{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:05:45Z","timestamp":1777583145676,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s12640-019-00113-y","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T19:46:58Z","timestamp":1572032818000},"page":"48-57","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Autophagy and Ubiquitin-Proteasome System Coordinate to Regulate the Protein Quality Control of Neurodegenerative Disease-Associated DCTN1"],"prefix":"10.1007","volume":"37","author":[{"given":"Nana","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qilian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-0509","authenticated-orcid":false,"given":"Zheng","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,10,25]]},"reference":[{"key":"113_CR1","doi-asserted-by":"publisher","first-page":"E1817","DOI":"10.1073\/pnas.1305623110","volume":"110","author":"M Decressac","year":"2013","unstructured":"Decressac M, Mattsson B, Weikop P, Lundblad M, Jakobsson J, Bjorklund A (2013) TFEB-mediated autophagy rescues midbrain dopamine neurons from alpha-synuclein toxicity. Proc Natl Acad Sci U S A 110:E1817\u2013E1826. \nhttps:\/\/doi.org\/10.1073\/pnas.1305623110","journal-title":"Proc Natl Acad Sci U S A"},{"key":"113_CR2","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1083\/jcb.132.4.617","volume":"132","author":"CJ Echeverri","year":"1996","unstructured":"Echeverri CJ, Paschal BM, Vaughan KT, Vallee RB (1996) Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. J Cell Biol 132:617\u2013633","journal-title":"J Cell Biol"},{"key":"113_CR3","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/aps.2017.25","volume":"38","author":"LM Fang","year":"2017","unstructured":"Fang LM, Li B, Guan JJ, Xu HD, Shen GH, Gao QG, Qin ZH (2017) Transcription factor EB is involved in autophagy-mediated chemoresistance to doxorubicin in human cancer cells. Acta Pharmacol Sin 38:1305\u20131316. \nhttps:\/\/doi.org\/10.1038\/aps.2017.25","journal-title":"Acta Pharmacol Sin"},{"key":"113_CR4","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/ng.293","volume":"41","author":"MJ Farrer","year":"2009","unstructured":"Farrer MJ, Hulihan MM, Kachergus JM, Dachsel JC, Stoessl AJ et al (2009) DCTN1 mutations in Perry syndrome. Nat Genet 41:163\u2013165. \nhttps:\/\/doi.org\/10.1038\/ng.293","journal-title":"Nat Genet"},{"key":"113_CR5","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ejmg.2014.01.002","volume":"57","author":"J Finsterer","year":"2014","unstructured":"Finsterer J, Burgunder JM (2014) Recent progress in the genetics of motor neuron disease. Eur J Med Genet 57:103\u2013112. \nhttps:\/\/doi.org\/10.1016\/j.ejmg.2014.01.002","journal-title":"Eur J Med Genet"},{"key":"113_CR6","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1126\/science.1083129","volume":"300","author":"M Hafezparast","year":"2003","unstructured":"Hafezparast M, Klocke R, Ruhrberg C, Marquardt A, Ahmad-Annuar A, Bowen S, Lalli G, Witherden AS, Hummerich H, Nicholson S, Morgan PJ, Oozageer R, Priestley JV, Averill S, King VR, Ball S, Peters J, Toda T, Yamamoto A, Hiraoka Y, Augustin M, Korthaus D, Wattler S, Wabnitz P, Dickneite C, Lampel S, Boehme F, Peraus G, Popp A, Rudelius M, Schlegel J, Fuchs H, Hrabe de Angelis M, Schiavo G, Shima DT, Russ AP, Stumm G, Martin JE, Fisher EM (2003) Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science 300:808\u2013812. \nhttps:\/\/doi.org\/10.1126\/science.1083129","journal-title":"Science"},{"key":"113_CR7","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1016\/j.yexcr.2008.01.035","volume":"314","author":"M Harada","year":"2008","unstructured":"Harada M, Strnad