{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T01:10:32Z","timestamp":1772673032345,"version":"3.50.1"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s12640-022-00513-7","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T09:03:09Z","timestamp":1651050189000},"page":"874-883","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Targeting Insulin-Like Growth Factor-I in Management of Neurological Disorders"],"prefix":"10.1007","volume":"40","author":[{"given":"Rashita","family":"Makkar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-7708","authenticated-orcid":false,"given":"Tapan","family":"Behl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aayush","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhbir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelam","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafiz A.","family":"Makeen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Albratty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan A.","family":"Alhazmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldulkarim M.","family":"Meraya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"issue":"1","key":"513_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12967-015-0762-z","volume":"14","author":"GA Aguirre","year":"2016","unstructured":"Aguirre GA, De Ita JR, de la Garza RG, Castilla-Cortazar I (2016) Insulin-like growth factor-1 deficiency and metabolic syndrome. J Transl Med 14(1):3","journal-title":"J Transl Med"},{"key":"513_CR2","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.tins.2011.12.007","volume":"35","author":"CM Alberini","year":"2012","unstructured":"Alberini CM, Chen DY (2012) Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2. Trends Neurosci 35:274\u2013283","journal-title":"Trends Neurosci"},{"key":"513_CR3","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders. 5th ed. Arlington: American Psychiatric Association.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"513_CR4","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.mce.2017.06.010","volume":"464","author":"LJ Anderson","year":"2018","unstructured":"Anderson LJ, Tamayose JM, Garcia JM (2018) Use of growth hormone, IGF-I, and insulin for anabolic purpose: pharmacological basis, methods of detection, and adverse effects. Mol Cell Endocrinol 464:65\u201374","journal-title":"Mol Cell Endocrinol"},{"key":"513_CR5","doi-asserted-by":"crossref","unstructured":"Annunziata M, Granata R, Ghigo E (2011) The IGF system. Acta Diabetol 48(1):1\u20139","DOI":"10.1007\/s00592-010-0227-z"},{"issue":"1","key":"513_CR6","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1097\/MNH.0b013e32834dc1a2","volume":"21","author":"LA Bach","year":"2012","unstructured":"Bach LA (2012) The insulin-like growth factor system in kidney disease and hypertension. Curr Opin Nephrol Hypertens 21(1):86\u201391","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"513_CR7","doi-asserted-by":"crossref","unstructured":"Benarroch EE (2012a) Insulin-like growth factors in the brain and their potential clinical implications. Neurology 20;79(21):2148\u201353","DOI":"10.1212\/WNL.0b013e3182752eef"},{"key":"513_CR8","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1212\/WNL.0b013e3182752eef","volume":"79","author":"EE Benarroch","year":"2012","unstructured":"Benarroch EE (2012b) Insulin-like growth factors in the brain and their potential clinical implications. Neurology 79:2148\u20132153","journal-title":"Neurology"},{"key":"513_CR9","doi-asserted-by":"publisher","first-page":"95","DOI":"10.2174\/187152409788452108","volume":"9","author":"O Bibollet-Bahena","year":"2009","unstructured":"Bibollet-Bahena O, Cui QL, Almazan G (2009) The insulin-like growth factor-1 axis and its potential as a therapeutic target in central nervous system (CNS) disorders. Cent Nerv Syst Agents Med Chem 9:95\u2013109","journal-title":"Cent Nerv Syst Agents Med Chem"},{"key":"513_CR10","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nature08983","volume":"464","author":"NA Bishop","year":"2010","unstructured":"Bishop NA, Lu T, Yankner BA (2010) Neural mechanisms of ageing and cognitive decline. Nature 464:529\u2013535","journal-title":"Nature"},{"issue":"1","key":"513_CR11","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ghir.2007.06.003","volume":"18","author":"DJ Bridgewater","year":"2008","unstructured":"Bridgewater