{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:00:28Z","timestamp":1790326828091,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:00:00Z","timestamp":1515369600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["205648"],"award-info":[{"award-number":["205648"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s12640-017-9863-1","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T07:24:30Z","timestamp":1515396270000},"page":"634-640","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Thallium-Induced Toxicity in Rat Brain Crude Synaptosomal\/Mitochondrial Fractions is Sensitive to Anti-excitatory and Antioxidant Agents"],"prefix":"10.1007","volume":"33","author":[{"given":"Marisol","family":"Maya-L\u00f3pez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Ver\u00f3nica","family":"Mireles-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monserrat","family":"Ram\u00edrez-Toledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Laura","family":"Col\u00edn-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Galv\u00e1n-Arzate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"T\u00fanez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Santamar\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"key":"9863_CR1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.biopha.2015.07.025","volume":"74","author":"AH Bhat","year":"2015","unstructured":"Bhat AH, Dar KB, Anees S, Zargar MA, Masood A, Sofi MA, Ganie SA (2015) Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight. Biomed Pharmacother 74:101\u2013110. https:\/\/doi.org\/10.1016\/j.biopha.2015.07.025","journal-title":"Biomed Pharmacother"},{"key":"9863_CR2","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/B978-0-444-59453-2.00055-X","volume-title":"Handbook on the Toxicology of Metals. Volume II: Specific Metals","author":"R Blain","year":"2015","unstructured":"Blain R, Kazantzis G (2015) Thallium. In: Nordberg GF, Fowler BA, Nordberg M (eds) Handbook on the Toxicology of Metals. Volume II: Specific Metals. Elsevier, Amsterdam, pp 1229\u20131240"},{"issue":"2","key":"9863_CR3","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/0003-2697(86)90640-8","volume":"157","author":"KM Chan","year":"1986","unstructured":"Chan KM, Delfert D, Junger KD (1986) A direct colorimetric assay for Ca2+-stimulated ATPase activity. Anal Biochem 157(2):375\u2013380. https:\/\/doi.org\/10.1016\/0003-2697(86)90640-8","journal-title":"Anal Biochem"},{"key":"9863_CR4","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.neuint.2015.06.011","volume":"89","author":"AL Col\u00edn-Gonz\u00e1lez","year":"2015","unstructured":"Col\u00edn-Gonz\u00e1lez AL, Ali SF, T\u00fanez I, Santamar\u00eda A (2015) On the antioxidant, neuroprotective and anti-inflammatory properties of S-allyl cysteine: an update. Neurochem Int 89:83\u201391. https:\/\/doi.org\/10.1016\/j.neuint.2015.06.011","journal-title":"Neurochem Int"},{"issue":"10","key":"9863_CR5","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1007\/s11064-016-1973-2","volume":"41","author":"AL Col\u00edn-Gonz\u00e1lez","year":"2016","unstructured":"Col\u00edn-Gonz\u00e1lez AL, Paz-Loyola AL, de Lima ME, Galv\u00e1n-Arzate S, Seminotti B, Ribeiro CA, Leipnitz G, Souza DO, Wajner M, Santamar\u00eda A (2016) Experimental evidence that 3-methylglutaric acid disturbs mitochondrial function and induced oxidative stress in rat brain synaptosomes: new converging mechanisms. Neurochem Res 41(10):2619\u20132626. https:\/\/doi.org\/10.1007\/s11064-016-1973-2","journal-title":"Neurochem Res"},{"issue":"2","key":"9863_CR6","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1002\/tox.21900","volume":"30","author":"MR Eskandari","year":"2015","unstructured":"Eskandari MR, Mashayekhi V, Aslani M, Hosseini MJ (2015) Toxicity of thallium on isolated rat liver mitochondria: the role of oxidative stress and MPT pore opening. Environ Toxicol 