{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T20:23:23Z","timestamp":1788639803318,"version":"build-2803163510"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T00:00:00Z","timestamp":1484524800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31171151"],"award-info":[{"award-number":["31171151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371212"],"award-info":[{"award-number":["31371212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471372"],"award-info":[{"award-number":["81471372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1007\/s12640-016-9696-3","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T00:16:52Z","timestamp":1484525812000},"page":"505-520","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline"],"prefix":"10.1007","volume":"31","author":[{"given":"Hong-Tao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Lian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Lan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Juan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qing","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Qing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Ping","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,16]]},"reference":[{"key":"9696_CR1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1001\/archpsyc.62.8.829","volume":"62","author":"S Akbarian","year":"2005","unstructured":"Akbarian S, Ruehl MG, Bliven E, Luiz LA, Peranelli AC, Baker SP, Roberts RC, Bunney WJ, Conley RC, Jones EG et al (2005) Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia. Arch Gen Psychiatry 62:829\u2013840","journal-title":"Arch Gen Psychiatry"},{"key":"9696_CR2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/dev.10120","volume":"43","author":"H Arakawa","year":"2003","unstructured":"Arakawa H (2003) The effects of isolation rearing on open-field behavior in male rats depends on developmental stages. Dev Psychobiol 43:11\u201319","journal-title":"Dev Psychobiol"},{"key":"9696_CR3","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1189\/jlb.0212100","volume":"92","author":"W Beumer","year":"2012","unstructured":"Beumer W, Gibney SM, Drexhage RC, Pont-Lezica L, Doorduin J, Klein HC, Steiner J, Connor TJ, Harkin A, Versnel MA, Drexhage HA (2012) The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes. J Leukoc Biol 92:959\u2013975","journal-title":"J Leukoc Biol"},{"key":"9696_CR4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/neuro.08.014.2009","volume":"3","author":"SD Bilbo","year":"2009","unstructured":"Bilbo SD, Schwarz JM (2009) Early-life programming of later-life brain and behavior: a critical role for the immune system. Front Behav Neurosci 3:14","journal-title":"Front Behav Neurosci"},{"key":"9696_CR5","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/npp.2008.154","volume":"34","author":"OJ Bosch","year":"2009","unstructured":"Bosch OJ, Nair HP, Ahern TH, Neumann ID, Young LJ (2009) The CRF system mediates increased passive stress-coping behavior following the loss of a bonded partner in a monogamous rodent. NEUROPSYCHOPHARMACOL 34:1406\u20131415","journal-title":"NEUROPSYCHOPHARMACOL"},{"key":"9696_CR6","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbr.2014.02.022","volume":"265","author":"W Cao","year":"2014","unstructured":"Cao W, Duan J, Wang X, Zhong X, Hu Z, Huang F, Wang H, Zhang J, Li F, Zhang J et al (2014) Early enriched environment induces an increased conversion of proBDNF to BDNF in the adult rat\u2019s hippocampus. Behav Brain Res 265:76\u201383","journal-title":"Behav Brain Res"},{"key":"9696_CR7","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1096\/fj.08-106450","volume":"22","author":"S Chourbaji","year":"2008","unstructured":"Chourbaji S, Vogt MA, Fumagalli F, Sohr R, Frasca A, Brandwein C, Hortnagl H, Riva MA, Sprengel R, Gass P (2008) AMPA receptor subunit 1 (GluR-A) knockout mice model the glutamate hypothesis of depression. FASEB J 22:3129\u20133134","journal-title":"FASEB