{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T16:59:57Z","timestamp":1768409997127,"version":"3.49.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"San-Ei Gen F.F.I., Inc."},{"DOI":"10.13039\/501100009483","name":"Institute of Global Innovation Research, Tokyo University of Agriculture and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s12640-022-00574-8","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T09:02:56Z","timestamp":1662973376000},"page":"2278-2296","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Continuous Exposure to Alpha-Glycosyl Isoquercitrin from Gestation Ameliorates Disrupted Hippocampal Neurogenesis in Rats Induced by Gestational Injection of Valproic Acid"],"prefix":"10.1007","volume":"40","author":[{"given":"Kazumi","family":"Takashima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromu","family":"Okano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Ojiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihoko","family":"Koyanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert R.","family":"Maronpot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinori","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3417-9697","authenticated-orcid":false,"given":"Makoto","family":"Shibutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"574_CR1","doi-asserted-by":"publisher","first-page":"431","DOI":"10.2131\/jts.38.431","volume":"38","author":"H Akane","year":"2013","unstructured":"Akane H, Saito F, Yamanaka H, Shiraki A, Imatanaka N, Akahori Y, Morita R, Mitsumori K, Shibutani M (2013) Methacarn as a whole brain fixative for gene and protein expression analyses of specific brain regions in rats. J Toxicol Sci 38:431\u2013443. https:\/\/doi.org\/10.2131\/jts.38.431","journal-title":"J Toxicol Sci"},{"key":"574_CR2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3358\/shokueishi.41.54","volume":"41","author":"T Akiyama","year":"2000","unstructured":"Akiyama T, Washino T, Yamada T, Koda T, Maitani T (2000) Constituents of enzymatically modified isoquercitrin and enzymatically modified rutin (extract). Food Hyg Saf Sci (Shokuhin Eiseigaku Zasshi) 41:46\u201360. https:\/\/doi.org\/10.3358\/shokueishi.41.54","journal-title":"Food Hyg Saf Sci (shokuhin Eiseigaku Zasshi)"},{"key":"574_CR3","doi-asserted-by":"publisher","unstructured":"Baio J, Wiggins L, Christensen DL, Maenner MJ, Daniels J, Warren Z, Kurzius-Spencer M, Zahorodny W, Robinson Rosenberg C, White T, Durkin MS, Imm P, Nikolaou L, Yeargin-Allsopp M, Lee LC, Harrington R, Lopez M, Fitzgerald RT, Hewitt A, Pettygrove S, Constantino JN, Vehorn A, Shenouda J, Hall-Lande J, Van Naarden Braun K, Dowling NF (2018) Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 Sites, United States, 2014. MMWR Surveill Summ 67:1\u201323. https:\/\/doi.org\/10.15585\/mmwr.ss6706a1","DOI":"10.15585\/mmwr.ss6706a1"},{"key":"574_CR4","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1093\/cercor\/bhp133","volume":"20","author":"D Balschun","year":"2010","unstructured":"Balschun D, Moechars D, Callaerts-Vegh Z, Vermaercke B, Van Acker N, Andries L, D\u2019Hooge R (2010) Vesicular glutamate transporter VGLUT1 has a role in hippocampal long-term potentiation and spatial reversal learning. Cereb Cortex 20:684\u2013693. https:\/\/doi.org\/10.1093\/cercor\/bhp133","journal-title":"Cereb Cortex"},{"key":"574_CR5","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nrn2054","volume":"8","author":"S Bauer","year":"2007","unstructured":"Bauer S, Kerr BJ, Patterson PH (2007) The neuropoietic cytokine family in development, plasticity, disease and injury. Nat Rev Neurosci 8:221\u2013232. https:\/\/doi.org\/10.1038\/nrn2054","journal-title":"Nat Rev Neurosci"},{"key":"574_CR6","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.1242\/dev.088005","volume":"140","author":"DA Berg","year":"2013","unstructured":"Berg DA, Belnoue L, Song H, Simon A (2013) Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain. Development 140:2548\u20132561. https:\/\/doi.org\/10.1242\/dev.088005","journal-title":"Development"},{"key":"574_CR7","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.1007\/s12035-019-01742-2","volume":"57","author":"G Bj\u00f8rklund","year":"2020","unstructured":"Bj\u00f8rklund G, Meguid NA, El-Bana MA, Tinkov AA, Saad K, Dadar M, Hemimi M, Skalny AV, Hosnedlov\u00e1 B, Kizek R, Osredkar J, Urbina MA, Fabjan T, El-Houfey AA, Ka\u0142u\u017cna-Czapli\u0144ska J, G\u0105tarek P, Chirumbolo S (2020) Oxidative stress in autism spectrum disorder. Mol Neurobiol 57:2314\u20132332. https:\/\/doi.org\/10.1007\/s12035-019-01742-2","journal-title":"Mol Neurobiol"},{"key":"574_CR8","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.brainres.2012.11.048","volume":"1495","author":"R