{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:11:54Z","timestamp":1777417914424,"version":"3.51.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,1,19]],"date-time":"2013-01-19T00:00:00Z","timestamp":1358553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1007\/s12640-013-9376-5","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T14:42:52Z","timestamp":1358520172000},"page":"176-190","source":"Crossref","is-referenced-by-count":12,"title":["Putative Agmatinase Inhibitor for Hypoxic-Ischemic New Born Brain Damage"],"prefix":"10.1007","volume":"24","author":[{"given":"John E.","family":"Piletz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Klenotich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian Long","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Valente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vyvyca","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soeb Nam","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Yangzheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,1,19]]},"reference":[{"key":"9376_CR1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.neures.2005.05.002","volume":"52","author":"A Askalany","year":"2005","unstructured":"Askalany A, Yamakura T, Petrenko A, Kohno T, Sakimura K, Baba H (2005) Effect of agmatine on heteromeric N-methyl-d-aspartate receptor channels. Neurosci Res 52:387\u2013392","journal-title":"Neurosci Res"},{"key":"9376_CR2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00726-010-0657-5","volume":"40","author":"HG Bernstein","year":"2011","unstructured":"Bernstein HG, Derst C, Stich C, Pruss H, Peters D, Krauss M, Bogerts B, Veh RW, Laube G (2011) The agmatine-degrading enzyme agmatinase: a key to agmatine signaling in rat and human brain? Amino Acids 40:453\u2013465","journal-title":"Amino Acids"},{"key":"9376_CR3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neuropharm.2011.07.012","volume":"62","author":"HG Bernstein","year":"2012","unstructured":"Bernstein HG, Stich C, Jager K, Dobrowolny H, Wick M, Steiner J, Veh R, Bogerts B, Laube G (2012) Agmatinase, an inactivator of the putative endogenous antidepressant agmatine, is strongly upregulated in hippocampal interneurons of subjects with mood disorders. Neuropharmacology 62:237\u2013246","journal-title":"Neuropharmacology"},{"key":"9376_CR4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jchromb.2011.11.016","volume":"880","author":"L Betancourt","year":"2012","unstructured":"Betancourt L, Rada P, Paredes D, Hernandez L (2012) In vivo monitoring of cerebral agmatine by microdialysis and capillary electrophoresis. J Chromatogr B Analyt Technol Biomed Life Sci 880:58\u201365","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"9376_CR5","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s11064-008-9765-y","volume":"34","author":"J Brown","year":"2009","unstructured":"Brown J, Achille N, Neafsey EJ, Collins MA (2009) Binge ethanol-induced neurodegeneration in rat organotypic brain slice cultures: effects of PLA2 inhibitor mepacrine and docosahexaenoic acid (DHA). Neurochem Res 34:260\u2013267","journal-title":"Neurochem Res"},{"key":"9376_CR6","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1023\/A:1018961521106","volume":"11","author":"U Calis","year":"1994","unstructured":"Calis U, Finch JR, Soltis EE, Digenis GA (1994) Synthesis of novel aminopropylguanidine derivatives with potential antihypertensive activity. Pharm Res 11:1211\u20131215","journal-title":"Pharm Res"},{"key":"9376_CR7","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1042\/bj20040035","volume":"379","author":"CS Coleman","year":"2004","unstructured":"Coleman CS, Hu G, Pegg AE (2004) Putrescine biosynthesis in mammalian tissues. Biochem J 379:849\u2013855","journal-title":"Biochem J"},{"key":"9376_CR8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1124\/mol.59.1.24","volume":"59","author":"DR