{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:44:46Z","timestamp":1788371086307,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Key research project of Health Commission of Sichuan Province","award":["19ZD009"],"award-info":[{"award-number":["19ZD009"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s12640-022-00529-z","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T06:03:37Z","timestamp":1659420217000},"page":"1405-1414","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Repeated Sevoflurane Exposures in Neonatal Rats Increased the Brain Vulnerability to Future Stress Exposure and Resulted in Fear Extinction Deficit"],"prefix":"10.1007","volume":"40","author":[{"given":"Ben-zhen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-hua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-qin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-chao","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"529_CR1","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.tins.2017.07.001","volume":"40","author":"Y Ben-Ari","year":"2017","unstructured":"Ben-Ari Y (2017) NKCC1 chloride importer antagonists attenuate many neurological and psychiatric disorders. Trends Neurosci 40:536\u2013554","journal-title":"Trends Neurosci"},{"key":"529_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12035-019-01751-1","volume":"57","author":"OH Cabrera","year":"2020","unstructured":"Cabrera OH, Tesic V, Tat QL et al (2020) Sevoflurane-induced dysregulation of cation-chloride cotransporters NKCC1 and KCC2 in neonatal mouse brain. Mol Neurobiol 57:1\u201310","journal-title":"Mol Neurobiol"},{"key":"529_CR3","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.1007\/s00213-014-3572-8","volume":"231","author":"SK Crowley","year":"2014","unstructured":"Crowley SK, Girdler SS (2014) Neurosteroid, GABAergic and hypothalamic pituitary adrenal (HPA) axis regulation: what is the current state of knowledge in humans? Psychopharmacology 231:3619\u20133634","journal-title":"Psychopharmacology"},{"key":"529_CR4","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.biopsych.2019.07.009","volume":"86","author":"J DePierro","year":"2019","unstructured":"DePierro J, Lepow L, Feder A, Yehuda R (2019) Translating molecular and neuroendocrine findings in posttraumatic stress disorder and resilience to novel therapies. Biol Psychiatry 86:454\u2013463","journal-title":"Biol Psychiatry"},{"key":"529_CR5","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1038\/nm1301","volume":"11","author":"VI Dzhala","year":"2005","unstructured":"Dzhala VI, Talos DM, Sdrulla DA et al (2005) NKCC1 transporter facilitates seizures in the developing brain. Nat Med 11:1205\u20131213","journal-title":"Nat Med"},{"key":"529_CR6","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.neuron.2009.08.022","volume":"63","author":"J Glykys","year":"2009","unstructured":"Glykys J, Dzhala VI, Kuchibhotla KV et al (2009) Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures. Neuron 63:657\u2013672","journal-title":"Neuron"},{"key":"529_CR7","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1037\/tra0000298","volume":"10","author":"N Haruvi-Lamdan","year":"2018","unstructured":"Haruvi-Lamdan N, Horesh D, Golan O (2018) PTSD and autism spectrum disorder: co-morbidity, gaps in research, and potential shared mechanisms. Psychol Trauma 10:290\u2013299","journal-title":"Psychol Trauma"},{"key":"529_CR8","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s40489-015-0052-y","volume":"2","author":"DW Hoover","year":"2015","unstructured":"Hoover DW (2015) The effects of psychological trauma on children with autism spectrum disorders: a research review. Rev J Autism Dev Disord 2:287\u2013299","journal-title":"Rev J Autism Dev Disord"},{"key":"529_CR9","doi-asserted-by":"publisher","first-page":"11878","DOI":"10.1038\/s41598-017-12183-z","volume":"7","author":"D Hu","year":"2017","unstructured":"Hu D, Yu Z, Zhang Y et al (2017) Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress. Sci Rep 7:11878","journal-title":"Sci Rep"},{"key":"529_CR10","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0006-2952(01)00696-7","volume":"62","author":"C Ikonomidou","year":"2001","unstructured":"Ikonomidou C, Bittigau P, Koch C et al (2001) Neurotransmitters and apoptosis in the developing brain. Biochem Pharmacol 62:401\u2013405","journal-title":"Biochem Pharmacol"},{"key":"529_CR11","doi-asserted-by":"publisher","first-page":"3759","DOI":"10.1007\/s12035-016-9943-x","volume":"54","author":"M Ji","year":"2017","unstructured":"Ji M, Wang Z, Sun X et al (2017) Repeated neonatal sevoflurane exposure-induced developmental