J"},{"key":"9696_CR8","doi-asserted-by":"crossref","first-page":"11451","DOI":"10.1523\/JNEUROSCI.1758-09.2009","volume":"29","author":"HR Covington","year":"2009","unstructured":"Covington HR, Maze I, LaPlant QC, Vialou VF, Ohnishi YN, Berton O, Fass DM, Renthal W, Rush AR, Wu EY et al (2009) Antidepressant actions of histone deacetylase inhibitors. J Neurosci 29:11451\u201311460","journal-title":"J Neurosci"},{"key":"9696_CR9","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.neuron.2011.06.007","volume":"71","author":"HR Covington","year":"2011","unstructured":"Covington HR, Maze I, Sun H, Bomze HM, DeMaio KD, Wu EY, Dietz DM, Lobo MK, Ghose S, Mouzon E et al (2011) A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron 71:656\u2013670","journal-title":"Neuron"},{"key":"9696_CR10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jneuroim.2008.01.009","volume":"195","author":"S Das","year":"2008","unstructured":"Das S, Mishra MK, Ghosh J, Basu A (2008) Japanese encephalitis virus infection induces IL-18 and IL-1beta in microglia and astrocytes: correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death. J Neuroimmunol 195:60\u201372","journal-title":"J Neuroimmunol"},{"key":"9696_CR11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neubiorev.2004.10.008","volume":"29","author":"ER Kloet de","year":"2005","unstructured":"de Kloet ER, Sibug RM, Helmerhorst FM, Schmidt MV (2005) Stress, genes and the mechanism of programming the brain for later life. Neurosci Biobehav Rev 29:271\u2013281","journal-title":"Neurosci Biobehav Rev"},{"key":"9696_CR12","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1017\/S1461145710001410","volume":"14","author":"B Dean","year":"2011","unstructured":"Dean B (2011) Understanding the role of inflammatory-related pathways in the pathophysiology and treatment of psychiatric disorders: evidence from human peripheral studies and CNS studies. Int J Neuropsychopharmacol 14:997\u20131012","journal-title":"Int J Neuropsychopharmacol"},{"key":"9696_CR13","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tips.2004.10.001","volume":"25","author":"M Domercq","year":"2004","unstructured":"Domercq M, Matute C (2004) Neuroprotection by tetracyclines. Trends Pharmacol Sci 25:609\u2013612","journal-title":"Trends Pharmacol Sci"},{"key":"9696_CR14","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nature09231","volume":"465","author":"C Dulac","year":"2010","unstructured":"Dulac C (2010) Brain function and chromatin plasticity. Nature 465:728\u2013735","journal-title":"Nature"},{"key":"9696_CR15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/dev.420100205","volume":"10","author":"DF Einon","year":"1977","unstructured":"Einon DF, Morgan MJ (1977) A critical period for social isolation in the rat. Dev Psychobiol 10:123\u2013132","journal-title":"Dev Psychobiol"},{"key":"9696_CR16","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbr.2007.03.011","volume":"180","author":"N Ferdman","year":"2007","unstructured":"Ferdman N, Murmu RP, Bock J, Braun K, Leshem M (2007) Weaning age, social isolation, and gender, interact to determine adult explorative and social behavior, and dendritic and spine morphology in prefrontal cortex of rats. Behav Brain Res 180:174\u2013182","journal-title":"Behav Brain Res"},{"key":"9696_CR17","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.neubiorev.2008.03.003","volume":"32","author":"KC Fone","year":"2008","unstructured":"Fone KC, Porkess MV (2008) Behavioural and neurochemical effects of post-weaning social isolation in rodents\u2014relevance to developmental neuropsychiatric disorders. Neurosci Biobehav Rev 32:1087\u20131102","journal-title":"Neurosci Biobehav Rev"},{"key":"9696_CR18","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neuron.2012.08.016","volume":"75","author":"TB Franklin","year":"2012","unstructured":"Franklin TB, Saab BJ, Mansuy IM (2012) Neural mechanisms of stress resilience and vulnerability. Neuron 75:747\u2013761","journal-title":"Neuron"},{"key":"9696_CR19","doi-asserted-by":"crossref","first-page":"608654","DOI":"10.1155\/2013\/608654","volume":"2013","author":"LR