{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:33:25Z","timestamp":1790184805675,"version":"4.1.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Apoio de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["CAPES\/PVE\u2013 189576\/09-2014"],"award-info":[{"award-number":["CAPES\/PVE\u2013 189576\/09-2014"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Apoio de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["CAPES\/PVE\u2013 189576\/09-2014"],"award-info":[{"award-number":["CAPES\/PVE\u2013 189576\/09-2014"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Apoio de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["CAPES\/PVE\u2013 189576\/09-2014"],"award-info":[{"award-number":["CAPES\/PVE\u2013 189576\/09-2014"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Apoio de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["CAPES\/PVE\u2013 189576\/09-2014"],"award-info":[{"award-number":["CAPES\/PVE\u2013 189576\/09-2014"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o para Ci\u00eancia e Tecnologia","award":["SFRH\/BD\/143286\/2019"],"award-info":[{"award-number":["SFRH\/BD\/143286\/2019"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["CNPQ Edital Universal\/2018 - 429127\/2018-9"],"award-info":[{"award-number":["CNPQ Edital Universal\/2018 - 429127\/2018-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["CNPQ Edital Universal\/2018 - 429127\/2018-9"],"award-info":[{"award-number":["CNPQ Edital Universal\/2018 - 429127\/2018-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CENAPAD-SP (National Center for High Performance Computing in S\u00e3o Paulo), UNICAMP \/ FINEP \u2013 MCT","award":["proj651"],"award-info":[{"award-number":["proj651"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["EXC 2067\/1- 390729940"],"award-info":[{"award-number":["EXC 2067\/1- 390729940"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s12640-022-00559-7","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T08:02:31Z","timestamp":1661241751000},"page":"2135-2147","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species"],"prefix":"10.1007","volume":"40","author":[{"given":"Cleonice Creusa","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thyago R.","family":"Cardim-Pires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Shvachiy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Arturo","family":"Fonseca-Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1urea Maria A. N.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carla S.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica","family":"Teles-Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estael","family":"Ochoa-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"de F\u00e1tima Dias Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando L.","family":"Palhano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Segura-Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyse B.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra R.","family":"do Bomfim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoelito C.","family":"dos Santos Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco Henrique A.","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Silva","family":"da Rocha Pita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Lima","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanier","family":"N\u00fa\u00f1ez-Figueredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Fleming","family":"Outeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora","family":"Foguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Diogenes Amaral","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"559_CR1","doi-asserted-by":"publisher","unstructured":"Abraham MJ, Murtola T, Schulz R, P\u00e1ll S, Smith JC, Hess B, Lindahl E (2015)\u00a0Gromacs: high performance molecular simulations through multi-level parallelism from laptops to supercomputers. SoftwareX 