{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:09:07Z","timestamp":1790017747083,"version":"4.0.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1007\/s12640-019-00079-x","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T08:02:43Z","timestamp":1561536163000},"page":"756-763","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Rhynchophylline Attenuates Tourette Syndrome via BDNF\/NF-\u03baB Pathway In Vivo and In Vitro"],"prefix":"10.1007","volume":"36","author":[{"given":"Hongyan","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaruo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"79_CR1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/j.1365-2567.2005.02205.x","volume":"116","author":"I Bellinghausen","year":"2005","unstructured":"Bellinghausen I, K\u00f6nig B, B\u00f6ttcher I, Knop J, Saloga J (2005) Regulatory activity of human CD4 + CD25 + T cells depends on allergen concentration, type of allergen and atopy status of the donor. Immunology 116:103\u2013111","journal-title":"Immunology"},{"key":"79_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00787-015-0742-0","volume":"25","author":"Y Ben-Shlomo","year":"2016","unstructured":"Ben-Shlomo Y, Scharf JM, Miller LL, Mathews CA (2016) Parental mood during pregnancy and post-natally is associated with offspring risk of Tourette syndrome or chronic tics: prospective data from the Avon Longitudinal Study of Parents and Children (ALSPAC). Eur Child Adolesc Psychiatry 25:1\u20139","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"79_CR3","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1136\/jnnp.73.5.588","volume":"73","author":"JW Chang","year":"2002","unstructured":"Chang JW, Choi JY, Lee BW, Kang UJ, Chung SS (2002) Unilateral globus pallidus internus stimulation improves delayed onset post-traumatic cervical dystonia with an ipsilateral focal basal ganglia lesion. J Neurol Neurosurg Psychiatry 73:588\u2013590","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"79_CR4","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1007\/s10753-017-0546-0","volume":"40","author":"X Fan","year":"2017","unstructured":"Fan X, Zhu JY, Sun Y, Luo L, Yan J, Yang X, Yu J, Tang WQ, Ma W, Liang HP (2017) Evodiamine inhibits zymosan-induced inflammation in vitro and in vivo: inactivation of NF-\u03baB by inhibiting I\u03baB\u03b1 phosphorylation. Inflammation 40:1012\u20131027","journal-title":"Inflammation"},{"key":"79_CR5","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1212\/CPJ.0000000000000348","volume":"7","author":"O Fr\u00fcndt","year":"2017","unstructured":"Fr\u00fcndt O, Woods D, Ganos C (2017) Behavioral therapy for Tourette syndrome and chronic tic disorders. Neurol Clin Pract 7:148\u2013156","journal-title":"Neurol Clin Pract"},{"key":"79_CR6","first-page":"4436","volume":"15","author":"L Guo","year":"2018","unstructured":"Guo L, Ren L, Zhang C (2018) Relationship between depression and inflammatory factors and brain-derived neurotrophic factorin patients with perimenopause syndrome. Exp Ther Med 15:4436\u20134440","journal-title":"Exp Ther Med"},{"key":"79_CR7","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3389\/fnins.2015.00117","volume":"9","author":"J Hawksley","year":"2015","unstructured":"Hawksley J, Cavanna AE, Nagai Y (2015) The role of the autonomic nervous system in Tourette syndrome. Front Neurosci 9:117","journal-title":"Front Neurosci"},{"key":"79_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cbi.2017.04.017","volume":"27","author":"YC Ho","year":"2017","unstructured":"Ho YC, Lee SS, Yang ML, Huang-Liu R, Lee CY, Li YC, Kuan YH (2017) Zerumbone reduced the inflammatory response of acute lung injury in endotoxin-treated mice via Akt-NF\u03baB pathway. Chem Biol Interact 27:9\u201314","journal-title":"Chem Biol Interact"},{"key":"79_CR9","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1007\/s11011-017-0051-z","volume":"32","author":"H Long","year":"2017","unstructured":"Long H, Chunyan W, Yue\u2019e Y (2017a) LY294002, a PI3K inhibitor, attenuates Tourette syndrome in rats. Metab Brain Dis 32:1619\u20131625","journal-title":"Metab Brain Dis"},{"key":"79_CR10","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1007\/s11011-017-0084-3","volume":"32","author":"H Long","year":"2017","unstructured":"Long H, Zhenyang S, Chunyan W, Qingqing P (2017b) Lipopolysaccharide aggravated DOI-induced Tourette syndrome: elaboration for recurrence of Tourette syndrome. Metab Brain Dis 32:1929\u20131934","journal-title":"Metab Brain Dis"},{"key":"79_CR11","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13046-017-0518-0","volume":"36","author":"Z Lu","year":"2017","unstructured":"Lu Z, Li Y, Wang J, Che Y, Sun S, Huang J, Chen Z, He J (2017) Long non-coding RNA NKILA inhibits migration and invasion of non-small cell lung cancer via NF-\u03baB\/snail pathway. J Exp Clin Cancer Res 36:54","journal-title":"J Exp Clin Cancer Res"},{"issue":"4","key":"79_CR12","doi-asserted-by":"publisher","first-page":"506","DOI":"10.3390\/molecules22040506","volume":"22","author":"Ting Ma","year":"2017","unstructured":"Ma T, Wang Z, Zhang YM, Luo JG, Kong LY (2017) Bioassay-guided