{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:34:58Z","timestamp":1773801298382,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s12640-022-00522-6","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T10:03:21Z","timestamp":1654077801000},"page":"1086-1095","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Melatonin Attenuates Methamphetamine-Induced Alteration of Amyloid \u03b2 Precursor Protein Cleaving Enzyme Expressions via Melatonin Receptor in Human Neuroblastoma Cells"],"prefix":"10.1007","volume":"40","author":[{"given":"Chutikorn","family":"Nopparat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuttree","family":"Boontor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiraporn","family":"Panmanee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9403-6252","authenticated-orcid":false,"given":"Piyarat","family":"Govitrapong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"issue":"25","key":"522_CR1","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.2174\/138161210793176572","volume":"16","author":"P Agostinho","year":"2010","unstructured":"Agostinho P, Cunha RA, Oliveira C (2010) Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer\u2019s disease. Curr Pharm Des 16(25):2766\u20132778. https:\/\/doi.org\/10.2174\/138161210793176572","journal-title":"Curr Pharm Des"},{"key":"522_CR2","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.2147\/CIA.S116218","volume":"11","author":"E Bagyinszky","year":"2016","unstructured":"Bagyinszky E, Youn YC, An SS, Kim S (2016) Mutations, associated with early-onset Alzheimer\u2019s disease, discovered in Asian countries. Clin Interv Aging 11:1467\u20131488. https:\/\/doi.org\/10.2147\/CIA.S116218","journal-title":"Clin Interv Aging"},{"issue":"7","key":"522_CR3","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1089\/neu.2008.0849","volume":"26","author":"JM Bjork","year":"2009","unstructured":"Bjork JM, Grant SJ (2009) Does traumatic brain injury increase risk for substance abuse? J Neurotrauma 26(7):1077\u20131082. https:\/\/doi.org\/10.1089\/neu.2008.0849","journal-title":"J Neurotrauma"},{"key":"522_CR4","first-page":"283","volume-title":"Handbook of Plant Ecophysiology Techniques","author":"NP Bonjoch","year":"2001","unstructured":"Bonjoch NP, Tamayo PR (2001) Protein Content Quantification by Bradford Method. In: Reigosa MJ (ed) Handbook of Plant Ecophysiology Techniques. Kluwer Academic Publishers, Dordrecht, The Netherlands, pp 283\u2013295"},{"key":"522_CR5","doi-asserted-by":"publisher","unstructured":"Cardinali DP (2019) Melatonin: clinical perspectives in neurodegeneration. Frontiers in Endocrinology 10(480).\u00a0https:\/\/doi.org\/10.3389\/fendo.2019.00480","DOI":"10.3389\/fendo.2019.00480"},{"key":"522_CR6","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.tiv.2018.10.012","volume":"54","author":"L Chen","year":"2019","unstructured":"Chen L, Yu P, Zhang L, Zou Y, Zhang Y, Jiang L, Gao R, Xiao H, Qian Y, Wang J (2019) Methamphetamine exposure induces neuropathic protein \u03b2-Amyloid expression. Toxicol in Vitro 54:304\u2013309. https:\/\/doi.org\/10.1016\/j.tiv.2018.10.012","journal-title":"Toxicol in Vitro"},{"issue":"1","key":"522_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12017-009-8104-z","volume":"12","author":"VW Chow","year":"2010","unstructured":"Chow VW, Mattson MP, Wong PC, Gleichmann M (2010) An overview of APP processing enzymes and products. NeuroMol Med 12(1):1\u201312. https:\/\/doi.org\/10.1007\/s12017-009-8104-z","journal-title":"NeuroMol Med"},{"issue":"21","key":"522_CR8","doi-asserted-by":"publisher","first-page":"R906","DOI":"10.1016\/j.cub.2006.09.056","volume":"16","author":"R Dahm","year":"2006","unstructured":"Dahm R (2006) Alzheimer\u2019s