{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:07:16Z","timestamp":1783397236696,"version":"3.54.6"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s12640-017-9830-x","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T05:20:56Z","timestamp":1509340856000},"page":"239-246","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Methionine Administration in Pregnant Rats Causes Memory Deficit in the Offspring and Alters Ultrastructure in Brain Tissue"],"prefix":"10.1007","volume":"33","author":[{"given":"Bruna Martins","family":"Schweinberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Felipe","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Marcon","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francieli","family":"Rohden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Rigon","family":"da Luz Soster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wania Aparecida","family":"Partata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Faccioni-Heuser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela T. S.","family":"Wyse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,30]]},"reference":[{"key":"9830_CR1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jbt.21573","volume":"28","author":"H Akkaya","year":"2014","unstructured":"Akkaya H, Kilic E, Dinc SE, Yilmaz B (2014) Postacute effects of kisspeptin-10 on neuronal injury induced by L-methionine in rats. J Biochem Mol Toxicol 28:373\u2013377","journal-title":"J Biochem Mol Toxicol"},{"key":"9830_CR2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2174\/1570159X11666131120223201","volume":"12","author":"KH Alzoubi","year":"2014","unstructured":"Alzoubi KH, Khabour OF, Al-Azzam SI, Tashtoush MH, Mhaidat NM (2014) Metformin eased cognitive impairment induced by chronic L-methionine administration: potential role of oxidative stress. Curr Neuropharmacol 12:186\u2013192","journal-title":"Curr Neuropharmacol"},{"key":"9830_CR3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1600-0404.1994.tb05403.x","volume":"154","author":"GM Bressa","year":"1994","unstructured":"Bressa GM (1994) S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl 154:7\u201314","journal-title":"Acta Neurol Scand Suppl"},{"key":"9830_CR4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.beproc.2008.02.019","volume":"78","author":"GR Brown","year":"2008","unstructured":"Brown GR, Nemes C (2008) The exploratory behaviour of rats in the hole-board apparatus: is head-dipping a valid measure of neophilia? Behav Process 78:442\u2013448","journal-title":"Behav Process"},{"key":"9830_CR5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.59566\/IJBS.2014.10085","volume":"10","author":"GR Lores Arnaiz de","year":"2014","unstructured":"de Lores Arnaiz GR, Ordieres MG (2014) Brain Na+,K+-ATPase activity in aging and disease. Int J Biomed Sci 10:85\u2013102","journal-title":"Int J Biomed Sci"},{"key":"9830_CR6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2147\/JMDH.S77766","volume":"8","author":"F Pierro Di","year":"2015","unstructured":"Di Pierro F, Orsi R, Settembre R (2015) Role of betaine in improving the antidepressant effect of S-adenosyl-methionine in patients with mild-to-moderate depression. J Multidiscip Healthc 8:39\u201345","journal-title":"J Multidiscip Healthc"},{"key":"9830_CR7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","volume":"31","author":"A Ennaceur","year":"1988","unstructured":"Ennaceur A, Delacour J (1988) A new one-trial test for neurobiological studies of memory in rats. 1 Behavioral data. Behav Brain Res 31:47\u201359","journal-title":"Behav Brain Res"},{"key":"9830_CR8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/7854_2012_231","volume":"15","author":"A G\u00f3mez-Palacio-Schjetnan","year":"2013","unstructured":"G\u00f3mez-Palacio-Schjetnan A, Escobar ML (2013) Neurotrophins and synaptic plasticity. Curr Top Behav Neurosci 15:117\u2013136","journal-title":"Curr