DJ, Dionne JM, Butt MJ, Pin CL, Matsell DG (2008) The role of the type I insulin-like growth factor receptor (IGF-IR) in glomerular integrity. Growth Horm IGF Res 18(1):26\u201337","journal-title":"Growth Horm IGF Res"},{"key":"513_CR12","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.neuroscience.2011.11.029","volume":"202","author":"RC Cassilhas","year":"2012","unstructured":"Cassilhas RC, Lee KS, Fernandes J et al (2012) Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms. Neuroscience 202:309\u2013317","journal-title":"Neuroscience"},{"issue":"1","key":"513_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12967-020-02223-0","volume":"18","author":"I Castilla-Cort\u00e1zar","year":"2020","unstructured":"Castilla-Cort\u00e1zar I, Aguirre GA, Femat-Rold\u00e1n G, Mart\u00edn-Estal I, Espinosa L (2020) Is insulin-like growth factor-1 involved in Parkinson\u2019s disease development? J Transl Med 18(1):1\u20137","journal-title":"J Transl Med"},{"key":"513_CR14","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s12031-008-9041-2","volume":"35","author":"D Chesik","year":"2008","unstructured":"Chesik D, De Keyser J, Wilczak N (2008) Insulin-like growth factor system regulates oligodendroglial cell behavior: therapeutic potential in CNS. J Mol Neurosci 35:81\u201390","journal-title":"J Mol Neurosci"},{"key":"513_CR15","doi-asserted-by":"crossref","unstructured":"Chigogora S, Zaninotto P, Kivimaki M, Steptoe A, Batty GD (2016) Insulin-like growth factor 1 and risk of depression in older people: the English Longitudinal Study of Ageing.\u00a0Transl\u00a0Psychiatry\u00a06(9):e898-","DOI":"10.1038\/tp.2016.167"},{"issue":"6","key":"513_CR16","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1677\/JME-09-0021","volume":"43","author":"SI Chisalita","year":"2009","unstructured":"Chisalita SI, Johansson GS, Liefvendahl E, Back K, Arnqvist HJ (2009) Human aortic smooth muscle cells are insulin resistant at the receptor level but sensitive to IGF1 and IGF2. J Mol Endocrinol 43(6):231\u2013239","journal-title":"J Mol Endocrinol"},{"key":"513_CR17","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/nrn2474","volume":"9","author":"E Cohen","year":"2008","unstructured":"Cohen E, Dillin A (2008) The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci 9:759\u2013767","journal-title":"Nat Rev Neurosci"},{"key":"513_CR18","doi-asserted-by":"crossref","unstructured":"Darcet F, Gardier AM, Gaillard R, David DJ, Guilloux JP (2016). Cognitive dysfunction in major depressive disorder. A translational review in animal models of the disease. Pharmaceuticals (Basel). 9(1):E9.","DOI":"10.3390\/ph9010009"},{"issue":"3","key":"513_CR19","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1161\/01.ATV.0000105902.89459.09","volume":"24","author":"P Delafontaine","year":"2004","unstructured":"Delafontaine P, Song YH, Li Y (2004) Expression, regulation, and function of IGF1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler Thromb Vasc Biol 24(3):435\u2013444","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"513_CR20","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/da.22227","volume":"31","author":"RS Duman","year":"2014","unstructured":"Duman RS (2014) Neurobiology of stress, depression, and rapid acting antidepressants: remodeling synaptic connections. Depress Anxiety 31:4","journal-title":"Depress Anxiety"},{"issue":"1","key":"513_CR21","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1385\/NMM:5:1:011","volume":"5","author":"RS Duman","year":"2004","unstructured":"Duman RS (2004) Role of neurotrophic factors in the etiology and treatment of mood disorders. NeuroMolecular Med 5(1):11\u201325","journal-title":"NeuroMolecular Med"},{"key":"513_CR22","doi-asserted-by":"crossref","unstructured":"Dunger DB, Ong KK, Sandhu MS (2003) Serum insulin-like growth factor-I levels and potential risk of type 2 diabetes. Horm Res. (60 suppl 3):131\u2013135.","DOI":"10.1159\/000074514"},{"issue":"12","key":"513_CR23","doi-asserted-by":"publisher","first-page":"4673","DOI":"10.1210\/jc.2012-2063","volume":"97","author":"E Duron","year":"2012","unstructured":"Duron E, Funalot B, Brunel N, Coste J, Quinquis L, Viollet C, Belmin J, Jouanny P, Pasquier F, Treluyer JM, Epelbaum J (2012a) Insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Alzheimer\u2019s disease. J Clin Endocrinol Metab 97(12):4673\u20134681","journal-title":"J