Med"},{"key":"9310_CR12","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.bcp.2006.06.023","volume":"72","author":"L Geraets","year":"2006","unstructured":"Geraets L, Moonen HJJ, Wouters EFM, Bast A, Hageman GJ (2006) Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations. Biochem Pharmacol 72:902\u2013910","journal-title":"Biochem Pharmacol"},{"key":"9310_CR13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pediatrneurol.2008.09.016","volume":"40","author":"S Girard","year":"2009","unstructured":"Girard S, Kadhim H, Roy M, Lavoie K, Brochu ME, Larouche A, Sebire G (2009) Role of perinatal inflammation in cerebral palsy. Pediatr Neurol 40:168\u2013174","journal-title":"Pediatr Neurol"},{"key":"9310_CR14","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/09553009214551221","volume":"61","author":"A Green","year":"1992","unstructured":"Green A, Prager A, Stoudt PM, Murray D (1992) Relationships between DNA damage and the survival of radiosensitive mutant Chinese hamster cell lines exposed to gamma-radiation. Part 1: intrinsic radiosensitivity. Int J Radiat Biol 61:465\u2013472","journal-title":"Int J Radiat Biol"},{"key":"9310_CR15","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1203\/00006450-199610000-00015","volume":"40","author":"H Hagberg","year":"1996","unstructured":"Hagberg H, Gilland E, Bona E, Hanson LA, Hahlin-Zoric M, Biennow M, Holst M, McRae A, S\u00f6der O (1996) Enhanced expression of interlukin (IL)-1 and IL-6 messenger RNA and bioactive protein after hypoxia-ischemia in neonatal rats. Pediatr Res 40:603\u2013609","journal-title":"Pediatr Res"},{"key":"9310_CR16","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1515\/BC.1999.118","volume":"380","author":"PO Hassa","year":"1999","unstructured":"Hassa PO, Hottinger MO (1999) A role of poly(ADP-ribose) polymerase in NF-\u03baB transcriptional activation. Biol Chem 380:953\u2013959","journal-title":"Biol Chem"},{"key":"9310_CR17","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s12640-010-9208-9","volume":"19","author":"M Herrera-Marschitz","year":"2011","unstructured":"Herrera-Marschitz M, Morales P, Leyton L, Bustamante D, Klawitter V, Espina-Marchant P, Allende C, Lisboa F, Cunich G, Jara-Caviedes A, Neira T, Gutierrez-Hernandez MA, Gonzalez-Lira V, Simola N, Schmitt A, Morelli M, Tasker RA, Gebicke-Haerter PJ (2011) Perinatal asphyxia: current status and approaches towards neuroprotective strategies, focus on sentinel proteins. Neurotox Res 19:603\u2013627","journal-title":"Neurotox Res"},{"key":"9310_CR18","first-page":"259","volume":"25","author":"SJ Hong","year":"2004","unstructured":"Hong SJ, Dawson TM, Dawson VL (2004) Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signalling. TIPS 25:259\u2013264","journal-title":"TIPS"},{"key":"9310_CR19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1101\/gad.12.2.149","volume":"12","author":"NV Iyer","year":"1998","unstructured":"Iyer NV, Kotch LE, Agani F, Leung SW, Laugner E, Wenger RH, Gassmann M, Gearhart JD, Lawler AM, Yu AY, Semenza GL (1998) Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 12:149\u2013162","journal-title":"Genes Dev"},{"key":"9310_CR20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nrd1718","volume":"4","author":"P Jagtap","year":"2005","unstructured":"Jagtap P, Szabo C (2005) Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nature Rev 4:421\u2013440","journal-title":"Nature Rev"},{"key":"9310_CR21","doi-asserted-by":"crossref","first-page":"17771","DOI":"10.1074\/jbc.271.30.17771","volume":"271","author":"B-H Jiang","year":"1996","unstructured":"Jiang B-H, Rue E, Wang GL, Roe R, Semenza GL (1996) Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 271:17771\u201317778","journal-title":"J Biol Chem"},{"key":"9310_CR22","doi-asserted-by":"crossref","first-page":"7136","DOI":"10.1073\/pnas.0508606103","volume":"103","author":"TM Kauppinen","year":"2006","unstructured":"Kauppinen TM, Chan WY, Suh SW, Wiggins AK, Huang EJ, Swanson RA (2006) Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases1\/2. Proc Natl Acad Sci USA 103:7136\u20137141","journal-title":"Proc Natl Acad Sci USA"},{"key":"9310_CR23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00726-006-0372-4","volume":"31","author":"V Klawitter","year":"2006","unstructured":"Klawitter V, Morales P, Bustamante D, Goiny M, Herrera-Marschitz M (2006) Plasticity of the central nervous (CNS) following perinatal asphyxia. Does nicotinamide provide neuroprotection? Amino Acids 31:377\u2013384","journal-title":"Amino