{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:42:05Z","timestamp":1777635725032,"version":"3.51.4"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,5,19]],"date-time":"2012-05-19T00:00:00Z","timestamp":1337385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1007\/s12640-012-9330-y","type":"journal-article","created":{"date-parts":[[2012,5,18]],"date-time":"2012-05-18T13:43:52Z","timestamp":1337348632000},"page":"69-78","source":"Crossref","is-referenced-by-count":21,"title":["Reciprocal Induction Between \u03b1-Synuclein and \u03b2-Amyloid in Adult Rat Neurons"],"prefix":"10.1007","volume":"23","author":[{"given":"Shohreh","family":"Majd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariba","family":"Chegini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Chataway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Fu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Gai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,5,19]]},"reference":[{"key":"9330_CR1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0304-3940(91)90354-V","volume":"131","author":"SJ Allen","year":"1991","unstructured":"Allen SJ, MacGowan SH, Treanor JJ, Feeney R, Wilcock GK, Dawbarn D (1991) Normal beta-NGF content in Alzheimer\u2019s disease cerebral cortex and hippocampus. Neurosci Lett 131:135\u2013139","journal-title":"Neurosci Lett"},{"key":"9330_CR2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0006-8993(92)90380-R","volume":"569","author":"DM Araujo","year":"1992","unstructured":"Araujo DM, Cotman CW (1992) Beta-amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer\u2019s disease. Brain Res 569:141\u2013145","journal-title":"Brain Res"},{"key":"9330_CR3","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/jnr.10452","volume":"70","author":"RL Bowen","year":"2002","unstructured":"Bowen RL, Smith MA, Harris PL, Kubat Z, Martins RN, Castellani RJ, Perry G, Atwood CS (2002) Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer\u2019s disease pathology. J Neurosci Res 70:514\u2013518","journal-title":"J Neurosci Res"},{"key":"9330_CR4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0165-0270(96)00136-7","volume":"71","author":"GJ Brewer","year":"1997","unstructured":"Brewer GJ (1997) Isolation and culture of adult rat hippocampal neurons. J Neurosci Methods 71:143\u2013155","journal-title":"J Neurosci Methods"},{"key":"9330_CR5","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0197-4580(98)00091-8","volume":"19","author":"GJ Brewer","year":"1998","unstructured":"Brewer GJ (1998) Age-related toxicity to lactate, glutamate, and beta-amyloid in cultured adult neurons. Neurobiol Aging 19:561\u2013568","journal-title":"Neurobiol Aging"},{"key":"9330_CR6","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.neurobiolaging.2005.01.019","volume":"27","author":"GJ Brewer","year":"2006","unstructured":"Brewer GJ, Reichensperger JD, Brinton RD (2006) Prevention of age-related dysregulation of calcium dynamics by estrogen in neurons. Neurobiol Aging 27:306\u2013317","journal-title":"Neurobiol Aging"},{"key":"9330_CR7","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1179\/016164103101202002","volume":"25","author":"R Cacabelos","year":"2003","unstructured":"Cacabelos R, Fernandez-Novoa L, Lombardi V, Corzo L, Pichel V, Kubota Y (2003) Cerebrovascular risk factors in Alzheimer\u2019s disease: brain hemodynamics and pharmacogenomic implications. Neurol Res 25:567\u2013580","journal-title":"Neurol Res"},{"key":"9330_CR8","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.bbrc.2007.02.163","volume":"356","author":"L Chen","year":"2007","unstructured":"Chen L, Jin J, Davis J, Zhou Y, Wang Y, Liu J, Lockhart PJ, Zhang J (2007) Oligomeric alpha-synuclein inhibits tubulin polymerization. Biochem Biophys Res Commun 356:548\u2013553","journal-title":"Biochem Biophys Res Commun"},{"key":"9330_CR9","doi-asserted-by":"crossref","first-page":"7060","DOI":"10.1073\/pnas.0909314107","volume":"107","author":"HC Chiang","year":"2010","unstructured":"Chiang HC, Wang L, Xie Z, Yau A, Zhong Y (2010) PI3 kinase signalling is involved in Abeta-induced memory loss in Drosophila. Proc Natl Acad Sci USA 107:7060\u20137065","journal-title":"Proc Natl Acad Sci USA"},{"issue":"113\u2013116","key":"9330_CR10","first-page":"119","volume":"12","author":"DD