1\u20132:19\u201325. https:\/\/doi.org\/10.1016\/j.softx.2015.06.001","DOI":"10.1016\/j.softx.2015.06.001"},{"issue":"15","key":"559_CR2","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1007\/s00018-010-0592-3","volume":"68","author":"B Alvarez-Castelao","year":"2011","unstructured":"Alvarez-Castelao B, Casta\u00f1o JG (2011) Synphilin-1 inhibits alpha-synuclein degradation by the proteasome. Cell Mol Life Sci 68(15):2643\u20132654","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"559_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-13993-7","volume":"11","author":"CS Arlehamn","year":"2020","unstructured":"Arlehamn CS, Lindestam RD, Pham J, Kuan R, Frazier A, Dutra JR, Phillips E, Mallal S, Roederer M, Marder KS (2020) \u0391-synuclein-specific T cell reactivity is associated with preclinical and early Parkinson\u2019s disease. Nat Commun 11(1):1\u201311","journal-title":"Nat Commun"},{"issue":"1","key":"559_CR4","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/mds.27895","volume":"35","author":"G Bellomo","year":"2020","unstructured":"Bellomo G, Paciotti S, Gatticchi L, Parnetti L (2020) The vicious cycle between \u0391-synuclein aggregation and autophagic-lysosomal dysfunction. Mov Disord 35(1):34\u201344","journal-title":"Mov Disord"},{"issue":"4","key":"559_CR5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062277","volume":"8","author":"A Bender","year":"2013","unstructured":"Bender A, Desplats P, Spencer B, Rockenstein E, Adame A, Elstner M, Laub C, Mueller S, Koob AO, Mante M (2013) Tom40 mediates mitochondrial dysfunction induced by \u0391-synuclein accumulation in Parkinson\u2019s disease.\". PLoS ONE 8(4):e62277","journal-title":"PLoS ONE"},{"key":"559_CR6","doi-asserted-by":"publisher","unstructured":"Berendsen HJ, Grigera JR, Straatsma TP (1987)\u00a0The missing term in effective pair potentials. J Phys Chem 91(24):6269\u20136271. https:\/\/doi.org\/10.1021\/j100308a038","DOI":"10.1021\/j100308a038"},{"issue":"8","key":"559_CR7","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.1063\/1.448118","volume":"81","author":"HJC Berendsen","year":"1984","unstructured":"Berendsen HJC, van Postma JPM, van Gunsteren WF, DiNola ARHJ, Haak JR (1984) Molecular dynamics with coupling to an external bath. J Chem Phys 81(8):3684\u20133690","journal-title":"J Chem Phys"},{"issue":"1\u20133","key":"559_CR8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0010-4655(95)00042-E","volume":"91","author":"HJC Berendsen","year":"1995","unstructured":"Berendsen HJC, van der Spoel D, van Drunen R (1995) Gromacs: a message-passing parallel molecular dynamics implementation. Comput Phys Commun 91(1\u20133):43\u201356","journal-title":"Comput Phys Commun"},{"issue":"3","key":"559_CR9","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s12640-015-9560-x","volume":"29","author":"A Brice\u00f1o","year":"2016","unstructured":"Brice\u00f1o A, Mu\u00f1oz P, Brito P, Huenchuguala S, Segura-Aguilar J, Paris IB (2016) Aminochrome toxicity is mediated by inhibition of microtubules polymerization through the formation of adducts with tubulin. Neurotox Res 29(3):381\u2013393","journal-title":"Neurotox Res"},{"key":"559_CR10","doi-asserted-by":"publisher","unstructured":"Bussi G, Donadio D, Parrinello M (2007)\u00a0Canonical sampling through velocity rescaling. J Chem Phys 126(1):014101. https:\/\/doi.org\/10.1063\/1.2408420","DOI":"10.1063\/1.2408420"},{"issue":"19","key":"559_CR11","doi-asserted-by":"publisher","first-page":"4915","DOI":"10.1111\/febs.12471","volume":"280","author":"E Coelho-Cerqueira","year":"2013","unstructured":"Coelho-Cerqueira E, Carmo-Gon\u00e7alves P, Pinheiro AS, Cortines J, Follmer C (2013) \u0391-synuclein as an intrinsically disordered monomer\u2013fact or artefact? FEBS J 280(19):4915\u20134927","journal-title":"FEBS J"},{"issue":"12","key":"559_CR12","doi-asserted-by":"publisher","first-page":"10089","DOI":"10.1063\/1.464397","volume":"98","author":"T Darden","year":"1993","unstructured":"Darden T, York D, Pedersen L (1993) Particle mesh Ewald: an N\u22c5 log (N) method for Ewald sums in large systems. J Chem Phys 98(12):10089\u201310092","journal-title":"J Chem