{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T23:34:07Z","timestamp":1769556847085,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T00:00:00Z","timestamp":1520467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Vice Chancellor of Neuroscience Reserch Center of Shahid Beheshti University of Medical Sciences"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s12640-018-9884-4","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T05:36:40Z","timestamp":1520487400000},"page":"273-284","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Human Umbilical Cord Matrix Stem Cells Reverse Oxidative Stress-Induced Cell Death and Ameliorate Motor Function and Striatal Atrophy in Rat Model of Huntington Disease"],"prefix":"10.1007","volume":"34","author":[{"given":"Mohammad Javad","family":"Ebrahimi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Aliaghaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi Eskandarian","family":"Boroujeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariba","family":"Khodagholi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gholamhoussein","family":"Meftahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Amin","family":"Abdollahifar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houssein","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Danyali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahtab","family":"Daftari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousef","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,3,8]]},"reference":[{"key":"9884_CR1","unstructured":"Aliaghaei A, Gardaneh M, Maghsoudi N, Salehinejad P, Gharib E (2016) Dopaminergic induction of umbilical cord mesenchymal stem cells by conditioned medium of choroid plexus epithelial cells reduces Apomorphine-induced rotation in parkinsonian rats. Arch Iran Med 19"},{"key":"9884_CR2","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.mcn.2007.11.001","volume":"37","author":"K Bantubungi","year":"2008","unstructured":"Bantubungi K, Blum D, Cuvelier L, Wislet-Gendebien S, Rogister B, Brouillet E, Schiffmann SN (2008) Stem cell factor and mesenchymal and neural stem cell transplantation in a rat model of Huntington's disease. Mol Cell Neurosci 37:454\u2013470","journal-title":"Mol Cell Neurosci"},{"key":"9884_CR3","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.4103\/1673-5374.211201","volume":"12","author":"ME Boroujeni","year":"2017","unstructured":"Boroujeni ME, Gardaneh M (2017) Umbilical cord: an unlimited source of cells differentiable towards dopaminergic neurons. Neural Regen Res 12:1186","journal-title":"Neural Regen Res"},{"key":"9884_CR4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3923\/ajb.2012.27.36","volume":"7","author":"M Boroujeni","year":"2012","unstructured":"Boroujeni M, Gowda P, Johnson J, Rao J, Saremy S (2012) The proliferation and differentiation capacity of bone marrow derived-human mesenchymal stem cells in early and late doubling. Asian J Biochem 7:27\u201336","journal-title":"Asian J Biochem"},{"key":"9884_CR5","doi-asserted-by":"crossref","unstructured":"Boroujeni ME, Gardaneh M, Shahriari MH, Aliaghaei A, Hasani S (2017) Synergy between choroid plexus epithelial cell-conditioned medium and knockout serum replacement converts human adipose-derived stem cells to dopamine-secreting neurons. Rejuvenation Res","DOI":"10.1089\/rej.2016.1887"},{"key":"9884_CR6","doi-asserted-by":"publisher","first-page":"e1451","DOI":"10.1371\/journal.pone.0001451","volume":"3","author":"KC Chao","year":"2008","unstructured":"Chao KC, Chao KF, Fu YS, Liu SH (2008) Islet-like clusters derived from mesenchymal stem cells in Wharton's jelly of the human umbilical cord for transplantation to control type 1 diabetes. PLoS One 