Christensen","year":"2007","unstructured":"Christensen DD (2007) Alzheimer\u2019s disease: progress in the development of anti-amyloid disease-modifying therapies. CNS Spectr 12(113\u2013116):119\u2013123","journal-title":"CNS Spectr"},{"key":"9330_CR11","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0169-328X(97)00192-7","volume":"49","author":"B Connor","year":"1997","unstructured":"Connor B, Beilharz EJ, Williams C, Synek B, Gluckman PD, Faull RL, Dragunow M (1997) Insulin-like growth factor-I (IGF-I) immunoreactivity in the Alzheimer\u2019s disease temporal cortex and hippocampus. Brain Res Mol Brain Res 49:283\u2013290","journal-title":"Brain Res Mol Brain Res"},{"key":"9330_CR12","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1096\/fasebj.13.15.2225","volume":"13","author":"A Copani","year":"1999","unstructured":"Copani A, Condorelli F, Caruso A, Vancheri C, Sala A, Giuffrida Stella AM, Canonico PL, Nicoletti F, Sortino MA (1999) Mitotic signalling by beta-amyloid causes neuronal death. FASEB J 13:2225\u20132234","journal-title":"FASEB J"},{"key":"9330_CR13","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0306-9877(96)90189-9","volume":"46","author":"JG Crawford","year":"1996","unstructured":"Crawford JG (1996) Alzheimer\u2019s disease risk factors as related to cerebral blood flow. Med Hypotheses 46:367\u2013377","journal-title":"Med Hypotheses"},{"key":"9330_CR14","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1046\/j.1471-4159.1995.65020931.x","volume":"65","author":"J Davis-Salinas","year":"1995","unstructured":"Davis-Salinas J, Saporito-Irwin SM, Cotman CW, Van Nostrand WE (1995) Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells. J Neurochem 65:931\u2013934","journal-title":"J Neurochem"},{"key":"9330_CR15","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/BF00712843","volume":"10","author":"RJ Donnelly","year":"1990","unstructured":"Donnelly RJ, Friedhoff AJ, Beer B, Blume AJ, Vitek MP (1990) Interleukin-1 stimulates the beta-amyloid precursor protein promoter. Cell Mol Neurobiol 10:485\u2013495","journal-title":"Cell Mol Neurobiol"},{"key":"9330_CR16","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1042\/bst0300559","volume":"30","author":"OM El-Agnaf","year":"2002","unstructured":"El-Agnaf OM, Irvine GB (2002) Aggregation and neurotoxicity of alpha-synuclein and related peptides. Biochem Soc Trans 30:559\u2013565","journal-title":"Biochem Soc Trans"},{"key":"9330_CR17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0014-5793(98)01418-5","volume":"440","author":"OM El-Agnaf","year":"1998","unstructured":"El-Agnaf OM, Jakes R, Curran MD, Middleton D, Ingenito R, Bianchi E, Pessi A, Neill D, Wallace A (1998) Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments. FEBS Lett 440:71\u201375","journal-title":"FEBS Lett"},{"key":"9330_CR18","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0092-8674(00)80748-5","volume":"97","author":"FG Gervais","year":"1999","unstructured":"Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, Ruffolo SC, Thornberry NA, Xanthoudakis S, Zamboni RJ, Roy S, Nicholson DW (1999) Involvement of caspases in proteolytic cleavage of Alzheimer\u2019s amyloid-beta precursor protein and amyloidogenic Abeta peptide formation. Cell 97:395\u2013406","journal-title":"Cell"},{"key":"9330_CR19","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1126\/science.1082324","volume":"300","author":"BI Giasson","year":"2003","unstructured":"Giasson BI, Forman MS, Higuchi M, Golbe LI, Graves CL, Kotzbauer PT, Trojanowski JQ, Lee VM (2003) Initiation and synergistic fibrillization of tau and alpha-synuclein. Science 300:636\u2013640","journal-title":"Science"},{"key":"9330_CR20","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1212\/01.wnl.0000326146.60732.d6","volume":"71","author":"SN Gomperts","year":"2008","unstructured":"Gomperts SN, Rentz DM, Moran E, Becker JA, Locascio JJ, Klunk WE, Mathis CA, Elmaleh DR, Shoup T, Fischman AJ, Hyman BT, Growdon JH, Johnson KA (2008) Imaging amyloid deposition in Lewy body diseases. Neurology 71:903\u2013910","journal-title":"Neurology"},{"key":"9330_CR21","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1111\/j.1471-4159.2006.04015.x","volume":"98","author":"K Heinitz","year":"2006","unstructured":"Heinitz