P, Toivola DM, Omary MB (2008) Autophagy modulates keratin-containing inclusion formation and apoptosis in cell culture in a context-dependent fashion. Exp Cell Res 314:1753\u20131764. \nhttps:\/\/doi.org\/10.1016\/j.yexcr.2008.01.035","journal-title":"Exp Cell Res"},{"key":"113_CR8","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.neuron.2010.09.039","volume":"68","author":"N Hirokawa","year":"2010","unstructured":"Hirokawa N, Niwa S, Tanaka Y (2010) Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease. Neuron 68:610\u2013638. \nhttps:\/\/doi.org\/10.1016\/j.neuron.2010.09.039","journal-title":"Neuron"},{"key":"113_CR9","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.3390\/ijms13011225","volume":"13","author":"K Ikenaka","year":"2012","unstructured":"Ikenaka K, Katsuno M, Kawai K, Ishigaki S, Tanaka F, Sobue G (2012) Disruption of axonal transport in motor neuron diseases. Int J Mol Sci 13:1225\u20131238. \nhttps:\/\/doi.org\/10.3390\/ijms13011225","journal-title":"Int J Mol Sci"},{"key":"113_CR10","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/S0962-8924(00)01852-3","volume":"10","author":"RR Kopito","year":"2000","unstructured":"Kopito RR (2000) Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol 10:524\u2013530","journal-title":"Trends Cell Biol"},{"key":"113_CR11","doi-asserted-by":"publisher","first-page":"13982","DOI":"10.1523\/JNEUROSCI.4226-07.2007","volume":"27","author":"C Lai","year":"2007","unstructured":"Lai C, Lin X, Chandran J, Shim H, Yang WJ, Cai H (2007) The G59S mutation in p150(glued) causes dysfunction of dynactin in mice. J Neurosci 27:13982\u201313990. \nhttps:\/\/doi.org\/10.1523\/JNEUROSCI.4226-07.2007","journal-title":"J Neurosci"},{"key":"113_CR12","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1083\/jcb.200511068","volume":"172","author":"JR Levy","year":"2006","unstructured":"Levy JR, Sumner CJ, Caviston JP, Tokito MK, Ranganathan S, Ligon LA, Wallace KE, LaMonte BH, Harmison GG, Puls I, Fischbeck KH, Holzbaur ELF (2006) A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation. J Cell Biol 172:733\u2013745. \nhttps:\/\/doi.org\/10.1083\/jcb.200511068","journal-title":"J Cell Biol"},{"issue":"3","key":"113_CR13","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.ymthe.2017.01.018","volume":"25","author":"Dan Liu","year":"2017","unstructured":"Liu D, Tang H, Li XY, Deng MF, Wei N, Wang X, Zhou YF, Wang DQ, Fu P, Wang JZ, H\u00e9bert SS, Chen JG, Lu Y, Zhu LQ (2017) Targeting the HDAC2\/HNF-4A\/miR-101b\/AMPK pathway rescues tauopathy and dendritic abnormalities in Alzheimer\u2019s disease. Mol Ther 25:752\u2013764. \nhttps:\/\/doi.org\/10.1016\/j.ymthe.2017.01.018","journal-title":"Molecular Therapy"},{"key":"113_CR14","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.apsb.2016.06.005","volume":"7","author":"G Lv","year":"2017","unstructured":"Lv G, Sun D, Zhang J, Xie X, Wu X, Fang W, Tian J, Yan C, Wang H, Fu F (2017) Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo. Acta Pharm Sin B 7:52\u201358. \nhttps:\/\/doi.org\/10.1016\/j.apsb.2016.06.005","journal-title":"Acta Pharm Sin B"},{"key":"113_CR15","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1080\/17435390.2018.1425503","volume":"12","author":"X Ma","year":"2018","unstructured":"Ma X, Lee S, Fei X, Fang G, Huynh T, Chong Y, Chai Z, Ge C, Zhou R (2018) Inhibition of the proteasome activity by graphene oxide contributes to its cytotoxicity. Nanotoxicology 12:185\u2013200. \nhttps:\/\/doi.org\/10.1080\/17435390.2018.1425503","journal-title":"Nanotoxicology"},{"key":"113_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/cne.903570103","volume":"357","author":"RH