delays of parvalbumin interneurons and cognitive impairments are reversed by environmental enrichment. Mol Neurobiol 54:3759\u20133570","journal-title":"Mol Neurobiol"},{"key":"529_CR12","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.psyneuen.2017.04.001","volume":"81","author":"L Ju","year":"2017","unstructured":"Ju L, Yang J, Gravenstein N et al (2017) Role of environmental stressors in determining the developmental outcome of neonatal anesthesia. Psychoneuroendocrino 81:96\u2013104","journal-title":"Psychoneuroendocrino"},{"key":"529_CR13","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.bja.2018.04.034","volume":"121","author":"L Ju","year":"2018","unstructured":"Ju L, Yang L, Morey TE et al (2018) Role of epigenetic mechanisms in transmitting the effects of neonatal sevoflurane exposure to the next generation of male, but not female, rats. Br J Anaesth 121:406\u2013416","journal-title":"Br J Anaesth"},{"key":"529_CR14","doi-asserted-by":"publisher","first-page":"3475","DOI":"10.1007\/s10803-015-2392-y","volume":"45","author":"CM Kerns","year":"2015","unstructured":"Kerns CM, Newschaffer CJ, Berkowitz SJ (2015) Traumatic childhood events and autism spectrum disorder. J Autism Dev Disord 45:3475\u20133486","journal-title":"J Autism Dev Disord"},{"key":"529_CR15","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1111\/j.0953-816X.2003.03152.x","volume":"19","author":"R Khazipov","year":"2004","unstructured":"Khazipov R, Khalilov I, Tyzio R et al (2004) Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus. Eur J Neurosci 19:590\u2013600","journal-title":"Eur J Neurosci"},{"key":"529_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.10","volume":"7","author":"E Lemonnier","year":"2017","unstructured":"Lemonnier E, Villeneuve N, Sonie S et al (2017) Effects of bumetanide on neurobehavioral function in children and adolescents with autism spectrum disorders. Transl Psychiatry 7:e1056","journal-title":"Transl Psychiatry"},{"key":"529_CR17","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.neuroscience.2021.08.001","volume":"472","author":"D Lin","year":"2021","unstructured":"Lin D, Liu J, Florveus A et al (2021) Exposure to sevoflurane, but not ketamine, during early-life brain development has long-lasting effects on GABAA receptor mediated inhibitory neurotransmission. Neuroscience 472:116\u2013127","journal-title":"Neuroscience"},{"key":"529_CR18","doi-asserted-by":"crossref","unstructured":"Lin D, Liu J, Kramberg L et al (2016) Early-life single-episode sevoflurane exposure impairs social behavior and cognition later in life. Brain Behav e00514","DOI":"10.1002\/brb3.514"},{"key":"529_CR19","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.3389\/fneur.2019.01407","volume":"10","author":"R Liu","year":"2020","unstructured":"Liu R, Wang J, Liang S, Zhang G, Yang X (2020) Role of NKCC1 and KCC2 in epilepsy: from expression to function. Front Neurol 10:1407","journal-title":"Front Neurol"},{"key":"529_CR20","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/npp.2016.90","volume":"42","author":"C M\u00e9nard","year":"2017","unstructured":"M\u00e9nard C, Pfau ML, Hodes GE, Russo SJ (2017) Immune and neuroendocrine mechanisms of stress vulnerability and resilience. Neuropsychophar 42:62\u201380","journal-title":"Neuropsychophar"},{"key":"529_CR21","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3389\/fncel.2012.00004","volume":"6","author":"I Mody","year":"2012","unstructured":"Mody I, Maguire J (2012) The reciprocal regulation of stress hormones and GABA(A) receptors. Front Cell Neurosci 6:4","journal-title":"Front Cell Neurosci"},{"key":"529_CR22","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3389\/fendo.2018.00176","volume":"9","author":"AM Molaie","year":"2018","unstructured":"Molaie AM, Maguire J (2018) Neuroendocrine abnormalities following traumatic brain injury: an important contributor to neuropsychiatric sequelae. Front Endocrinol 9:176","journal-title":"Front Endocrinol"},{"key":"529_CR23","doi-asserted-by":"publisher","first-page":"3419","DOI":"10.1523\/JNEUROSCI.1377-08.2009","volume":"29","author":"CK Pfeffer","year":"2009","unstructured":"Pfeffer CK, Stein V, Keating DJ et al (2009) NKCC1-dependent GABAergic excitation drives synaptic network maturation during early hippocampal development. J Neurosci 29:3419\u20133430","journal-title":"J Neurosci"},{"key":"529_CR24","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.biopsych.2006.03.010","volume":"60","author":"GJ Quirk","year":"2006","unstructured":"Quirk GJ, Garcia R, Gonz\u00e1lez-Lima F (2006) Prefrontal mechanisms in extinction of conditioned fear. Biol Psychiatry 