K, Beck M, Schliebs R, Perez-Polo JR (2006) Toxicity mediated by soluble oligomers of beta-amyloid (1-42) on cholinergic SN56.B5.G4 cells. J Neurochem 98:1930\u20131945","journal-title":"J Neurochem"},{"key":"9330_CR22","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00894-008-0296-x","volume":"14","author":"GB Irvine","year":"2008","unstructured":"Irvine GB, El-Agnaf OM, Shankar GM, Walsh DM (2008) Protein aggregation in the brain: the molecular basis for Alzheimer\u2019s and Parkinson\u2019s diseases. Mol Med 14:451\u2013464","journal-title":"Mol Med"},{"key":"9330_CR23","doi-asserted-by":"crossref","first-page":"45320","DOI":"10.1074\/jbc.M103736200","volume":"276","author":"A Iwata","year":"2001","unstructured":"Iwata A, Maruyama M, Kanazawa I, Nukina N (2001) Alpha-synuclein affects the MAPK pathway and accelerates cell death. J Biol Chem 276:45320\u201345329","journal-title":"J Biol Chem"},{"key":"9330_CR24","doi-asserted-by":"crossref","first-page":"15240","DOI":"10.1074\/jbc.M312497200","volume":"279","author":"SV Kalivendi","year":"2004","unstructured":"Kalivendi SV, Cunningham S, Kotamraju S, Joseph J, Hillard CJ, Kalyanaraman B (2004) Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide. J Biol Chem 279:15240\u201315247","journal-title":"J Biol Chem"},{"key":"9330_CR25","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0896-6273(03)00124-7","volume":"37","author":"F Kamenetz","year":"2003","unstructured":"Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R (2003) APP processing and synaptic function. Neuron 37:925\u2013937","journal-title":"Neuron"},{"key":"9330_CR26","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/jnr.21548","volume":"86","author":"EM Kawamoto","year":"2008","unstructured":"Kawamoto EM, Lepsch LB, Boaventura MF (2008) Amyloid beta-peptide activates nuclear factor-kappaB through an N-methyl-d-aspartate signalling pathway in cultured cerebellar cells. J Neurosci Res 86:845\u2013860","journal-title":"J Neurosci Res"},{"key":"9330_CR27","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/embo-reports\/kvd107","volume":"1","author":"MD Ledesma","year":"2000","unstructured":"Ledesma MD, Da Silva JS, Crassaerts K, Delacourte A, De Strooper B, Dotti CG (2000) Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer\u2019s disease brains. EMBO Rep 1:530\u2013535","journal-title":"EMBO Rep"},{"key":"9330_CR28","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1523\/JNEUROSCI.19-03-00940.1999","volume":"19","author":"RK Lee","year":"1999","unstructured":"Lee RK, Knapp S, Wurtman RJ (1999) Prostaglandin E2 stimulates amyloid precursor protein gene expression: inhibition by immunosuppressants. J Neurosci 19:940\u2013947","journal-title":"J Neurosci"},{"key":"9330_CR29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.tins.2004.01.007","volume":"27","author":"VM Lee","year":"2004","unstructured":"Lee VM, Giasson BI, Trojanowski JQ (2004) More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases. Trends Neurosci 27:129\u2013134","journal-title":"Trends Neurosci"},{"key":"9330_CR30","doi-asserted-by":"crossref","first-page":"9367","DOI":"10.1523\/JNEUROSCI.0849-05.2005","volume":"25","author":"S Lesn\u00e9","year":"2005","unstructured":"Lesn\u00e9 S, Ali C, Gabriel C, Croci N, MacKenzie ET, Glabe CG, Plotkine M, Marchand-Verrecchia C, Vivien D, Buisson A (2005) NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production. J Neurosci 25:9367\u20139377","journal-title":"J Neurosci"},{"key":"9330_CR31","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1046\/j.1471-4159.1996.67030978.x","volume":"67","author":"Y Luo","year":"1996","unstructured":"Luo Y, Sunderland T, Wolozin B (1996) Physiologic levels of beta-amyloid activate phosphatidylinositol 3-kinase with the involvement of tyrosine phosphorylation. J Neurochem 67:978\u2013987","journal-title":"J Neurochem"},{"key":"9330_CR32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.brainres.2007.09.033","volume":"1185","author":"S Majd","year":"2007","unstructured":"Majd S, Rastegar K, Zarifkar A, Takhshid MA (2007) Fibrillar beta-amyloid (Abeta) (1-42) elevates extracellular Abeta in cultured hippocampal neurons of adult rats. Brain Res 1185:321\u2013327","journal-title":"Brain