isolation of anti-inflammatory components from the bulbs of Lilium brownii var. viridulum and identifying the underlying mechanism through acting on the NF-\u03baB\/MAPKs pathway. Molecules. \n                    https:\/\/doi.org\/10.3390\/molecules22040506","journal-title":"Molecules"},{"key":"79_CR13","first-page":"42","volume":"74","author":"I Sakakibara","year":"1994","unstructured":"Sakakibara I (1994) Discrimination of nine species of Uncaria (Rubiaceae), original plants of Chinese natural medicine, Diao-Teng-gou, based on stem anatomy and HPLC analysis. Journal of Japanese Botany 74:42\u201352","journal-title":"Journal of Japanese Botany"},{"key":"79_CR14","doi-asserted-by":"publisher","unstructured":"Sleiman SF, Henry J, Al-Haddad R, El Hayek L, Abou Haidar E, Stringer T, Ulja D, Karuppagounder SS, Holson EB, Ratan RR, Ninan I, Chao MV (2016) Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body \u03b2-hydroxybutyrate. Elife. \n                    https:\/\/doi.org\/10.7554\/eLife.15092","DOI":"10.7554\/eLife.15092"},{"key":"79_CR15","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/S0278-5846(01)00194-4","volume":"25","author":"Y Tizabi","year":"2001","unstructured":"Tizabi Y, Russell LT, Johnson M, Darmani NA (2001) Nicotine attenuates DOI-induced head-twitch response in mice: implications for tourette syndrome. Prog Neuro-Psychopharmacol Biol Psychiatry 25:1445\u20131457","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"79_CR16","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1093\/brain\/awu311","volume":"138","author":"Y Worbe","year":"2015","unstructured":"Worbe Y, Marrakchi-Kacem L, Lecomte S, Valabregue R, Poupon F, Guevara P, Tucholka A, Mangin JF, Vidailhet M, Lehericy S, Hartmann A, Poupon C (2015) Altered structural connectivity of cortico-striato-pallido-thalamic networks in Gilles de la Tourette syndrome. Brain 138:472\u2013482","journal-title":"Brain"},{"key":"79_CR17","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12974-017-0930-6","volume":"14","author":"D Xu","year":"2017","unstructured":"Xu D, Lian D, Wu J, Liu Y, Zhu M, Sun J, He D, Li L (2017) Brain-derived neurotrophic factor reduces inflammation and hippocampal apoptosis in experimental Streptococcus pneumoniae meningitis. Neuroinflammation 14:156","journal-title":"Neuroinflammation"},{"key":"79_CR18","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.2147\/NDT.S106330","volume":"12","author":"W Zhang","year":"2016","unstructured":"Zhang W, Wei L, Yu W, Cui X, Liu X, Wang Q, Wang S (2016) Effect of Jian-Pi-Zhi-Dong Decoction on striatal glutamate and \u03b3-aminobutyric acid levels detected using microdialysis in a rat model of Tourette syndrome. Neuropsychiatr Dis Treat 12:1233\u20131242","journal-title":"Neuropsychiatr Dis Treat"},{"key":"79_CR19","unstructured":"Zhang F and Sun AS (2010) Effects of isorhynchophylline on angiotensinII-induced proliferation in rat vascular smooth muscle cells. Selected and awarded essays on outstanding academic papers of natural science in Guizhou province"},{"key":"79_CR20","doi-asserted-by":"publisher","first-page":"S137","DOI":"10.1016\/j.eurpsy.2016.01.220","volume":"33","author":"S Zinna","year":"2016","unstructured":"Zinna S, Kyriakopoulos M (2016) Clinical correlates of comorbid chronic tics and Tourette syndrome in a National Inpatient Children\u2019s Unit. Eur Psychiatry 33:S137\u2013S137","journal-title":"Eur Psychiatry"},{"key":"79_CR21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jep.2010.08.041","volume":"132","author":"JY Zhou","year":"2010","unstructured":"Zhou JY, Zhou SW (2010) Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity. J Ethnopharmacol 132:15\u201327","journal-title":"J Ethnopharmacol"},{"key":"79_CR22","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.fitote.2012.02.010","volume":"83","author":"JY Zhou","year":"2012","unstructured":"Zhou JY, Zhou SW (2012) Isorhynchophylline: a plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases. Fitoterapia 83:617\u2013626","journal-title":"Fitoterapia"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-019-00079-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12640-019-00079-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-019-00079-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T23:40:01Z","timestamp":1593042001000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12640-019-00079-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,26]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["79"],"URL":"https:\/\/doi.org\/10.1007\/s12640-019-00079-x","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,26]]},"assertion":[{"value":"4 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All of the experiments were performed in full compliance with the guidelines of the Principles of Laboratory Animal Care and the Guide for the Care and Use of Laboratory Animals approved by the National Institutes of Health (NIH Publication No. 85-23, revised 1996). Animal care and experimental protocols were approved by the Nanjing University of Chinese Medicine Committee.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Guidelines"}}]}}