3:e1451","journal-title":"PLoS One"},{"key":"9884_CR7","doi-asserted-by":"publisher","first-page":"E9","DOI":"10.3171\/FOC\/2008\/24\/3-4\/E8","volume":"24","author":"CD Clelland","year":"2008","unstructured":"Clelland CD, Barker RA, Watts C (2008) Cell therapy in Huntington disease. Neurosurg Focus 24:E9","journal-title":"Neurosurg Focus"},{"key":"9884_CR8","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.bbr.2010.05.023","volume":"214","author":"ND Dey","year":"2010","unstructured":"Dey ND, Bombard MC, Roland BP, Davidson S, Lu M, Rossignol J, Sandstrom MI, Skeel RL, Lescaudron L, Dunbar GL (2010) Genetically engineered mesenchymal stem cells reduce behavioral deficits in the YAC 128 mouse model of Huntington's disease. Behav Brain Res 214:193\u2013200","journal-title":"Behav Brain Res"},{"key":"9884_CR9","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315\u2013317","journal-title":"Cytotherapy"},{"key":"9884_CR10","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1038\/mt.2013.132","volume":"21","author":"SM Ellison","year":"2013","unstructured":"Ellison SM, Trabalza A, Tisato V, Pazarentzos E, Lee S, Papadaki V, Goniotaki D, Morgan S, Mirzaei N, Mazarakis ND (2013) Dose-dependent neuroprotection of VEGF165 in Huntington's disease striatum. Mol Ther 21:1862\u20131875","journal-title":"Mol Ther"},{"key":"9884_CR11","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s12015-010-9168-8","volume":"7","author":"C-G Fan","year":"2011","unstructured":"Fan C-G, Zhang Q-j, Zhou J-r (2011) Therapeutic potentials of mesenchymal stem cells derived from human umbilical cord. Stem Cell Rev 7:195\u2013207","journal-title":"Stem Cell Rev"},{"key":"9884_CR12","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/scrt341","volume":"4","author":"KD Fink","year":"2013","unstructured":"Fink KD, Rossignol J, Crane AT, Davis KK, Bombard MC, Bavar AM, Clerc S, Lowrance SA, Song C, Lescaudron L (2013) Transplantation of umbilical cord-derived mesenchymal stem cells into the striata of R6\/2 mice: behavioral and neuropathological analysis. Stem Cell Res Ther 4:130","journal-title":"Stem Cell Res Ther"},{"key":"9884_CR13","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1089\/scd.2011.0674","volume":"21","author":"ST-F Hsiao","year":"2011","unstructured":"Hsiao ST-F, Asgari A, Lokmic Z, Sinclair R, Dusting GJ, Lim SY, Dilley RJ (2011) Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue. Stem Cells Dev 21:2189\u20132203","journal-title":"Stem Cells Dev"},{"key":"9884_CR14","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3109\/08916939109007636","volume":"8","author":"M Jendro","year":"1991","unstructured":"Jendro M, Goronzy JJ, Weyand CM (1991) Structural and functional characterization of HLA-DR molecules circulating in the serum. Autoimmunity 8:289\u2013296","journal-title":"Autoimmunity"},{"key":"9884_CR15","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.ymthe.2004.02.016","volume":"9","author":"AP Kells","year":"2004","unstructured":"Kells AP, Fong DM, Dragunow M, During MJ, Young D, Connor B (2004) AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease. Mol Ther 9:682\u2013688","journal-title":"Mol Ther"},{"key":"9884_CR16","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s13287-015-0248-1","volume":"6","author":"I Kerkis","year":"2015","unstructured":"Kerkis I, Haddad MS, Valverde CW, Glosman S (2015) Neural and mesenchymal stem cells in animal models of Huntington\u2019s disease: past experiences and future challenges. Stem Cell Res Ther 6:232","journal-title":"Stem Cell Res Ther"},{"key":"9884_CR17","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s13770-013-0010-7","volume":"10","author":"HO Kim","year":"2013","unstructured":"Kim HO, Choi S-M, Kim H-S (2013) Mesenchymal stem cell-derived secretome and microvesicles as a cell-free therapeutics for neurodegenerative disorders. Tissue Eng Regen Med 10:93\u2013101","journal-title":"Tissue Eng Regen Med"},{"key":"9884_CR18","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1038\/mt.2013.108","volume":"21","author":"D Krakora","year":"2013","unstructured":"Krakora D, Mulcrone P, Meyer M, Lewis C, Bernau K, Gowing G, Zimprich C, Aebischer P, Svendsen CN, Suzuki M (2013) Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model. Mol Ther 21:1602\u20131610","journal-title":"Mol Ther"},{"key":"9884_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1734-1140(10)70238-3","volume":"62","author":"P Kumar","year":"2010","unstructured":"Kumar P, Kalonia H, Kumar A (2010) Huntington\u2019s disease: pathogenesis to animal models. Pharmacol Rep 62:1\u201314","journal-title":"Pharmacol Rep"},{"key":"9884_CR20","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1002\/stem.401","volume":"28","author":"H Lee","year":"2010","unstructured":"Lee H, Lee JK, Min WK, Bae JH, He X, Schuchman EH, Bae JS, Jin HK (2010) Bone marrow-derived mesenchymal stem cells prevent the loss of Niemann-pick type C mouse Purkinje neurons by correcting sphingolipid metabolism and increasing Sphingosine-1-phosphate. Stem Cells 28:821\u2013831","journal-title":"Stem Cells"},{"key":"9884_CR21","doi-asserted-by":"publisher","first-page":"e22924","DOI":"10.1371\/journal.pone.0022924","volume":"6","author":"Y-T Lin","year":"2011","unstructured":"Lin Y-T, Chern Y, Shen C-KJ, Wen H-L, Chang Y-C, Li H, Cheng T-H, Hsieh-Li HM (2011) Human mesenchymal stem cells prolong survival and ameliorate motor deficit through trophic support in Huntington's disease mouse models. PLoS One 6:e22924","journal-title":"PLoS One"},{"key":"9884_CR22","doi-asserted-by":"publisher","first-page":"62","DOI":"10.5581\/1516-8484.20130017","volume":"35","author":"CV Machado","year":"2013","unstructured":"Machado CV, Telles PDS, Nascimento ILO (2013) Immunological characteristics of mesenchymal stem cells. Rev Bras Hematol Hemoter 35:62\u201367","journal-title":"Rev Bras Hematol Hemoter"},{"key":"9884_CR23","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0014-4886(03)00044-X","volume":"181","author":"JL McBride","year":"2003","unstructured":"McBride JL, During MJ, Wuu J, Chen E-Y, Leurgans SE, Kordower JH (2003) Structural and functional neuroprotection in a rat model of Huntington\u2019s disease by viral gene transfer of GDNF. Exp Neurol 181:213\u2013223","journal-title":"Exp Neurol"},{"key":"9884_CR24","doi-asserted-by":"publisher","first-page":"9345","DOI":"10.1073\/pnas.0508875103","volume":"103","author":"JL McBride","year":"2006","unstructured":"McBride JL, Ramaswamy S, Gasmi M, Bartus RT, Herzog CD, Brandon EP, Zhou L, Pitzer MR, Berry-Kravis EM, Kordower JH (2006) Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington\u2019s disease. Proc Natl Acad Sci 103:9345\u20139350","journal-title":"Proc Natl Acad Sci"},{"key":"9884_CR25","doi-asserted-by":"publisher","first-page":"e54","DOI":"10.1038\/emm.2013.94","volume":"45","author":"MB Murphy","year":"2013","unstructured":"Murphy MB, Moncivais K, Caplan AI (2013) Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med 45:e54","journal-title":"Exp Mol Med"},{"key":"9884_CR26","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1097\/00005072-199111000-00005","volume":"50","author":"RH Myers","year":"1991","unstructured":"Myers RH, Vonsattel JP, Paskevich PA, Kiely DK, Stevens TJ, Cupples LA, Richardson EP Jr, Bird ED (1991) Decreased neuronal and increased oligodendroglial densities in Huntington's disease caudate nucleus. J Neuropathol Exp Neurol 50:729\u2013742","journal-title":"J Neuropathol Exp