{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:27:34Z","timestamp":1787963254285,"version":"build-2784847793"},"reference-count":233,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s12640-021-00396-0","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T19:04:29Z","timestamp":1642532669000},"page":"298-318","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Regulation of Neurodegeneration-associated Protein Fragments by the N-degron Pathways"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9671-9340","authenticated-orcid":false,"given":"Mohamed A.","family":"Eldeeb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Ragheb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa H.","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Fahlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"key":"396_CR1","doi-asserted-by":"publisher","first-page":"4277","DOI":"10.1523\/JNEUROSCI.5078-05.2006","volume":"26","author":"CG Almeida","year":"2006","unstructured":"Almeida CG, Takahashi RH, Gouras GK (2006) \u03b2-Amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system. J Neurosci 26:4277\u20134288","journal-title":"J Neurosci"},{"key":"396_CR2","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.bbamcr.2011.08.007","volume":"1823","author":"DC Altieri","year":"2012","unstructured":"Altieri DC, Stein GS, Lian JB, Languino LR (2012) TRAP-1, the mitochondrial Hsp90. Biochim Biophys Acta Mol Cell Res 1823:767\u2013773","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"396_CR3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/978-3-540-34449-0_5","volume-title":"Alternative splicing and disease","author":"A Andreadis","year":"2006","unstructured":"Andreadis A (2006) Misregulation of tau alternative splicing in neurodegeneration and dementia. In: Jeanteur P (ed) Alternative splicing and disease. Springer, Berlin Heidelberg, Berlin, Heidelberg, pp 89\u2013107"},{"key":"396_CR4","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.bbrc.2006.10.093","volume":"351","author":"T Arai","year":"2006","unstructured":"Arai T, Hasegawa M, Akiyama H et al (2006) TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun 351:602\u2013611. https:\/\/doi.org\/10.1016\/j.bbrc.2006.10.093","journal-title":"Biochem Biophys Res Commun"},{"key":"396_CR5","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1212\/WNL.42.3.631","volume":"42","author":"PV Arriagada","year":"1992","unstructured":"Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer\u2019s disease. Neurology 42:631\u2013639. https:\/\/doi.org\/10.1212\/WNL.42.3.631","journal-title":"Neurology"},{"key":"396_CR6","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/emboj.2010.310","volume":"30","author":"YM Ayala","year":"2011","unstructured":"Ayala YM, De Conti L, Avenda\u00f1o-V\u00e1zquez SE et al (2011) TDP-43 regulates its mRNA levels through a negative feedback loop. EMBO J 30:277\u2013288. https:\/\/doi.org\/10.1038\/emboj.2010.310","journal-title":"EMBO J"},{"key":"396_CR7","doi-asserted-by":"publisher","first-page":"3778","DOI":"10.1242\/jcs.038950","volume":"121","author":"YM Ayala","year":"2008","unstructured":"Ayala YM, Zago P, Ambrogio A et al (2008) Structural determinants of the cellular localization and shuttling of TDP-43. J Cell Sci 121:3778\u20133785. https:\/\/doi.org\/10.1242\/jcs.038950","journal-title":"J Cell Sci"},{"key":"396_CR8","first-page":"879","volume":"152","author":"M Baba","year":"1998","unstructured":"Baba M, Nakajo S, Tu P-H et al (1998) Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson\u2019s disease and dementia with Lewy bodies. Am J Pathol 152:879","journal-title":"Am J Pathol"},{"key":"396_CR9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1126\/science.3018930","volume":"234","author":"A Bachmair","year":"1986","unstructured":"Bachmair A, Finley D, Varshavsky A (1986) In vivo half-life of a protein is a function of its amino-terminal residue. Science 234:179\u2013186","journal-title":"Science"},{"key":"396_CR10","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.dadm.2016.09.002","volume":"6","author":"JE Baker","year":"2017","unstructured":"Baker JE, Lim YY, Pietrzak RH et al (2017) Cognitive impairment and decline in cognitively normal older adults with high amyloid-\u03b2: A meta-analysis. Alzheimers Dement 6:108\u2013121. https:\/\/doi.org\/10.1016\/j.dadm.2016.09.002","journal-title":"Alzheimers Dement"},{"key":"396_CR11","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3389\/fnagi.2019.00204","volume":"11","author":"P Barbier","year":"2019","unstructured":"Barbier P, Zejneli O, Martinho M et al (2019) Role of Tau as a microtubule-associated protein: structural and functional aspects. Front Aging Neurosci 11:204. https:\/\/doi.org\/10.3389\/fnagi.2019.00204","journal-title":"Front Aging Neurosci"},{"key":"396_CR12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fgene.2017.00058","volume":"8","author":"EP Barykin","year":"2017","unstructured":"Barykin EP, Mitkevich VA, Kozin SA, Makarov AA (2017) Amyloid \u03b2 modification: a key to the sporadic Alzheimer\u2019s disease? Front Genet 8:58","journal-title":"Front Genet"},{"key":"396_CR13","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.neuron.2013.09.004","volume":"79","author":"JT Bendor","year":"2013","unstructured":"Bendor JT, Logan TP, Edwards RH (2013) The function of \u03b1-synuclein. Neuron 79:1044\u20131066","journal-title":"Neuron"},{"key":"396_CR14","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3389\/fnins.2019.00335","volume":"13","author":"BA Berning","year":"2019","unstructured":"Berning BA, Walker AK (2019) The pathobiology of TDP-43 C-terminal fragments in ALS and FTLD. Front Neurosci 13:335","journal-title":"Front Neurosci"},{"key":"396_CR15","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1083\/jcb.131.5.1327","volume":"131","author":"R Brandt","year":"1995","unstructured":"Brandt R, L\u00e9ger J, Lee G (1995) Interaction of tau with the neural plasma membrane mediated by tau\u2019s amino-terminal projection domain. J Cell Biol 131:1327\u20131340","journal-title":"J Cell Biol"},{"key":"396_CR16","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.molcel.2013.02.009","volume":"50","author":"CS Brower","year":"2013","unstructured":"Brower CS, Piatkov KI, Varshavsky A (2013) Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway. Mol Cell 50:161\u2013171","journal-title":"Mol Cell"},{"key":"396_CR17","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0165-0173(00)00019-9","volume":"33","author":"L Bu\u00e9e","year":"2000","unstructured":"Bu\u00e9e L, Bussi\u00e8re T, Bu\u00e9e-Scherrer V et al (2000) Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Rev 33:95\u2013130. https:\/\/doi.org\/10.1016\/S0165-0173(00)00019-9","journal-title":"Brain Res Rev"},{"key":"396_CR18","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1080\/14728222.2018.1439923","volume":"22","author":"E Buratti","year":"2018","unstructured":"Buratti E (2018) TDP-43 post-translational modifications in health and disease. Expert Opin Ther Targets 22:279\u2013293. https:\/\/doi.org\/10.1080\/14728222.2018.1439923","journal-title":"Expert Opin Ther Targets"},{"key":"396_CR19","doi-asserted-by":"publisher","first-page":"867","DOI":"10.2741\/2727","volume":"13","author":"E Buratti","year":"2008","unstructured":"Buratti E, Baralle FE (2008) Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease. Front Biosci 13:867\u2013878","journal-title":"Front Biosci"},{"key":"396_CR20","doi-asserted-by":"publisher","first-page":"37572","DOI":"10.1074\/jbc.M505557200","volume":"280","author":"E Buratti","year":"2005","unstructured":"Buratti E, Brindisi A, Giombi M et al (2005) TDP-43 binds heterogeneous nuclear ribonucleoprotein A\/B through its C-terminal tail an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing. J Biol Chem 280:37572\u201337584","journal-title":"J Biol Chem"},{"key":"396_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/wrna.100","volume":"3","author":"A Busch","year":"2012","unstructured":"Busch A, Hertel KJ (2012) Evolution of SR protein and hnRNP splicing regulatory factors. Wires RNA 3:1\u201312. https:\/\/doi.org\/10.1002\/wrna.100","journal-title":"Wires RNA"},{"key":"396_CR22","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.mod.2012.11.001","volume":"130","author":"JH Caldwell","year":"2013","unstructured":"Caldwell JH, Klevanski M, Saar M, M\u00fcller UC (2013) Roles of the amyloid precursor protein family in the peripheral nervous system. Mech Dev 130:433\u2013446. https:\/\/doi.org\/10.1016\/j.mod.2012.11.001","journal-title":"Mech Dev"},{"key":"396_CR23","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1096\/fj.06-5716fje","volume":"20","author":"R Carrotta","year":"2006","unstructured":"Carrotta R, Carlo MD, Manno M et al (2006) Toxicity of recombinant \u03b2-amyloid prefibrillar oligomers on the morphogenesis of the sea urchin Paracentrotus lividus. FASEB J 20:1916\u20131917. https:\/\/doi.org\/10.1096\/fj.06-5716fje","journal-title":"FASEB J"},{"key":"396_CR24","doi-asserted-by":"publisher","first-page":"5609","DOI":"10.1096\/fj.201700292RR","volume":"31","author":"R Cascella","year":"2017","unstructured":"Cascella R, Fani G, Capitini C et al (2017) Quantitative assessment of the degradation of aggregated TDP-43 mediated by the ubiquitin proteasome system and macroautophagy. FASEB J 31:5609\u20135624. https:\/\/doi.org\/10.1096\/fj.201700292RR","journal-title":"FASEB J"},{"key":"396_CR25","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/0361-9230(93)90276-H","volume":"30","author":"G Chakraborty","year":"1993","unstructured":"Chakraborty G, Ingoglia NA (1993) N-terminal arginylation and ubiquitin-mediated proteolysis in nerve regeneration. Brain Res Bull 30:439\u2013445. https:\/\/doi.org\/10.1016\/0361-9230(93)90276-H","journal-title":"Brain Res Bull"},{"key":"396_CR26","doi-asserted-by":"publisher","first-page":"16725","DOI":"10.1038\/s41598-018-35130-y","volume":"8","author":"HH Chen","year":"2018","unstructured":"Chen HH, Liu P, Auger P et al (2018) Calpain-mediated tau fragmentation is altered in Alzheimer\u2019s disease progression. Sci Rep 8:16725. https:\/\/doi.org\/10.1038\/s41598-018-35130-y","journal-title":"Sci Rep"},{"key":"396_CR27","doi-asserted-by":"crossref","unstructured":"Chen SJ, Wu X, Wadas B et al (2017) An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes. Science 355: eaal3655.","DOI":"10.1126\/science.aal3655"},{"key":"396_CR28","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/0888-7543(95)80237-G","volume":"26","author":"X Chen","year":"1995","unstructured":"Chen X, de Silva HR, Pettenati MJ (1995) The human NACP\/alpha-synuclein gene: Chromosome assignment to 4q21. 