Melloni Jr","year":"1995","unstructured":"Melloni RH Jr, Tokito MK, Holzbaur EL (1995) Expression of the p150Glued component of the dynactin complex in developing and adult rat brain. J Comp Neurol 357:15\u201324. \nhttps:\/\/doi.org\/10.1002\/cne.903570103","journal-title":"J Comp Neurol"},{"key":"113_CR17","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1212\/01.WNL.0000134608.83927.B1","volume":"63","author":"C Munch","year":"2004","unstructured":"Munch C, Sedlmeier R, Meyer T, Homberg V, Sperfeld AD, Kurt A, Prudlo J, Peraus G, Hanemann CO, Stumm G, Ludolph AC (2004) Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS. Neurology 63:724\u2013726","journal-title":"Neurology"},{"key":"113_CR18","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1002\/ana.20631","volume":"58","author":"C Munch","year":"2005","unstructured":"Munch C, Rosenbohm A, Sperfeld AD, Uttner I, Reske S et al (2005) Heterozygous R1101K mutation of the DCTN1 gene in a family with ALS and FTD. Ann Neurol 58:777\u2013780. \nhttps:\/\/doi.org\/10.1002\/ana.20631","journal-title":"Ann Neurol"},{"issue":"6","key":"113_CR19","doi-asserted-by":"publisher","first-page":"1268-1283.e6","DOI":"10.1016\/j.neuron.2018.02.027","volume":"97","author":"Aude Nicolas","year":"2018","unstructured":"Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, van der Spek RA, Pliner HA, Shankaracharya, Smith BN, Marangi G, Topp SD, Abramzon Y, Gkazi AS, Eicher JD, Kenna A, Mora G, Calvo A, Mazzini L, Riva N, Mandrioli J, Caponnetto C, Battistini S, Volanti P, la Bella V, Conforti FL, Borghero G, Messina S, Simone IL, Trojsi F, Salvi F, Logullo FO, D\u2019Alfonso S, Corrado L, Capasso M, Ferrucci L, Moreno CAM, Kamalakaran S, Goldstein DB, Gitler AD, Harris T, Myers RM, Phatnani H, Musunuri RL, Evani US, Abhyankar A, Zody MC, Kaye J, Finkbeiner S, Wyman SK, LeNail A, Lima L, Fraenkel E, Svendsen CN, Thompson LM, van Eyk JE, Berry JD, Miller TM, Kolb SJ, Cudkowicz M, Baxi E, Benatar M, Taylor JP, Rampersaud E, Wu G, Wuu J, Lauria G, Verde F, Fogh I, Tiloca C, Comi GP, Sorar\u00f9 G, Cereda C, Corcia P, Laaksovirta H, Myllykangas L, Jansson L, Valori M, Ealing J, Hamdalla H, Rollinson S, Pickering-Brown S, Orrell RW, Sidle KC, Malaspina A, Hardy J, Singleton AB, Johnson JO, Arepalli S, Sapp PC, McKenna-Yasek D, Polak M, Asress S, al-Sarraj S, King A, Troakes C, Vance C, de Belleroche J, Baas F, ten Asbroek ALMA, Mu\u00f1oz-Blanco JL, Hernandez DG, Ding J, Gibbs JR, Scholz SW, Floeter MK, Campbell RH, Landi F, Bowser R, Pulst SM, Ravits JM, MacGowan DJL, Kirby J, Pioro EP, Pamphlett R, Broach J, Gerhard G, Dunckley TL, Brady CB, Kowall NW, Troncoso JC, le Ber I, Mouzat K, Lumbroso S, Heiman-Patterson TD, Kamel F, van den Bosch L, Baloh RH, Strom TM, Meitinger T, Shatunov A, van Eijk KR, de Carvalho M, Kooyman M, Middelkoop B, Moisse M, McLaughlin RL, van Es MA, Weber M, Boylan KB, van Blitterswijk M, Rademakers R, Morrison KE, Basak AN, Mora JS, Drory VE, Shaw PJ, Turner MR, Talbot K, Hardiman O, Williams KL, Fifita JA, Nicholson GA, Blair IP, Rouleau GA, Esteban-P\u00e9rez J, Garc\u00eda-Redondo A, al-Chalabi A, Rogaeva E, Zinman L, Ostrow LW, Maragakis NJ, Rothstein JD, Simmons Z, Cooper-Knock J, Brice A, Goutman SA, Feldman EL, Gibson SB, Taroni F, Ratti A, Gellera C, van Damme P, Robberecht W, Fratta P, Sabatelli M, Lunetta C, Ludolph AC, Andersen PM, Weishaupt JH, Camu W, Trojanowski JQ, van Deerlin VM, Brown RH Jr, van den Berg LH, Veldink JH, Harms MB, Glass JD, Stone DJ, Tienari P, Silani V, Chi\u00f2 A, Shaw CE, Traynor BJ, Landers JE, Logullo FO, Simone I, Logroscino G, Salvi F, Bartolomei I, Borghero G, Murru MR, Costantino