Res"},{"key":"9330_CR33","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s11064-011-0435-0","volume":"36","author":"S Majd","year":"2011","unstructured":"Majd S, Smardencas A, Parish CL, Drago J (2011) Development of an in vitro model to evaluate the regenerative capacity of adult brain-derived tyrosine hydroxylase-expressing dopaminergic neurons. Neurochem Res 36:967\u2013977","journal-title":"Neurochem Res"},{"key":"9330_CR34","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1523\/JNEUROSCI.23-08-03095.2003","volume":"23","author":"AB Manning-Bog","year":"2003","unstructured":"Manning-Bog AB, McCormack AL, Purisai MG, Bolin LM, Di Monte DA (2003) Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration. J Neurosci 23:3095\u20133099","journal-title":"J Neurosci"},{"key":"9330_CR35","doi-asserted-by":"crossref","first-page":"12245","DOI":"10.1073\/pnas.211412398","volume":"98","author":"E Masliah","year":"2001","unstructured":"Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, Mucke L (2001) Beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer\u2019s disease and Parkinson\u2019s disease. Proc Natl Acad Sci USA 98:12245\u201312250","journal-title":"Proc Natl Acad Sci USA"},{"key":"9330_CR36","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1582-4934.2005.tb00485.x","volume":"9","author":"Z Nagy","year":"2005","unstructured":"Nagy Z (2005) The last neuronal division: a unifying hypothesis for the pathogenesis of Alzheimer\u2019s disease. J Cell Mol Med 9:531\u2013541","journal-title":"J Cell Mol Med"},{"key":"9330_CR37","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/nm1485","volume":"12","author":"Y Ni","year":"2006","unstructured":"Ni Y, Zhao X, Bao G, Zou L, Teng L, Wang Z, Song M, Xiong J, Bai Y, Pei G (2006) Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation. Nat Med 12:1390\u20131396","journal-title":"Nat Med"},{"key":"9330_CR38","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jmb.2007.05.069","volume":"371","author":"T Okada","year":"2007","unstructured":"Okada T, Wakabayashi M, Ikeda K, Matsuzaki K (2007) Formation of toxic fibrils of Alzheimer\u2019s amyloid beta-protein-(1\u201340) by monosialoganglioside GM1, a neuronal membrane component. J Mol Biol 371:481\u2013489","journal-title":"J Mol Biol"},{"key":"9330_CR39","doi-asserted-by":"crossref","first-page":"34088","DOI":"10.1074\/jbc.M111.243907","volume":"286","author":"J Ol\u00e1h","year":"2011","unstructured":"Ol\u00e1h J, Vincze O, Vir\u00f3k D, Simon D, Bozs\u00f3 Z, T\u00f5k\u00e9si N, Horv\u00e1th I, Hlavanda E, Kov\u00e1cs J, Magyar A, Sz\u0169cs M, Orosz F, Penke B, Ov\u00e1di J (2011) Interactions of pathological hallmark proteins: tubulin polymerization promoting protein\/p25, beta-amyloid, and alpha-synuclein. J Biol Chem 286:34088\u201334100","journal-title":"J Biol Chem"},{"key":"9330_CR100","unstructured":"Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ (2008) Formation of toxic oligomeric alpha-synuclein species in living cells. PLoS 3:1\u20139"},{"key":"9330_CR40","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/brain\/awn349","volume":"132","author":"KE Paleologou","year":"2009","unstructured":"Paleologou KE, Kragh CL, Mann DM, Salem SA, Al-Shami R, Allsop D, Hassan AH, Jensen PH, El-Agnaf OM (2009) Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies. Brain 132:1093\u20131101","journal-title":"Brain"},{"key":"9330_CR41","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/jnr.10602","volume":"72","author":"JR Patel","year":"2003","unstructured":"Patel JR, Brewer GJ (2003) Age-related changes in neuronal glucose uptake in response to glutamate and beta-amyloid. J Neurosci Res 72:527\u2013536","journal-title":"J Neurosci Res"},{"key":"9330_CR42","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0006-291X(90)91735-B","volume":"167","author":"D Quon","year":"1990","unstructured":"Quon D, Catalano R, Cordell B (1990) Fibroblast growth factor induces beta-amyloid precursor mRNA in glial but not neuronal cultured cells. Biochem Biophys Res Commun 167:96\u2013102","journal-title":"Biochem Biophys Res Commun"},{"key":"9330_CR43","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s10024-003-7080-9","volume":"7","author":"R Raghavan","year":"2004","unstructured":"Raghavan R, Kruijff L, Sterrenburg MD, Rogers BB, Hladik CL, White CL III (2004) Alpha-synuclein