3\u2013q22 and TaqI RFLP analysis. Genomics 26:425\u2013427","journal-title":"Genomics"},{"key":"396_CR29","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3389\/fneur.2013.00122","volume":"4","author":"A Chesser","year":"2013","unstructured":"Chesser A, Pritchard S, Johnson GV (2013) Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease. Front Neurol 4:122","journal-title":"Front Neurol"},{"key":"396_CR30","doi-asserted-by":"publisher","first-page":"5862","DOI":"10.1021\/bi0500123","volume":"44","author":"CN Chirita","year":"2005","unstructured":"Chirita CN, Congdon EE, Yin H, Kuret J (2005) Triggers of full-length tau aggregation: a role for partially folded intermediates. Biochemistry 44:5862\u20135872. https:\/\/doi.org\/10.1021\/bi0500123","journal-title":"Biochemistry"},{"key":"396_CR31","doi-asserted-by":"publisher","first-page":"14168","DOI":"10.1074\/jbc.M111.222430","volume":"286","author":"D-H Choi","year":"2011","unstructured":"Choi D-H, Kim Y-J, Kim Y-G et al (2011) Role of matrix metalloproteinase 3-mediated \u03b1-synuclein cleavage in dopaminergic cell death. J Biol Chem 286:14168\u201314177","journal-title":"J Biol Chem"},{"key":"396_CR32","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s10571-017-0574-1","volume":"38","author":"FP Chong","year":"2018","unstructured":"Chong FP, Ng KY, Koh RY, Chye SM (2018) Tau proteins and tauopathies in Alzheimer\u2019s disease. Cell Mol Neurobiol 38:965\u2013980. https:\/\/doi.org\/10.1007\/s10571-017-0574-1","journal-title":"Cell Mol Neurobiol"},{"key":"396_CR33","doi-asserted-by":"publisher","first-page":"15635","DOI":"10.1074\/jbc.M111.333450","volume":"287","author":"C Colombrita","year":"2012","unstructured":"Colombrita C, Onesto E, Megiorni F et al (2012) TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells. J Biol Chem 287:15635\u201315647. https:\/\/doi.org\/10.1074\/jbc.M111.333450","journal-title":"J Biol Chem"},{"key":"396_CR34","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1126\/science.1063522","volume":"294","author":"KA Conway","year":"2001","unstructured":"Conway KA, Rochet J-C, Bieganski RM, Lansbury PT (2001) Kinetic stabilization of the \u03b1-synuclein protofibril by a dopamine-\u03b1-synuclein adduct. Science 294:1346\u20131349","journal-title":"Science"},{"key":"396_CR35","doi-asserted-by":"publisher","first-page":"3590","DOI":"10.1074\/jbc.272.6.3590","volume":"272","author":"B De Strooper","year":"1997","unstructured":"De Strooper B, Beullens M, Contreras B et al (1997) Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer\u2019s disease-associated presenilins. J Biol Chem 272:3590\u20133598. https:\/\/doi.org\/10.1074\/jbc.272.6.3590","journal-title":"J Biol Chem"},{"key":"396_CR36","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1093\/hmg\/ddq526","volume":"20","author":"E Deas","year":"2010","unstructured":"Deas E, Plun-Favreau H, Gandhi S et al (2010) PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum Mol Genet 20:867\u2013879","journal-title":"Hum Mol Genet"},{"key":"396_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.febslet.2004.11.018","volume":"579","author":"P Delobel","year":"2005","unstructured":"Delobel P, Leroy O, Hamdane M et al (2005) Proteasome inhibition and Tau proteolysis: an unexpected regulation. FEBS Lett 579:1\u20135. https:\/\/doi.org\/10.1016\/j.febslet.2004.11.018","journal-title":"FEBS Lett"},{"key":"396_CR38","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/S0028-3908(03)00140-0","volume":"45","author":"KK Dev","year":"2003","unstructured":"Dev KK, Hofele K, Barbieri S et al (2003) Part II: \u03b1-synuclein and its molecular pathophysiological role in neurodegenerative disease. Neuropharmacology 45:14\u201344","journal-title":"Neuropharmacology"},{"key":"396_CR39","first-page":"449","volume-title":"Wilson L","author":"F Devred","year":"2010","unstructured":"Devred F, Barbier P, Lafitte D et al (2010) Chapter 23 - Microtubule and MAPs: thermodynamics of complex formation by AUC, ITC, fluorescence, and NMR. In: Correia JJ (ed) Wilson L. Methods Cell Biol, Academic Press, pp 449\u2013480"},{"key":"396_CR40","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1146\/annurev-biochem-061516-044908","volume":"86","author":"I Dikic","year":"2017","unstructured":"Dikic I (2017) Proteasomal and autophagic degradation systems. Annu Rev Biochem 86:193\u2013224","journal-title":"Annu Rev Biochem"},{"key":"396_CR41","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1111\/nph.14619","volume":"218","author":"N Dissmeyer","year":"2018","unstructured":"Dissmeyer N, Rivas S, Graciet E (2018) Life and death of proteins after protease cleavage: protein degradation by the N-end rule pathway. New Phytol 218:929\u2013935","journal-title":"New Phytol"},{"key":"396_CR42","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1126\/science.1152993","volume":"319","author":"R Dixit","year":"2008","unstructured":"Dixit R, Ross JL, Goldman YE, Holzbaur ELF (2008) Differential regulation of dynein and kinesin motor proteins by tau. Science 319:1086\u20131089. https:\/\/doi.org\/10.1126\/science.1152993","journal-title":"Science"},{"key":"396_CR43","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/nrm760","volume":"3","author":"G Dreyfuss","year":"2002","unstructured":"Dreyfuss G, Kim VN, Kataoka N (2002) Messenger-RNA-binding proteins and the messages they carry. Nat Rev Mol Cell Biol 3:195\u2013205. https:\/\/doi.org\/10.1038\/nrm760","journal-title":"Nat Rev Mol Cell Biol"},{"key":"396_CR44","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1002\/cm.20243","volume":"65","author":"M Dubey","year":"2008","unstructured":"Dubey M, Chaudhury P, Kabiru H, Shea TB (2008) Tau inhibits anterograde axonal transport and perturbs stability in growing axonal neurites in part by displacing kinesin cargo: Neurofilaments attenuate tau-mediated neurite instability. Cell Motil 65:89\u201399. https:\/\/doi.org\/10.1002\/cm.20243","journal-title":"Cell Motil"},{"key":"396_CR45","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1101\/gad.262758.115","volume":"29","author":"TM Durcan","year":"2015","unstructured":"Durcan TM, Fon EA (2015) The three \u2018P\u2019s of mitophagy: PARKIN, PINK1, and post-translational modifications. Genes Dev 29:989\u2013999","journal-title":"Genes Dev"},{"key":"396_CR46","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/s41594-019-0291-1","volume":"26","author":"M Eldeeb","year":"2019","unstructured":"Eldeeb M, Esmaili M, Fahlman R (2019a) Degradation of proteins with N-terminal glycine. Nat Struct Mol Biol 26:761\u2013763","journal-title":"Nat Struct Mol Biol"},{"key":"396_CR47","doi-asserted-by":"publisher","first-page":"343","DOI":"10.2174\/0929866523666160108115809","volume":"23","author":"M Eldeeb","year":"2016","unstructured":"Eldeeb M, Fahlman R (2016a) The-N-end rule: the beginning determines the end. Protein Pept Lett 23:343\u2013348","journal-title":"Protein Pept Lett"},{"key":"396_CR48","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.tcb.2020.04.007","volume":"30","author":"MA Eldeeb","year":"2020","unstructured":"Eldeeb MA, Bayne AN, Trempe J-F, Fon EA (2020a) Fine-tuning TOM-mitochondrial import via ubiquitin. Trends Cell Biol 30:425\u2013427. https:\/\/doi.org\/10.1016\/j.tcb.2020.04.007","journal-title":"Trends Cell Biol"},{"key":"396_CR49","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.18632\/oncotarget.1931","volume":"5","author":"MA Eldeeb","year":"2014","unstructured":"Eldeeb MA, Fahlman RP (2014) The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway. Oncotarget 5:2714\u20132722","journal-title":"Oncotarget"},{"key":"396_CR50","doi-asserted-by":"publisher","first-page":"22757","DOI":"10.1074\/jbc.M116.737387","volume":"291","author":"MA Eldeeb","year":"2016","unstructured":"Eldeeb MA, Fahlman RP (2016b) Phosphorylation impacts N-end rule degradation of the proteolytically activated form of BMX kinase. J Biol Chem 291:22757\u201322768","journal-title":"J Biol Chem"},{"key":"396_CR51","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.tibs.2018.04.008","volume":"43","author":"MA Eldeeb","year":"2018","unstructured":"Eldeeb MA, Fahlman RP (2018) Does too much MAGIC lead to mitophagy? Trends Biochem Sci 43:485\u2013487","journal-title":"Trends Biochem Sci"},{"key":"396_CR52","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.tibs.2018.12.008","volume":"44","author":"MA Eldeeb","year":"2019","unstructured":"Eldeeb MA, Fahlman RP, Esmaili M, Fon EA (2019b) Formylation of eukaryotic cytoplasmic proteins: linking stress to degradation. Trends Biochem Sci 44:181\u2013183. https:\/\/doi.org\/10.1016\/j.tibs.2018.12.008","journal-title":"Trends Biochem Sci"},{"key":"396_CR53","doi-asserted-by":"publisher","first-page":"3414","DOI":"10.3390\/ijms19113414","volume":"19","author":"MA Eldeeb","year":"2018","unstructured":"Eldeeb MA, Fahlman RP, Esmaili M, Ragheb MA (2018a) Regulating apoptosis by degradation: the N-end rule-mediated regulation of apoptotic proteolytic fragments in mammalian cells. Int J Mol Sci 19:3414","journal-title":"Int J Mol Sci"},{"key":"396_CR54","doi-asserted-by":"publisher","first-page":"1800167","DOI":"10.1002\/bies.201800167","volume":"41","author":"MA Eldeeb","year":"2019","unstructured":"Eldeeb MA, Fahlman RP, Ragheb MA, Esmaili M (2019c) Does N-terminal protein acetylation lead to protein degradation? BioEssays 41:1800167","journal-title":"BioEssays"},{"key":"396_CR55","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1139\/bcb-2017-0274","volume":"96","author":"MA Eldeeb","year":"2018","unstructured":"Eldeeb MA, Leitao LC, Fahlman RP (2018b) Emerging branches of the N-end rule pathways are revealing the sequence complexities of N-termini dependent protein degradation. Biochem Cell Biol 96:289\u2013294","journal-title":"Biochem Cell Biol"},{"key":"396_CR56","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s00294-020-01062-2","volume":"66","author":"MA Eldeeb","year":"2020","unstructured":"Eldeeb MA, Ragheb MA (2020) N-degron-mediated degradation and regulation of mitochondrial PINK1 kinase. Curr Genet 66:693\u2013701. https:\/\/doi.org\/10.1007\/s00294-020-01062-2","journal-title":"Curr Genet"},{"key":"396_CR57","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s00294-020-01056-0","volume":"66","author":"MA Eldeeb","year":"2020","unstructured":"Eldeeb MA, Ragheb MA, Esmaili M (2020b) How does protein degradation regulate TOM machinery-dependent mitochondrial import? Curr Genet 66:501\u2013505. https:\/\/doi.org\/10.1007\/s00294-020-01056-0","journal-title":"Curr Genet"},{"key":"396_CR58","doi-asserted-by":"publisher","first-page":"251","DOI":"10.2174\/0929866526666191026111951","volume":"27","author":"MA Eldeeb","year":"2020","unstructured":"Eldeeb MA, Ragheb MA, Esmaili M, Hussein F (2020c) Physiological state dictates the proteasomal-mediated purging of misfolded protein fragments. Protein Pept Lett 27:251\u2013255. https:\/\/doi.org\/10.2174\/0929866526666191026111951","journal-title":"Protein Pept Lett"},{"key":"396_CR59","doi-asserted-by":"publisher","first-page":"R588","DOI":"10.1016\/j.cub.2019.05.004","volume":"29","author":"MA Eldeeb","year":"2019","unstructured":"Eldeeb MA, Ragheb MA, Fon EA (2019d) Cell death: N-degrons fine-tune pyroptotic cell demise. Curr Biol 29:R588\u2013R591","journal-title":"Curr Biol"},{"key":"396_CR60","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/jnc.14838","volume":"151","author":"MA Eldeeb","year":"2019","unstructured":"Eldeeb MA, Siva-Piragasam R, Ragheb MA et al (2019e) A molecular toolbox for studying protein degradation in mammalian cells. J Neurochem 151:520\u2013533. https:\/\/doi.org\/10.1111\/jnc.14838","journal-title":"J Neurochem"},{"key":"396_CR61","doi-asserted-by":"publisher","first-page":"2000212","DOI":"10.1002\/bies.202000212","volume":"43","author":"MA Eldeeb","year":"2021","unstructured":"Eldeeb MA, Zorca CE, Ragheb MA et al (2021) Fine-tuning ER-phagy by post-translational modifications. BioEssays 43:2000212. https:\/\/doi.org\/10.1002\/bies.202000212","journal-title":"BioEssays"},{"key":"396_CR62","doi-asserted-by":"publisher","first-page":"19393","DOI":"10.1038\/srep19393","volume":"6","author":"M F\u00e1","year":"2016","unstructured":"F\u00e1 M, Puzzo D, Piacentini R et al (2016) Extracellular tau oligomers produce an immediate impairment of LTP and memory. Sci Rep 6:19393. https:\/\/doi.org\/10.1038\/srep19393","journal-title":"Sci Rep"},{"key":"396_CR63","doi-asserted-by":"publisher","first-page":"15616","DOI":"10.1073\/pnas.1901805116","volume":"116","author":"VM Fava","year":"2019","unstructured":"Fava VM, Xu YZ, Lettre G et al (2019) Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson\u2019s disease. Proc Natl Acad Sci U S A 116:15616\u201315624","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR64","doi-asserted-by":"publisher","first-page":"676","DOI":"10.2119\/molmed.2010.00220","volume":"17","author":"A Ferreira","year":"2011","unstructured":"Ferreira A, Bigio EH (2011) Calpain-mediated Tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies. Mol Med 17:676\u2013685. https:\/\/doi.org\/10.2119\/molmed.2010.00220","journal-title":"Mol Med"},{"key":"396_CR65","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1021\/pr901076y","volume":"9","author":"BD Freibaum","year":"2010","unstructured":"Freibaum BD, Chitta RK, High AA, Taylor JP (2010) Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. J Proteome Res 9:1104\u20131120","journal-title":"J Proteome Res"},{"key":"396_CR66","doi-asserted-by":"publisher","first-page":"10032","DOI":"10.1073\/pnas.1630428100","volume":"100","author":"TC Gamblin","year":"2003","unstructured":"Gamblin TC, Chen F, Zambrano A et al (2003) Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer\u2019s disease. Proc Natl Acad Sci U S A 100:10032\u201310037. https:\/\/doi.org\/10.1073\/pnas.1630428100","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2010.09.008","volume":"32","author":"S Garg","year":"2011","unstructured":"Garg S, Timm T, Mandelkow E-M et al (2011) Cleavage of Tau by calpain in Alzheimer\u2019s disease: the quest for the toxic 17 kD fragment. Neurobiol Aging 32:1\u201314. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2010.09.008","journal-title":"Neurobiol Aging"},{"key":"396_CR68","doi-asserted-by":"publisher","first-page":"8065","DOI":"10.1074\/jbc.RA117.000490","volume":"293","author":"A Gauthier-Kemper","year":"2018","unstructured":"Gauthier-Kemper A, Alonso MS, S\u00fcndermann F et al (2018) Annexins A2 and A6 interact with the extreme N-terminus of tau and thereby contribute to tau\u2019s axonal localization. J Biol Chem 293:8065\u20138076","journal-title":"J Biol Chem"},{"key":"396_CR69","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1750-1326-4-13","volume":"4","author":"TF Gendron","year":"2009","unstructured":"Gendron TF, Petrucelli L (2009) The role of tau in neurodegeneration. Mol Neurodegener 4:13. https:\/\/doi.org\/10.1186\/1750-1326-4-13","journal-title":"Mol Neurodegener"},{"key":"396_CR70","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nrneurol.2013.223","volume":"9","author":"E Giacobini","year":"2013","unstructured":"Giacobini E, Gold G (2013) Alzheimer disease therapy-moving from amyloid-\u03b2 to tau. Nat Rev Neurol 9:677\u2013686. https:\/\/doi.org\/10.1038\/nrneurol.2013.223","journal-title":"Nat Rev Neurol"},{"key":"396_CR71","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.tcb.2014.05.001","volume":"24","author":"DJ Gibbs","year":"2014","unstructured":"Gibbs DJ, Bacardit J, Bachmair A, Holdsworth MJ (2014) The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions. Trends Cell Biol 24:603\u2013611","journal-title":"Trends Cell Biol"},{"key":"396_CR72","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/349704a0","volume":"349","author":"A Goate","year":"1991","unstructured":"Goate A, Chartier-Harlin M-C, Mullan M et al (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer\u2019s disease. Nature 349:704\u2013706. https:\/\/doi.org\/10.1038\/349704a0","journal-title":"Nature"},{"key":"396_CR73","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1002\/1873-3468.13108","volume":"592","author":"M Goedert","year":"2018","unstructured":"Goedert M (2018) Tau filaments in neurodegenerative diseases. FEBS Lett 592:2383\u20132391. https:\/\/doi.org\/10.1002\/1873-3468.13108","journal-title":"FEBS Lett"},{"key":"396_CR74","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1146\/annurev-neuro-072116-031153","volume":"40","author":"M Goedert","year":"2017","unstructured":"Goedert M, Eisenberg DS, Crowther RA (2017) Propagation of tau aggregates and neurodegeneration. Annu Rev Neurosci 40:189\u2013210","journal-title":"Annu Rev Neurosci"},{"key":"396_CR75","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/0896-6273(89)90210-9","volume":"3","author":"M Goedert","year":"1989","unstructured":"Goedert M, Spillantini M, Jakes R et al (1989a) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer\u2019s disease. Neuron 3:519\u2013526","journal-title":"Neuron"},{"key":"396_CR76","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1002\/j.1460-2075.1989.tb03390.x","volume":"8","author":"M Goedert","year":"1989","unstructured":"Goedert M, Spillantini MG, Potier MC et al (1989b) Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain. EMBO J 8:393\u2013399. https:\/\/doi.org\/10.1002\/j.1460-2075.1989.tb03390.x","journal-title":"EMBO J"},{"key":"396_CR77","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1111\/j.1474-9726.2010.00632.x","volume":"9","author":"B Gong","year":"2010","unstructured":"Gong B, Chen F, Pan Y et al (2010) SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer\u2019s disease amyloidosis and improves synaptic function. Aging Cell 9:1018\u20131031","journal-title":"Aging Cell"},{"key":"396_CR78","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0002-9440(10)64700-1","volume":"156","author":"GK Gouras","year":"2000","unstructured":"Gouras GK, Tsai J, Naslund J et al (2000) Intraneuronal A\u03b242 accumulation in human brain. Am J Pathol 156:15\u201320. https:\/\/doi.org\/10.1016\/S0002-9440(10)64700-1","journal-title":"Am J Pathol"},{"key":"396_CR79","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1074\/jbc.272.1.58","volume":"272","author":"L Gregori","year":"1997","unstructured":"Gregori L, Hainfeld JF, Simon MN, Goldgaber D (1997) Binding of amyloid \u03b2 protein to the 20 S proteasome. J Biol Chem 272:58\u201362","journal-title":"J Biol Chem"},{"key":"396_CR80","doi-asserted-by":"publisher","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","volume":"83","author":"I Grundke-Iqbal","year":"1986","unstructured":"Grundke-Iqbal I, Iqbal K, Tung YC et al (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A 83:4913\u20134917. https:\/\/doi.org\/10.1073\/pnas.83.13.4913","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR81","doi-asserted-by":"crossref","unstructured":"Guo L, Shorter J (2017) Biology and pathobiology of TDP-43 and emergent therapeutic strategies. Cold Spring Harb Perspect Med 7: a024554.","DOI":"10.1101\/cshperspect.a024554"},{"key":"396_CR82","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s00401-017-1707-9","volume":"133","author":"T Guo","year":"2017","unstructured":"Guo T, Noble W, Hanger DP (2017) Roles of tau protein in health and disease. Acta Neuropathol 133:665\u2013704. https:\/\/doi.org\/10.1007\/s00401-017-1707-9","journal-title":"Acta Neuropathol"},{"key":"396_CR83","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.4161\/15548627.2014.981914","volume":"10","author":"M Haller","year":"2014","unstructured":"Haller M, Hock AK, Giampazolias E et al (2014) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy 10:2269\u20132278. https:\/\/doi.org\/10.4161\/15548627.2014.981914","journal-title":"Autophagy"},{"key":"396_CR84","doi-asserted-by":"publisher","first-page":"51654","DOI":"10.1074\/jbc.M404500200","volume":"279","author":"CA Hansson","year":"2004","unstructured":"Hansson CA, Frykman S, Farmery MR et al (2004) Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria. J Biol Chem 279:51654\u201351660. https:\/\/doi.org\/10.1074\/jbc.M404500200","journal-title":"J Biol Chem"},{"key":"396_CR85","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1073\/pnas.0705363105","volume":"105","author":"ME Haque","year":"2008","unstructured":"Haque ME, Thomas KJ, D\u2019Souza C et al (2008) Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. Proc Natl Acad Sci U S A 105:1716\u20131721","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR86","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","volume":"297","author":"J Hardy","year":"2002","unstructured":"Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapeutics. Science 297:353\u2013356. https:\/\/doi.org\/10.1126\/science.1072994","journal-title":"Science"},{"key":"396_CR87","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1126\/science.1566067","volume":"256","author":"JA Hardy","year":"1992","unstructured":"Hardy JA, Higgins GA (1992) Alzheimer\u2019s disease: the amyloid cascade hypothesis. Science 256:184\u2013186","journal-title":"Science"},{"key":"396_CR88","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1111\/j.1471-4159.2006.04184.x","volume":"99","author":"G He","year":"2006","unstructured":"He G, Qing H, Cai F et al (2006) Ubiquitin\u2013proteasome pathway mediates degradation of APH-1. J Neurochem 99:1403\u20131412. https:\/\/doi.org\/10.1111\/j.1471-4159.2006.04184.x","journal-title":"J