E, Pani C, Puddu R, Caredda C, Piras V, Tranquilli S, Cuccu S, Corongiu D, Melis M, Milia A, Marrosu F, Marrosu MG, Floris G, Cannas A, Tranquilli S, Capasso M, Caponnetto C, Mancardi G, Origone P, Mandich P, Conforti FL, Cavallaro S, Mora G, Marinou K, Sideri R, Penco S, Mosca L, Lunetta C, Pinter GL, Corbo M, Riva N, Carrera P, Volanti P, Mandrioli J, Fini N, Fasano A, Tremolizzo L, Arosio A, Ferrarese C, Trojsi F, Tedeschi G, Monsurr\u00f2 MR, Piccirillo G, Femiano C, Ticca A, Ortu E, la Bella V, Spataro R, Colletti T, Sabatelli M, Zollino M, Conte A, Luigetti M, Lattante S, Marangi G, Santarelli M, Petrucci A, Pugliatti M, Pirisi A, Parish LD, Occhineri P, Giannini F, Battistini S, Ricci C, Benigni M, Cau TB, Loi D, Calvo A, Moglia C, Brunetti M, Barberis M, Restagno G, Casale F, Marrali G, Fuda G, Ossola I, Cammarosano S, Canosa A, Ilardi A, Manera U, Grassano M, Tanel R, Pisano F, Harms MB, Goldstein DB, Shneider NA, Goutman S, Simmons Z, Miller TM, Chandran S, Pal S, Manousakis G, Appel SH, Simpson E, Wang L, Baloh RH, Gibson S, Bedlack R, Lacomis D, Sareen D, Sherman A, Bruijn L, Penny M, Allen AS, Appel S, Baloh RH, Bedlack RS, Boone BE, Brown R, Carulli JP, Chesi A, Chung WK, Cirulli ET, Cooper GM, Couthouis J, Day-Williams AG, Dion PA, Gibson S, Gitler AD, Glass JD, Goldstein DB, Han Y, Harms MB, Harris T, Hayes SD, Jones AL, Keebler J, Krueger BJ, Lasseigne BN, Levy SE, Lu YF, Maniatis T, McKenna-Yasek D, Miller TM, Myers RM, Petrovski S, Pulst SM, Raphael AR, Ravits JM, Ren Z, Rouleau GA, Sapp PC, Shneider NA, Simpson E, Sims KB, Staropoli JF, Waite LL, Wang Q, Wimbish JR, Xin WW, Phatnani H, Kwan J, Sareen D, Broach JR, Simmons Z, Arcila-Londono X, Lee EB, van Deerlin VM, Shneider NA, Fraenkel E, Ostrow LW, Baas F, Zaitlen N, Berry JD, Malaspina A, Fratta P, Cox GA, Thompson LM, Finkbeiner S, Dardiotis E, Miller TM, Chandran S, Pal S, Hornstein E, MacGowan DJ, Heiman-Patterson T, Hammell MG, Patsopoulos NA, Dubnau J, Nath A, Kaye J, Finkbeiner S, Wyman S, LeNail A, Lima L, Fraenkel E, Rothstein JD, Svendsen CN, Thompson LM, van Eyk J, Maragakis NJ, Berry JD, Glass JD, Miller TM, Kolb SJ, Baloh RH, Cudkowicz M, Baxi E, Benatar M, Taylor JP, Wu G, Rampersaud E, Wuu J, Rademakers R, Z\u00fcchner S, Schule R, McCauley J, Hussain S, Cooley A, Wallace M, Clayman C, Barohn R, Statland J, Ravits J, Swenson A, Jackson C, Trivedi J, Khan S, Katz J, Jenkins L, Burns T, Gwathmey K, Caress J, McMillan C, Elman L, Pioro E, Heckmann J, So Y, Walk D, Maiser S, Zhang J, Silani V, Ticozzi N, Gellera C, Ratti A, Taroni F, Lauria G, Verde F, Fogh I, Tiloca C, Comi GP, Sorar\u00f9 G, Cereda C, D\u2019Alfonso S, Corrado L, de Marchi F, Corti S, Ceroni M, Mazzini L, Siciliano G, Filosto M, Inghilleri M, Peverelli S, Colombrita C, Poletti B, Maderna L, del Bo R, Gagliardi S, Querin G, Bertolin C, Pensato V, Castellotti B, Camu W, Mouzat K, Lumbroso S, Corcia P, Meininger V, Besson G, Lagrange E, Clavelou P, Guy N, Couratier P, Vourch P, Danel V, Bernard E, Lemasson G, al Kheifat A, al-Chalabi A, Andersen P, Basak AN, Blair IP, Chio A, Cooper-Knock J, Corcia P, Couratier P, de Carvalho M, Dekker A, Drory V, Redondo AG, Gotkine M, Hardiman O, Hide W, Iacoangeli A, Glass J, Kenna K, Kiernan M, Kooyman M, Landers J, McLaughlin R, Middelkoop B, Mill J, Neto MM, Moisse M, Pardina JM, Morrison K, Newhouse S, Pinto S, Pulit S, Robberecht W, Shatunov A, Shaw P, Shaw C, Silani V, Sproviero W, Tazelaar G, Ticozzi N, van Damme P, van den Berg L, van der Spek R, van Eijk K, van Es M, van Rheenen W, van Vugt J, Veldink J, Weber M, Williams KL, Zatz M, Bauer DC, Twine NA (2018) Genome-wide analyses identify KIF5A as a novel