Phys"},{"key":"559_CR13","doi-asserted-by":"crossref","unstructured":"de Ara\u00fajo FM, Ferreira RS, Souza CS, Santos CCD, Rodrigues TLRS, Juliana Helena C, e Silva, Juciano Gasparotto, Daniel Pens Gelain, Ramon S El-Bach\u00e1, Costa Maria de F\u00e1tima D (2018) Aminochrome decreases Ngf, Gdnf and induces neuroinflammation in organotypic midbrain slice cultures. Neurotoxicology 66:98\u2013106","DOI":"10.1016\/j.neuro.2018.03.009"},{"key":"559_CR14","doi-asserted-by":"crossref","unstructured":"De Ara\u00fajo FM, Frota AF, de Jesus LB, Macedo TC, Cuenca-Bermejo L, Sanchez-Rodrigo C, Ferreira KM, de Oliveira JV, de Fatima Dias Costa M, Segura-Aguilar J, Costa SL\u00a0(2022) Aminochrome induces neuroinflammation and dopaminergic neuronal loss: a new preclinical model to find anti-inflammatory and neuroprotective drugs for Parkinson\u2019s disease. Cell Mol Neurobiol\u00a01\u201317.","DOI":"10.1007\/s10571-021-01173-5"},{"key":"559_CR15","doi-asserted-by":"publisher","unstructured":"Fernandes L, Messias B, Pereira-Neves A, Azevedo EP, Ara\u00fajo J, Foguel D, Palhano FL\u00a0(2020)\u00a0Green tea polyphenol microparticles based on the oxidative coupling of Egcg inhibit amyloid aggregation\/cytotoxicity and serve as a platform for drug delivery. ACS Biomater Sci Eng 6(8):4414\u20134423. https:\/\/doi.org\/10.1021\/acsbiomaterials.0c00188","DOI":"10.1021\/acsbiomaterials.0c00188"},{"issue":"8","key":"559_CR16","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1179\/1743132813Y.0000000216","volume":"35","author":"YN Figueredo","year":"2013","unstructured":"Figueredo YN, Rodr\u00edguez EO, Reyes YV, Dom\u00ednguez CC, Parra AL, S\u00e1nchez JR, Hern\u00e1ndez RD, Verdecia MP, Pardo GL, Andreu. (2013) Characterization of the anxiolytic and sedative profile of Jm-20: a novel benzodiazepine\u2013dihydropyridine hybrid molecule. Neurol Res 35(8):804\u2013812","journal-title":"Neurol Res"},{"key":"559_CR17","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.neuro.2020.11.005","volume":"82","author":"LA Fonseca-Fonseca","year":"2021","unstructured":"Fonseca-Fonseca LA, Amaral VD, da Silva M, Wong-Guerra J-S, Yaquis ASP, Ochoa-Rodr\u00edguez E, Verdecia-Reyes Y, Mendes F, de Ara\u00fajo R, Santana C, Outeiro TF (2021) Jm-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson\u2019s disease: mitochondrial protection and antioxidant properties. Neurotoxicology 82:89\u201398","journal-title":"Neurotoxicology"},{"key":"559_CR18","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neulet.2018.10.008","volume":"690","author":"LA Fonseca-Fonseca","year":"2019","unstructured":"Fonseca-Fonseca LA, Wong-Guerra M, Ram\u00edrez-S\u00e1nchez J, Montano-Peguero Y, Yaquis ASP, Rodr\u00edguez AM, Amaral VD, da Silva S, Costa L, Pardo-Andreu GL, N\u00fa\u00f1ez-Figueredo Y (2019) Jm-20, a novel hybrid molecule, protects against rotenone-induced neurotoxicity in experimental model of Parkinson\u2019s disease. Neurosci Lett 690:29\u201335","journal-title":"Neurosci Lett"},{"issue":"W1","key":"559_CR19","doi-asserted-by":"publisher","first-page":"W337","DOI":"10.1093\/nar\/gkx333","volume":"45","author":"R F\u00e4hrrolfes","year":"2017","unstructured":"F\u00e4hrrolfes R, Bietz S, Flachsenberg F, Meyder A, Nittinger E, Otto T, Volkamer A, Rarey M (2017) Proteins plus: a web portal for structure analysis of macromolecules.\". Nucleic Acids Res 45(W1):W337\u2013W343","journal-title":"Nucleic Acids Res"},{"key":"559_CR20","unstructured":"Gomes D, Sousa G, da Silva A, Pascutti P (2012)\u00a0Surfinmd. Accessed 2 Jun\u00a02021. Form of Item. https:\/\/lmdm.biof.ufrj.br\/software\/surfinmd\/index"},{"key":"559_CR21","doi-asserted-by":"crossref","unstructured":"Gupta E, Gupta SR, Kumar A, Kulshreshtha A, Niraj RR (2019)\u00a0Molecular docking study to identify potent inhibitors of alpha-synuclein aggregation of Parkinson\u2019s disease","DOI":"10.21276\/ijcmr.2019.6.11.25"},{"issue":"12","key":"559_CR22","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","volume":"18","author":"B Hess","year":"1997","unstructured":"Hess