Neurochem"},{"key":"396_CR89","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1111\/j.1471-4159.2007.04449.x","volume":"101","author":"G He","year":"2007","unstructured":"He G, Qing H, Tong Y et al (2007) Degradation of nicastrin involves both proteasome and lysosome. J Neurochem 101:982\u2013992","journal-title":"J Neurochem"},{"key":"396_CR90","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1007\/s00018-008-8532-1","volume":"66","author":"Y He","year":"2009","unstructured":"He Y, Smith R (2009) Nuclear functions of heterogeneous nuclear ribonucleoproteins A\/B. Cell Mol Life Sci 66:1239\u20131256. https:\/\/doi.org\/10.1007\/s00018-008-8532-1","journal-title":"Cell Mol Life Sci"},{"key":"396_CR91","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.molcel.2015.08.016","volume":"60","author":"J-M Heo","year":"2015","unstructured":"Heo J-M, Ordureau A, Paulo JA et al (2015) The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of OPTN\/NDP52 recruitment and TBK1 activation to promote mitophagy. Mol Cell 60:7\u201320","journal-title":"Mol Cell"},{"key":"396_CR92","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1128\/mcb.9.4.1381","volume":"9","author":"A Himmler","year":"1989","unstructured":"Himmler A, Drechsel D, Kirschner MW, Martin DW (1989) Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains. Mol Cell Biol 9:1381\u20131388. https:\/\/doi.org\/10.1128\/mcb.9.4.1381","journal-title":"Mol Cell Biol"},{"key":"396_CR93","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1179\/1743132813Y.0000000288","volume":"36","author":"L Hong","year":"2014","unstructured":"Hong L, Huang H-C, Jiang Z-F (2014) Relationship between amyloid-beta and the ubiquitin\u2013proteasome system in Alzheimer\u2019s disease. Neurol Res 36:276\u2013282. https:\/\/doi.org\/10.1179\/1743132813Y.0000000288","journal-title":"Neurol Res"},{"key":"396_CR94","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-981-10-6674-0_10","volume-title":"Mitochondrial DNA and Diseases","author":"J Hou","year":"2017","unstructured":"Hou J, Eldeeb M, Wang X (2017) Beyond deubiquitylation: Usp30-mediated regulation of mitochondrial homeostasis. In: Sun H, Wang X (eds) Mitochondrial DNA and Diseases. Springer, Singapore, pp 133\u2013148"},{"key":"396_CR95","doi-asserted-by":"publisher","first-page":"11253","DOI":"10.1073\/pnas.1818530116","volume":"116","author":"Z-W Hu","year":"2019","unstructured":"Hu Z-W, Vugmeyster L, Au DF et al (2019) Molecular structure of an N-terminal phosphorylated \u03b2-amyloid fibril. Proc Natl Acad Sci U S A 116:11253\u201311258. https:\/\/doi.org\/10.1073\/pnas.1818530116","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR96","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1126\/science.1183147","volume":"327","author":"C-S Hwang","year":"2010","unstructured":"Hwang C-S, Shemorry A, Varshavsky A (2010) N-terminal acetylation of cellular proteins creates specific degradation signals. Science 327:973\u2013977","journal-title":"Science"},{"key":"396_CR97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002918","volume":"8","author":"K Iijima-Ando","year":"2012","unstructured":"Iijima-Ando K, Sekiya M, Maruko-Otake A et al (2012) Loss of axonal mitochondria promotes Tau-mediated neurodegeneration and Alzheimer\u2019s disease\u2013related Tau phosphorylation Via PAR-1. PLoS Genet 8:e1002918. https:\/\/doi.org\/10.1371\/journal.pgen.1002918","journal-title":"PLoS Genet"},{"key":"396_CR98","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/BF02935561","volume":"5","author":"K Iqbal","year":"1991","unstructured":"Iqbal K, Grundke-Iqbal I (1991) Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer\u2019s disease. Mol Neurobiol 5:399\u2013410. https:\/\/doi.org\/10.1007\/BF02935561","journal-title":"Mol Neurobiol"},{"key":"396_CR99","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/nrn2967","volume":"12","author":"LM Ittner","year":"2011","unstructured":"Ittner LM, G\u00f6tz J (2011) Amyloid-\u03b2 and tau - a toxic pas de deux in Alzheimer\u2019s disease. Nat Rev Neurosci 12:67\u201372. https:\/\/doi.org\/10.1038\/nrn2967","journal-title":"Nat Rev Neurosci"},{"key":"396_CR100","doi-asserted-by":"publisher","first-page":"4693","DOI":"10.1021\/bi00069a001","volume":"32","author":"JT Jarrett","year":"1993","unstructured":"Jarrett JT, Berger EP, Lansbury PT Jr (1993) The carboxy terminus of the b amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer\u2019s disease. Biochemistry 32:4693\u20134697","journal-title":"Biochemistry"},{"key":"396_CR101","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1083\/jcb.201008084","volume":"191","author":"SM Jin","year":"2010","unstructured":"Jin SM, Lazarou M, Wang C et al (2010) Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol 191:933\u2013942","journal-title":"J Cell Biol"},{"key":"396_CR102","doi-asserted-by":"publisher","first-page":"24944","DOI":"10.1074\/jbc.M114.580357","volume":"289","author":"S Kageyama","year":"2014","unstructured":"Kageyama S, Sou Y-s, Uemura T et al (2014) Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway. J Biol Chem 289:24944\u201324955","journal-title":"J Biol Chem"},{"key":"396_CR103","doi-asserted-by":"publisher","first-page":"e00243","DOI":"10.1128\/MCB.00243-18","volume":"38","author":"YAT Kasu","year":"2018","unstructured":"Kasu YAT, Alemu S, Lamari A et al (2018) The N termini of TAR DNA-binding protein 43 (TDP43) C-terminal fragments influence degradation, aggregation propensity, and morphology. Mol Cell Biol 38:e00243-e1218. https:\/\/doi.org\/10.1128\/MCB.00243-18","journal-title":"Mol Cell Biol"},{"key":"396_CR104","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.1073\/pnas.1112427109","volume":"109","author":"Y Kawahara","year":"2012","unstructured":"Kawahara Y, Mieda-Sato A (2012) TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. Proc Natl Acad Sci U S A 109:3347\u20133352. https:\/\/doi.org\/10.1073\/pnas.1112427109","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR105","doi-asserted-by":"publisher","first-page":"6134","DOI":"10.18632\/aging.102177","volume":"11","author":"OI Kechko","year":"2019","unstructured":"Kechko OI, Petrushanko IY, Brower CS et al (2019) Beta-amyloid induces apoptosis of neuronal cells by inhibition of the Arg\/N-end rule pathway proteolytic activity. Aging (albany NY) 11:6134\u20136152","journal-title":"Aging (albany NY)"},{"key":"396_CR106","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1046\/j.1471-4159.2003.01642.x","volume":"85","author":"S Keck","year":"2003","unstructured":"Keck S, Nitsch R, Grune T, Ullrich O (2003) Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer\u2019s disease. J Neurochem 85:115\u2013122. https:\/\/doi.org\/10.1046\/j.1471-4159.2003.01642.x","journal-title":"J Neurochem"},{"key":"396_CR107","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1046\/j.1471-4159.2000.0750436.x","volume":"75","author":"JN Keller","year":"2000","unstructured":"Keller JN, Hanni KB, Markesbery WR (2000) Impaired proteasome function in Alzheimer\u2019s disease. J Neurochem 75:436\u2013439. https:\/\/doi.org\/10.1046\/j.1471-4159.2000.0750436.x","journal-title":"J Neurochem"},{"key":"396_CR108","doi-asserted-by":"publisher","first-page":"5583","DOI":"10.1523\/JNEUROSCI.16-18-05583.1996","volume":"16","author":"M Kempf","year":"1996","unstructured":"Kempf M, Clement A, Faissner A et al (1996) Tau binds to the distal axon early in development of polarity in a microtubule-and microfilament-dependent manner. J Neurosci 16:5583\u20135592","journal-title":"J Neurosci"},{"key":"396_CR109","doi-asserted-by":"publisher","unstructured":"Kim J-M, Seok O-H, Ju S et al (2018) Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway. Science 362: eaat0174. https:\/\/doi.org\/10.1126\/science.aat0174.","DOI":"10.1126\/science.aat0174"},{"key":"396_CR110","doi-asserted-by":"publisher","first-page":"163","DOI":"10.5483\/BMBRep.2019.52.3.069","volume":"52","author":"JM Kim","year":"2019","unstructured":"Kim JM (2019) N-terminal formylmethionine as a novel initiator and N-degron of eukaryotic proteins. BMB Rep 52:163\u2013164. https:\/\/doi.org\/10.5483\/BMBRep.2019.52.3.069","journal-title":"BMB Rep"},{"key":"396_CR111","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1006\/nbdi.1999.0280","volume":"7","author":"S-H Kim","year":"2000","unstructured":"Kim S-H, Lah JJ, Thinakaran G et al (2000) Subcellular localization of presenilins: association with a unique membrane pool in cultured cells. Neurobiol Dis 7:99\u2013117","journal-title":"Neurobiol Dis"},{"key":"396_CR112","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","volume":"290","author":"DJ Klionsky","year":"2000","unstructured":"Klionsky DJ, Emr SD (2000) Autophagy as a regulated pathway of cellular degradation. Science 290:1717\u20131721. https:\/\/doi.org\/10.1126\/science.290.5497.1717","journal-title":"Science"},{"key":"396_CR113","doi-asserted-by":"crossref","unstructured":"Kondapalli C, Kazlauskaite A, Zhang N et al (2012) PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol 2: 120080.","DOI":"10.1098\/rsob.120080"},{"key":"396_CR114","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1016\/j.febslet.2009.12.047","volume":"584","author":"VI Korolchuk","year":"2010","unstructured":"Korolchuk VI, Menzies FM, Rubinsztein DC (2010) Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems. FEBS Lett 584:1393\u20131398. https:\/\/doi.org\/10.1016\/j.febslet.2009.12.047","journal-title":"FEBS Lett"},{"key":"396_CR115","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/nature13392","volume":"510","author":"F Koyano","year":"2014","unstructured":"Koyano F, Okatsu K, Kosako H et al (2014) Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature 510:162\u2013166. https:\/\/doi.org\/10.1038\/nature13392","journal-title":"Nature"},{"key":"396_CR116","doi-asserted-by":"publisher","first-page":"1700060","DOI":"10.1002\/pmic.201700060","volume":"17","author":"DA Kramer","year":"2017","unstructured":"Kramer DA, Eldeeb MA, Wuest M et al (2017) Proteomic characterization of EL4 lymphoma-derived tumors upon chemotherapy treatment reveals potential roles for lysosomes and caspase-6 during tumor cell death in vivo. Proteomics 17:1700060. https:\/\/doi.org\/10.1002\/pmic.201700060","journal-title":"Proteomics"},{"key":"396_CR117","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/S0955-0674(99)80051-9","volume":"11","author":"AM Krecic","year":"1999","unstructured":"Krecic AM, Swanson MS (1999) hnRNP complexes: composition, structure, and function. Curr Opin Cell Biol 11:363\u2013371. https:\/\/doi.org\/10.1016\/S0955-0674(99)80051-9","journal-title":"Curr Opin Cell Biol"},{"key":"396_CR118","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1016\/j.neurobiolaging.2011.11.009","volume":"33","author":"U Kr\u00fcger","year":"2012","unstructured":"Kr\u00fcger U, Wang Y, Kumar S, Mandelkow E-M (2012) Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Neurobiol Aging 33:2291\u20132305. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2011.11.009","journal-title":"Neurobiol Aging"},{"key":"396_CR119","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/alzrt258","volume":"6","author":"MP Kummer","year":"2014","unstructured":"Kummer MP, Heneka MT (2014) Truncated and modified amyloid-beta species. Alz Res Therapy 6:28. https:\/\/doi.org\/10.1186\/alzrt258","journal-title":"Alz Res Therapy"},{"key":"396_CR120","doi-asserted-by":"publisher","first-page":"6448","DOI":"10.1073\/pnas.95.11.6448","volume":"95","author":"MP Lambert","year":"1998","unstructured":"Lambert MP, Barlow AK, Chromy BA et al (1998) Diffusible, nonfibrillar ligands derived from A\u03b21\u201342 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A 95:6448\u20136453. https:\/\/doi.org\/10.1073\/pnas.95.11.6448","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR121","doi-asserted-by":"publisher","first-page":"3922","DOI":"10.1073\/pnas.96.7.3922","volume":"96","author":"S Lammich","year":"1999","unstructured":"Lammich S, Kojro E, Postina R et al (1999) Constitutive and regulated \u03b1-secretase cleavage of Alzheimer\u2019s amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci U S A 96:3922\u20133927. https:\/\/doi.org\/10.1073\/pnas.96.7.3922","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR122","doi-asserted-by":"publisher","first-page":"10039","DOI":"10.1021\/bi1016233","volume":"49","author":"CA Lasagna-Reeves","year":"2010","unstructured":"Lasagna-Reeves CA, Castillo-Carranza DL, Guerrero-Mu\u00f1oz MJ et al (2010) Preparation and characterization of neurotoxic tau oligomers. Biochemistry 49:10039\u201310041. https:\/\/doi.org\/10.1021\/bi1016233","journal-title":"Biochemistry"},{"key":"396_CR123","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.devcel.2011.12.014","volume":"22","author":"M Lazarou","year":"2012","unstructured":"Lazarou M, Jin SM, Kane LA, Youle RJ (2012) Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell 22:320\u2013333","journal-title":"Dev Cell"},{"key":"396_CR124","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/nrn3121","volume":"13","author":"EB Lee","year":"2012","unstructured":"Lee EB, Lee VMY, Trojanowski JQ (2012) Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nat Rev Neurosci 13:38\u201350. https:\/\/doi.org\/10.1038\/nrn3121","journal-title":"Nat Rev Neurosci"},{"key":"396_CR125","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.1242\/jcs.111.21.3167","volume":"111","author":"G Lee","year":"1998","unstructured":"Lee G, Newman ST, Gard DL et al (1998) Tau interacts with src-family non-receptor tyrosine kinases. J Cell Sci 111:3167\u20133177","journal-title":"J Cell Sci"},{"key":"396_CR126","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.neuroscience.2010.04.078","volume":"169","author":"KJ Lee","year":"2010","unstructured":"Lee KJ, Moussa CEH, Lee Y et al (2010) Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines. Neuroscience 169:344\u2013356. https:\/\/doi.org\/10.1016\/j.neuroscience.2010.04.078","journal-title":"Neuroscience"},{"key":"396_CR127","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1083\/jcb.200301115","volume":"163","author":"M-S Lee","year":"2003","unstructured":"Lee M-S, Kao S-C, Lemere CA et al (2003) APP processing is regulated by cytoplasmic phosphorylation. J Cell Biol 163:83\u201395. https:\/\/doi.org\/10.1083\/jcb.200301115","journal-title":"J Cell Biol"},{"key":"396_CR128","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1146\/annurev.neuro.24.1.1121","volume":"24","author":"VM Lee","year":"2001","unstructured":"Lee VM, Goedert M, Trojanowski JQ (2001) Neurodegenerative tauopathies. Annu Rev Neurosci 24:1121\u20131159","journal-title":"Annu Rev Neurosci"},{"key":"396_CR129","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1038\/sj.emboj.7600757","volume":"24","author":"M Leyssen","year":"2005","unstructured":"Leyssen M, Ayaz D, H\u00e9bert SS et al (2005) Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. EMBO J 24:2944\u20132955. https:\/\/doi.org\/10.1038\/sj.emboj.7600757","journal-title":"EMBO J"},{"key":"396_CR130","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1083\/jcb.201302044","volume":"201","author":"YR Li","year":"2013","unstructured":"Li YR, King OD, Shorter J, Gitler AD (2013) Stress granules as crucibles of ALS pathogenesis. J Cell Biol 201:361\u2013372","journal-title":"J Cell Biol"},{"key":"396_CR131","doi-asserted-by":"publisher","first-page":"5301","DOI":"10.1016\/S0021-9258(17)42989-9","volume":"259","author":"G Lindwall","year":"1984","unstructured":"Lindwall G, Cole RD (1984) Phosphorylation affects the ability of tau protein to promote microtubule assembly. J Biol Chem 259:5301\u20135305","journal-title":"J Biol Chem"},{"key":"396_CR132","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.neuron.2013.07.033","volume":"79","author":"S-C Ling","year":"2013","unstructured":"Ling S-C, Polymenidou M, Cleveland DW (2013) Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis. Neuron 79:416\u2013438","journal-title":"Neuron"},{"key":"396_CR133","doi-asserted-by":"publisher","first-page":"10804","DOI":"10.1073\/pnas.0400348101","volume":"101","author":"F Liu","year":"2004","unstructured":"Liu F, Iqbal K, Grundke-Iqbal I et al (2004) O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer\u2019s disease. Proc Natl Acad Sci U S A 101:10804\u201310809. https:\/\/doi.org\/10.1073\/pnas.0400348101","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR134","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1002\/1097-4547(20001015)62:2<302::aid-jnr15>3.0.co;2-l","volume":"62","author":"M L\u00f3pez Salon","year":"2000","unstructured":"L\u00f3pez Salon M, Morelli L, Casta\u00f1o EM et al (2000) Defective ubiquitination of cerebral proteins in Alzheimer\u2019s disease. J Neurosci Res 62:302\u2013310. https:\/\/doi.org\/10.1002\/1097-4547(20001015)62:2%3c302::aid-jnr15%3e3.0.co;2-l","journal-title":"J Neurosci Res"},{"key":"396_CR135","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0014-4886(02)00060-2","volume":"180","author":"M Lopez Salon","year":"2003","unstructured":"Lopez Salon M, Pasquini L, Besio Moreno M et al (2003) Relationship between \u03b2-amyloid degradation and the 26S proteasome in neural cells. Exp Neurol 180:131\u2013143. https:\/\/doi.org\/10.1016\/S0014-4886(02)00060-2","journal-title":"Exp Neurol"},{"key":"396_CR136","doi-asserted-by":"publisher","first-page":"15733","DOI":"10.1074\/jbc.M000389200","volume":"275","author":"T Maas","year":"2000","unstructured":"Maas T, Eidenm\u00fcller J, Brandt R (2000) Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments. J Biol Chem 275:15733\u201315740","journal-title":"J Biol Chem"},{"key":"396_CR137","doi-asserted-by":"publisher","first-page":"14697","DOI":"10.3390\/ijms150814697","volume":"15","author":"ILD Ma\u00efo","year":"2014","unstructured":"Ma\u00efo ILD, Barbier P, Allegro D et al (2014) Quantitative analysis of tau-microtubule interaction using FRET. Int J Mol Sci 15:14697\u201314714","journal-title":"Int J Mol Sci"},{"key":"396_CR138","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/0197-4580(95)00025-A","volume":"16","author":"EM Mandelkow","year":"1995","unstructured":"Mandelkow EM, Biernat J, Drewes G et al (1995) Tau domains, phosphorylation, and interactions with microtubules. Neurobiol Aging 16:355\u2013362. https:\/\/doi.org\/10.1016\/0197-4580(95)00025-A","journal-title":"Neurobiol Aging"},{"key":"396_CR139","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1001\/jama.296.6.661","volume":"296","author":"DM Maraganore","year":"2006","unstructured":"Maraganore DM, De Andrade M, Elbaz A et al (2006) Collaborative analysis of \u03b1-synuclein gene promoter variability and Parkinson disease. JAMA 296:661\u2013670","journal-title":"JAMA"},{"key":"396_CR140","doi-asserted-by":"publisher","first-page":"2804","DOI":"10.1523\/JNEUROSCI.08-08-02804.1988","volume":"8","author":"L Maroteaux","year":"1988","unstructured":"Maroteaux L, Campanelli JT, Scheller RH (1988) Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci 8:2804\u20132815","journal-title":"J Neurosci"},{"key":"396_CR141","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/978-0-387-77374-2_8","volume":"623","author":"R Martinez-Contreras","year":"2007","unstructured":"Martinez-Contreras R, Cloutier P, Shkreta L et al (2007) hnRNP proteins and splicing control. Adv Exp Med Biol 623:123\u2013147. https:\/\/doi.org\/10.1007\/978-0-387-77374-2_8","journal-title":"Adv Exp Med Biol"},{"key":"396_CR142","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1083\/jcb.200910140","volume":"189","author":"N Matsuda","year":"2010","unstructured":"Matsuda N, Sato S, Shiba K et al (2010) PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol 189:211\u2013221","journal-title":"J Cell Biol"},{"key":"396_CR143","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/nature02621","volume":"430","author":"MP Mattson","year":"2004","unstructured":"Mattson MP (2004) Pathways towards and away from Alzheimer\u2019s disease. Nature 430:631\u2013639. https:\/\/doi.org\/10.1038\/nature02621","journal-title":"Nature"},{"key":"396_CR144","doi-asserted-by":"publisher","first-page":"17768","DOI":"10.1074\/jbc.RA119.008310","volume":"294","author":"PK Menon","year":"2019","unstructured":"Menon PK, Koistinen NA, Iverfeldt K, Strom AL (2019) Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin b. J Biol Chem 294:17768\u201317776. https:\/\/doi.org\/10.1074\/jbc.RA119.008310","journal-title":"J Biol Chem"},{"key":"396_CR145","doi-asserted-by":"publisher","first-page":"6000","DOI":"10.1093\/nar\/gki897","volume":"33","author":"PA Mercado","year":"2005","unstructured":"Mercado PA, Ayala YM, Romano M et al (2005) Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene. Nucleic Acids Res 33:6000\u20136010. https:\/\/doi.org\/10.1093\/nar\/gki897","journal-title":"Nucleic Acids Res"},{"key":"396_CR146","doi-asserted-by":"publisher","first-page":"4671","DOI":"10.3390\/ijms15034671","volume":"15","author":"A Mietelska-Porowska","year":"2014","unstructured":"Mietelska-Porowska A, Wasik U, Goras M et al (2014) Tau protein modifications and interactions: their role in function and dysfunction. Int J Mol Sci 15:4671\u20134713","journal-title":"Int J Mol Sci"},{"key":"396_CR147","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1365-2613.2007.00568.x","volume":"89","author":"S Mondrag\u00f3n-Rodr\u00edguez","year":"2008","unstructured":"Mondrag\u00f3n-Rodr\u00edguez