ALS Gene. Neuron 97:1268\u20131283 e1266. \nhttps:\/\/doi.org\/10.1016\/j.neuron.2018.02.027","journal-title":"Neuron"},{"key":"113_CR20","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/nm.3232","volume":"19","author":"RA Nixon","year":"2013","unstructured":"Nixon RA (2013) The role of autophagy in neurodegenerative disease. Nat Med 19:983\u2013997. \nhttps:\/\/doi.org\/10.1038\/nm.3232","journal-title":"Nat Med"},{"key":"113_CR21","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.parkreldis.2010.07.001","volume":"16","author":"S Ohshima","year":"2010","unstructured":"Ohshima S, Tsuboi Y, Yamamoto A, Kawakami M, Farrer MJ, Kira JI, Shii H (2010) Autonomic failures in Perry syndrome with DCTN1 mutation. Parkinsonism Relat Disord 16:612\u2013614. \nhttps:\/\/doi.org\/10.1016\/j.parkreldis.2010.07.001","journal-title":"Parkinsonism Relat Disord"},{"key":"113_CR22","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/ng1123","volume":"33","author":"I Puls","year":"2003","unstructured":"Puls I, Jonnakuty C, LaMonte BH, Holzbaur EL, Tokito M et al (2003) Mutant dynactin in motor neuron disease. Nat Genet 33:455\u2013456. \nhttps:\/\/doi.org\/10.1038\/ng1123","journal-title":"Nat Genet"},{"key":"113_CR23","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/ana.20468","volume":"57","author":"I Puls","year":"2005","unstructured":"Puls I, Oh SJ, Sumner CJ, Wallace KE, Floeter MK, Mann EA, Kennedy WR, Wendelschafer-Crabb G, Vortmeyer A, Powers R, Finnegan K, Holzbaur ELF, Fischbeck KH, Ludlow CL (2005) Distal spinal and bulbar muscular atrophy caused by dynactin mutation. Ann Neurol 57:687\u2013694. \nhttps:\/\/doi.org\/10.1002\/ana.20468","journal-title":"Ann Neurol"},{"key":"113_CR24","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/s41580-018-0004-3","volume":"19","author":"SL Reck-Peterson","year":"2018","unstructured":"Reck-Peterson SL, Redwine WB, Vale RD, Carter AP (2018) The cytoplasmic dynein transport machinery and its many cargoes. Nat Rev Mol Cell Biol 19:382\u2013398. \nhttps:\/\/doi.org\/10.1038\/s41580-018-0004-3","journal-title":"Nat Rev Mol Cell Biol"},{"key":"113_CR25","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1038\/aps.2016.42","volume":"37","author":"ZX Ren","year":"2016","unstructured":"Ren ZX, Zhao YF, Cao T, Zhen XC (2016) Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson\u2019s disease by suppressing glycogen synthase kinase-3 beta activity. Acta Pharmacol Sin 37:1315\u20131324. \nhttps:\/\/doi.org\/10.1038\/aps.2016.42","journal-title":"Acta Pharmacol Sin"},{"key":"113_CR26","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1038\/nrm1742","volume":"6","author":"CA Ross","year":"2005","unstructured":"Ross CA, Poirier MA (2005) Opinion: what is the role of protein aggregation in neurodegeneration? Nat Rev Mol Cell Biol 6:891\u2013898","journal-title":"Nat Rev Mol Cell Biol"},{"key":"113_CR27","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1126\/science.1174447","volume":"325","author":"M Sardiello","year":"2009","unstructured":"Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, Gennarino VA, di Malta C, Donaudy F, Embrione V, Polishchuk RS, Banfi S, Parenti G, Cattaneo E, Ballabio A (2009) A gene network regulating lysosomal biogenesis and function. Science 325:473\u2013477. \nhttps:\/\/doi.org\/10.1126\/science.1174447","journal-title":"Science"},{"key":"113_CR28","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1146\/annurev.cellbio.20.012103.094623","volume":"20","author":"TA Schroer","year":"2004","unstructured":"Schroer TA (2004) Dynactin. Annu Rev Cell Dev Biol 20:759\u2013779. \nhttps:\/\/doi.org\/10.1146\/annurev.cellbio.20.012103.094623","journal-title":"Annu