Demady","year":"2001","unstructured":"Demady DR, Jianmongkol S, Vuletich JL, Bender AT, Osawa Y (2001) Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme. Mol Pharmacol 59:24\u201329","journal-title":"Mol Pharmacol"},{"key":"9376_CR9","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0028-3908(03)00199-0","volume":"45","author":"S Demehri","year":"2003","unstructured":"Demehri S, Homayoun H, Honar H, Riazi K, Vafaie K, Roushanzamir F, Dehpour A (2003) Agmatine exerts anticonvulsant effect in mice: modulation by alpha 2-adrenoceptors and nitric oxide. Neuropharmacology 45:534\u2013542","journal-title":"Neuropharmacology"},{"key":"9376_CR10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1196\/annals.1304.017","volume":"1009","author":"Y Feng","year":"2003","unstructured":"Feng Y, LeBlanc M (2003) Effect of agmatine on the time course of brain inflammatory cytokines after injury in rat pups. Ann N Y Acad Sci 1009:152\u2013156","journal-title":"Ann N Y Acad Sci"},{"key":"9376_CR11","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1203\/00006450-200210000-00023","volume":"52","author":"Y Feng","year":"2002","unstructured":"Feng Y, Piletz JE, Leblanc MH (2002) Agmatine suppresses nitric oxide production and attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatr Res 52:606\u2013611","journal-title":"Pediatr Res"},{"key":"9376_CR12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1042\/bj3160247","volume":"316","author":"E Galea","year":"1996","unstructured":"Galea E, Regunathan S, Eliopoulos V, Feinstein DL, Reis DJ (1996) Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine. Biochem J 316:247\u2013249","journal-title":"Biochem J"},{"key":"9376_CR13","first-page":"41","volume":"58","author":"GM Gilad","year":"1996","unstructured":"Gilad GM, Salame K, Rabey JM, Gilad VH (1996) Agmatine treatment is neuroprotective in rodent brain injury models. Life Sci 58:41\u201346","journal-title":"Life Sci"},{"key":"9376_CR14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/01.wnr.0000192739.38653.aa","volume":"17","author":"CJ Goracke-Postle","year":"2006","unstructured":"Goracke-Postle CJ, Nguyen HO, Stone LS, Fairbanks CA (2006) Release of tritiated agmatine from spinal synaptosomes. Neuroreport 17:13\u201317","journal-title":"Neuroreport"},{"key":"9376_CR15","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1471-4159.2006.04193.x","volume":"100","author":"CJ Goracke-Postle","year":"2007","unstructured":"Goracke-Postle CJ, Overland AC, Stone LS, Fairbanks CA (2007) Agmatine transport into spinal nerve terminals is modulated by polyamine analogs. J Neurochem 100:132\u2013141","journal-title":"J Neurochem"},{"key":"9376_CR16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/exnr.2001.7746","volume":"171","author":"OS Gorbatyuk","year":"2001","unstructured":"Gorbatyuk OS, Milner TA, Wang G, Regunathan S, Reis DJ (2001) Localization of agmatine in vasopressin and oxytocin neurons of the rat hypothalamic paraventricular and supraoptic nuclei. Exp Neurol 171:235\u2013245","journal-title":"Exp Neurol"},{"key":"9376_CR17","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2165\/00023210-200721110-00002","volume":"21","author":"A Halaris","year":"2007","unstructured":"Halaris A, Piletz J (2007) Agmatine: metabolic pathway and spectrum of activity in brain. CNS Drugs 21:885\u2013900","journal-title":"CNS Drugs"},{"key":"9376_CR18","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3390\/11060393","volume":"11","author":"H He","year":"2006","unstructured":"He H, Liu M, Zheng Z, Liu Y, Xiao J, Su R, Hu C, Li J, Li S (2006) Synthesis and analgesic activity evaluation of some agmatine derivatives. Molecules 11:393\u2013402","journal-title":"Molecules"},{"key":"9376_CR19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0006-8993(90)91255-F","volume":"506","author":"KH Holmes","year":"1990","unstructured":"Holmes KH, Bilkey