Frick","year":"2013","unstructured":"Frick LR, Williams K, Pittenger C (2013) Microglial dysregulation in psychiatric disease. CLIN DEV IMMUNOL 2013:608654","journal-title":"CLIN DEV IMMUNOL"},{"key":"9696_CR20","doi-asserted-by":"crossref","first-page":"16607","DOI":"10.1074\/jbc.M115.661777","volume":"290","author":"K Fujimaki","year":"2015","unstructured":"Fujimaki K, Ogihara T, Morris DL, Oda H, Iida H, Fujitani Y, Mirmira RG, Evans-Molina C, Watada H (2015) SET7\/9 enzyme regulates cytokine-induced expression of inducible nitric-oxide synthase through methylation of lysine 4 at histone 3 in the islet \u03b2 cell. J Biol Chem 290:16607\u201316618","journal-title":"J Biol Chem"},{"key":"9696_CR21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.dcn.2014.07.001","volume":"11","author":"P Ganguly","year":"2015","unstructured":"Ganguly P, Brenhouse HC (2015) Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity. Dev Cogn Neurosci 11:18\u201330","journal-title":"Dev Cogn Neurosci"},{"key":"9696_CR22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.yfrne.2008.10.001","volume":"30","author":"I Goshen","year":"2009","unstructured":"Goshen I, Yirmiya R (2009) Interleukin-1 (IL-1): a central regulator of stress responses. Front Neuroendocrinol 30:30\u201345","journal-title":"Front Neuroendocrinol"},{"key":"9696_CR23","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.biopsych.2007.04.011","volume":"62","author":"AJ Grippo","year":"2007","unstructured":"Grippo AJ, Lamb DG, Carter CS, Porges SW (2007) Social isolation disrupts autonomic regulation of the heart and influences negative affective behaviors. Biol Psychiatry 62:1162\u20131170","journal-title":"Biol Psychiatry"},{"key":"9696_CR24","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1523\/JNEUROSCI.3732-09.2010","volume":"30","author":"S Gupta","year":"2010","unstructured":"Gupta S, Kim SY, Artis S, Molfese DL, Schumacher A, Sweatt JD, Paylor RE, Lubin FD (2010) Histone methylation regulates memory formation. J Neurosci 30:3589\u20133599","journal-title":"J Neurosci"},{"key":"9696_CR25","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejphar.2015.01.006","volume":"750","author":"A Haj-Mirzaian","year":"2015","unstructured":"Haj-Mirzaian A, Amiri S, Kordjazy N, Rahimi-Balaei M, Haj-Mirzaian A, Marzban H, Aminzadeh A, Dehpour AR, Mehr SE (2015) Blockade of NMDA receptors reverses the depressant, but not anxiogenic effect of adolescence social isolation in mice. Eur J Pharmacol 750:160\u2013166","journal-title":"Eur J Pharmacol"},{"key":"9696_CR26","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-physiol-021909-135843","volume":"72","author":"MM Halassa","year":"2010","unstructured":"Halassa MM, Haydon PG (2010) Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annu Rev Physiol 72:335\u2013355","journal-title":"Annu Rev Physiol"},{"key":"9696_CR27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1615\/CritRevNeurobiol.v12.i1-2.50","volume":"12","author":"FS Hall","year":"1998","unstructured":"Hall FS (1998) Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences. Crit Rev Neurobiol 12:129\u2013162","journal-title":"Crit Rev Neurobiol"},{"key":"9696_CR28","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev.clinpsy.1.102803.143938","volume":"1","author":"C Hammen","year":"2005","unstructured":"Hammen C (2005) Stress and depression. Annu Rev Clin Psychol 1:293\u2013319","journal-title":"Annu Rev Clin Psychol"},{"key":"9696_CR29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.brainresrev.2009.05.005","volume":"61","author":"K Hashimoto","year":"2009","unstructured":"Hashimoto K (2009) Emerging role of glutamate in the pathophysiology of major depressive disorder. Brain Res Rev 61:105\u2013123","journal-title":"Brain Res Rev"},{"key":"9696_CR30","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0006-3223(01)01157-X","volume":"49","author":"C Heim","year":"2001","unstructured":"Heim C, Nemeroff CB (2001) The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry 49:1023\u20131039","journal-title":"Biol Psychiatry"},{"key":"9696_CR31","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/cercor\/bhr229","volume":"22","author":"M Hinwood","year":"2012","unstructured":"Hinwood M, Morandini J, Day TA, Walker FR (2012) Evidence that microglia mediate the neurobiological effects of chronic psychological stress on the medial prefrontal cortex. Cereb Cortex 22:1442\u20131454","journal-title":"Cereb Cortex"},{"key":"9696_CR32","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.bbi.2014.06.200","volume":"42","author":"C Hoyo-Becerra","year":"2014","unstructured":"Hoyo-Becerra C, Schlaak JF, Hermann DM (2014) Insights from interferon-alpha-related depression for the pathogenesis of depression associated with inflammation. Brain Behav Immun 42:222\u2013231","journal-title":"Brain Behav Immun"},{"key":"9696_CR33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neubiorev.2014.01.008","volume":"40","author":"RA Iseme","year":"2014","unstructured":"Iseme RA, McEvoy M, Kelly B, Agnew L, Attia J, Walker FR (2014) Autoantibodies and depression: evidence for a causal link? Neurosci Biobehav Rev 40:62\u201379","journal-title":"Neurosci Biobehav Rev"},{"key":"9696_CR34","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijdevneu.2011.10.001","volume":"30","author":"JW Jahng","year":"2012","unstructured":"Jahng JW, Yoo SB, Ryu V, Lee JH (2012) Hyperphagia and depression-like behavior by adolescence social isolation in female rats. Int J Dev Neurosci 30:47\u201353","journal-title":"Int J Dev Neurosci"},{"key":"9696_CR35","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1196\/annals.1410.012","volume":"1148","author":"R Jankord","year":"2008","unstructured":"Jankord R, Herman JP (2008) Limbic regulation of hypothalamo-pituitary-adrenocortical function during acute and chronic stress. Ann N Y Acad Sci 1148:64\u201373","journal-title":"Ann N Y Acad Sci"},{"key":"9696_CR36","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1176\/ajp.156.6.837","volume":"156","author":"KS Kendler","year":"1999","unstructured":"Kendler KS, Karkowski LM, Prescott CA (1999) Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry 156:837\u2013841","journal-title":"Am J Psychiatry"},{"key":"9696_CR37","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1152\/physrev.00011.2010","volume":"91","author":"H Kettenmann","year":"2011","unstructured":"Kettenmann H, Hanisch UK, Noda M, Verkhratsky A (2011) Physiology of microglia. Physiol Rev 91:461\u2013553","journal-title":"Physiol Rev"},{"key":"9696_CR38","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbr.2008.09.040","volume":"196","author":"HS Kim","year":"2009","unstructured":"Kim HS, Suh YH (2009) Minocycline and neurodegenerative diseases. Behav Brain Res 196:168\u2013179","journal-title":"Behav Brain Res"},{"key":"9696_CR39","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/mp.2013.155","volume":"19","author":"T Kreisel","year":"2013","unstructured":"Kreisel T, Frank MG, Licht T, Reshef R, Ben-Menachem-Zidon O, Baratta MV, Maier SF, Yirmiya R (2013) Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. MOL PSYCHIATR 19:699\u2013709","journal-title":"MOL PSYCHIATR"},{"key":"9696_CR40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1023\/A:1021171129766","volume":"33","author":"MD Lapiz","year":"2003","unstructured":"Lapiz MD, Fulford A, Muchimapura S, Mason R, Parker T, Marsden CA (2003) Influence of postweaning social isolation in the rat on brain development, conditioned behavior, and neurotransmission. Neurosci Behav Physiol 33:13\u201329","journal-title":"Neurosci Behav Physiol"},{"key":"9696_CR41","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.pbb.2003.11.011","volume":"77","author":"A Leng","year":"2004","unstructured":"Leng A, Feldon J, Ferger B (2004) Long-term social isolation and medial prefrontal cortex: dopaminergic and cholinergic neurotransmission. Pharmacol Biochem Behav 77:371\u2013379","journal-title":"Pharmacol Biochem Behav"},{"key":"9696_CR42","first-page":"27","volume":"4","author":"CQ Li","year":"2008","unstructured":"Li CQ, Xu JM, Liu D, Zhang JY, Dai RP (2008) Brain derived neurotrophic factor (BDNF) contributes to the pain hypersensitivity following surgical incision in the rats. Mol Pain 4:27","journal-title":"Mol Pain"},{"key":"9696_CR43","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.brainresbull.2012.05.015","volume":"88","author":"F Li","year":"2012","unstructured":"Li F, Li M, Cao W, Xu Y, Luo Y, Zhong X, Zhang J, Dai R, Zhou XF, Li Z, Li C (2012) Anterior cingulate cortical lesion attenuates food foraging in rats. Brain Res Bull 88:602\u2013608","journal-title":"Brain Res Bull"},{"key":"9696_CR44","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1038\/npp.2014.128","volume":"39","author":"CQ Li","year":"2014","unstructured":"Li CQ, Luo YW, Bi FF, Cui TT, Song L, Cao WY, Zhang JY, Li F, Xu JM, Hao W et al (2014) Development of anxiety-like behavior via hippocampal IGF-2 signaling in the offspring of parental morphine exposure: effect of enriched environment. NEUROPSYCHOPHARMACOL 39:2777\u20132787","journal-title":"NEUROPSYCHOPHARMACOL"},{"key":"9696_CR45","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.neuropharm.2014.10.011","volume":"89","author":"Y Luo","year":"2015","unstructured":"Luo Y, Xu Y, Cao W, Zhong X, Duan J, Wang X, Hu Z, Li F, Zhang J, Zhou M et al (2015) Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress. Neuropharmacology 89:318\u2013324","journal-title":"Neuropharmacology"},{"key":"9696_CR46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11011-008-9118-1","volume":"24","author":"M Maes","year":"2009","unstructured":"Maes M, Yirmyia R, Noraberg J, Brene S, Hibbeln J, Perini G, Kubera M, Bob P, Lerer B, Maj M (2009) The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab Brain Dis 24:27\u201353","journal-title":"Metab Brain Dis"},{"key":"9696_CR47","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.gde.2005.01.005","volume":"15","author":"R Margueron","year":"2005","unstructured":"Margueron R, Trojer P, Reinberg D (2005) The key to development: interpreting the histone code? CURR OPIN GENET DEV 15:163\u2013176","journal-title":"CURR OPIN GENET DEV"},{"key":"9696_CR48","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/nrm1761","volume":"6","author":"C Martin","year":"2005","unstructured":"Martin C, Zhang Y (2005) The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol 6:838\u2013849","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9696_CR49","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1126\/science.1179438","volume":"327","author":"I Maze","year":"2010","unstructured":"Maze I, Covington HR, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E, Neve RL, Haggarty SJ et al (2010) Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 327:213\u2013216","journal-title":"Science"},{"key":"9696_CR50","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/npp.2012.124","volume":"38","author":"I Maze","year":"2013","unstructured":"Maze I, Noh KM, Allis CD (2013) Histone regulation in the CNS: basic principles of epigenetic plasticity. NEUROPSYCHOPHARMACOL 38:3\u201322","journal-title":"NEUROPSYCHOPHARMACOL"},{"key":"9696_CR51","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2006.09.011","volume":"1127","author":"RE McCullumsmith","year":"2007","unstructured":"McCullumsmith RE, Kristiansen LV, Beneyto M, Scarr E, Dean B, Meador-Woodruff JH (2007) Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder. Brain Res 1127:108\u2013118","journal-title":"Brain Res"},{"key":"9696_CR52","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1080\/10615806.2014.888060","volume":"27","author":"OA McInnis","year":"2014","unstructured":"McInnis OA, Matheson K, Anisman H (2014) Living with the unexplained: coping, distress, and depression among women with chronic fatigue syndrome and\/or fibromyalgia compared to an autoimmune disorder. Anxiety Stress Coping 27:601\u2013618","journal-title":"Anxiety Stress Coping"},{"key":"9696_CR53","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0306-4522(02)00107-0","volume":"112","author":"S