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Though pesticides primarily target pests by affecting their nervous system and causing other lethal effects, these chemical entities also exert toxic effects in inadvertently exposed humans through inhalation or ingestion. Mounting pieces of evidence from cellular, animal, and clinical studies indicate that pesticide-exposed models display metabolite alterations of pathways involved in neurodegenerative diseases. Hence, identifying common\u00a0key metabolites\/metabolic pathways between pesticide-induced metabolic reprogramming and neurodegenerative diseases is necessary to understand the etiology of pesticides in the rise of neurodegenerative disorders. The present review provides an overview of specific metabolic pathways, including tryptophan metabolism, glutathione metabolism, dopamine metabolism, energy metabolism, mitochondrial dysfunction, fatty acids, and lipid metabolism that are specifically altered in response to pesticides. Furthermore, we  discuss how these metabolite alterations are linked to the pathogenesis of neurodegenerative diseases and\u00a0to identify novel biomarkers for targeted therapeutic approaches.\n<\/jats:p>","DOI":"10.1007\/s12640-022-00534-2","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T08:03:12Z","timestamp":1656921792000},"page":"1539-1552","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Pesticides Exposure-Induced Changes in Brain Metabolome: Implications in the Pathogenesis of Neurodegenerative Disorders"],"prefix":"10.1007","volume":"40","author":[{"given":"Joel Arvin","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha K.","family":"Narasimhamurthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjunath B.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman Sunil","family":"Dsouza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1888-6252","authenticated-orcid":false,"given":"Kamalesh Dattaram","family":"Mumbrekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"534_CR1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.tox.2016.10.012","volume":"372","author":"L Abdullah","year":"2016","unstructured":"Abdullah L, Evans JE, Joshi U et al (2016) Translational potential of long-term decreases in mitochondrial lipids in a mouse model of Gulf War Illness. 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