Neurol"},{"key":"9884_CR27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.55782\/ane-2014-1971","volume":"74","author":"A Noorafshan","year":"2014","unstructured":"Noorafshan A, Abdollahifar M-A, Asadi-Golshan R, Rashidian-Rashidabadi A, Karbalay-Doust S (2014) Curcumin and sertraline prevent the reduction of the number of neurons and glial cells and the volume of rats\u2019 medial prefrontal cortex induced by stress. Acta Neurobiol Exp 74:44\u201353","journal-title":"Acta Neurobiol Exp"},{"key":"9884_CR28","doi-asserted-by":"publisher","first-page":"69","DOI":"10.5114\/fn.2015.49976","volume":"53","author":"A Noorafshan","year":"2015","unstructured":"Noorafshan A, Abdollahifar M-A, Karbalay-Doust S, Asadi-Golshan R, Rashidian-Rashidabadi A (2015) Sertraline and curcumin prevent stress-induced morphological changes of dendrites and neurons in the medial prefrontal cortex of rats. Folia Neuropathol 53:69\u201379","journal-title":"Folia Neuropathol"},{"key":"9884_CR29","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.mcn.2011.12.001","volume":"49","author":"SD Olson","year":"2012","unstructured":"Olson SD, Kambal A, Pollock K, Mitchell G-M, Stewart H, Kalomoiris S, Cary W, Nacey C, Pepper K, Nolta JA (2012) Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin. Mol Cell Neurosci 49:271\u2013281","journal-title":"Mol Cell Neurosci"},{"key":"9884_CR30","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.nurt.2008.02.003","volume":"5","author":"AL Peterson","year":"2008","unstructured":"Peterson AL, Nutt JG (2008) Treatment of Parkinson\u2019s disease with trophic factors. Neurotherapeutics 5:270\u2013280","journal-title":"Neurotherapeutics"},{"key":"9884_CR31","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/sj.gt.3302847","volume":"14","author":"J Pineda","year":"2007","unstructured":"Pineda J, Rubio N, Akerud P, Urban N, Badimon L, Arenas E, Alberch J, Blanco J, Canals J (2007) Neuroprotection by GDNF-secreting stem cells in a Huntington's disease model: optical neuroimage tracking of brain-grafted cells. Gene Ther 14:118\u2013128","journal-title":"Gene Ther"},{"key":"9884_CR32","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/nrn3570","volume":"14","author":"MA Pouladi","year":"2013","unstructured":"Pouladi MA, Morton AJ, Hayden MR (2013) Choosing an animal model for the study of Huntington's disease. Nat Rev Neurosci 14:708\u2013721","journal-title":"Nat Rev Neurosci"},{"key":"9884_CR33","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1093\/ilar.48.4.356","volume":"48","author":"S Ramaswamy","year":"2007","unstructured":"Ramaswamy S, McBride JL, Kordower JH (2007) Animal models of Huntington's disease. ILAR J 48:356\u2013373","journal-title":"ILAR J"},{"key":"9884_CR34","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nrneurol.2014.24","volume":"10","author":"CA Ross","year":"2014","unstructured":"Ross CA, Aylward EH, Wild EJ, Langbehn DR, Long JD, Warner JH, Scahill RI, Leavitt BR, Stout JC, Paulsen JS (2014) Huntington disease: natural history, biomarkers and prospects for therapeutics. Nat Rev Neurol 10:204\u2013216","journal-title":"Nat Rev Neurol"},{"key":"9884_CR35","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.bbr.2010.11.006","volume":"217","author":"J Rossignol","year":"2011","unstructured":"Rossignol J, Boyer C, L\u00e9v\u00e8que X, Fink KD, Thinard R, Blanchard F, Dunbar GL, Lescaudron L (2011) Mesenchymal stem cell transplantation and DMEM administration in a 3NP rat model of Huntington's disease: morphological and behavioral outcomes. Behav Brain Res 217:369\u2013378","journal-title":"Behav Brain Res"},{"key":"9884_CR36","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.expneurol.2011.12.045","volume":"234","author":"O