DK, Laverty R, Goddard GV (1990) The N-methyl-d-aspartate antagonists aminophosphonovalerate and carboxypiperazinephosphonate retard the development and expression of kindled seizures. Brain Res 506:227\u2013235","journal-title":"Brain Res"},{"key":"9376_CR20","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.lfs.2008.10.006","volume":"84","author":"S Hong","year":"2009","unstructured":"Hong S, Kim CY, Lee JE, Seong GJ (2009) Agmatine protects cultured retinal ganglion cells from tumor necrosis factor-alpha-induced apoptosis. Life Sci 84:28\u201332","journal-title":"Life Sci"},{"key":"9376_CR21","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1042\/BJ20041260","volume":"388","author":"O Horyn","year":"2005","unstructured":"Horyn O, Luhovyy B, Lazarow A, Daikhin Y, Nissim I, Yudkoff M, Nissim I (2005) Biosynthesis of agmatine in isolated mitochondria and perfused rat liver: studies with 15N-labelled arginine. Biochem J 388:419\u2013425","journal-title":"Biochem J"},{"key":"9376_CR22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1196\/annals.1304.006","volume":"1009","author":"MJ Huang","year":"2003","unstructured":"Huang MJ, Regunathan S, Botta M, Lee K, McClendon E, Yi GB, Pedersen ML, Berkowitz DB, Wang G, Travagli M, Piletz JE (2003) Structure-activity analysis of guanidine group in agmatine for brain agmatinase. Ann N Y Acad Sci 1009:52\u201363","journal-title":"Ann N Y Acad Sci"},{"key":"9376_CR23","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/j.1471-4159.2005.03544.x","volume":"96","author":"AH Iyo","year":"2006","unstructured":"Iyo AH, Zhu MY, Ordway GA, Regunathan S (2006) Expression of arginine decarboxylase in brain regions and neuronal cells. J Neurochem 96:1042\u20131050","journal-title":"J Neurochem"},{"key":"9376_CR24","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1526-4637.2010.00808.x","volume":"11","author":"O Keynan","year":"2010","unstructured":"Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM (2010) Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 11:356\u2013368","journal-title":"Pain Med"},{"key":"9376_CR25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.expneurol.2004.05.029","volume":"189","author":"J Kim","year":"2004","unstructured":"Kim J, Yenari M, Giffard R, Cho S, Park K, Lee J (2004) Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury. Exp Neurol 189:122\u2013130","journal-title":"Exp Neurol"},{"key":"9376_CR26","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1152\/jn.2000.83.2.1031","volume":"83","author":"NR Kreisman","year":"2000","unstructured":"Kreisman NR, Soliman S, Gozal D (2000) Regional differences in hypoxic depolarization and swelling in hippocampal slices. J Neurophysiol 83:1031\u20131038","journal-title":"J Neurophysiol"},{"key":"9376_CR27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.brainres.2009.05.046","volume":"1281","author":"WT Lee","year":"2009","unstructured":"Lee WT, Hong S, Yoon SH, Kim JH, Park KA, Seong GJ, Lee JE (2009) Neuroprotective effects of agmatine on oxygen-glucose deprived primary-cultured astrocytes and nuclear translocation of nuclear factor-kappa B. Brain Res 1281:64\u201370","journal-title":"Brain Res"},{"key":"9376_CR28","first-page":"543","volume":"67","author":"A Legido","year":"2007","unstructured":"Legido A, Valencia I, Katsetos CD, Delivoria-Papadopoulos M (2007) Neuroprotection in perinatal hypoxic-ischemic encephalopathy. Effective treatment and future perspectives. Medicina 67:543\u2013555","journal-title":"Medicina"},{"key":"9376_CR29","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1126\/science.7906055","volume":"263","author":"G Li","year":"1994","unstructured":"Li G, Regunathan S, Barrow CJ, Eshraghi J, Cooper R, Reis DJ (1994) Agmatine: an endogenous clonidine-displacing substance in the brain. Science 263:966\u2013969","journal-title":"Science"},{"key":"9376_CR30","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1749-6632.1995.tb32418.x","volume":"763","author":"G