Acids"},{"key":"9310_CR24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00221-006-0842-7","volume":"180","author":"V Klawitter","year":"2007","unstructured":"Klawitter V, Morales P, Bustamante D, Gomez-Urquijo S, H\u00f6kfelt T, Herrera-Marschitz M (2007) Neuronal plasticity of basal ganglia following perinatal asphyxia: neuroprotection by nicotinamide. Exp Brain Res 180:139\u2013152","journal-title":"Exp Brain Res"},{"key":"9310_CR25","doi-asserted-by":"crossref","first-page":"873","DOI":"10.4161\/cc.5.8.2690","volume":"5","author":"U Kolthur-Seetharam","year":"2006","unstructured":"Kolthur-Seetharam U, Dantzer F, McBurney MW, de Murcia G, Sassone-Corsi P (2006) Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage. Cell Cycle 5:873\u2013877","journal-title":"Cell Cycle"},{"key":"9310_CR26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1053\/j.semperi.2010.09.011","volume":"34","author":"JE Lawn","year":"2010","unstructured":"Lawn JE, Kerber K, Enweronu-Laryea C, Cousens S (2010) 3.6 million neonatal deaths-what is progressing and what is not? Semin Perinatol 34:371\u2013386","journal-title":"Semin Perinatol"},{"key":"9310_CR27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature05096","volume":"443","author":"JW Lee","year":"2006","unstructured":"Lee JW, Beene K, Nangie LA, Longo-Guess CM, Cook SA, Davisson MT, Sundberg JP, Schimmel P, Ackerman SL (2006) Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration. Nature 443:50\u201355","journal-title":"Nature"},{"key":"9310_CR28","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000056758","volume":"81","author":"B Lubec","year":"2002","unstructured":"Lubec B, Labudova O, Hoeger H, Kirchner L, Lubec G (2002) Expression of transcription factors in the brain of rats with perinatal asphyxia. Biol Neonate 81:266\u2013278","journal-title":"Biol Neonate"},{"key":"9310_CR29","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.ijdevneu.2005.08.002","volume":"23","author":"SS Martin","year":"2005","unstructured":"Martin SS, Perez-Polo JR, Noppens KM, Grafe MR (2005) Biphasic changes in the levels of poly(ADP ribose) polymerase-1 and caspase 3 in the immature brain following hypoxia\u2013ischemia. Int J Dev Neurosci 23:673\u2013686","journal-title":"Int J Dev Neurosci"},{"key":"9310_CR30","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/j.bbrc.2005.10.159","volume":"338","author":"HJJ Moonen","year":"2005","unstructured":"Moonen HJJ, Geraets L, Vaarhorst A, Wouters EFM, Bast A, Hageman GJ (2005) Theophylline prevents NAD+ depletion via PARP-1 inhibition in human pulmonary epithelial cells. Biochem Biophys Res Commun 338:1805\u20131810","journal-title":"Biochem Biophys Res Commun"},{"key":"9310_CR31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00221-009-2103-z","volume":"202","author":"P Morales","year":"2010","unstructured":"Morales P, Simola N, Bustamante D, Lisboa F, Fiedler J, Gebicke-Haerter P, Morelli M, Tasker RA, Herrera-Marschitz M (2010) Nicotinamide prevents the effect of perinatal asphyxia on apoptosis, non-spatial working memory and anxiety in rats. Exp Brain Res 202:1\u201314","journal-title":"Exp Brain Res"},{"key":"9310_CR32","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"1992","unstructured":"Paxinos G, Watson C (1992) The rat brain in stereotaxic coordinates, 3rd edn. Academic Press, New York","edition":"3"},{"key":"9310_CR33","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuroscience.2011.10.045","volume":"201","author":"M Perez de la Mora","year":"2012","unstructured":"Perez de la Mora M, Gallegos-Cari A, Crespo-Ramirez M, Marcellino D, Hansson AC, Fuxe K (2012) Distribution of dopamine D2-like receptors in the rat amygdala and their role in the modulation of unconditioned fear and anxiety. Neuroscience 201:252\u2013266","journal-title":"Neuroscience"},{"key":"9310_CR34","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0304-3940(00)00854-5","volume":"281","author":"Y Sakakibara","year":"2000","unstructured":"Sakakibara Y, Mitha AP, Ogilvy CS, Maynard KI (2000) Post-treatment with nicotinamide (vitamin B(3)) reduces the infarct volume following permanent focal cerebral ischemia in female Sprague-Dawley and Wistar rats. Neurosci Lett 281:111\u2013114","journal-title":"Neurosci Lett"},{"key":"9310_CR35","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1093\/nar\/gkg703","volume":"31","author":"N Schultz","year":"2003","unstructured":"Schultz N, Lopez E, Saleh-Gohari N, Helleday T (2003) Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids Res 