B, Bekker H, Berendsen HJC, Fraaije JGEM (1997) Lincs: a linear constraint solver for molecular simulations. J Comput Chem 18(12):1463\u20131472","journal-title":"J Comput Chem"},{"key":"559_CR23","doi-asserted-by":"crossref","unstructured":"Hess B, Kutzner C, Van Der Spoel D, Lindahl E\u00a0(2008)\u00a0Gromacs 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation\u00a0S1549-9618(70)00301-6.","DOI":"10.1021\/ct700301q"},{"issue":"11","key":"559_CR24","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1021\/acschemneuro.8b00177","volume":"9","author":"C-J Hsieh","year":"2018","unstructured":"Hsieh C-J, Ferrie JJ, Kuiying Xu, Lee I, Graham TJA, Zhude Tu, Jennifer Yu, Dhavale D, Kotzbauer P, James E, Petersson. (2018) Alpha synuclein fibrils contain multiple binding sites for small molecules. ACS Chem Neurosci 9(11):2521\u20132527","journal-title":"ACS Chem Neurosci"},{"issue":"5","key":"559_CR25","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s10571-015-0264-9","volume":"36","author":"Z Hu","year":"2016","unstructured":"Hu Z, Wang W, Ling J, Jiang C (2016) \u0391-mangostin inhibits \u0391-synuclein-induced microglial neuroinflammation and neurotoxicity. Cell Mol Neurobiol 36(5):811\u2013820","journal-title":"Cell Mol Neurobiol"},{"key":"559_CR26","doi-asserted-by":"crossref","unstructured":"Huenchuguala S, Mun\u0303oz P, Segura-Aguilar J (2017)\u00a0The importance of mitophagy in maintaining mitochondrial function in U373mg cells. Bafilomycin A1 restores aminochrome-induced mitochondrial damage. ACS Chem Neurosci\u00a08(10):2247\u20132253","DOI":"10.1021\/acschemneuro.7b00152"},{"issue":"4","key":"559_CR27","doi-asserted-by":"publisher","first-page":"618","DOI":"10.4161\/auto.27720","volume":"10","author":"S Huenchuguala","year":"2014","unstructured":"Huenchuguala S, Mu\u00f1oz P, Zavala P, Villa M, Cuevas C, Ahumada U, Graumann R, Nore BF, Couve E, Mannervik B (2014) Glutathione transferase Mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction. Autophagy 10(4):618\u2013630","journal-title":"Autophagy"},{"key":"559_CR28","doi-asserted-by":"publisher","unstructured":"Kabsch W, Sander C (1983)\u00a0Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. Biopolymers 22(12):2577\u2013637. https:\/\/doi.org\/10.1002\/bip.360221211","DOI":"10.1002\/bip.360221211"},{"issue":"5","key":"559_CR29","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/ane.12563","volume":"134","author":"K Kalinderi","year":"2016","unstructured":"Kalinderi K, Bostantjopoulou S, Fidani L (2016) The genetic background of Parkinson\u2019s disease: current progress and future prospects. Acta Neurol Scand 134(5):314\u2013326","journal-title":"Acta Neurol Scand"},{"key":"559_CR30","doi-asserted-by":"publisher","unstructured":"Lindahl E, Berk H, van der Spoel D (2001) Gromacs 3.0: a package for molecular simulation and trajectory analysis. Mol Model Ann\u00a07(8):306\u2013317. https:\/\/doi.org\/10.1007\/s008940100045","DOI":"10.1007\/s008940100045"},{"issue":"11","key":"559_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004741","volume":"10","author":"DF L\u00e1zaro","year":"2014","unstructured":"L\u00e1zaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Kr\u00f6hnert K, Klucken J, Pereira MD (2014) Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation. PLoS Genet 10(11):e1004741","journal-title":"PLoS Genet"},{"issue":"8","key":"559_CR32","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1002\/jcc.540130805","volume":"13","author":"S Miyamoto","year":"1992","unstructured":"Miyamoto S, Kollman PA (1992) Settle: an analytical version of the shake and rattle algorithm for rigid water models. J Comput Chem 13(8):952\u2013962","journal-title":"J Comput Chem"},{"issue":"1","key":"559_CR33","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/toxsci\/kfv016","volume":"145","author":"P Mu\u00f1oz","year":"2015","unstructured":"Mu\u00f1oz P, Cardenas S, Huenchuguala S, Brice\u00f1o A, Couve E, Paris I, Segura-Aguilar J (2015) Dt-diaphorase prevents aminochrome-induced alpha-synuclein oligomer