Clin Endocrinol Metab"},{"key":"513_CR24","doi-asserted-by":"publisher","first-page":"4673","DOI":"10.1210\/jc.2012-2063","volume":"97","author":"E Duron","year":"2012","unstructured":"Duron E, Funalot B, Brunel N et al (2012b) Insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Alzheimer\u2019s disease. J Clin Endocrinol Metab 97:4673\u20134681","journal-title":"J Clin Endocrinol Metab"},{"key":"513_CR25","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/nrn3209","volume":"13","author":"AM Fernandez","year":"2012","unstructured":"Fernandez AM, Torres-Aleman I (2012) The many faces of insulin-like peptide signalling in the brain. Nat Rev Neurosci 13:225\u2013239","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"513_CR26","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.yfrne.2014.02.002","volume":"35","author":"GE Gillies","year":"2014","unstructured":"Gillies GE, Pienaar IS, Vohra S, Qamhawi Z (2014) Sex differences in Parkinson\u2019s disease. Front Neuroendocrinol 35(3):370\u2013384","journal-title":"Front Neuroendocrinol"},{"key":"513_CR27","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/ncpneuro0124","volume":"2","author":"MN Haan","year":"2006","unstructured":"Haan MN (2006) Therapy insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer\u2019s disease. Nat Clin Pract Neurol 2:159\u2013166","journal-title":"Nat Clin Pract Neurol"},{"key":"513_CR28","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1471-2377-14-64","volume":"14","author":"J Hertze","year":"2014","unstructured":"Hertze J, N\u00a8agga K, Minthon L, Hansson O, (2014) Changes in cerebrospinal fluid and blood plasma levels of IGF-II and its binding proteins in Alzheimer\u2019s disease: an observational study. BMC Neurol 14:64","journal-title":"BMC Neurol"},{"issue":"4","key":"513_CR29","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1159\/000445751","volume":"46","author":"L Hirsch","year":"2016","unstructured":"Hirsch L, Jette N, Frolkis A, Steeves T, Pringsheim T (2016) The incidence of Parkinson\u2019s disease: a systematic review and meta-analysis. Neuroepidemiology 46(4):292\u2013300","journal-title":"Neuroepidemiology"},{"issue":"4","key":"513_CR30","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1136\/jnnp.2007.131045","volume":"79","author":"J Jankovic","year":"2008","unstructured":"Jankovic J (2008) Parkinson\u2019s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 79(4):368\u2013376","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1\u20132","key":"513_CR31","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.mce.2008.07.012","volume":"296","author":"GS Johansson","year":"2008","unstructured":"Johansson GS, Chisalita SI, Arnqvist HJ (2008) Human microvascular endothelial cells are sensitive to IGF-I but resistant to insulin at the receptor level. Mol Cell Endocrinol 296(1\u20132):58\u201363","journal-title":"Mol Cell Endocrinol"},{"key":"513_CR32","doi-asserted-by":"crossref","unstructured":"Johansson P, \u00fb Aberg D, Johansson JO et al (2013) Serum but not cerebrospinal fluid levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) are increased in Alzheimer\u2019s disease. Psychoneuroendocrinology. 38:1729\u20131737","DOI":"10.1016\/j.psyneuen.2013.02.006"},{"issue":"23","key":"513_CR33","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1001\/jama.289.23.3095","volume":"289","author":"RC Kessler","year":"2003","unstructured":"Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR et al (2003) The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 289(23):3095\u20133105","journal-title":"JAMA"},{"key":"513_CR34","doi-asserted-by":"crossref","unstructured":"Kim B, Elzinga SE, Henn RE, McGinley LM, Feldman EL (2019) The effects of insulin and insulin-like growth factor I on amyloid precursor protein phosphorylation in in vitro and in vivo models of Alzheimer\u2019s disease. Neurobiol Dis 132:104541","DOI":"10.1016\/j.nbd.2019.104541"},{"issue":"1","key":"513_CR35","doi-asserted-by":"publisher","first-page":"50","DOI":"10.2174\/157339911794273900","volume":"7","author":"PA Kumar","year":"2011","unstructured":"Kumar PA, Brosius FC III, Menon RK (2011) The glomerular podocyte as a target of growth hormone action: implications for the pathogenesis of diabetic nephropathy. Curr Diabetes Rev 7(1):50\u201355","journal-title":"Curr Diabetes