Li","year":"1995","unstructured":"Li G, Regunathan S, Reis DJ (1995) Agmatine is synthesized by a mitochondrial arginine decarboxylase in rat brain. Ann N Y Acad Sci 763:325\u2013329","journal-title":"Ann N Y Acad Sci"},{"key":"9376_CR31","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.neuroscience.2009.01.039","volume":"159","author":"P Liu","year":"2009","unstructured":"Liu P, Bergin DH (2009) Differential effects of i.c.v. microinfusion of agmatine on spatial working and reference memory in the rat. Neuroscience 159:951\u2013961","journal-title":"Neuroscience"},{"key":"9376_CR32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.6030\/1939-067X-1.1.1","volume":"1","author":"S Liu","year":"2008","unstructured":"Liu S, Levine SR (2008) The continued promise of neuroprotection for acute stroke treatment. J Exp Stroke Transl Med 1:1\u20138","journal-title":"J Exp Stroke Transl Med"},{"key":"9376_CR33","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/hipo.20561","volume":"19","author":"P Liu","year":"2009","unstructured":"Liu P, Jing Y, Collie ND, Chary S, Zhang H (2009) Memory-related changes in l-citrulline and agmatine in the rat brain. Hippocampus 19:597\u2013602","journal-title":"Hippocampus"},{"issue":"3","key":"9376_CR34","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s00726-011-1195-5","volume":"43","author":"VI Madai","year":"2011","unstructured":"Madai VI, Poller WC, Peters D, Berger J, Paliege K, Bernard R, Veh RW, Laube G (2011) Synaptic localisation of agmatinase in rat cerebral cortex revealed by virtual pre-embedding. Amino Acids 43(3):1399\u20131403","journal-title":"Amino Acids"},{"key":"9376_CR35","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.pharmthera.2011.12.005","volume":"133","author":"GJ Molderings","year":"2012","unstructured":"Molderings GJ, Haenisch B (2012) Agmatine (decarboxylated l-arginine): physiological role and therapeutic potential. Pharmacol Ther 133:351\u2013365","journal-title":"Pharmacol Ther"},{"key":"9376_CR36","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1476-5381.2009.00278.x","volume":"157","author":"SM Morris Jr","year":"2009","unstructured":"Morris SM Jr (2009) Recent advances in arginine metabolism: roles and regulation of the arginases. Br J Pharmacol 157:922\u2013930","journal-title":"Br J Pharmacol"},{"key":"9376_CR37","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S1385-299X(98)00050-6","volume":"3","author":"J Noraberg","year":"1999","unstructured":"Noraberg J, Kristensen BW, Zimmer J (1999) Markers for neuronal degeneration in organotypic slice cultures. Brain Res Brain Res Protoc 3:278\u2013290","journal-title":"Brain Res Brain Res Protoc"},{"key":"9376_CR38","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.brainres.2007.04.050","volume":"1159","author":"AF Paszcuk","year":"2007","unstructured":"Paszcuk AF, Gadotti VM, Tibola D, Quintao NL, Rodrigues AL, Calixto JB, Santos AR (2007) Anti-hypernociceptive properties of agmatine in persistent inflammatory and neuropathic models of pain in mice. Brain Res 1159:124\u2013133","journal-title":"Brain Res"},{"key":"9376_CR39","unstructured":"Piletz J, Huang M-J, Lee K (2008) Mammalian agmatinase inhibitory substance. In: Mammalian agmatinase inhibitory substance. US Patent 7347984 B2, Jackson State University, Assignee, pp 1\u201318"},{"key":"9376_CR40","first-page":"274","volume":"2","author":"JE Piletz","year":"2009","unstructured":"Piletz JE, Halaris A, Iqbal O, Fareed D, Hoppensteadt D, Fareed J, Zhu H, Sinacore J, DeVane CL (2009) Nitric oxide branch of arginine metabolism in depression: effect of venlafaxine. Intl J Health Sci 2:274\u2013281","journal-title":"Intl J Health Sci"},{"key":"9376_CR41","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1196\/annals.1304.002","volume":"1009","author":"S