Rev Cell Dev Biol"},{"key":"113_CR29","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1126\/science.1204592","volume":"332","author":"C Settembre","year":"2011","unstructured":"Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F et al (2011) TFEB links autophagy to lysosomal biogenesis. Science 332:1429\u20131433. \nhttps:\/\/doi.org\/10.1126\/science.1204592","journal-title":"Science"},{"key":"113_CR30","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1093\/hmg\/ddv005","volume":"24","author":"Z Tao","year":"2015","unstructured":"Tao Z, Wang H, Xia Q, Li K, Jiang X et al (2015) Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity. Hum Mol Genet 24:2426\u20132441. \nhttps:\/\/doi.org\/10.1093\/hmg\/ddv005","journal-title":"Hum Mol Genet"},{"key":"113_CR31","doi-asserted-by":"publisher","first-page":"142ra197","DOI":"10.1126\/scitranslmed.3003799","volume":"4","author":"T Tsunemi","year":"2012","unstructured":"Tsunemi T, Ashe TD, Morrison BE, Soriano KR, Au J, Roque RAV, Lazarowski ER, Damian VA, Masliah E, la Spada AR (2012) PGC-1alpha rescues Huntington\u2019s disease proteotoxicity by preventing oxidative stress and promoting TFEB function. Sci Transl Med 4:142ra197. \nhttps:\/\/doi.org\/10.1126\/scitranslmed.3003799","journal-title":"Sci Transl Med"},{"key":"113_CR32","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1083\/jcb.131.6.1507","volume":"131","author":"KT Vaughan","year":"1995","unstructured":"Vaughan KT, Vallee RB (1995) Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued. J Cell Biol 131:1507\u20131516","journal-title":"J Cell Biol"},{"key":"113_CR33","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/aps.2012.194","volume":"34","author":"Y Wang","year":"2013","unstructured":"Wang Y, Qin ZH (2013) Coordination of autophagy with other cellular activities. Acta Pharmacol Sin 34:585\u2013594. \nhttps:\/\/doi.org\/10.1038\/aps.2012.194","journal-title":"Acta Pharmacol Sin"},{"key":"113_CR34","doi-asserted-by":"publisher","first-page":"28576","DOI":"10.1074\/jbc.M111.299990","volume":"287","author":"H Wang","year":"2012","unstructured":"Wang H, Ying Z, Wang G (2012) Ataxin-3 regulates aggresome formation of copper-zinc superoxide dismutase (SOD1) by editing K63-linked polyubiquitin chains. J Biol Chem 287:28576\u201328585. \nhttps:\/\/doi.org\/10.1074\/jbc.M111.299990","journal-title":"J Biol Chem"},{"key":"113_CR35","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.biopsych.2017.07.023","volume":"83","author":"X Wang","year":"2018","unstructured":"Wang X, Liu D, Huang HZ, Wang ZH, Hou TY, Yang X, Pang P, Wei N, Zhou YF, Dupras MJ, Calon F, Wang YT, Man HY, Chen JG, Wang JZ, H\u00e9bert SS, Lu Y, Zhu LQ (2018) A novel MicroRNA-124\/PTPN1 signal pathway mediates synaptic and memory deficits in Alzheimer\u2019s disease. Biol Psychiatry 83:395\u2013405. \nhttps:\/\/doi.org\/10.1016\/j.biopsych.2017.07.023","journal-title":"Biol Psychiatry"},{"key":"113_CR36","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1073\/pnas.92.5.1634","volume":"92","author":"CM Waterman-Storer","year":"1995","unstructured":"Waterman-Storer CM, Karki S, Holzbaur EL (1995) The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). Proc Natl Acad Sci U S A 92:1634\u20131638","journal-title":"Proc Natl Acad Sci U S A"},{"key":"113_CR37","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/aps.2012.14","volume":"33","author":"JC Wu","year":"2012","unstructured":"Wu JC, Qi L, Wang Y, Kegel KB, Yoder J, Difiglia M, Qin ZH, Lin F (2012) The regulation of N-terminal huntingtin (Htt552) accumulation by Beclin1. Acta Pharmacol Sin 