Rev"},{"issue":"5","key":"513_CR36","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ghir.2011.07.008","volume":"21","author":"D Landau","year":"2011","unstructured":"Landau D, Biada J, Chen Y, Sood S, Yakar S, Leroith D, Segev Y, Rabkin R (2011) A marked deficiency in circulating and renal IGF-I peptide does not inhibit compensatory renal enlargement in uninephrectomized mice. Growth Horm IGF Res 21(5):279\u2013284","journal-title":"Growth Horm IGF Res"},{"key":"513_CR37","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.neuropharm.2011.06.003","volume":"61","author":"CC Lee","year":"2011","unstructured":"Lee CC, Huang CC, Hsu KS (2011) Insulin promotes dendritic spine and synapse formation by the PI3K\/Akt\/mTOR and Rac1 signaling pathways. Neuropharmacology 61:867\u2013879","journal-title":"Neuropharmacology"},{"key":"513_CR38","doi-asserted-by":"publisher","first-page":"239","DOI":"10.5483\/BMBRep.2009.42.5.239","volume":"42","author":"E Lee","year":"2009","unstructured":"Lee E, Son H (2009) Adult hippocampal neurogenesis and related neurotrophic factors. BMB Rep 42:239\u2013244","journal-title":"BMB Rep"},{"issue":"1","key":"513_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12888-020-02636-7","volume":"20","author":"OA Levada","year":"2020","unstructured":"Levada OA, Troyan AS, Pinchuk IY (2020) Serum insulin-like growth factor-1 as a potential marker for MDD diagnosis, its clinical characteristics, and treatment efficacy validation: data from an open-label vortioxetine study. BMC Psychiatry 20(1):1","journal-title":"BMC Psychiatry"},{"issue":"1","key":"513_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12991-017-0161-3","volume":"16","author":"OA Levada","year":"2017","unstructured":"Levada OA, Troyan AS (2017) Insulin-like growth factor-1: a possible marker for emotional and cognitive disturbances, and treatment effectiveness in major depressive disorder. Ann Gen Psychiatry 16(1):1\u20139","journal-title":"Ann Gen Psychiatry"},{"issue":"12","key":"513_CR41","doi-asserted-by":"publisher","first-page":"117862641984217","DOI":"10.1177\/1178626419842176","volume":"17","author":"MS Lewitt","year":"2019","unstructured":"Lewitt MS, Boyd GW (2019) The role of insulin-like growth factors and insulin-like growth factor-binding proteins in the nervous system. Biochem Insights 17(12):117862641984217","journal-title":"Biochem Insights"},{"key":"513_CR42","doi-asserted-by":"crossref","unstructured":"Li Y, Pehrson AL, Waller JA, Dale E, Sanchez C, Gulinello M (2015) A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc\/Arg3.1)\u2019s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression. Front Neurosci 9:279","DOI":"10.3389\/fnins.2015.00279"},{"key":"513_CR43","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.mcn.2010.02.006","volume":"44","author":"M Llorens-Mart\u00edn","year":"2010","unstructured":"Llorens-Mart\u00edn M, Torres-Alem\u00e1n I, Trejo JL (2010) Exercise modulates insulin-like growth factor 1-dependent and -independent effects on adult hippocampal neurogenesis and behaviour. Mol Cell Neurosci 44:109\u2013117","journal-title":"Mol Cell Neurosci"},{"key":"513_CR44","doi-asserted-by":"crossref","unstructured":"Muller E, Dunstheimer D, Klammt J et al (2012) Clinical and functional characterization of a patient carrying a compound heterozygous pericentrin mutation and a heterozygous IGF1 receptor mutation. PLoS One 7:e38220","DOI":"10.1371\/journal.pone.0038220"},{"key":"513_CR45","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.beem.2010.08.005","volume":"25","author":"I Netchine","year":"2011","unstructured":"Netchine I, Azzi S, Le Bouc Y, Savage MO (2011) IGF1 molecular anomalies demonstrate its critical role in fetal, postnatal growth and brain development. Best Pract Res Clin Endocrinol Metab 25:181\u2013190","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"513_CR46","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.neuron.2010.08.007","volume":"67","author":"T Nishijima","year":"2010","unstructured":"Nishijima T, Piriz J, Duflot S et al (2010) Neuronal activity drives localized blood-brain-barrier transport of serum insulin-like growth factor-I into the CNS. Neuron 67:834\u2013846","journal-title":"Neuron"},{"issue":"5","key":"513_CR47","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1210\/er.2009-0010","volume":"30","author":"C Ohlsson","year":"2009","unstructured":"Ohlsson