Muchimapura","year":"2002","unstructured":"Muchimapura S, Fulford AJ, Mason R, Marsden CA (2002) Isolation rearing in the rat disrupts the hippocampal response to stress. Neuroscience 112:697\u2013705","journal-title":"Neuroscience"},{"key":"9696_CR54","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/syn.10167","volume":"47","author":"S Muchimapura","year":"2003","unstructured":"Muchimapura S, Mason R, Marsden CA (2003) Effect of isolation rearing on pre- and post-synaptic serotonergic function in the rat dorsal hippocampus. Synapse 47:209\u2013217","journal-title":"Synapse"},{"key":"9696_CR55","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.biopsych.2012.11.009","volume":"73","author":"L Musazzi","year":"2013","unstructured":"Musazzi L, Treccani G, Mallei A, Popoli M (2013) The action of antidepressants on the glutamate system: regulation of glutamate release and glutamate receptors. Biol Psychiatry 73:1180\u20131188","journal-title":"Biol Psychiatry"},{"key":"9696_CR56","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","volume":"34","author":"EJ Nestler","year":"2002","unstructured":"Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM (2002) Neurobiology of depression. Neuron 34:13\u201325","journal-title":"Neuron"},{"key":"9696_CR57","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S1097-2765(03)00092-3","volume":"11","author":"HH Ng","year":"2003","unstructured":"Ng HH, Robert F, Young RA, Struhl K (2003) Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol Cell 11:709\u2013719","journal-title":"Mol Cell"},{"key":"9696_CR58","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.biopha.2007.12.005","volume":"62","author":"CU Pae","year":"2008","unstructured":"Pae CU, Marks DM, Han C, Patkar AA (2008) Does minocycline have antidepressant effect? BIOMED PHARMACOTHER 62:308\u2013311","journal-title":"BIOMED PHARMACOTHER"},{"key":"9696_CR59","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.molmed.2011.02.003","volume":"17","author":"CJ Peter","year":"2011","unstructured":"Peter CJ, Akbarian S (2011) Balancing histone methylation activities in psychiatric disorders. Trends Mol Med 17:372\u2013379","journal-title":"Trends Mol Med"},{"key":"9696_CR60","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.4161\/epi.6.9.16924","volume":"6","author":"M Qiang","year":"2011","unstructured":"Qiang M, Danny A, Lieu M, Carreon S, Li J (2011) Histone H3K9 modifications are a local chromatin event involved in ethanol-induced neuroadaptation of the NR2B gene. EPIGENETICS 6:1095\u20131104","journal-title":"EPIGENETICS"},{"key":"9696_CR61","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuroscience.2015.05.018","volume":"300","author":"GZ R\u00e9us","year":"2015","unstructured":"R\u00e9us GZ, Fries GR, Stertz L, Badawy M, Passos IC, Barichello T, Kapczinski F, Quevedo J (2015) The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders. Neuroscience 300:141\u2013154","journal-title":"Neuroscience"},{"key":"9696_CR62","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1523\/JNEUROSCI.4485-14.2015","volume":"35","author":"K Riazi","year":"2015","unstructured":"Riazi K, Galic MA, Kentner AC, Reid AY, Sharkey KA, Pittman QJ (2015) Microglia-dependent alteration of glutamatergic synaptic transmission and plasticity in the hippocampus during peripheral inflammation. J Neurosci 35:4942\u20134952","journal-title":"J Neurosci"},{"key":"9696_CR63","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/026988119601000107","volume":"10","author":"TW Robbins","year":"1996","unstructured":"Robbins TW, Jones GH, Wilkinson LS (1996) Behavioural and neurochemical effects of early social deprivation in the rat. J Psychopharmacol 10:39\u201347","journal-title":"J Psychopharmacol"},{"key":"9696_CR64","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuropharm.2011.07.036","volume":"62","author":"G Sanacora","year":"2012","unstructured":"Sanacora G, Treccani G, Popoli M (2012) Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders. Neuropharmacology 