S, Basurto-Islas G, Santa-Maria I et al (2008) Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer\u2019s disease. Int J Exp Pathol 89:81\u201390. https:\/\/doi.org\/10.1111\/j.1365-2613.2007.00568.x","journal-title":"Int J Exp Pathol"},{"key":"396_CR148","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1126\/science.1249161","volume":"344","author":"VA Morais","year":"2014","unstructured":"Morais VA, Haddad D, Craessaerts K et al (2014) PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science 344:203\u2013207","journal-title":"Science"},{"key":"396_CR149","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1038\/ncomms3250","volume":"4","author":"E Morel","year":"2013","unstructured":"Morel E, Chamoun Z, Lasiecka ZM et al (2013) Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system. Nat Commun 4:2250. https:\/\/doi.org\/10.1038\/ncomms3250","journal-title":"Nat Commun"},{"key":"396_CR150","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1002\/ana.20438","volume":"57","author":"JC Mueller","year":"2005","unstructured":"Mueller JC, Fuchs J, Hofer A et al (2005) Multiple regions of \u03b1-synuclein are associated with Parkinson\u2019s disease. Ann Neurol 57:535\u2013541","journal-title":"Ann Neurol"},{"key":"396_CR151","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/nrn.2017.29","volume":"18","author":"UC M\u00fcller","year":"2017","unstructured":"M\u00fcller UC, Deller T, Korte M (2017) Not just amyloid: physiological functions of the amyloid precursor protein family. Nat Rev Neurosci 18:281\u2013298. https:\/\/doi.org\/10.1038\/nrn.2017.29","journal-title":"Nat Rev Neurosci"},{"key":"396_CR152","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1038\/nn.4018","volume":"18","author":"ES Musiek","year":"2015","unstructured":"Musiek ES, Holtzman DM (2015) Three dimensions of the amyloid hypothesis: time, space and \u2018wingmen.\u2019 Nat Neurosci 18:800\u2013806. https:\/\/doi.org\/10.1038\/nn.4018","journal-title":"Nat Neurosci"},{"key":"396_CR153","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/S0955-0674(97)80016-6","volume":"9","author":"S Nakielny","year":"1997","unstructured":"Nakielny S, Dreyfuss G (1997) Nuclear export of proteins and RNAs. Curr Opin Cell Biol 9:420\u2013429. https:\/\/doi.org\/10.1016\/S0955-0674(97)80016-6","journal-title":"Curr Opin Cell Biol"},{"key":"396_CR154","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1016\/j.febslet.2013.05.010","volume":"587","author":"NN Nalivaeva","year":"2013","unstructured":"Nalivaeva NN, Turner AJ (2013) The amyloid precursor protein: a biochemical enigma in brain development, function and disease. FEBS Lett 587:2046\u20132054. https:\/\/doi.org\/10.1016\/j.febslet.2013.05.010","journal-title":"FEBS Lett"},{"key":"396_CR155","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3109\/21678421.2012.734520","volume":"14","author":"RK Narayanan","year":"2013","unstructured":"Narayanan RK, Mangelsdorf M, Panwar A et al (2013) Identification of RNA bound to the TDP-43 ribonucleoprotein complex in the adult mouse brain. Amyotroph Lateral Scler Frontotemporal Degener 14:252\u2013260. https:\/\/doi.org\/10.3109\/21678421.2012.734520","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"396_CR156","doi-asserted-by":"crossref","unstructured":"Narendra DP, Jin SM, Tanaka A et al (2010) PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 8: e1000298.","DOI":"10.1371\/journal.pbio.1000298"},{"key":"396_CR157","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1126\/science.1134108","volume":"314","author":"M Neumann","year":"2006","unstructured":"Neumann M, Sampathu DM, Kwong LK et al (2006) Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314:130\u2013133. https:\/\/doi.org\/10.1126\/science.1134108","journal-title":"Science"},{"key":"396_CR158","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/nm.3232","volume":"19","author":"RA Nixon","year":"2013","unstructured":"Nixon RA (2013) The role of autophagy in neurodegenerative disease. Nat Med 19:983\u2013997. https:\/\/doi.org\/10.1038\/nm.3232","journal-title":"Nat Med"},{"key":"396_CR159","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/boc.201200060","volume":"105","author":"R Nouar","year":"2013","unstructured":"Nouar R, Devred F, Breuzard G, Peyrot V (2013) FRET and FRAP imaging: approaches to characterise tau and stathmin interactions with microtubules in cells. Biol Cell 105:149\u2013161. https:\/\/doi.org\/10.1111\/boc.201200060","journal-title":"Biol Cell"},{"key":"396_CR160","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/j.1460-2075.1993.tb05665.x","volume":"12","author":"M Novak","year":"1993","unstructured":"Novak M, Kabat J, Wischik CM (1993) Molecular characterization of the minimal protease resistant tau unit of the Alzheimer\u2019s disease paired helical filament. EMBO J 12:365\u2013370. https:\/\/doi.org\/10.1002\/j.1460-2075.1993.tb05665.x","journal-title":"EMBO J"},{"key":"396_CR161","doi-asserted-by":"publisher","first-page":"18349","DOI":"10.1073\/pnas.0806270105","volume":"105","author":"AK Paravastu","year":"2008","unstructured":"Paravastu AK, Leapman RD, Yau W-M, Tycko R (2008) Molecular structural basis for polymorphism in Alzheimer\u2019s \u03b2-amyloid fibrils. Proc Natl Acad Sci U S A 105:18349\u201318354. https:\/\/doi.org\/10.1073\/pnas.0806270105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR162","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s12013-013-9623-7","volume":"67","author":"C Park","year":"2013","unstructured":"Park C, Cuervo AM (2013) Selective autophagy: talking with the UPS. Cell Biochem Biophys 67:3\u201313. https:\/\/doi.org\/10.1007\/s12013-013-9623-7","journal-title":"Cell Biochem Biophys"},{"key":"396_CR163","doi-asserted-by":"publisher","first-page":"26687","DOI":"10.1074\/jbc.M304009200","volume":"278","author":"SH Pasternak","year":"2003","unstructured":"Pasternak SH, Bagshaw RD, Guiral M et al (2003) Presenilin-1, nicastrin, amyloid precursor protein, and \u03b3-secretase activity are co-localized in the lysosomal membrane. J Biol Chem 278:26687\u201326694","journal-title":"J Biol Chem"},{"key":"396_CR164","doi-asserted-by":"publisher","first-page":"23063","DOI":"10.1074\/jbc.M111.237974","volume":"286","author":"KR Patterson","year":"2011","unstructured":"Patterson KR, Remmers C, Fu Y et al (2011) Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease. J Biol Chem 286:23063\u201323076","journal-title":"J Biol Chem"},{"key":"396_CR165","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/S0169-328X(01)00257-1","volume":"95","author":"JE Payton","year":"2001","unstructured":"Payton JE, Perrin RJ, Clayton DF, George JM (2001) Protein\u2013protein interactions of alpha-synuclein in brain homogenates and transfected cells. Mol Brain Res 95:138\u2013145","journal-title":"Mol Brain Res"},{"key":"396_CR166","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1113\/jphysiol.2006.111203","volume":"575","author":"HA Pearson","year":"2006","unstructured":"Pearson HA, Peers C (2006) Physiological roles for amyloid \u03b2 peptides. J Physiol 575:5\u201310. https:\/\/doi.org\/10.1113\/jphysiol.2006.111203","journal-title":"J Physiol"},{"key":"396_CR167","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1016\/j.bpj.2008.11.056","volume":"96","author":"P Picone","year":"2009","unstructured":"Picone P, Carrotta R, Montana G et al (2009) A\u03b2 oligomers and fibrillar aggregates induce different apoptotic pathways in LAN5 neuroblastoma cell cultures. Biophys J 96:4200\u20134211. https:\/\/doi.org\/10.1016\/j.bpj.2008.11.056","journal-title":"Biophys J"},{"key":"396_CR168","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1007\/s12640-019-00116-9","volume":"37","author":"P Picone","year":"2020","unstructured":"Picone P, Nuzzo D, Giacomazza D, Di Carlo M (2020) \u03b2-Amyloid peptide: the cell compartment multi-faceted interaction in Alzheimer\u2019s disease. Neurotox Res 37:250\u2013263. https:\/\/doi.org\/10.1007\/s12640-019-00116-9","journal-title":"Neurotox Res"},{"key":"396_CR169","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1038\/ncb1644","volume":"9","author":"H Plun-Favreau","year":"2007","unstructured":"Plun-Favreau H, Klupsch K, Moisoi N et al (2007) The mitochondrial protease HtrA2 is regulated by Parkinson\u2019s disease-associated kinase PINK1. Nat Cell Biol 9:1243\u20131252","journal-title":"Nat Cell Biol"},{"key":"396_CR170","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/nn.2779","volume":"14","author":"M Polymenidou","year":"2011","unstructured":"Polymenidou M, Lagier-Tourenne C, Hutt KR et al (2011) Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat Neurosci 14:459\u2013468. https:\/\/doi.org\/10.1038\/nn.2779","journal-title":"Nat Neurosci"},{"key":"396_CR171","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.cell.2005.08.033","volume":"123","author":"KV Prasanth","year":"2005","unstructured":"Prasanth KV, Prasanth SG, Xuan Z et al (2005) Regulating gene expression through RNA nuclear retention. Cell 123:249\u2013263","journal-title":"Cell"},{"key":"396_CR172","doi-asserted-by":"publisher","first-page":"13434","DOI":"10.1039\/C5CC05264E","volume":"51","author":"K Rajasekhar","year":"2015","unstructured":"Rajasekhar K, Chakrabarti M, Govindaraju T (2015) Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer\u2019s disease. Chem Commun 51:13434\u201313450. https:\/\/doi.org\/10.1039\/C5CC05264E","journal-title":"Chem Commun"},{"key":"396_CR173","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1002\/dvdy.24599","volume":"247","author":"A Ramkumar","year":"2018","unstructured":"Ramkumar A, Jong BY, Ori-McKenney KM (2018) ReMAPping the microtubule landscape: how phosphorylation dictates the activities of microtubule-associated proteins. Dev Dyn 247:138\u2013155. https:\/\/doi.org\/10.1002\/dvdy.24599","journal-title":"Dev Dyn"},{"key":"396_CR174","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.brainres.2011.07.052","volume":"1415","author":"PH Reddy","year":"2011","unstructured":"Reddy PH (2011) Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer\u2019s disease. Brain Res 1415:136\u2013148. https:\/\/doi.org\/10.1016\/j.brainres.2011.07.052","journal-title":"Brain Res"},{"key":"396_CR175","doi-asserted-by":"publisher","first-page":"3996","DOI":"10.1038\/sj.emboj.7600860","volume":"24","author":"C Reinhard","year":"2005","unstructured":"Reinhard C, H\u00e9bert SS, De Strooper B (2005) The amyloid-\u03b2 precursor protein: integrating structure with biological function. EMBO J 24:3996\u20134006. https:\/\/doi.org\/10.1038\/sj.emboj.7600860","journal-title":"EMBO J"},{"key":"396_CR176","doi-asserted-by":"publisher","first-page":"7450","DOI":"10.1073\/pnas.91.16.7450","volume":"91","author":"JM