60:337\u2013343","journal-title":"Biol Psychiatry"},{"key":"529_CR25","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1097\/ALN.0b013e3181974fa2","volume":"110","author":"M Satomoto","year":"2009","unstructured":"Satomoto M, Satoh Y, Terui K et al (2009) Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice. Anesthesiology 110:628\u2013637","journal-title":"Anesthesiology"},{"key":"529_CR26","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1093\/bja\/aew064","volume":"117","author":"Z Sun","year":"2016","unstructured":"Sun Z, Satomoto M, Adachi YU, Kinoshita H, Makita K (2016) Inhibiting NADPH oxidase protects against long-term memory impairment induced by neonatal sevoflurane exposure in mice. Br J Anaesth 117:80\u201386","journal-title":"Br J Anaesth"},{"key":"529_CR27","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1097\/ALN.0000000000000366","volume":"121","author":"S Tan","year":"2014","unstructured":"Tan S, Xu C, Zhu W et al (2014) Endocrine and neurobehavioral abnormalities induced by propofol administered to neonatal rats. Anesthesiology 121:1010\u20131017","journal-title":"Anesthesiology"},{"key":"529_CR28","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1126\/science.1247190","volume":"343","author":"R Tyzio","year":"2014","unstructured":"Tyzio R, Nardou R, Ferrari DC et al (2014) Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. Science 343:675\u2013679","journal-title":"Science"},{"key":"529_CR29","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.psyneuen.2015.06.016","volume":"60","author":"C Xu","year":"2015","unstructured":"Xu C, Tan S, Zhang J et al (2015) Neonatal anesthesia with sevoflurane: developmental neuroendocrine abnormalities and alleviating effects of the corticosteroid and Cl- importer antagonists. Psychoneuroendocrino 60:173\u2013181","journal-title":"Psychoneuroendocrino"},{"key":"529_CR30","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.neulet.2018.08.019","volume":"685","author":"J Yang","year":"2018","unstructured":"Yang J, Ju L, Yang C et al (2018) Effects of combined brief etomidate anesthesia and postnatal stress on amygdala expression of Cl- cotransporters and corticotropin-releasing hormone and alcohol intake in adult rats. Neurosci Lett 685:83\u201389","journal-title":"Neurosci Lett"},{"key":"529_CR31","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.neuropharm.2018.08.014","volume":"141","author":"X Yu","year":"2018","unstructured":"Yu X, Zhang F, Jinshan Shi J (2018) Neonatal exposure to sevoflurane caused cognitive deficits by dysregulating SK2 channels and GluA2-lacking AMPA receptors in juvenile rat hippocampus. Neuropharmacology 141:66\u201375","journal-title":"Neuropharmacology"},{"key":"529_CR32","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1097\/ALN.0000000000003452","volume":"133","author":"Y Yu","year":"2020","unstructured":"Yu Y, Yang Y, Tan H et al (2020) Tau contributes to sevoflurane-induced neurocognitive impairment in neonatal mice. Anesthesiology 133:595\u2013610","journal-title":"Anesthesiology"},{"key":"529_CR33","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1093\/bja\/aev339","volume":"115","author":"M Zhang","year":"2015","unstructured":"Zhang M, Ji M, Zhao Q et al (2015) Neurobehavioural abnormalities induced by repeated exposure of neonatal rats to sevoflurane can be aggravated by social isolation and enrichment deprivation initiated after exposure to the anaesthetic. Br J Anaesth 115:752\u2013760","journal-title":"Br J Anaesth"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-022-00529-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-022-00529-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-022-00529-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T07:41:45Z","timestamp":1664264505000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12640-022-00529-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,2]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["529"],"URL":"https:\/\/doi.org\/10.1007\/s12640-022-00529-z","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,2]]},"assertion":[{"value":"26 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present study was approved by the Ethics Committee of West China Hospital, Sichuan University, and was conducted in accordance with the ARRIVE guidelines and the Guide for the Care and Use of Laboratory Animals from the National Institutes of Health (Bethesda, MD, USA).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors have seen and approved the manuscript to be published and contributed intellectually to this work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}