formation and neurotoxicity. Toxicol Sci 145(1):37\u201347","journal-title":"Toxicol Sci"},{"issue":"2","key":"559_CR34","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s12640-012-9326-7","volume":"22","author":"P Mu\u00f1oz","year":"2012","unstructured":"Mu\u00f1oz P, Huenchuguala S, Paris I, Cuevas C, Villa M, Caviedes P, Segura-Aguilar J, Tizabi Y (2012) Protective effects of nicotine against aminochrome-induced toxicity in substantia nigra derived cells: implications for Parkinson\u2019s disease. Neurotox Res 22(2):177\u2013180","journal-title":"Neurotox Res"},{"issue":"1","key":"559_CR35","first-page":"125","volume":"3","author":"VL Ngoungoure","year":"2019","unstructured":"Ngoungoure VL, Ndam PM, Tizabi Y, Valdes R, Moundipa PF, Segura-Aguilar J (2019) Protective effects of crude plant extracts against aminochrome-induced toxicity in human astrocytoma cells: implications for Parkinson\u2019s disease. Clinical Pharmacology and Translational Medicine 3(1):125","journal-title":"Clinical Pharmacology and Translational Medicine"},{"issue":"4","key":"559_CR36","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.pharep.2018.02.013","volume":"70","author":"Y Nu\u00f1ez-Figueredo","year":"2018","unstructured":"Nu\u00f1ez-Figueredo Y, Ram\u00edrez-S\u00e1nchez J, Pardo GL, Andreu E-R, Verdecia-Reyes Y, Souza DO (2018) Multi-targeting effects of a new synthetic molecule (Jm-20) in experimental models of cerebral ischemia. Pharmacol Rep 70(4):699\u2013704","journal-title":"Pharmacol Rep"},{"key":"559_CR37","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ejphar.2014.01.021","volume":"726","author":"Y Nu\u00f1ez-Figueredo","year":"2014","unstructured":"Nu\u00f1ez-Figueredo Y, Ram\u00edrez-S\u00e1nchez J, Delgado-Hern\u00e1ndez R, Porto-Verdecia M, Ochoa-Rodr\u00edguez E, Verdecia-Reyes Y, Marin-Prida J, Gonz\u00e1lez-Durruthy M, Uyemura SA, Rodrigues FP (2014) Jm-20, a novel benzodiazepine\u2013dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro. Eur J Pharmacol 726:57\u201365","journal-title":"Eur J Pharmacol"},{"key":"559_CR38","doi-asserted-by":"crossref","unstructured":"Ordonez DG, Lee MK, Feany MB\u00a0(2018)\u00a0\u0391-synuclein induces mitochondrial dysfunction through spectrin and the actin cytoskeleton. Neuron 97(1):108\u2013124. e6.","DOI":"10.1016\/j.neuron.2017.11.036"},{"issue":"3","key":"559_CR39","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1074\/jbc.M807100200","volume":"284","author":"FL Palhano","year":"2009","unstructured":"Palhano FL, Leme LP, Busnardo RG, Foguel D (2009) Trapping the monomer of a non-amyloidogenic variant of transthyretin: exploring its possible use as a therapeutic strategy against transthyretin amyloidogenic diseases. J Biol Chem 284(3):1443\u20131453","journal-title":"J Biol Chem"},{"issue":"2","key":"559_CR40","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1093\/toxsci\/kfr060","volume":"121","author":"I Paris","year":"2011","unstructured":"Paris I, Munoz P, Huenchuguala S, Couve E, Sanders LH, Greenamyre JT, Caviedes P, Segura-Aguilar J (2011) Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line. Toxicol Sci 121(2):376\u2013388","journal-title":"Toxicol Sci"},{"key":"559_CR41","doi-asserted-by":"publisher","unstructured":"Pronk S, P\u00e1ll S, Schulz R, Larsson P, Bjelkmar P, Apostolov R, Shirts MR, Smith JC, Kasson PM, van der Spoel D, Hess B, Lindahl E (2013)\u00a0Gromacs 4.5: A high-throughput and highly parallel open source molecular simulation toolkit. Bioinformatics 29(7):845\u201354. https:\/\/doi.org\/10.1093\/bioinformatics\/btt055","DOI":"10.1093\/bioinformatics\/btt055"},{"key":"559_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2020.107547","volume":"97","author":"P Rond\u00f3n-Villarreal","year":"2020","unstructured":"Rond\u00f3n-Villarreal P, L\u00f3pez WOC (2020) Identification of potential natural neuroprotective molecules for Parkinson\u2019s disease by using chemoinformatics and molecular docking. J Mol Graph Model 97:107547","journal-title":"J Mol Graph