62:63\u201377","journal-title":"Neuropharmacology"},{"key":"9696_CR65","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature01080","volume":"419","author":"H Santos-Rosa","year":"2002","unstructured":"Santos-Rosa H, Schneider R, Bannister AJ, Sherriff J, Bernstein BE, Emre NC, Schreiber SL, Mellor J, Kouzarides T (2002) Active genes are tri-methylated at K4 of histone H3. Nature 419:407\u2013411","journal-title":"Nature"},{"key":"9696_CR66","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.neuron.2009.11.019","volume":"64","author":"A Schaefer","year":"2009","unstructured":"Schaefer A, Sampath SC, Intrator A, Min A, Gertler TS, Surmeier DJ, Tarakhovsky A, Greengard P (2009) Control of cognition and adaptive behavior by the GLP\/G9a epigenetic suppressor complex. Neuron 64:678\u2013691","journal-title":"Neuron"},{"key":"9696_CR67","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ncb1076","volume":"6","author":"R Schneider","year":"2004","unstructured":"Schneider R, Bannister AJ, Myers FA, Thorne AW, Crane-Robinson C, Kouzarides T (2004) Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat Cell Biol 6:73\u201377","journal-title":"Nat Cell Biol"},{"key":"9696_CR68","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.biopsych.2006.06.036","volume":"62","author":"FA Schroeder","year":"2007","unstructured":"Schroeder FA, Lin CL, Crusio WE, Akbarian S (2007) Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol Psychiatry 62:55\u201364","journal-title":"Biol Psychiatry"},{"key":"9696_CR69","first-page":"699","volume":"64","author":"CA Shively","year":"2002","unstructured":"Shively CA, Williams JK, Laber-Laird K, Anton RF (2002) Depression and coronary artery atherosclerosis and reactivity in female cynomolgus monkeys. Psychosom Med 64:699\u2013706","journal-title":"Psychosom Med"},{"key":"9696_CR70","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.tig.2003.09.007","volume":"19","author":"RR Sims","year":"2003","unstructured":"Sims RR, Nishioka K, Reinberg D (2003) Histone lysine methylation: a signature for chromatin function. Trends Genet 19:629\u2013639","journal-title":"Trends Genet"},{"key":"9696_CR71","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0306-9877(91)90272-Z","volume":"35","author":"RS Smith","year":"1991","unstructured":"Smith RS (1991) The macrophage theory of depression. Med Hypotheses 35:298\u2013306","journal-title":"Med Hypotheses"},{"key":"9696_CR72","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/1742-2094-9-275","volume":"9","author":"J Takaki","year":"2012","unstructured":"Takaki J, Fujimori K, Miura M, Suzuki T, Sekino Y, Sato K (2012) L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the \u2018collusion\u2019 hypothesis for increased extracellular L-glutamate concentration in neuroinflammation. J Neuroinflammation 9:275","journal-title":"J Neuroinflammation"},{"key":"9696_CR73","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1503\/jpn.120050","volume":"38","author":"AL Takatsu-Coleman","year":"2013","unstructured":"Takatsu-Coleman AL, Patti CL, Zanin KA, Zager A, Carvalho RC, Borcoi AR, Ceccon LM, Berro LF, Tufik S, Andersen ML, Frussa-Filho R (2013) Short-term social isolation induces depressive-like behaviour and reinstates the retrieval of an aversive task: mood-congruent memory in male mice? J Psychiatry Neurosci 38:259\u2013268","journal-title":"J Psychiatry Neurosci"},{"key":"9696_CR74","doi-asserted-by":"crossref","first-page":"16064","DOI":"10.1523\/JNEUROSCI.4158-11.2011","volume":"31","author":"ME Tremblay","year":"2011","unstructured":"Tremblay ME, Stevens B, Sierra A, Wake H, Bessis A, Nimmerjahn A (2011a) The role of microglia in the healthy brain. J Neurosci 31:16064\u201316069","journal-title":"J Neurosci"},{"key":"9696_CR75","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nn1659","volume":"9","author":"NM Tsankova","year":"2006","unstructured":"Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ (2006) Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 