30(2):232\u2013241. https:\/\/doi.org\/10.1002\/tox.21900","journal-title":"Environ Toxicol"},{"issue":"1","key":"9863_CR7","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/jat.2550050106","volume":"5","author":"L Favari","year":"1985","unstructured":"Favari L, Mourelle M (1985) Thallium replaces potassium in activation of the (Na+,K+)-ATPase of rat liver plasma membranes. J Appl Toxicol 5(1):32\u201334. https:\/\/doi.org\/10.1002\/jat.2550050106","journal-title":"J Appl Toxicol"},{"key":"9863_CR8","doi-asserted-by":"crossref","first-page":"610813","DOI":"10.1155\/2015\/610813","volume":"2015","author":"R Fischer","year":"2015","unstructured":"Fischer R, Maier O (2015) Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF. Oxidative Med Cell Longev 2015:610813","journal-title":"Oxidative Med Cell Longev"},{"issue":"1","key":"9863_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0378-4274(98)00126-X","volume":"99","author":"S Galv\u00e1n-Arzate","year":"1998","unstructured":"Galv\u00e1n-Arzate S, Santamar\u00eda A (1998) Thallium toxicity. Toxicol Lett 99(1):1\u201313. https:\/\/doi.org\/10.1016\/S0378-4274(98)00126-X","journal-title":"Toxicol Lett"},{"issue":"7","key":"9863_CR10","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.fct.2005.02.006","volume":"43","author":"S Galv\u00e1n-Arzate","year":"2005","unstructured":"Galv\u00e1n-Arzate S, Pedraza-Chaverr\u00ed J, Medina-Campos ON, Maldonado PD, V\u00e1zquez-Rom\u00e1n B, R\u00edos C, Santamar\u00eda A (2005) Delayed effects of thallium in the rat brain: regional changes in lipid peroxidation and behavioral markers, but moderate alterations in antioxidants, after a single administration. Food Chem Toxicol 43(7):1037\u20131045. https:\/\/doi.org\/10.1016\/j.fct.2005.02.006","journal-title":"Food Chem Toxicol"},{"issue":"3","key":"9863_CR11","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.taap.2006.07.003","volume":"216","author":"CE Hanzel","year":"2006","unstructured":"Hanzel CE, Verstraeten SV (2006) Thallium induces hydrogen peroxide generation by impairing mitochondrial function. Toxicol Appl Pharmacol 216(3):485\u2013492. https:\/\/doi.org\/10.1016\/j.taap.2006.07.003","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"9863_CR12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.taap.2008.12.029","volume":"236","author":"CE Hanzel","year":"2009","unstructured":"Hanzel CE, Verstraeten SV (2009) Tl (I) and Tl (III) activate both mitochondrial and extrinsic pathways of apoptosis in rat pheochromocytoma (PC12) cells. Toxicol Appl Pharmacol 236(1):59\u201370. https:\/\/doi.org\/10.1016\/j.taap.2008.12.029","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"9863_CR13","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0041-008X(67)90104-4","volume":"10","author":"MM Herman","year":"1967","unstructured":"Herman MM, Bensch KG (1967) Light and electron microscopic studies of acute and chronic thallium intoxication in rats. Toxicol Appl Pharmacol 10(2):199\u2013222. https:\/\/doi.org\/10.1016\/0041-008X(67)90104-4","journal-title":"Toxicol Appl Pharmacol"},{"key":"9863_CR14","first-page":"1113","volume":"24","author":"L Hong","year":"2003","unstructured":"Hong L, Xiang-Lin Y, Ying W, Xiao-Qiao T, Dong-Ying J, Hui-Bi X (2003) Protective effects of scutellarin on superoxide-induced oxidative stress in rat cortical synaptosomes. Acta Pharmacol Sin 24:1113\u20131117","journal-title":"Acta Pharmacol Sin"},{"issue":"3","key":"9863_CR15","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s10863-009-9225-7","volume":"41","author":"SM Korotkov","year":"2009","unstructured":"Korotkov SM (2009) Effects of Tl+ on ion permeability, membrane potential and respiration of isolated rat liver mitochondria. J Bioenerg Biomembr 41(3):277\u2013287. https:\/\/doi.org\/10.1007\/s10863-009-9225-7","journal-title":"J Bioenerg