Sadan","year":"2012","unstructured":"Sadan O, Shemesh N, Barzilay R, Dadon-Nahum M, Blumenfeld-Katzir T, Assaf Y, Yeshurun M, Djaldetti R, Cohen Y, Melamed E (2012) Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington's disease. Exp Neurol 234:417\u2013427","journal-title":"Exp Neurol"},{"key":"9884_CR37","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1634\/stemcells.2007-0381","volume":"26","author":"M Secco","year":"2008","unstructured":"Secco M, Zucconi E, Vieira NM, Foga\u00e7a LL, Cerqueira A, Carvalho MDF, Jazedje T, Okamoto OK, Muotri AR, Zatz M (2008) Multipotent stem cells from umbilical cord: cord is richer than blood! Stem Cells 26:146\u2013150","journal-title":"Stem Cells"},{"key":"9884_CR38","doi-asserted-by":"publisher","first-page":"e9347","DOI":"10.1371\/journal.pone.0009347","volume":"5","author":"BR Snyder","year":"2010","unstructured":"Snyder BR, Chiu AM, Prockop DJ, Chan AW (2010) Human multipotent stromal cells (MSCs) increase neurogenesis and decrease atrophy of the striatum in a transgenic mouse model for Huntington's disease. PLoS One 5:e9347","journal-title":"PLoS One"},{"key":"9884_CR39","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1172\/JCI200317977","volume":"111","author":"Y Sun","year":"2003","unstructured":"Sun Y, Jin K, Xie L, Childs J, Mao XO, Logvinova A, Greenberg DA (2003) VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest 111:1843\u20131851","journal-title":"J Clin Invest"},{"key":"9884_CR40","doi-asserted-by":"publisher","first-page":"878","DOI":"10.3390\/molecules15020878","volume":"15","author":"I T\u00fanez","year":"2010","unstructured":"T\u00fanez I, Tasset I, P\u00e9rez-De La Cruz V, Santamar\u00eda A (2010) 3-Nitropropionic acid as a tool to study the mechanisms involved in Huntington\u2019s disease: past, present and future. Molecules 15:878\u2013916","journal-title":"Molecules"},{"key":"9884_CR41","first-page":"1669","volume":"19","author":"M Volm","year":"1999","unstructured":"Volm M, Mattern J, Koom\u00e4gi R (1999) Inverse correlation between apoptotic (Fas ligand, caspase-3) and angiogenic factors (VEGF, microvessel density) in squamous cell lung carcinomas. Anticancer Res 19:1669\u20131671","journal-title":"Anticancer Res"},{"key":"9884_CR42","first-page":"33","volume-title":"The neuropathology of Huntington\u2019s disease","author":"HJ Waldvogel","year":"2014","unstructured":"Waldvogel HJ, Kim EH, Tippett LJ, Vonsattel J-PG, Faull RL (2014) The neuropathology of Huntington\u2019s disease. Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease. Springer, In, pp 33\u201380"},{"key":"9884_CR43","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1634\/stemcells.2004-0013","volume":"22","author":"HS Wang","year":"2004","unstructured":"Wang HS, Hung SC, Peng ST, Huang CC, Wei HM, Guo YJ, Fu YS, Lai MC, Chen CC (2004) Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord. Stem Cells 22:1330\u20131337","journal-title":"Stem Cells"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12640-018-9884-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-018-9884-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-018-9884-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T21:33:01Z","timestamp":1719869581000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12640-018-9884-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,8]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["9884"],"URL":"https:\/\/doi.org\/10.1007\/s12640-018-9884-4","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,8]]},"assertion":[{"value":"20 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Ethics Committee of the University approved this animal experiment (IR SBMU.PHNS.REC.1395.7).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}