C, Mohan S, Sjogren K, Tivesten A, Isgaard J, Isaksson O, Jansson JO, Svensson J (2009) The role of liver-derived insulin-like growth factor-I. Endocr Rev 30(5):494\u2013535","journal-title":"Endocr Rev"},{"issue":"13","key":"513_CR48","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1002\/mds.25945","volume":"29","author":"T Pringsheim","year":"2014","unstructured":"Pringsheim T, Jette N, Frolkis A, Steeves TDL (2014) The prevalence of Parkinson\u2019s disease: a systematic review and meta-analysis. Mov Disord 29(13):1583\u20131590","journal-title":"Mov Disord"},{"issue":"1","key":"513_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1479-5876-10-224","volume":"10","author":"JE Puche","year":"2012","unstructured":"Puche JE, Castilla-Cort\u00e1zar I (2012) Human conditions of insulin-like growth factor-I (IGF-I) deficiency. J Transl Med 10(1):1\u201329","journal-title":"J Transl Med"},{"issue":"4","key":"513_CR50","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.ghir.2004.02.001","volume":"14","author":"R Rabkin","year":"2004","unstructured":"Rabkin R, Schaefer F (2004) New concepts: growth hormone, insulin-like growth factor-I and the kidney. Growth Horm IGF Res 14(4):270\u2013276","journal-title":"Growth Horm IGF Res"},{"key":"513_CR51","doi-asserted-by":"publisher","first-page":"521","DOI":"10.3389\/fncel.2015.00521","volume":"9","author":"D Rial","year":"2016","unstructured":"Rial D, Lemos C, Pinheiro H, Duarte JM, Gon\u00e7alves FQ, Real JI et al (2016) Depression as a glial-based synaptic dysfunction. Front Cell Neurosci 9:521","journal-title":"Front Cell Neurosci"},{"key":"513_CR52","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1210\/er.2004-0024","volume":"26","author":"VC Russo","year":"2005","unstructured":"Russo VC, Gluckman PD, Feldman EL, Werther GA (2005a) The insulin-like growth factor system and its pleiotropic functions in brain. Endocr Rev 26:916\u2013943","journal-title":"Endocr Rev"},{"issue":"7","key":"513_CR53","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1210\/er.2004-0024","volume":"26","author":"VC Russo","year":"2005","unstructured":"Russo VC, Gluckman PD, Feldman EL, Werther GA (2005b) The insulin-like growth factor system and its pleiotropic functions in brain. Endocr Rev 26(7):916\u2013943","journal-title":"Endocr Rev"},{"key":"513_CR54","doi-asserted-by":"publisher","first-page":"9225","DOI":"10.1074\/jbc.M808425200","volume":"284","author":"C Sawallisch","year":"2009","unstructured":"Sawallisch C, Berhorster K, Disanza A et al (2009) The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. J Biol Chem 284:9225\u20139236","journal-title":"J Biol Chem"},{"issue":"7526","key":"513_CR55","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/515180a","volume":"515","author":"K Smith","year":"2014","unstructured":"Smith K (2014) Mental health: a world of depression. Nature 515(7526):181","journal-title":"Nature"},{"issue":"2","key":"513_CR56","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1124\/pr.109.002469","volume":"62","author":"TJ Smith","year":"2010","unstructured":"Smith TJ (2010) Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases? Pharmacol Rev 62(2):199\u2013236","journal-title":"Pharmacol Rev"},{"issue":"Suppl 2","key":"513_CR57","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/jnc.13580","volume":"139","author":"JD Sweatt","year":"2016","unstructured":"Sweatt JD (2016) Neural plasticity and behavior\u2014sixty years of conceptual advances. J Neurochem 139(Suppl 2):179\u2013199","journal-title":"J Neurochem"},{"key":"513_CR58","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.2337\/dc11-0308","volume":"34","author":"ZS Tan","year":"2011","unstructured":"Tan ZS, Beiser AS, Fox CS et al (2011) Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study. Diabetes Care 34:1766\u20131770","journal-title":"Diabetes Care"},{"key":"513_CR59","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1111\/acel.12490","volume":"15","author":"A Teumer","year":"2016","unstructured":"Teumer A, Qi Q, Nethander M et al (2016) Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. Aging Cell 15:811\u2013824","journal-title":"Aging Cell"},{"key":"513_CR60","doi-asserted-by":"crossref","unstructured":"Tu KY, Wu MK, Chen YW, Lin PY, Wang HY, Wu CK, Tseng PT (2016) Significantly higher peripheral insulin-like growth factor-1 levels in patients with major depressive disorder or bipolar disorder than in healthy controls: a meta-analysis and review under guideline of PRISMA. Medicine. 