33:743\u2013751. \nhttps:\/\/doi.org\/10.1038\/aps.2012.14","journal-title":"Acta Pharmacol Sin"},{"key":"113_CR38","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1093\/hmg\/ddv450","volume":"25","author":"Q Xia","year":"2016","unstructured":"Xia Q, Wang G, Wang H, Hu Q, Ying Z (2016a) Folliculin, a tumor suppressor associated with Birt-Hogg-Dube (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation. Hum Mol Genet 25:83\u201396. \nhttps:\/\/doi.org\/10.1093\/hmg\/ddv450","journal-title":"Hum Mol Genet"},{"key":"113_CR39","doi-asserted-by":"publisher","first-page":"121","DOI":"10.15252\/embj.201591998","volume":"35","author":"Q Xia","year":"2016","unstructured":"Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J, Ying Z, Wang G (2016b) TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion. EMBO J 35:121\u2013142. \nhttps:\/\/doi.org\/10.15252\/embj.201591998","journal-title":"EMBO J"},{"key":"113_CR40","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.taap.2018.01.015","volume":"341","author":"Y Yang","year":"2018","unstructured":"Yang Y, Guan D, Lei L, Lu J, Liu JQ, Yang G, Yan C, Zhai R, Tian J, Bi Y, Fu F, Wang H (2018) H6, a novel hederagenin derivative, reverses multidrug resistance in vitro and in vivo. Toxicol Appl Pharmacol 341:98\u2013105. \nhttps:\/\/doi.org\/10.1016\/j.taap.2018.01.015","journal-title":"Toxicol Appl Pharmacol"},{"key":"113_CR41","doi-asserted-by":"publisher","first-page":"4268","DOI":"10.1093\/hmg\/ddp380","volume":"18","author":"Z Ying","year":"2009","unstructured":"Ying Z, Wang H, Fan H, Zhu X, Zhou J, Fei E, Wang G (2009) Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation. Hum Mol Genet 18:4268\u20134281","journal-title":"Hum Mol Genet"},{"key":"113_CR42","doi-asserted-by":"publisher","first-page":"20835","DOI":"10.1074\/jbc.M110.200808","volume":"286","author":"Z Ying","year":"2011","unstructured":"Ying Z, Wang H, Fan H, Wang G (2011) The endoplasmic reticulum (ER)-associated degradation system regulates aggregation and degradation of mutant neuroserpin. J Biol Chem 286:20835\u201320844. \nhttps:\/\/doi.org\/10.1074\/jbc.M110.200808","journal-title":"J Biol Chem"},{"key":"113_CR43","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.bbrc.2007.05.068","volume":"359","author":"N Zhang","year":"2007","unstructured":"Zhang N, Liu J, Ding X, Aikhionbare F, Jin C, Yao X (2007) FBXL5 interacts with p150Glued and regulates its ubiquitination. Biochem Biophys Res Commun 359:34\u201339. \nhttps:\/\/doi.org\/10.1016\/j.bbrc.2007.05.068","journal-title":"Biochem Biophys Res Commun"},{"key":"113_CR44","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/aps.2013.12","volume":"34","author":"L Zhou","year":"2013","unstructured":"Zhou L, Wang HF, Ren HG, Chen D, Gao F, Hu QS, Fu C, Xu RJ, Ying Z, Wang GH (2013) Bcl-2-dependent upregulation of autophagy by sequestosome 1\/p62 in vitro. Acta Pharmacol Sin 34:651\u2013656. \nhttps:\/\/doi.org\/10.1038\/aps.2013.12","journal-title":"Acta Pharmacol Sin"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-019-00113-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12640-019-00113-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-019-00113-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T23:42:23Z","timestamp":1603496543000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12640-019-00113-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,25]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["113"],"URL":"https:\/\/doi.org\/10.1007\/s12640-019-00113-y","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,25]]},"assertion":[{"value":"8 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}