Regunathan","year":"2003","unstructured":"Regunathan S, Piletz J (2003) Regulation of inducible nitric oxide synthase and agmatine synthesis in macrophages and astrocytes. Ann N Y Acad Sci 1009:20\u201329","journal-title":"Ann N Y Acad Sci"},{"key":"9376_CR42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1749-6632.1999.tb09343.x","volume":"881","author":"DJ Reis","year":"1999","unstructured":"Reis DJ, Regunathan S (1999) Agmatine: an endogenous ligand at imidazoline receptors is a novel neurotransmitter. Ann N Y Acad Sci 881:65\u201380","journal-title":"Ann N Y Acad Sci"},{"key":"9376_CR43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","volume":"9","author":"JE Rice 3rd","year":"1981","unstructured":"Rice JE 3rd, Vannucci RC, Brierley JB (1981) The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 9:131\u2013141","journal-title":"Ann Neurol"},{"key":"9376_CR44","first-page":"E110","volume":"277","author":"NagasakiA Salimuddin","year":"1999","unstructured":"Salimuddin NagasakiA, Gotoh T, Isobe H, Mori M (1999) Regulation of the genes for arginase isoforms and related enzymes in mouse macrophages by lipopolysaccharide. Am J Physiol 277:E110\u2013E117","journal-title":"Am J Physiol"},{"key":"9376_CR45","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1046\/j.1471-4159.1996.67041761.x","volume":"67","author":"M Sastre","year":"1996","unstructured":"Sastre M, Regunathan S, Galea E, Reis DJ (1996) Agmatinase activity in rat brain: a metabolic pathway for the degradation of agmatine. J Neurochem 67:1761\u20131765","journal-title":"J Neurochem"},{"key":"9376_CR46","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1042\/bj3301405","volume":"330","author":"M Sastre","year":"1998","unstructured":"Sastre M, Galea E, Feinstein D, Reis DJ, Regunathan S (1998) Metabolism of agmatine in macrophages: modulation by lipopolysaccharide and inhibitory cytokines. Biochem J 330:1405\u20131409","journal-title":"Biochem J"},{"key":"9376_CR47","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00726-004-0078-4","volume":"26","author":"J Satriano","year":"2004","unstructured":"Satriano J (2004) Arginine pathways and the inflammatory response: interregulation of nitric oxide and polyamines: review article. Amino Acids 26:321\u2013329","journal-title":"Amino Acids"},{"key":"9376_CR48","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neuroscience.2011.07.007","volume":"192","author":"S Seo","year":"2011","unstructured":"Seo S, Liu P, Leitch B (2011) Spatial learning-induced accumulation of agmatine and glutamate at hippocampal CA1 synaptic terminals. Neuroscience 192:28\u201336","journal-title":"Neuroscience"},{"key":"9376_CR49","doi-asserted-by":"crossref","unstructured":"Shopsin B (2012) The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr. doi: 10.1111\/j.1601-5215.2012.00675.x.","DOI":"10.1111\/j.1601-5215.2012.00675.x"},{"key":"9376_CR50","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ejphar.2008.03.022","volume":"587","author":"RB Su","year":"2008","unstructured":"Su RB, Lu XQ, Huang Y, Liu Y, Gong ZH, Wei XL, Wu N, Li J (2008) Effects of intragastric agmatine on morphine-induced physiological dependence in beagle dogs and rhesus monkeys. Eur J Pharmacol 587:155\u2013162","journal-title":"Eur J Pharmacol"},{"key":"9376_CR51","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1203\/00006450-200001000-00015","volume":"47","author":"M Tsuji","year":"2000","unstructured":"Tsuji M, Higuchi Y, Shiraishi K, Kume T, Akaike A, Hattori H (2000) Protective effect of aminoguanidine on hypoxic-ischemic brain damage and temporal profile of brain nitric oxide in neonatal rat. Pediatr Res 47:79\u201383","journal-title":"Pediatr Res"},{"key":"9376_CR52","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.abb.2007.01.002","volume":"461","author":"E Uribe","year":"2007","unstructured":"Uribe E, Salas M, Enriquez S, Orellana MS, Carvajal N (2007) Cloning and