discovery. Curr Biol 16(21):R906-910. https:\/\/doi.org\/10.1016\/j.cub.2006.09.056","journal-title":"Curr Biol"},{"issue":"2","key":"522_CR9","first-page":"194","volume":"3","author":"R Hardeland","year":"2012","unstructured":"Hardeland R (2012) Melatonin in aging and disease -multiple consequences of reduced secretion, options and limits of treatment. Aging Dis 3(2):194\u2013225","journal-title":"Aging Dis"},{"issue":"1","key":"522_CR10","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s00213-013-3228-0","volume":"231","author":"AJ Hutchinson","year":"2014","unstructured":"Hutchinson AJ, Ma J, Liu J, Hudson RL, Dubocovich ML (2014) Role of MT1 melatonin receptors in methamphetamine-induced locomotor sensitization in C57BL\/6 mice. Psychopharmacology 231(1):257\u2013267. https:\/\/doi.org\/10.1007\/s00213-013-3228-0","journal-title":"Psychopharmacology"},{"key":"522_CR11","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.brainres.2016.08.045","volume":"1650","author":"P Jumnongprakhon","year":"2016","unstructured":"Jumnongprakhon P, Govitrapong P, Tocharus C, Tocharus J (2016) Inhibitory effect of melatonin on cerebral endothelial cells dysfunction induced by methamphetamine via NADPH oxidase-2. Brain Res 1650:84\u201392. https:\/\/doi.org\/10.1016\/j.brainres.2016.08.045","journal-title":"Brain Res"},{"key":"522_CR12","doi-asserted-by":"publisher","unstructured":"Kojro E, Fahrenholz F (2005) The non-amyloidogenic pathway: structure and function of \u03b1-secretases. Subcell Biochem 105\u2013127.\u00a0https:\/\/doi.org\/10.1007\/0-387-23226-5_5","DOI":"10.1007\/0-387-23226-5_5"},{"issue":"2","key":"522_CR13","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1600-079X.2008.00648.x","volume":"46","author":"P Kongsuphol","year":"2009","unstructured":"Kongsuphol P, Mukda S, Nopparat C, Villarroel A, Govitrapong P (2009) Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells. J Pineal Res 46(2):199\u2013206. https:\/\/doi.org\/10.1111\/j.1600-079X.2008.00648.x","journal-title":"J Pineal Res"},{"key":"522_CR14","doi-asserted-by":"publisher","unstructured":"Kumar D, Ganeshpurkar A, Kumar D, Modi G, Gupta SK, Singh SK (2018a) Secretase inhibitors for the treatment of Alzheimer\u2019s disease: long road ahead. Eur J Med Chem 148:436\u2013452. https:\/\/doi.org\/10.1016\/j.ejmech.2018.02.035","DOI":"10.1016\/j.ejmech.2018.02.035"},{"key":"522_CR15","doi-asserted-by":"publisher","unstructured":"Kumar K, Kumar A, Keegan RM, Deshmukh R (2018b) Recent advances in the neurobiology and neuropharmacology of Alzheimer\u2019s disease. Biomed Pharmacother 98:297\u2013307.\u00a0https:\/\/doi.org\/10.1016\/j.biopha.2017.12.053","DOI":"10.1016\/j.biopha.2017.12.053"},{"key":"522_CR16","doi-asserted-by":"publisher","first-page":"4982453","DOI":"10.1155\/2018\/4982453","volume":"2018","author":"F Limanaqi","year":"2018","unstructured":"Limanaqi F, Gambardella S, Biagioni F, Busceti CL, Fornai F (2018) Epigenetic effects induced by methamphetamine and methamphetamine-dependent oxidative stress. Oxid Med Cell Longev 2018:4982453. https:\/\/doi.org\/10.1155\/2018\/4982453","journal-title":"Oxid Med Cell Longev"},{"key":"522_CR17","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1146\/annurev-pharmtox-010814-124742","volume":"56","author":"J Liu","year":"2016","unstructured":"Liu J, Clough SJ, Hutchinson AJ, Adamah-Biassi EB, Popovska-Gorevski M, Dubocovich ML (2016) MT1 and MT2 melatonin receptors: a therapeutic perspective. Annu Rev Pharmacol Toxicol 56:361\u2013383. https:\/\/doi.org\/10.1146\/annurev-pharmtox-010814-124742","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"522_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.110109","volume":"111","author":"T