Roch","year":"1994","unstructured":"Roch JM, Masliah E, Roch-Levecq AC et al (1994) Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta\/A4 protein precursor. Proc Natl Acad Sci U S A 91:7450\u20137454. https:\/\/doi.org\/10.1073\/pnas.91.16.7450","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR177","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nature21695","volume":"543","author":"L Ruan","year":"2017","unstructured":"Ruan L, Zhou C, Jin E et al (2017) Cytosolic proteostasis through importing of misfolded proteins into mitochondria. Nature 543:443\u2013446. https:\/\/doi.org\/10.1038\/nature21695","journal-title":"Nature"},{"key":"396_CR178","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.1111\/j.1460-9568.2007.05555.x","volume":"25","author":"N Sahara","year":"2007","unstructured":"Sahara N, Maeda S, Murayama M et al (2007) Assembly of two distinct dimers and higher-order oligomers from full-length tau. Eur J Neurosci 25:3020\u20133029. https:\/\/doi.org\/10.1111\/j.1460-9568.2007.05555.x","journal-title":"Eur J Neurosci"},{"key":"396_CR179","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3389\/fnmol.2017.00082","volume":"10","author":"F Sambataro","year":"2017","unstructured":"Sambataro F, Pennuto M (2017) Post-translational modifications and protein quality control in motor neuron and polyglutamine diseases. Front Mol Neurosci 10:82. https:\/\/doi.org\/10.3389\/fnmol.2017.00082","journal-title":"Front Mol Neurosci"},{"key":"396_CR180","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1007\/s00018-016-2416-6","volume":"74","author":"N Santamaria","year":"2017","unstructured":"Santamaria N, Alhothali M, Alfonso MH et al (2017) Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis. Cell Mol Life Sci 74:1297\u20131318. https:\/\/doi.org\/10.1007\/s00018-016-2416-6","journal-title":"Cell Mol Life Sci"},{"key":"396_CR181","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/febs.12590","volume":"281","author":"S Schedin-Weiss","year":"2014","unstructured":"Schedin-Weiss S, Winblad B, Tjernberg LO (2014) The role of protein glycosylation in Alzheimer disease. FEBS J 281:46\u201362. https:\/\/doi.org\/10.1111\/febs.12590","journal-title":"FEBS J"},{"key":"396_CR182","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1242\/jcs.140087","volume":"127","author":"EL Scotter","year":"2014","unstructured":"Scotter EL, Vance C, Nishimura AL et al (2014) Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species. J Cell Sci 127:1263\u20131278. https:\/\/doi.org\/10.1242\/jcs.140087","journal-title":"J Cell Sci"},{"key":"396_CR183","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/S0962-8924(98)01363-4","volume":"8","author":"DJ Selkoe","year":"1998","unstructured":"Selkoe DJ (1998) The cell biology of \u03b2-amyloid precursor protein and presenilin in Alzheimer\u2019s disease. Trends Cell Biol 8:447\u2013453","journal-title":"Trends Cell Biol"},{"key":"396_CR184","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.bbrc.2009.04.006","volume":"383","author":"K Shiba","year":"2009","unstructured":"Shiba K, Arai T, Sato S et al (2009) Parkin stabilizes PINK1 through direct interaction. Biochem Biophys Res Commun 383:331\u2013335","journal-title":"Biochem Biophys Res Commun"},{"key":"396_CR185","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/42166","volume":"388","author":"MG Spillantini","year":"1997","unstructured":"Spillantini MG, Schmidt ML, Lee VM-Y et al (1997) \u03b1-Synuclein in Lewy bodies. Nature 388:839","journal-title":"Nature"},{"key":"396_CR186","doi-asserted-by":"crossref","unstructured":"Stefanis L (2012) \u03b1-Synuclein in Parkinson\u2019s disease. Cold Spring Harb Perspect Med 2: a009399.","DOI":"10.1101\/cshperspect.a009399"},{"key":"396_CR187","doi-asserted-by":"publisher","first-page":"3710","DOI":"10.1074\/jbc.RA118.001784","volume":"293","author":"K Stefanoska","year":"2018","unstructured":"Stefanoska K, Volkerling A, Bertz J et al (2018) An N-terminal motif unique to primate tau enables differential protein\u2013protein interactions. J Biol Chem 293:3710\u20133719","journal-title":"J Biol Chem"},{"key":"396_CR188","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1002\/ca.980080612","volume":"8","author":"RA Stelzmann","year":"1995","unstructured":"Stelzmann RA, Norman Schnitzlein H, Reed Murtagh F (1995) An english translation of alzheimer\u2019s 1907 paper, \u201c\u00fcber eine eigenartige erkankung der hirnrinde.\u201d Clin Anat 8:429\u2013431. https:\/\/doi.org\/10.1002\/ca.980080612","journal-title":"Clin Anat"},{"key":"396_CR189","doi-asserted-by":"publisher","first-page":"25216","DOI":"10.1074\/jbc.M503341200","volume":"280","author":"JY Sung","year":"2005","unstructured":"Sung JY, Park SM, Lee C-H et al (2005) Proteolytic cleavage of extracellular secreted \u03b1-synuclein via matrix metalloproteinases. J Biol Chem 280:25216\u201325224","journal-title":"J Biol Chem"},{"key":"396_CR190","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1016\/j.ajpath.2012.06.033","volume":"181","author":"H-C Tai","year":"2012","unstructured":"Tai H-C, Serrano-Pozo A, Hashimoto T et al (2012) The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. Am J Pathol 181:1426\u20131435","journal-title":"Am J Pathol"},{"key":"396_CR191","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/0006-291X(89)92760-5","volume":"165","author":"S Tanaka","year":"1989","unstructured":"Tanaka S, Shiojiri S, Takahashi Y et al (1989) Tissue-specific expression of three types of \u03b2-protein precursor mRNA: enhancement of protease inhibitor-harboring types in Alzheimer\u2019s disease brain. Biochem Biophys Res Commun 165:1406\u20131414. https:\/\/doi.org\/10.1016\/0006-291X(89)92760-5","journal-title":"Biochem Biophys Res Commun"},{"key":"396_CR192","doi-asserted-by":"publisher","first-page":"7120","DOI":"10.1128\/MCB.25.16.7120-7136.2005","volume":"25","author":"T Tasaki","year":"2005","unstructured":"Tasaki T, Mulder LCF, Iwamatsu A et al (2005) A Family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. Mol Cell Biol 25:7120\u20137136","journal-title":"Mol Cell Biol"},{"key":"396_CR193","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1146\/annurev-biochem-051710-093308","volume":"81","author":"T Tasaki","year":"2012","unstructured":"Tasaki T, Sriram SM, Park KS, Kwon YT (2012) The N-end rule pathway. Annu Rev Biochem 81:261\u2013289","journal-title":"Annu Rev Biochem"},{"key":"396_CR194","doi-asserted-by":"publisher","first-page":"42984","DOI":"10.1074\/jbc.M112.417600","volume":"287","author":"Y Tashiro","year":"2012","unstructured":"Tashiro Y, Urushitani M, Inoue H et al (2012) Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. J Biol Chem 287:42984\u201342994. https:\/\/doi.org\/10.1074\/jbc.M112.417600","journal-title":"J Biol Chem"},{"key":"396_CR195","doi-asserted-by":"publisher","first-page":"29615","DOI":"10.1074\/jbc.R800019200","volume":"283","author":"G Thinakaran","year":"2008","unstructured":"Thinakaran G, Koo EH (2008) Amyloid precursor protein trafficking, processing, and function. J Biol Chem 283:29615\u201329619","journal-title":"J Biol Chem"},{"key":"396_CR196","doi-asserted-by":"publisher","unstructured":"Timms RT, Zhang Z, Rhee DY et al (2019) A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Science 365: eaaw4912. https:\/\/doi.org\/10.1126\/science.aaw4912.","DOI":"10.1126\/science.aaw4912"},{"key":"396_CR197","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/nn.2778","volume":"14","author":"JR Tollervey","year":"2011","unstructured":"Tollervey JR, Curk T, Rogelj B et al (2011) Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. Nat Neurosci 14:452\u2013458. https:\/\/doi.org\/10.1038\/nn.2778","journal-title":"Nat Neurosci"},{"key":"396_CR198","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/978-1-4939-9179-2_12","volume-title":"Microcalorimetry of biological molecules","author":"PO Tsvetkov","year":"2019","unstructured":"Tsvetkov PO, La Rocca R, Malesinski S, Devred F (2019) Characterization of microtubule-associated proteins (MAPs) and tubulin interactions by isothermal titration calorimetry (ITC). In: Ennifar E (ed) Microcalorimetry of biological molecules. Humana Press, New York, NY, Methods in molecular biology, pp 151\u2013165"},{"key":"396_CR199","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0301-0082(03)00089-3","volume":"70","author":"PR Turner","year":"2003","unstructured":"Turner PR, O\u2019Connor K, Tate WP, Abraham WC (2003) Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol 70:1\u201332. https:\/\/doi.org\/10.1016\/S0301-0082(03)00089-3","journal-title":"Prog Neurobiol"},{"key":"396_CR200","doi-asserted-by":"publisher","first-page":"11282","DOI":"10.1073\/pnas.90.23.11282","volume":"90","author":"K U\u00e9da","year":"1993","unstructured":"U\u00e9da K, Fukushima H, Masliah E et al (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci U S A 90:11282\u201311286","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR201","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3389\/fnagi.2015.00018","volume":"7","author":"VN Uversky","year":"2015","unstructured":"Uversky VN (2015) Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders. Front Aging Neurosci 7:18. https:\/\/doi.org\/10.3389\/fnagi.2015.00018","journal-title":"Front Aging Neurosci"},{"key":"396_CR202","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1126\/science.1096284","volume":"304","author":"EM Valente","year":"2004","unstructured":"Valente EM, Abou-Sleiman PM, Caputo V et al (2004) Hereditary early-onset Parkinson\u2019s disease caused by mutations in PINK1. Science 304:1158\u20131160","journal-title":"Science"},{"key":"396_CR203","doi-asserted-by":"publisher","first-page":"34469","DOI":"10.1074\/jbc.X800009200","volume":"283","author":"A Varshavsky","year":"2008","unstructured":"Varshavsky A (2008) Discovery of cellular regulation by protein degradation. J Biol Chem 283:34469\u201334489","journal-title":"J Biol Chem"},{"key":"396_CR204","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1002\/pro.666","volume":"20","author":"A Varshavsky","year":"2011","unstructured":"Varshavsky A (2011) The N-end rule pathway and regulation by proteolysis. Protein Sci 20:1298\u20131345","journal-title":"Protein Sci"},{"key":"396_CR205","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev-biochem-061516-044859","volume":"86","author":"A Varshavsky","year":"2017","unstructured":"Varshavsky A (2017) The ubiquitin system, autophagy, and regulated protein degradation. Annu Rev Biochem 86:123\u2013128","journal-title":"Annu Rev Biochem"},{"key":"396_CR206","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1073\/pnas.1816596116","volume":"116","author":"A Varshavsky","year":"2019","unstructured":"Varshavsky