functional expression of a rodent brain cDNA encoding a novel protein with agmatinase activity, but not belonging to the arginase family. Arch Biochem Biophys 461:146\u2013150","journal-title":"Arch Biochem Biophys"},{"key":"9376_CR53","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.brainres.2006.02.024","volume":"1084","author":"WP Wang","year":"2006","unstructured":"Wang WP, Iyo AH, Miguel-Hidalgo J, Regunathan S, Zhu MY (2006) Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons. Brain Res 1084:210\u2013216","journal-title":"Brain Res"},{"key":"9376_CR54","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00221-004-2034-7","volume":"160","author":"J Yang","year":"2005","unstructured":"Yang J, Wang WZ, Shen FM, Su DF (2005) Cardiovascular effects of agmatine within the rostral ventrolateral medulla are similar to those of clonidine in anesthetized rats. Exp Brain Res 160:467\u2013472","journal-title":"Exp Brain Res"},{"key":"9376_CR55","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1097\/00001756-200009280-00031","volume":"11","author":"CG Yu","year":"2000","unstructured":"Yu CG, Marcillo AE, Fairbanks CA, Wilcox GL, Yezierski RP (2000) Agmatine improves locomotor function and reduces tissue damage following spinal cord injury. Neuroreport 11:3203\u20133207","journal-title":"Neuroreport"},{"key":"9376_CR56","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejphar.2010.02.029","volume":"634","author":"A Zarifkar","year":"2010","unstructured":"Zarifkar A, Choopani S, Ghasemi R, Naghdi N, Maghsoudi AH, Maghsoudi N, Rastegar K, Moosavi M (2010) Agmatine prevents LPS-induced spatial memory impairment and hippocampal apoptosis. Eur J Pharmacol 634:84\u201388","journal-title":"Eur J Pharmacol"},{"key":"9376_CR57","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ab.2003.11.006","volume":"326","author":"W Zhang","year":"2004","unstructured":"Zhang W, Kaye D (2004) Simultaneous determination of arginine and seven metabolites in plasma by reversed-phase liquid chromatography with a time-controlled ortho-phthaldialdehyde precolumn derivatization. Anal Biochem 326:87\u201392","journal-title":"Anal Biochem"},{"key":"9376_CR58","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bbagen.2003.11.006","volume":"1670","author":"M Zhu","year":"2004","unstructured":"Zhu M, Iyo A, Piletz J, Regunathan S (2004) Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine. Biochim Biophys Acta 1670:156\u2013164","journal-title":"Biochim Biophys Acta"},{"key":"9376_CR59","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1111\/j.1471-4159.2007.04867.x","volume":"103","author":"MY Zhu","year":"2007","unstructured":"Zhu MY, Wang WP, Huang J, Regunathan S (2007) Chronic treatment with glucocorticoids alters rat hippocampal and prefrontal cortical morphology in parallel with endogenous agmatine and arginine decarboxylase levels. J Neurochem 103:1811\u20131820","journal-title":"J Neurochem"},{"key":"9376_CR60","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/00001756-200203250-00005","volume":"13","author":"AD Zomkowski","year":"2002","unstructured":"Zomkowski AD, Hammes L, Lin J, Calixto JB, Santos AR, Rodrigues AL (2002) Agmatine produces antidepressant-like effects in two models of depression in mice. Neuroreport 13:387\u2013391","journal-title":"Neuroreport"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-013-9376-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12640-013-9376-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-013-9376-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T13:34:06Z","timestamp":1562592846000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12640-013-9376-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,19]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["9376"],"URL":"https:\/\/doi.org\/10.1007\/s12640-013-9376-5","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,19]]}}}