expression in the developing human brain. Pediatr Dev Pathol 7:506\u2013516","journal-title":"Pediatr Dev Pathol"},{"key":"9330_CR44","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/1097-4547(20000715)61:2<128::AID-JNR2>3.0.CO;2-H","volume":"61","author":"AK Raina","year":"2000","unstructured":"Raina AK, Zhu X, Rottkamp CA, Monteiro M, Takeda A, Smith MA (2000) Cyclin\u2019 toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease. J Neurosci Res 61:128\u2013133","journal-title":"J Neurosci Res"},{"key":"9330_CR45","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0962-8924(98)01363-4","volume":"8","author":"DJ Selkoe","year":"1998","unstructured":"Selkoe DJ (1998) The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer\u2019s disease. Trends Cell Biol 8:447\u2013453","journal-title":"Trends Cell Biol"},{"key":"9330_CR46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0304-3940(02)00297-5","volume":"326","author":"W Tamo","year":"2002","unstructured":"Tamo W, Imaizumi T, Tanji K, Yoshida H, Mori F, Yoshimoto M, Takahashi H, Fukuda I, Wakabayashi K, Satoh K (2002) Expression of alpha-synuclein, the precursor of non-amyloid beta component of Alzheimer\u2019s disease amyloid, in human cerebral blood vessels. Neurosci Lett 326:5\u20138","journal-title":"Neurosci Lett"},{"key":"9330_CR47","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1523\/JNEUROSCI.20-04-01386.2000","volume":"20","author":"CM Troy","year":"2000","unstructured":"Troy CM, Rabacchi SA, Friedman WJ, Frappier TF, Brown K, Shelanski ML (2000) Caspase-2 mediates neuronal cell death induced by beta-amyloid. J Neurosci 20:1386\u20131392","journal-title":"J Neurosci"},{"key":"9330_CR48","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1073\/pnas.90.23.11282","volume":"90","author":"K U\u00e9da","year":"1993","unstructured":"U\u00e9da K, Fukushima H, Masliah E, Xia Y, Iwai A, Yoshimoto M, Otero DA, Kondo J, Ihara Y, Saitoh T (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci USA 90:11282\u201311286","journal-title":"Proc Natl Acad Sci USA"},{"key":"9330_CR49","doi-asserted-by":"crossref","first-page":"12876","DOI":"10.1074\/jbc.M311652200","volume":"279","author":"GT Wong","year":"2004","unstructured":"Wong GT, Manfra D, Poulet FM, Zhang Q, Josien H, Bara T, Engstrom L, Pinzon-Ortiz M, Fine JS, Lee HJ, Zhang L, Higgins GA, Parker EM (2004) Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem 279:12876\u201312882","journal-title":"J Biol Chem"},{"key":"9330_CR50","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1523\/JNEUROSCI.3707-05.2006","volume":"26","author":"Y Yang","year":"2006","unstructured":"Yang Y, Varvel NH, Lamb BT, Herrup K (2006) Ectopic cell cycle events link human Alzheimer\u2019s disease and amyloid precursor protein transgenic mouse models. J Neurosci 26:775\u2013784","journal-title":"J Neurosci"},{"key":"9330_CR51","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.neuroscience.2006.12.028","volume":"145","author":"S Yu","year":"2007","unstructured":"Yu S, Li X, Liu G, Han J, Zhang C, Li Y, Xu S, Liu C, Gao Y, Yang H, U\u00e9da K, Chan P (2007) Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody. Neuroscience 145:539\u2013555","journal-title":"Neuroscience"},{"key":"9330_CR52","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1523\/JNEUROSCI.4376-04.2005","volume":"25","author":"B Ziolkowska","year":"2005","unstructured":"Ziolkowska B, Gieryk A, Bilecki W, Wawrzczak-Bargiela A, Wedzony K, Chocyk A, Danielson PE, Thomas EA, Hilbush BS, Sutcliffe JG, Przewlocki R (2005) Regulation of alpha-synuclein expression in limbic and motor brain regions of morphine-treated mice. J Neurosci 25:4996\u20135003","journal-title":"J Neurosci"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-012-9330-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12640-012-9330-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-012-9330-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T18:22:14Z","timestamp":1561746134000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12640-012-9330-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,19]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["9330"],"URL":"https:\/\/doi.org\/10.1007\/s12640-012-9330-y","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,19]]}}}