Biomembr"},{"issue":"4","key":"9863_CR16","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/jbt.21547","volume":"28","author":"SM Korotkov","year":"2014","unstructured":"Korotkov SM, Brailovskaya IV, Kormilitsyn BN, Furaev VV (2014) Tl+ showed negligible interaction with inner membrane sulfhydryl groups of rat liver mitochondria, but formed complexes with matrix proteins. J Biochem Mol Toxicol 28(4):149\u2013156. https:\/\/doi.org\/10.1002\/jbt.21547","journal-title":"J Biochem Mol Toxicol"},{"key":"9863_CR17","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.tiv.2015.04.006","volume":"29","author":"SM Korotkov","year":"2015","unstructured":"Korotkov SM, Emelyanova LV, Konovalova SA, Brailovskaya IV (2015) Tl+ induces the permeability transition pore in Ca2+-loaded rat liver mitochondria energized by glutamate and malate. Toxicol. In Vitro 29:1034\u20131041","journal-title":"Toxicol. In Vitro"},{"issue":"1","key":"9863_CR18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193(1):265\u2013275","journal-title":"J Biol Chem"},{"issue":"2","key":"9863_CR19","first-page":"261","volume":"9","author":"M Maya-L\u00f3pez","year":"2017","unstructured":"Maya-L\u00f3pez M, Col\u00edn-Gonz\u00e1lez AL, Aguilera G, de Lima ME, Colpo-Ceolin A, Rangel-L\u00f3pez E, Villeda-Hern\u00e1ndez J, Rembao-Boj\u00f3rquez D, T\u00fanez I, Luna-L\u00f3pez A, Lazzarini-Lechuga R, Gonz\u00e1lez-Puertos VY, Posadas-Rodr\u00edguez P, Silva-Palacios A, K\u00f6nigsberg M, Santamar\u00eda A (2017) Neuroprotective effect of WIN55,212-2 against 3-nitropropionic acid-induced toxicity in the rat brain: involvement of CB1 and NMDA receptors. Am J Transl Res 9(2):261\u2013274","journal-title":"Am J Transl Res"},{"issue":"1","key":"9863_CR20","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/S0006-291X(76)80273-2","volume":"69","author":"RL Melnick","year":"1976","unstructured":"Melnick RL, Monti LG, Motzkin SM (1976) Uncoupling of mitochondrial oxidative phosphorylation by thallium. Biochem Biophys Res Commun 69(1):68\u201373. https:\/\/doi.org\/10.1016\/S0006-291X(76)80273-2","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"9863_CR21","first-page":"445","volume":"35","author":"JP Mulkey","year":"1993","unstructured":"Mulkey JP, Oehme FW (1993) A review of thallium toxicity. Vet Hum Toxicol 35(5):445\u2013453","journal-title":"Vet Hum Toxicol"},{"issue":"6","key":"9863_CR22","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1177\/1091581815603936","volume":"34","author":"L Osorio-Rico","year":"2015","unstructured":"Osorio-Rico L, Villeda-Hern\u00e1ndez J, Santamar\u00eda A, K\u00f6nigsberg M, Galv\u00e1n-Arzate S (2015) The N-methyl-D-aspartate receptor antagonist MK-801 prevents thallium-induced behavioral and biochemical alterations in the rat brain. Int J Toxicol 34(6):505\u2013513. https:\/\/doi.org\/10.1177\/1091581815603936","journal-title":"Int J Toxicol"},{"key":"9863_CR23","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/978-3-319-60189-2_17","volume":"18","author":"L Osorio-Rico","year":"2017","unstructured":"Osorio-Rico L, Santamaria A, Galv\u00e1n-Arzate S (2017) Thallium toxicity: general issues, neurological symptoms, and neurotoxic mechanisms. Adv Neurobiol 18:345\u2013353. https:\/\/doi.org\/10.1007\/978-3-319-60189-2_17","journal-title":"Adv Neurobiol"},{"issue":"3","key":"9863_CR24","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1007\/s00204-016-1793-9","volume":"91","author":"MT Pino","year":"2017","unstructured":"Pino MT, Marotte C, Verstraeten SV (2017) Epidermal growth factor prevents thallium(I)- and thallium(III)-mediated rat pheochromocytoma (PC12) cell apoptosis. Arch Toxicol 91(3):1157\u20131174. https:\/\/doi.org\/10.1007\/s00204-016-1793-9","journal-title":"Arch Toxicol"},{"issue":"5","key":"9863_CR25","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1002\/tox.20590","volume":"25","author":"J Pourahmad","year":"2010","unstructured":"Pourahmad J, Eskandari MR, Daraei