Top Behav Neurosci"},{"key":"9830_CR9","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/jcbfm.2012.35","volume":"32","author":"C Howarth","year":"2012","unstructured":"Howarth C, Gleeson P, Attwell D (2012) Updated energy budgets for neural computation in the neocortex and cerebellum. J Cereb Blood Flow Metab 32:1222\u20131232","journal-title":"J Cereb Blood Flow Metab"},{"key":"9830_CR10","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1460-9568.1997.tb01427.x","volume":"9","author":"I Izquierdo","year":"1997","unstructured":"Izquierdo I, Quillfeldt JA, Zanatta MS, Quevedo J, Schaeffer E, Schimitz PK, Medina JH (1997) Sequential role of hippocampus and amygdala, entorhinal cortex and parietal cortex in formation and retrieval of memory for inhibitory avoidance in rats. Eur J Neurosci 9:786\u2013793","journal-title":"Eur J Neurosci"},{"key":"9830_CR11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1590\/S0100-879X2003000200011","volume":"36","author":"MR Lamprea","year":"2003","unstructured":"Lamprea MR, Cardenas FP, Silveira R, Walsh TJ, Morato S (2003) Effects of septal cholinergic lesion on rat exploratory behavior in an open-field. Braz J Med Biol Res 36:233\u2013238","journal-title":"Braz J Med Biol Res"},{"key":"9830_CR12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/ajmg.c.30293","volume":"157C","author":"SH Mudd","year":"2011","unstructured":"Mudd SH (2011) Hypermethioninemias of genetic and non-genetic origin: a review. Am J Med Genet C Semin Med Genet 157C:3\u201332","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"9830_CR13","first-page":"2007","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"SH Mudd","year":"2001","unstructured":"Mudd SH, Levy HL, Kraus JP (2001) Disorders of transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The Metabolic and Molecular Bases of Inherited Disease, 8th edn. McGraw-Hill, New York, pp 2007\u20132056","edition":"8"},{"key":"9830_CR14","first-page":"882","volume":"57","author":"SH Mudd","year":"1995","unstructured":"Mudd SH, Levy HL, Tangerman A, Boujet C, Buist N, Davidson-Mundt A, Hudgins L, Oyanagi K, Nagao M, Wilson WG (1995) Isolated persistent hypermethioninemia. Am J Hum Genet 57:882\u2013892","journal-title":"Am J Hum Genet"},{"key":"9830_CR15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0306-4530(86)90005-3","volume":"11","author":"CA Netto","year":"1986","unstructured":"Netto CA, Dias RD, Izquierdo I (1986) Differential effect of posttraining naloxone, beta-endorphin, leu-enkephalin and electroconvulsive shock administration upon memory of an open-field habituation and of a water-finding task. Psychoneuroendocrinology 11:437\u2013446","journal-title":"Psychoneuroendocrinology"},{"key":"9830_CR16","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bbr.2012.10.029","volume":"238","author":"H Ouchi","year":"2013","unstructured":"Ouchi H, Ono K, Murakami Y, Matsumoto K (2013) Social isolation induces deficit of latent learning performance in mice: a putative animal model of attention deficit\/hyperactivity disorder. Behav Brain Res 238:146\u2013153","journal-title":"Behav Brain Res"},{"issue":"Suppl 5","key":"9830_CR17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4088\/JCP.8157su1c.04","volume":"70","author":"GI Papakostas","year":"2009","unstructured":"Papakostas GI (2009) Evidence for S-adenosyl-L-methionine (SAM-e) for the treatment of major depressive disorder. J Clin Psychiatry 70(Suppl 5):18\u201322","journal-title":"J Clin Psychiatry"},{"key":"9830_CR18","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.archoralbio.2012.02.007","volume":"57","author":"P R\u00f6mer","year":"2012","unstructured":"R\u00f6mer P, Weing\u00e4rtner J, Desaga B, Kubein-Meesenburg D, Reicheneder C, Proff P (2012) Effect of excessive methionine on the development of the cranial growth plate in newborn rats. Arch Oral Biol 57:1225\u20131230","journal-title":"Arch Oral