Model"},{"issue":"1","key":"559_CR43","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1002\/prot.340090107","volume":"9","author":"C Sander","year":"1991","unstructured":"Sander C, Schneider R (1991) Database of homology-derived protein structures and the structural meaning of sequence alignment. Proteins 9(1):56\u201368. https:\/\/doi.org\/10.1002\/prot.340090107","journal-title":"Proteins"},{"key":"559_CR44","doi-asserted-by":"publisher","unstructured":"Santos CC, Mu\u00f1oz P, Almeida \u00c1M, de Lima David JP, David JM, Lima Costa S, Segura-Aguilar J, Silva VD\u00a0(2020)\u00a0The flavonoid agathisflavone from Poincianella pyramidalis prevents aminochrome neurotoxicity. Neurotox Res (3):579\u2013584. https:\/\/doi.org\/10.1007\/s12640-020-00237-6","DOI":"10.1007\/s12640-020-00237-6"},{"key":"559_CR45","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.tiv.2017.04.004","volume":"42","author":"CC Santos","year":"2017","unstructured":"Santos CC, Ara\u00fajo FM, Ferreira RS, Silva VB, Silva JHC, Grangeiro MS, Soares \u00c9N, \u00c9rica Patricia L, Pereira CS, Souza, and Silvia L Costa. (2017) Aminochrome induces microglia and astrocyte activation. Toxicol in Vitro 42:54\u201360","journal-title":"Toxicol in Vitro"},{"key":"559_CR46","doi-asserted-by":"publisher","unstructured":"Schmid N, Eichenberger AP, Choutko A, Riniker S, Winger M, Mark AE, van Gunsteren WF (2011)\u00a0Definition and testing of the gromos force-field versions 54a7 and 54b7. Eur Biophys J 40(7):843\u201356. https:\/\/doi.org\/10.1007\/s00249-011-0700-9","DOI":"10.1007\/s00249-011-0700-9"},{"key":"559_CR47","doi-asserted-by":"crossref","unstructured":"Segura-Aguilar J, Paris I (2014)\u00a0Mechanisms of dopamine oxidation and Parkinson\u2019s disease. Handbook of Neurotoxicity\/ed. Kostrzewa RM New York, NY: Springer New York: 865\u2013883","DOI":"10.1007\/978-1-4614-5836-4_16"},{"issue":"6","key":"559_CR48","doi-asserted-by":"publisher","first-page":"897","DOI":"10.4103\/1673-5374.208560","volume":"12","author":"J Segura-Aguilar","year":"2017","unstructured":"Segura-Aguilar J (2017) On the role of endogenous neurotoxins and neuroprotection in Parkinson\u2019s disease. Neural Regen Res 12(6):897","journal-title":"Neural Regen Res"},{"issue":"4","key":"559_CR49","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1007\/s12640-017-9856-0","volume":"34","author":"J Segura-Aguilar","year":"2018","unstructured":"Segura-Aguilar J (2018) Neurotoxins as preclinical models for Parkinson\u2019s disease. Neurotox Res 34(4):870\u2013877","journal-title":"Neurotox Res"},{"key":"559_CR50","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3389\/fnins.2019.00271","volume":"13","author":"J Segura-Aguilar","year":"2019","unstructured":"Segura-Aguilar J (2019) On the role of aminochrome in mitochondrial dysfunction and endoplasmic reticulum stress in Parkinson\u2019s disease. Front Neurosci 13:271","journal-title":"Front Neurosci"},{"key":"559_CR51","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/B978-0-12-822120-4.00002-2","volume-title":"Clinical Studies and Therapies in Parkinson's Disease : Translations from Preclinical Models","author":"J Segura-Aguilar","year":"2021","unstructured":"Segura-Aguilar J (2021) Dopamine oxidation to neuromelanin and neurotoxic metabolites. In: Segura-Aguilar J (ed) Clinical Studies and Therapies in Parkinson\u2019s Disease\u202f: Translations from Preclinical Models. Academic Press Inc., United States, pp 213\u2013223"},{"issue":"6","key":"559_CR52","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s00401-006-0132-2","volume":"112","author":"Y Shirakashi","year":"2006","unstructured":"Shirakashi Y, Kawamoto Y, Tomimoto H, Takahashi R, Ihara M (2006) \u0391-synuclein is colocalized with 14-3-3 and synphilin-1 in A53t transgenic mice. Acta Neuropathol 112(6):681\u2013689","journal-title":"Acta Neuropathol"},{"issue":"6","key":"559_CR53","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1096\/fj.03-1112rev","volume":"18","author":"A Sidhu","year":"2004","unstructured":"Sidhu A, Wersinger C, Vernier P (2004) Does \u0391-synuclein