Lwin","year":"2021","unstructured":"Lwin T, Yang JL, Ngampramuan S, Viwatpinyo K, Chancharoen P, Veschsanit N, Pinyomahakul J, Govitrapong P, Mukda S (2021) Melatonin ameliorates methamphetamine-induced cognitive impairments by inhibiting neuroinflammation via suppression of the TLR4\/MyD88\/NFkappaB signaling pathway in the mouse hippocampus. Prog Neuropsychopharmacol Biol Psychiatry 111:110109. https:\/\/doi.org\/10.1016\/j.pnpbp.2020.110109","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"3","key":"522_CR19","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1007\/s12640-019-00156-1","volume":"37","author":"J Namyen","year":"2020","unstructured":"Namyen J, Permpoonputtana K, Nopparat C, Tocharus J, Tocharus C, Govitrapong P (2020) Protective effects of melatonin on methamphetamine-induced blood-brain barrier dysfunction in rat model. Neurotox Res 37(3):640\u2013660. https:\/\/doi.org\/10.1007\/s12640-019-00156-1","journal-title":"Neurotox Res"},{"key":"522_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-021-03290-5","author":"C Nopparat","year":"2021","unstructured":"Nopparat C, Chaopae W, Boontem P, Sopha P, Wongchitrat P, Govitrapong P (2021) Melatonin attenuates high glucose-induced changes in beta amyloid precursor protein processing in human neuroblastoma cells. Neurochem Res. https:\/\/doi.org\/10.1007\/s11064-021-03290-5","journal-title":"Neurochem Res"},{"issue":"4","key":"522_CR21","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/j.1600-079X.2010.00805.x","volume":"49","author":"C Nopparat","year":"2010","unstructured":"Nopparat C, Porter JE, Ebadi M, Govitrapong P (2010) The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy. J Pineal Res 49(4):382\u2013389. https:\/\/doi.org\/10.1111\/j.1600-079X.2010.00805.x","journal-title":"J Pineal Res"},{"issue":"3","key":"522_CR22","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.pneurobio.2008.04.001","volume":"85","author":"SR Pandi-Perumal","year":"2008","unstructured":"Pandi-Perumal SR, Trakht I, Srinivasan V, Spence DW, Maestroni GJ, Zisapel N, Cardinali DP (2008) Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways. Prog Neurobiol 85(3):335\u2013353. https:\/\/doi.org\/10.1016\/j.pneurobio.2008.04.001","journal-title":"Prog Neurobiol"},{"key":"522_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2021.105121","volume":"148","author":"P Panmak","year":"2021","unstructured":"Panmak P, Nopparat C, Permpoonpattana K, Namyen J, Govitrapong P (2021) Melatonin protects against methamphetamine-induced Alzheimer\u2019s disease-like pathological changes in rat hippocampus. Neurochem Int 148:105121. https:\/\/doi.org\/10.1016\/j.neuint.2021.105121","journal-title":"Neurochem Int"},{"issue":"3","key":"522_CR24","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/jpi.12260","volume":"59","author":"J Panmanee","year":"2015","unstructured":"Panmanee J, Nopparat C, Chavanich N, Shukla M, Mukda S, Song W, Vincent B, Govitrapong P (2015) Melatonin regulates the transcription of betaAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells. J Pineal Res 59(3):308\u2013320. https:\/\/doi.org\/10.1111\/jpi.12260","journal-title":"J Pineal Res"},{"issue":"3\u20134","key":"522_CR25","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s00221-011-2952-0","volume":"217","author":"J Prox","year":"2012","unstructured":"Prox J, Rittger A, Saftig P (2012) Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin. Exp Brain Res 217(3\u20134):331\u2013341. https:\/\/doi.org\/10.1007\/s00221-011-2952-0","journal-title":"Exp Brain Res"},{"key":"522_CR26","doi-asserted-by":"publisher","unstructured":"Selkoe DJ, Hardy J (2016) The amyloid hypothesis of Alzheimer\u2019s disease at 25 years. EMBO Mol Med 8(6):595\u2013608.