31:4959\u20134964","journal-title":"Nucleic Acids Res"},{"key":"9310_CR36","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.1128\/MCB.12.12.5447","volume":"12","author":"G Semenza","year":"1992","unstructured":"Semenza G, Wang G (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythroprotein gen enhancer at a site required for transcriptional activation. Mol Cell Biol 12:5447\u20135454","journal-title":"Mol Cell Biol"},{"key":"9310_CR37","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1542\/peds.110.4.673","volume":"110","author":"LF Shalak","year":"2002","unstructured":"Shalak LF, Laptook AR, Jafri HS, Ramilo O, Perlman JM (2002) Clinical chorioamnionitis elevated cytokines and brain injury in term infants. Pediatrics 110:673\u2013680","journal-title":"Pediatrics"},{"key":"9310_CR38","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","volume":"150","author":"PK Smith","year":"1985","unstructured":"Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150:76\u201385","journal-title":"Anal Biochem"},{"key":"9310_CR39","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/365852a0","volume":"365","author":"P Sung","year":"1993","unstructured":"Sung P, Bailly V, Weber C, Thompson LH, Prakash L, Prakash S (1993) Human xeroderma pigmentosum group D gene encodes a DNA helicase. Nature 365:852\u2013855","journal-title":"Nature"},{"key":"9310_CR40","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1093\/nar\/26.11.2644","volume":"26","author":"C Trucco","year":"1998","unstructured":"Trucco C, Oliver FJ, deMurcia G, Menissier de Murcia J (1998) DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines. Nucleic Acids Res 26:2644\u20132649","journal-title":"Nucleic Acids Res"},{"key":"9310_CR41","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1124\/pr.54.3.375","volume":"54","author":"L Virag","year":"2002","unstructured":"Virag L, Szabo C (2002) The Therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev 54:375\u2013429","journal-title":"Pharmacol Rev"},{"key":"9310_CR42","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0361-9230(99)00185-9","volume":"50","author":"FJ Wan","year":"1999","unstructured":"Wan FJ, Lin HC, Kang BH, Tseng CJ, Tung CS (1999) d-amphetamine-induced depletion of energy and dopamine in the rat striatum is attenuated by nicotinamide pretreatment. Brain Res Bull 50:167\u2013171","journal-title":"Brain Res Bull"},{"key":"9310_CR43","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","volume":"92","author":"GL Wang","year":"1995","unstructured":"Wang GL, Jiang BH, Rue EA, Semenza GL (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix PAS heterodimer regulated by cellular O2 tension. PNS USA 92:5510\u20135514","journal-title":"PNS USA"},{"key":"9310_CR44","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/bbrc.1999.0154","volume":"255","author":"Q Yan","year":"1999","unstructured":"Yan Q, Briehl M, Crowley CL, Payne CM, Bernstein H, Bernstein C (1999) The NAD+ precursors, nicotinic acid and nicotinamide upregulate glyceraldehyde-3-phosphate dehydrogenase and glucose-6-phosphate dehydrogenase mRNA in Jurkat cells. Biochem Biophys Res Commun 255:133\u2013136","journal-title":"Biochem Biophys Res Commun"},{"key":"9310_CR45","first-page":"250","volume":"297","author":"SW Yu","year":"2002","unstructured":"Yu SW, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GC, Dawson TM, Dawson VL (2002) Mediation of poly(ADP-ribose) polymerase-1 dependent cell death by apoptosis-inducing factor. Science 297:250\u2013263","journal-title":"Science"},{"key":"9310_CR46","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1046\/j.1471-4159.1995.65031411.x","volume":"65","author":"J Zhang","year":"1995","unstructured":"Zhang J, Pieper A, Snyder SH (1995) Poly(ADP-ribose) synthase activation: an early indicator of neurotoxic DNA damage. J Neurochem 65:1411\u20131414","journal-title":"J Neurochem"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-012-9310-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12640-012-9310-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-012-9310-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T09:31:21Z","timestamp":1559467881000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12640-012-9310-2"}},"subtitle":["Nicotinamide and Theophylline on PARP-1 Activity"],"short-title":[],"issued":{"date-parts":[[2012,2,4]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["9310"],"URL":"https:\/\/doi.org\/10.1007\/s12640-012-9310-2","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,4]]}}}