B (2010) A comparison of hepatocyte cytotoxic mechanisms for thallium (I) and thallium (III). Environ Toxicol 25(5):456\u2013467. https:\/\/doi.org\/10.1002\/tox.20590","journal-title":"Environ Toxicol"},{"key":"9863_CR26","doi-asserted-by":"publisher","unstructured":"Puga Molina LC, Salvatierra Fr\u00e9chou DM, Verstraeten SV (2017) Early response of glutathione- and thioredoxin-dependent antioxidant defense systems to Tl(I)- and Tl(III)-mediated oxidative stress in adherent pheochromocytoma (PC12adh) cells. Arch Toxicol. https:\/\/doi.org\/10.1007\/s00204-017-2056-0","DOI":"10.1007\/s00204-017-2056-0"},{"key":"9863_CR27","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.neuroscience.2014.11.016","volume":"285","author":"E Rangel-L\u00f3pez","year":"2015","unstructured":"Rangel-L\u00f3pez E, Col\u00edn-Gonz\u00e1lez AL, Paz-Loyola AL, Pinz\u00f3n E, Torres I, Serratos IN, Castellanos P, Wajner M, Souza DO, Santamar\u00eda A (2015) Cannabinoid receptor agonists reduce the short-term mitochondrial dysfunction and oxidative stress linked to excitotoxicity in the rat brain. Neuroscience 285:97\u2013106. https:\/\/doi.org\/10.1016\/j.neuroscience.2014.11.016","journal-title":"Neuroscience"},{"key":"9863_CR28","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3389\/fphar.2013.00169","volume":"4","author":"P S\u00e1nchez-Bl\u00e1zquez","year":"2014","unstructured":"S\u00e1nchez-Bl\u00e1zquez P, Rodr\u00edguez-Mu\u00f1oz M, Garz\u00f3n J (2014) The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia. Front Pharmacol 4:169","journal-title":"Front Pharmacol"},{"issue":"48","key":"9863_CR29","doi-asserted-by":"publisher","first-page":"12923","DOI":"10.1021\/bi8017174","volume":"47","author":"Z Tao","year":"2008","unstructured":"Tao Z, Gameiro A, Grewer C (2008) Thallium ions can replace both sodium and potassium ions in the glutamate transporter EAAAC1. Biochemist 47(48):12923\u201312930. https:\/\/doi.org\/10.1021\/bi8017174","journal-title":"Biochemist"},{"issue":"1-2","key":"9863_CR30","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.tox.2006.01.028","volume":"222","author":"SV Verstraeten","year":"2006","unstructured":"Verstraeten SV (2006) Relationship between thallium (I)-mediated plasma membrane fluidification and cell oxidants production in Jurkat T cells. Toxicology 222(1-2):95\u2013102. https:\/\/doi.org\/10.1016\/j.tox.2006.01.028","journal-title":"Toxicology"},{"issue":"9","key":"9863_CR31","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1080\/10715760400000950","volume":"38","author":"MS Villaverde","year":"2004","unstructured":"Villaverde MS, Hanzel CE, Verstraeten SV (2004) In vitro interactions of thallium with components of glutathione-dependent antioxidant defense system. Free Radic Res 38(9):977\u2013984. https:\/\/doi.org\/10.1080\/10715760400000950","journal-title":"Free Radic Res"},{"key":"9863_CR32","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.neuroscience.2013.06.005","volume":"248","author":"J Yoshida","year":"2013","unstructured":"Yoshida J, Shigemura A, Ogino Y, Denbow DM, Furuse M (2013) Two receptors are involved in the central functions of kynurenic acid under an acute stress in neonatal chicks. Neuroscience 248:194\u2013200. https:\/\/doi.org\/10.1016\/j.neuroscience.2013.06.005","journal-title":"Neuroscience"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12640-017-9863-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-017-9863-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-017-9863-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T23:30:45Z","timestamp":1660260645000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12640-017-9863-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,8]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["9863"],"URL":"https:\/\/doi.org\/10.1007\/s12640-017-9863-1","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,8]]}}}