Biol"},{"key":"9830_CR19","doi-asserted-by":"crossref","unstructured":"Schweinberger BM, Rodrigues AF, Turcatel E, Pierozan P, Pettenuzzo LF, Grings M, Scaini G, Parisi MM, Leipnitz G, Streck EL, Barb\u00e9-Tuana FM, Wyse AT (2017) Maternal hypermethioninemia affects neurons number, neurotrophins levels, energy metabolism, and Na+,K+-ATPase Expression\/Content in Brain of Rat Offspring. Mol Neurobiol [Epub ahead of print]","DOI":"10.1007\/s12035-017-0383-z"},{"key":"9830_CR20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11011-013-9451-x","volume":"29","author":"BM Schweinberger","year":"2014","unstructured":"Schweinberger BM, Schwieder L, Scherer E, Sitta A, Vargas CR, Wyse AT (2014) Development of an animal model for gestational hypermethioninemia in rat and its effect on brain Na+,K+-ATPase\/Mg2+-ATPase activity and oxidative status of the offspring. Metab Brain Dis 29:153\u2013160","journal-title":"Metab Brain Dis"},{"key":"9830_CR21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/iep.12136","volume":"96","author":"BM Schweinberger","year":"2015","unstructured":"Schweinberger BM, Turcatel E, Rodrigues AF, Wyse AT (2015) Gestational hypermethioninaemia alters oxidative\/nitrative status in skeletal muscle and biomarkers of muscular injury and inflammation in serum of rat offspring. Int J Exp Pathol 96:277\u2013284","journal-title":"Int J Exp Pathol"},{"key":"9830_CR22","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1007\/s00726-016-2302-4","volume":"48","author":"BM Schweinberger","year":"2016","unstructured":"Schweinberger BM, Wyse AT (2016) Mechanistic basis of hypermethioninemia. Amino Acids 48:2479\u20132489","journal-title":"Amino Acids"},{"key":"9830_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2006.07.029","volume":"160","author":"FM Stefanello","year":"2007","unstructured":"Stefanello FM, Matt\u00e9 C, Scherer EB, Wannmacher CM, Wajner M, Wyse AT (2007b) Chemically induced model of hypermethioninemia in rats. J Neurosci Methods 160:1\u20134","journal-title":"J Neurosci Methods"},{"key":"9830_CR24","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1007\/s11064-007-9464-0","volume":"32","author":"FM Stefanello","year":"2007","unstructured":"Stefanello FM, Monteiro SC, Matt\u00e9 C, Scherer EB, Netto CA, Wyse AT (2007a) Hypermethioninemia increases cerebral acetylcholinesterase activity and impairs memory in rats. Neurochem Res 32:1868\u20131874","journal-title":"Neurochem Res"},{"key":"9830_CR25","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1007\/s11064-012-0749-6","volume":"37","author":"FC Vuaden","year":"2012","unstructured":"Vuaden FC, Savio LE, Piato AL, Pereira TC, Vianna MR, Bogo MR, Bonan CD, Wyse AT (2012) Long-term methionine exposure induces memory impairment on inhibitory avoidance task and alters acetylcholinesterase activity and expression in zebrafish (Danio rerio). Neurochem Res 37:1545\u20131553","journal-title":"Neurochem Res"},{"key":"9830_CR26","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.physbeh.2003.10.002","volume":"80","author":"ATS Wyse","year":"2004","unstructured":"Wyse ATS, Bavaresco CS, Reis EA, Zugno AI, Tagliari B, Calcagnotto T, Netto CA (2004) Training in inhibitory avoidance causes a reduction of Na+,K+-ATPase activity in rat hippocampus. Physiol Behav 80:475\u2013479","journal-title":"Physiol Behav"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12640-017-9830-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-017-9830-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-017-9830-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T03:59:14Z","timestamp":1719547154000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12640-017-9830-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,30]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["9830"],"URL":"https:\/\/doi.org\/10.1007\/s12640-017-9830-x","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,30]]}}}