9:519\u2013525","journal-title":"Nat Neurosci"},{"key":"9696_CR76","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cell.2007.08.016","volume":"131","author":"M Vermeulen","year":"2007","unstructured":"Vermeulen M, Mulder KW, Denissov S, Pijnappel WW, van Schaik FM, Varier RA, Baltissen MP, Stunnenberg HG, Mann M, Timmers HT (2007) Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Cell 131:58\u201369","journal-title":"Cell"},{"key":"9696_CR77","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.tins.2012.11.007","volume":"36","author":"H Wake","year":"2013","unstructured":"Wake H, Moorhouse AJ, Miyamoto A, Nabekura J (2013) Microglia: actively surveying and shaping neuronal circuit structure and function. Trends Neurosci 36:209\u2013217","journal-title":"Trends Neurosci"},{"key":"9696_CR78","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1471-244X-8-63","volume":"8","author":"K Weber","year":"2008","unstructured":"Weber K, Rockstroh B, Borgelt J, Awiszus B, Popov T, Hoffmann K, Schonauer K, Watzl H, Propster K (2008) Stress load during childhood affects psychopathology in psychiatric patients. BMC PSYCHIATRY 8:63","journal-title":"BMC PSYCHIATRY"},{"key":"9696_CR79","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bbr.2003.10.015","volume":"152","author":"IC Weiss","year":"2004","unstructured":"Weiss IC, Pryce CR, Jongen-Relo AL, Nanz-Bahr NI, Feldon J (2004) Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat. Behav Brain Res 152:279\u2013295","journal-title":"Behav Brain Res"},{"key":"9696_CR80","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrn.2016.69","volume":"17","author":"ES Wohleb","year":"2016","unstructured":"Wohleb ES, Franklin T, Iwata M, Duman RS (2016) Integrating neuroimmune systems in the neurobiology of depression. NAT REV NEUROSCI 17:497\u2013511","journal-title":"NAT REV NEUROSCI"},{"key":"9696_CR81","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.tins.2015.08.001","volume":"38","author":"R Yirmiya","year":"2015","unstructured":"Yirmiya R, Rimmerman N, Reshef R (2015) Depression as a microglial disease. Trends Neurosci 38:637\u2013658","journal-title":"Trends Neurosci"},{"key":"9696_CR82","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ijdevneu.2016.09.005","volume":"55","author":"X Zhang","year":"2016","unstructured":"Zhang X, Wang Q, Wang Y, Hu J, Jiang H, Cheng W, Ma Y, Liu M, Sun A, Zhang X, Li X (2016) Duloxetine prevents the effects of prenatal stress on depressive-like and anxiety-like behavior and hippocampal expression of pro-inflammatory cytokines in adult male offspring rats. Int J Dev Neurosci 55:41\u201348","journal-title":"Int J Dev Neurosci"},{"key":"9696_CR83","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.pnpbp.2009.06.016","volume":"33","author":"X Zhao","year":"2009","unstructured":"Zhao X, Sun L, Jia H, Meng Q, Wu S, Li N, He S (2009) Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats. Prog Neuro-Psychopharmacol Biol Psychiatry 33:1173\u20131177","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"9696_CR84","doi-asserted-by":"crossref","first-page":"9513","DOI":"10.1038\/srep09513","volume":"5","author":"Q Zhao","year":"2015","unstructured":"Zhao Q, Xie X, Fan Y, Zhang J, Jiang W, Wu X, Yan S, Chen Y, Peng C, You Z (2015) Phenotypic dysregulation of microglial activation in young offspring rats with maternal sleep deprivation-induced cognitive impairment. SCI REP-UK 5:9513","journal-title":"SCI REP-UK"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-016-9696-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12640-016-9696-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-016-9696-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T04:18:25Z","timestamp":1498364305000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12640-016-9696-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,16]]},"references-count":84,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["9696"],"URL":"https:\/\/doi.org\/10.1007\/s12640-016-9696-3","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,16]]}}}