\u00a0https:\/\/doi.org\/10.15252\/emmm.201606210","DOI":"10.15252\/emmm.201606210"},{"issue":"2","key":"522_CR27","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/jpi.12200","volume":"58","author":"M Shukla","year":"2015","unstructured":"Shukla M, Htoo HH, Wintachai P, Hernandez JF, Dubois C, Postina R, Xu H, Checler F, Smith DR, Govitrapong P, Vincent B (2015) Melatonin stimulates the nonamyloidogenic processing of betaAPP through the positive transcriptional regulation of ADAM10 and ADAM17. J Pineal Res 58(2):151\u2013165. https:\/\/doi.org\/10.1111\/jpi.12200","journal-title":"J Pineal Res"},{"key":"522_CR28","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.neuro.2015.08.008","volume":"50","author":"P Wongprayoon","year":"2015","unstructured":"Wongprayoon P, Govitrapong P (2015) Melatonin attenuates methamphetamine-induced neuroinflammation through the melatonin receptor in the SH-SY5Y cell line. Neurotoxicology 50:122\u2013130. https:\/\/doi.org\/10.1016\/j.neuro.2015.08.008","journal-title":"Neurotoxicology"},{"issue":"47","key":"522_CR29","doi-asserted-by":"publisher","first-page":"16465","DOI":"10.1021\/bi9816195","volume":"37","author":"W Xia","year":"1998","unstructured":"Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ (1998) Presenilin 1 Regulates the Processing of \u03b2-amyloid precursor protein C-terminal fragments and the generation of amyloid \u03b2-protein in endoplasmic reticulum and golgi. Biochemistry 37(47):16465\u201316471. https:\/\/doi.org\/10.1021\/bi9816195","journal-title":"Biochemistry"},{"key":"522_CR30","doi-asserted-by":"publisher","unstructured":"Yang X, Wang Y, Li Q, Zhong Y, Chen L, Du Y, He J, Liao L, Xiong K, Yi C-x, Yan J (2018a) The main molecular mechanisms underlying methamphetamine- induced neurotoxicity and implications for pharmacological treatment. Front Mole Neurosci 11(186).\u00a0https:\/\/doi.org\/10.3389\/fnmol.2018a.00186","DOI":"10.3389\/fnmol.2018a.00186"},{"key":"522_CR31","doi-asserted-by":"publisher","unstructured":"Yang X, Wang Y, Li Q, Zhong Y, Chen L, Du Y, He J, Liao L, Xiong K, Yi CX, Yan J (2018b) The main molecular mechanisms underlying methamphetamine- induced neurotoxicity and implications for pharmacological treatment. Front Mol Neurosci 11:186. https:\/\/doi.org\/10.3389\/fnmol.2018.00186","DOI":"10.3389\/fnmol.2018.00186"},{"issue":"5","key":"522_CR32","doi-asserted-by":"crossref","first-page":"181","DOI":"10.14712\/fb2016062050181","volume":"62","author":"R Zakaria","year":"2016","unstructured":"Zakaria R, Ahmad AH, Othman Z (2016) The potential role of melatonin on memory function: lessons from rodent studies. Folia Biol (praha) 62(5):181\u2013187","journal-title":"Folia Biol (praha)"},{"issue":"29","key":"522_CR33","doi-asserted-by":"publisher","first-page":"6915","DOI":"10.1523\/JNEUROSCI.0340-17.2017","volume":"37","author":"S Zhang","year":"2017","unstructured":"Zhang S, Wang Z, Cai F, Zhang M, Wu Y, Zhang J, Song W (2017) BACE1 cleavage site selection critical for amyloidogenesis and Alzheimer\u2019s pathogenesis. J Neurosci 37(29):6915. https:\/\/doi.org\/10.1523\/JNEUROSCI.0340-17.2017","journal-title":"J Neurosci"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-022-00522-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-022-00522-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-022-00522-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T06:55:13Z","timestamp":1727333713000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12640-022-00522-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["522"],"URL":"https:\/\/doi.org\/10.1007\/s12640-022-00522-6","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,1]]},"assertion":[{"value":"24 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}