A (2019) N-degron and C-degron pathways of protein degradation. Proc Natl Acad Sci U S A 116:358\u2013366","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR207","doi-asserted-by":"publisher","first-page":"138","DOI":"10.4103\/0972-2327.144284","volume":"18","author":"M Verma","year":"2015","unstructured":"Verma M, Vats A, Taneja V (2015) Toxic species in amyloid disorders: oligomers or mature fibrils. Ann Indian Acad Neurol 18:138\u2013145. https:\/\/doi.org\/10.4103\/0972-2327.144284","journal-title":"Ann Indian Acad Neurol"},{"key":"396_CR208","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1073\/pnas.0607919104","volume":"104","author":"M Vershinin","year":"2007","unstructured":"Vershinin M, Carter BC, Razafsky DS et al (2007) Multiple-motor based transport and its regulation by Tau. Proc Natl Acad Sci U S A 104:87\u201392. https:\/\/doi.org\/10.1073\/pnas.0607919104","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR209","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/j.1600-0854.2010.01149.x","volume":"12","author":"J Viswanathan","year":"2011","unstructured":"Viswanathan J, Haapasalo A, B\u00f6ttcher C et al (2011) Alzheimer\u2019s disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic 12:330\u2013348. https:\/\/doi.org\/10.1111\/j.1600-0854.2010.01149.x","journal-title":"Traffic"},{"key":"396_CR210","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1111\/jnc.13655","volume":"139","author":"A Voigt","year":"2016","unstructured":"Voigt A, Berlemann LA, Winklhofer KF (2016) The mitochondrial kinase PINK 1: functions beyond mitophagy. J Neurochem 139:232\u2013239","journal-title":"J Neurochem"},{"key":"396_CR211","doi-asserted-by":"publisher","first-page":"7241","DOI":"10.1093\/hmg\/ddv424","volume":"24","author":"AK Walker","year":"2015","unstructured":"Walker AK, Tripathy K, Restrepo CR et al (2015) An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice. Hum Mol Genet 24:7241\u20137254. https:\/\/doi.org\/10.1093\/hmg\/ddv424","journal-title":"Hum Mol Genet"},{"key":"396_CR212","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/nm0896-871","volume":"2","author":"J-Z Wang","year":"1996","unstructured":"Wang J-Z, Grundke-Iqbal I, Iqbal K (1996) Glycosylation of microtubule\u2013associated protein tau: an abnormal posttranslational modification in Alzheimer\u2019s disease. Nat Med 2:871\u2013875. https:\/\/doi.org\/10.1038\/nm0896-871","journal-title":"Nat Med"},{"key":"396_CR213","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.neulet.2009.11.055","volume":"469","author":"X Wang","year":"2010","unstructured":"Wang X, Fan H, Ying Z et al (2010) Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system. Neurosci Lett 469:112\u2013116. https:\/\/doi.org\/10.1016\/j.neulet.2009.11.055","journal-title":"Neurosci Lett"},{"key":"396_CR214","doi-asserted-by":"publisher","first-page":"294","DOI":"10.3389\/fnmol.2017.00294","volume":"10","author":"X Wang","year":"2017","unstructured":"Wang X, Zhou X, Li G et al (2017) Modifications and trafficking of APP in the pathogenesis of Alzheimer\u2019s disease. Front Mol Neurosci 10:294","journal-title":"Front Mol Neurosci"},{"key":"396_CR215","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1042\/bst20120071","volume":"40","author":"Y Wang","year":"2012","unstructured":"Wang Y, Mandelkow E (2012) Degradation of tau protein by autophagy and proteasomal pathways. Biochem Soc Trans 40:644\u2013652. https:\/\/doi.org\/10.1042\/bst20120071","journal-title":"Biochem Soc Trans"},{"key":"396_CR216","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nrn.2015.1","volume":"17","author":"Y Wang","year":"2016","unstructured":"Wang Y, Mandelkow E (2016) Tau in physiology and pathology. Nat Rev Neurosci 17:22\u201335. https:\/\/doi.org\/10.1038\/nrn.2015.1","journal-title":"Nat Rev Neurosci"},{"key":"396_CR217","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1021\/bi8019178","volume":"48","author":"A Weihofen","year":"2009","unstructured":"Weihofen A, Thomas KJ, Ostaszewski BL et al (2009) Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. Biochemistry 48:2045\u20132052","journal-title":"Biochemistry"},{"key":"396_CR218","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1073\/pnas.72.5.1858","volume":"72","author":"MD Weingarten","year":"1975","unstructured":"Weingarten MD, Lockwood AH, Hwo SY, Kirschner MW (1975) A protein factor essential for microtubule assembly. Proc Natl Acad Sci U S A 72:1858\u20131862. https:\/\/doi.org\/10.1073\/pnas.72.5.1858","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR219","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/jnc.13935","volume":"140","author":"LS Whyte","year":"2017","unstructured":"Whyte LS, Lau AA, Hemsley KM et al (2017) Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer\u2019s disease? J Neurochem 140:703\u2013717. https:\/\/doi.org\/10.1111\/jnc.13935","journal-title":"J Neurochem"},{"key":"396_CR220","doi-asserted-by":"publisher","first-page":"13302","DOI":"10.1074\/jbc.M800342200","volume":"283","author":"MJ Winton","year":"2008","unstructured":"Winton MJ, Igaz LM, Wong MM et al (2008) Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. J Biol Chem 283:13302\u201313309","journal-title":"J Biol Chem"},{"key":"396_CR221","doi-asserted-by":"publisher","first-page":"4884","DOI":"10.1073\/pnas.85.13.4884","volume":"85","author":"CM Wischik","year":"1988","unstructured":"Wischik CM, Novak M, Edwards PC et al (1988) Structural characterization of the core of the paired helical filament of Alzheimer disease. Proc Natl Acad Sci U S A 85:4884\u20134888. https:\/\/doi.org\/10.1073\/pnas.85.13.4884","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR222","doi-asserted-by":"publisher","first-page":"4070","DOI":"10.1073\/pnas.73.11.4070","volume":"73","author":"GB Witman","year":"1976","unstructured":"Witman GB, Cleveland DW, Weingarten MD, Kirschner MW (1976) Tubulin requires tau for growth onto microtubule initiating sites. Proc Natl Acad Sci U S A 73:4070\u20134074. https:\/\/doi.org\/10.1073\/pnas.73.11.4070","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR223","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.jmb.2008.03.017","volume":"378","author":"K-P Wu","year":"2008","unstructured":"Wu K-P, Kim S, Fela DA, Baum J (2008) Characterization of conformational and dynamic properties of natively unfolded human and mouse \u03b1-synuclein ensembles by NMR: implication for aggregation. J Mol Biol 378:1104\u20131115","journal-title":"J Mol Biol"},{"key":"396_CR224","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.mcn.2011.02.013","volume":"47","author":"S Xiao","year":"2011","unstructured":"Xiao S, Sanelli T, Dib S et al (2011) RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS. Mol Cell Neurosci 47:167\u2013180. https:\/\/doi.org\/10.1016\/j.mcn.2011.02.013","journal-title":"Mol Cell Neurosci"},{"key":"396_CR225","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.4161\/auto.24633","volume":"9","author":"K Yamano","year":"2013","unstructured":"Yamano K, Youle RJ (2013) PINK1 is degraded through the N-end rule pathway. Autophagy 9:1758\u20131769. https:\/\/doi.org\/10.4161\/auto.24633","journal-title":"Autophagy"},{"key":"396_CR226","doi-asserted-by":"publisher","first-page":"7787","DOI":"10.1073\/pnas.91.16.7787","volume":"91","author":"SD Yan","year":"1994","unstructured":"Yan SD, Chen X, Schmidt AM et al (1994) Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress. Proc Natl Acad Sci U S A 91:7787\u20137791. https:\/\/doi.org\/10.1073\/pnas.91.16.7787","journal-title":"Proc Natl Acad Sci U S A"},{"key":"396_CR227","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nm0795-693","volume":"1","author":"SD Yan","year":"1995","unstructured":"Yan SD, Yan SF, Chen X et al (1995) Non-enzymatically glycated tau in Alzheimer\u2019s disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid \u03b2-peptide. Nat Med 1:693\u2013699. https:\/\/doi.org\/10.1038\/nm0795-693","journal-title":"Nat Med"},{"key":"396_CR228","doi-asserted-by":"publisher","first-page":"27283","DOI":"10.1038\/srep27283","volume":"6","author":"Y Yin","year":"2016","unstructured":"Yin Y, Wang Y, Gao D et al (2016) Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor \u03b14 via activating calpain-2. Sci Rep 6:27283. https:\/\/doi.org\/10.1038\/srep27283","journal-title":"Sci Rep"},{"key":"396_CR229","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1515\/revneuro-2014-0076","volume":"26","author":"A Zare-Shahabadi","year":"2015","unstructured":"Zare-Shahabadi A, Masliah E, Johnson GV, Rezaei N (2015) Autophagy in Alzheimer\u2019s disease. Rev Neurosci 26:385\u2013395","journal-title":"Rev Neurosci"},{"key":"396_CR230","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1016\/j.febslet.2005.03.041","volume":"579","author":"YJ Zhang","year":"2005","unstructured":"Zhang YJ, Xu YF, Chen XQ et al (2005) Nitration and oligomerization of tau induced by peroxynitrite inhibit its microtubule-binding activity. FEBS Lett 579:2421\u20132427. https:\/\/doi.org\/10.1016\/j.febslet.2005.03.041","journal-title":"FEBS Lett"},{"key":"396_CR231","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1038\/nm.3700","volume":"20","author":"Z Zhang","year":"2014","unstructured":"Zhang Z, Song M, Liu X et al (2014) Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer\u2019s disease. Nat Med 20:1254\u20131262. https:\/\/doi.org\/10.1038\/nm.3700","journal-title":"Nat Med"},{"key":"396_CR232","doi-asserted-by":"publisher","unstructured":"Zhao M, Kim JR, van Bruggen R, Park J (2018) RNA-binding proteins in amyotrophic lateral sclerosis. Mol Cells 41: 818\u2013829. https:\/\/doi.org\/10.14348\/molcells.2018.0243.","DOI":"10.14348\/molcells.2018.0243"},{"key":"396_CR233","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1021\/cn100067e","volume":"1","author":"X Zhao","year":"2010","unstructured":"Zhao X, Yang J (2010) Amyloid-\u03b2 peptide is a substrate of the human 20S proteasome. ACS Chem Neurosci 1:655\u2013660","journal-title":"ACS Chem Neurosci"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-021-00396-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-021-00396-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-021-00396-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T08:44:29Z","timestamp":1676105069000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12640-021-00396-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,18]]},"references-count":233,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["396"],"URL":"https:\/\/doi.org\/10.1007\/s12640-021-00396-0","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,18]]},"assertion":[{"value":"8 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}