95(4)","DOI":"10.1097\/MD.0000000000002411"},{"issue":"3","key":"513_CR61","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.4049\/jimmunol.165.3.1331","volume":"165","author":"W Tu","year":"2000","unstructured":"Tu W, Cheung PT, Lau YL (2000) Insulin-like growth factor 1 promotes cord blood T cell maturation and inhibits its spontaneous and phytohemagglutinin-induced apoptosis through different mechanisms. J Immunol 165(3):1331\u20131336","journal-title":"J Immunol"},{"issue":"11","key":"513_CR62","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1093\/aje\/kwg068","volume":"157","author":"SK Van Den Eeden","year":"2003","unstructured":"Van Den Eeden SK (2003) Incidence of Parkinson\u2019s disease: variation by age, gender, and race\/ethnicity. Am J Epidemiol 157(11):1015\u20131022","journal-title":"Am J Epidemiol"},{"key":"513_CR63","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.pneurobio.2006.06.003","volume":"79","author":"LP van der Heide","year":"2006","unstructured":"van der Heide LP, Ramakers GM, Smidt MP (2006) Insulin signaling in the central nervous system: learning to survive. Prog Neurobiol 79:205\u2013221","journal-title":"Prog Neurobiol"},{"key":"513_CR64","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.psychres.2017.01.060","volume":"250","author":"CL Vandeleur","year":"2017","unstructured":"Vandeleur CL, Fassassi S, Castelao E, Glaus J, Strippoli MF, Lasserre AM et al (2017) Prevalence and correlates of DSM-5 major depressive and related disorders in the community. Psychiatry Res 250:50\u201358","journal-title":"Psychiatry Res"},{"issue":"4","key":"513_CR65","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1046\/j.1365-2567.2002.01525.x","volume":"107","author":"PT Walsh","year":"2002","unstructured":"Walsh PT, Smith LM, O\u2019Connor R (2002) Insulin-like growth factor-1 activates Akt and Jun N-terminal kinases (JNKs) in promoting the survival of T lymphocytes. Immunology 107(4):461\u2013471","journal-title":"Immunology"},{"issue":"18","key":"513_CR66","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1212\/WNL.0000000000000382","volume":"82","author":"AJ Westwood","year":"2014","unstructured":"Westwood AJ, Beiser A, DeCarli C, Harris TB, Chen TC, He XM, Roubenoff R, Pikula A, Au R, Braverman LE, Wolf PA (2014) Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy. Neurology 82(18):1613\u20131619","journal-title":"Neurology"},{"issue":"4","key":"513_CR67","doi-asserted-by":"publisher","first-page":"e291","DOI":"10.1212\/WNL.0000000000004854","volume":"90","author":"DM Williams","year":"2018","unstructured":"Williams DM, Karlsson IK, Pedersen NL, H\u00e4gg S (2018) Circulating insulin-like growth factors and Alzheimer disease: a Mendelian randomization study. Neurology 90(4):e291\u2013e297","journal-title":"Neurology"},{"key":"513_CR68","first-page":"12","volume":"20","author":"L Yang","year":"2018","unstructured":"Yang L, Wang H, Liu L, Xie A (2018) The role of insulin\/IGF-1\/PI3K\/Akt\/GSK3\u03b2 signaling in Parkinson\u2019s disease dementia. Front Neurosci 20:12","journal-title":"Front Neurosci"},{"key":"513_CR69","doi-asserted-by":"crossref","unstructured":"Yao ZG, Liu Y, Zhang L et al (2012) Co-location of HDAC2 and insulin signaling components in the adult mouse hippocampus. Cell Mol Neurobiol Epub.","DOI":"10.1007\/s10571-012-9859-6"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-022-00513-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-022-00513-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-022-00513-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T11:15:42Z","timestamp":1652354142000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12640-022-00513-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,27]]},"references-count":69,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["513"],"URL":"https:\/\/doi.org\/10.1007\/s12640-022-00513-7","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,27]]},"assertion":[{"value":"15 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"All the authors have given approval for publication of the current manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research Involving Human Participants and\/or Animals"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}