modulate dopaminergic synaptic content and tone at the synapse? FASEB J 18(6):637\u2013647","journal-title":"FASEB J"},{"issue":"9","key":"559_CR54","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.4103\/1673-5374.306082","volume":"16","author":"V Silva","year":"2021","unstructured":"Silva V, Segura-Aguilar J (2021) State and perspectives on flavonoid neuroprotection against aminochrome-induced neurotoxicity. Neural Regen Res 16(9):1797","journal-title":"Neural Regen Res"},{"issue":"11","key":"559_CR55","doi-asserted-by":"publisher","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","volume":"95","author":"MG Spillantini","year":"1998","unstructured":"Spillantini MG, Anthony Crowther R, Jakes R, Hasegawa M, Goedert M (1998) \u0391-synuclein in filamentous inclusions of Lewy bodies from Parkinson\u2019s disease and dementia with Lewy bodies. Proc Natl Acad Sci 95(11):6469\u20136473","journal-title":"Proc Natl Acad Sci"},{"key":"559_CR56","doi-asserted-by":"crossref","unstructured":"Stroet M, Caron B, Visscher KM, Geerke DP, Malde AK, Mark AE\u00a0(2018)\u00a0Automated topology builder version 3.0: prediction of solvation free enthalpies in water and hexane. J Chem Ther Comput 14(11):5834\u20135845","DOI":"10.1021\/acs.jctc.8b00768"},{"key":"559_CR57","doi-asserted-by":"publisher","unstructured":"Touw WG, Baakman C, Black J, Te Beek TA, Krieger E, Joosten RP, Vriend G (2015)\u00a0A series of Pdb-related databanks for everyday needs. Nucleic Acids Res 43(Database issue): D364\u20138. https:\/\/doi.org\/10.1093\/nar\/gku1028","DOI":"10.1093\/nar\/gku1028"},{"issue":"10","key":"559_CR58","doi-asserted-by":"publisher","first-page":"9595","DOI":"10.1074\/jbc.M411805200","volume":"280","author":"TS Ulmer","year":"2005","unstructured":"Ulmer TS, Bax Ad, Cole NB, Nussbaum RL (2005) Structure and dynamics of micelle-bound human \u0391-synuclein. J Biol Chem 280(10):9595\u20139603","journal-title":"J Biol Chem"},{"key":"559_CR59","doi-asserted-by":"publisher","unstructured":"Van Der Spoel D, Lindahl E, Hess B, Groenhof G, Mark AE, Berendsen HJ (2005)\u00a0Gromacs: fast, flexible, and free. J Comput Chem 26(16): 1701\u201318. https:\/\/doi.org\/10.1002\/jcc.20291","DOI":"10.1002\/jcc.20291"},{"issue":"9","key":"559_CR60","doi-asserted-by":"publisher","first-page":"4393","DOI":"10.1021\/jp0572535","volume":"110","author":"D van der Spoel","year":"2006","unstructured":"van der Spoel D, van Maaren PJ, Larsson P, T\u00eemneanu N (2006) Thermodynamics of hydrogen bonding in hydrophilic and hydrophobic media. J Phys Chem B 110(9):4393\u20134398","journal-title":"J Phys Chem B"},{"issue":"2","key":"559_CR61","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.taap.2014.08.014","volume":"280","author":"R Xiong","year":"2014","unstructured":"Xiong R, Siegel D, Ross D (2014) Quinone-induced protein handling changes: implications for major protein handling systems in quinone-mediated toxicity. Toxicol Appl Pharmacol 280(2):285\u2013295","journal-title":"Toxicol Appl Pharmacol"},{"issue":"4","key":"559_CR62","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1080\/10715760902801533","volume":"43","author":"ZD Zhou","year":"2009","unstructured":"Zhou ZD, Lim TM (2009) Dopamine (Da) induced irreversible proteasome inhibition via Da derived quinones. Free Radical Res 43(4):417\u2013430","journal-title":"Free Radical Res"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-022-00559-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-022-00559-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-022-00559-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,26]],"date-time":"2023-11-26T02:30:36Z","timestamp":1700965836000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12640-022-00559-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,23]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["559"],"URL":"https:\/\/doi.org\/10.1007\/s12640-022-00559-7","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,23]]},"assertion":[{"value":"16 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}