Bristot Silvestrin","year":"2013","unstructured":"Bristot Silvestrin R, Bambini-Junior V, Galland F, Daniele Bobermim L, Quincozes-Santos A, Torres Abib R, Zanotto C, Batassini C, Brolese G, Gon\u00e7alves CA, Riesgo R, Gottfried C (2013) Animal model of autism induced by prenatal exposure to valproate: altered glutamate metabolism in the hippocampus. Brain Res 1495:52\u201360. https:\/\/doi.org\/10.1016\/j.brainres.2012.11.048","journal-title":"Brain Res"},{"key":"574_CR9","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1212\/01.wnl.0000339399.64213.1a","volume":"71","author":"RL Bromley","year":"2008","unstructured":"Bromley RL, Mawer G, Clayton-Smith J, Baker GA, Liverpool and Manchester Neurodevelopment Group (2008) Autism spectrum disorders following in utero exposure to antiepileptic drugs. Neurology 71:1923\u20131924. https:\/\/doi.org\/10.1212\/01.wnl.0000339399.64213.1a","journal-title":"Neurology"},{"key":"574_CR10","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00441-017-2668-y","volume":"371","author":"C Catavero","year":"2018","unstructured":"Catavero C, Bao H, Song J (2018) Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis. Cell Tissue Res 371:33\u201346. https:\/\/doi.org\/10.1007\/s00441-017-2668-y","journal-title":"Cell Tissue Res"},{"key":"574_CR11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1159\/000509109","volume":"42","author":"D Chaliha","year":"2020","unstructured":"Chaliha D, Albrecht M, Vaccarezza M, Takechi R, Lam V, Al-Salami H, Mamo J (2020) A systematic review of the valproic-acid-induced rodent model of autism. Dev Neurosci 42:12\u201348. https:\/\/doi.org\/10.1159\/000509109","journal-title":"Dev Neurosci"},{"key":"574_CR12","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1152\/jn.2002.87.6.2851","volume":"87","author":"C Chen","year":"2002","unstructured":"Chen C, Magee JC, Bazan NG (2002) Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity. J Neurophysiol 87:2851\u20132857. https:\/\/doi.org\/10.1152\/jn.2002.87.6.2851","journal-title":"J Neurophysiol"},{"key":"574_CR13","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1001\/jama.2013.2270","volume":"309","author":"J Christensen","year":"2013","unstructured":"Christensen J, Gr\u00f8nborg TK, S\u00f8rensen MJ, Schendel D, Parner ET, Pedersen LH, Vestergaard M (2013) Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA 309:1696\u20131703. https:\/\/doi.org\/10.1001\/jama.2013.2270","journal-title":"JAMA"},{"key":"574_CR14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3389\/fnint.2018.00047","volume":"12","author":"OI Dadalko","year":"2018","unstructured":"Dadalko OI, Travers BG (2018) Evidence for brainstem contributions to autism spectrum disorders. Front Integr Neurosci 12:47. https:\/\/doi.org\/10.3389\/fnint.2018.00047","journal-title":"Front Integr Neurosci"},{"key":"574_CR15","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1159\/000492113","volume":"25","author":"I Deckmann","year":"2018","unstructured":"Deckmann I, Schwingel GB, Fontes-Dutra M, Bambini-Junior V, Gottfried C (2018) Neuroimmune alterations in autism: a translational analysis focusing on the animal model of autism induced by prenatal exposure to valproic acid. NeuroImmunoModulation 25:285\u2013299. https:\/\/doi.org\/10.1159\/000492113","journal-title":"NeuroImmunoModulation"},{"key":"574_CR16","doi-asserted-by":"publisher","first-page":"3090","DOI":"10.3390\/ijms19103090","volume":"19","author":"P Dlugosz","year":"2018","unstructured":"Dlugosz P, Nimpf J (2018) The reelin receptors apolipoprotein E receptor 2 (ApoER2) and VLDL receptor. Int J Mol Sci 19:3090. https:\/\/doi.org\/10.3390\/ijms19103090","journal-title":"Int J Mol Sci"},{"key":"574_CR17","doi-asserted-by":"publisher","first-page":"110185","DOI":"10.1016\/j.pnpbp.2020.110185","volume":"108","author":"EM Elnahas","year":"2021","unstructured":"Elnahas EM, Abuelezz SA, Mohamad MI, Nabil MM, Abdelraouf SM, Bahaa N, Hassan GA, Ibrahim EA, Ahmed AI, Aboul-Fotouh S (2021) Validation of prenatal versus postnatal valproic acid rat models of autism: a behavioral and neurobiological study. Prog Neuropsychopharmacol Biol Psychiatry 108:110185. https:\/\/doi.org\/10.1016\/j.pnpbp.2020.110185","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"574_CR18","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/0278-6915(95)00077-1","volume":"33","author":"JV Formica","year":"1995","unstructured":"Formica JV, Regelson W (1995) Review of the biology of Quercetin and related bioflavonoids. Food Chem Toxicol 33:1061\u20131080. https:\/\/doi.org\/10.1016\/0278-6915(95)00077-1","journal-title":"Food Chem Toxicol"},{"key":"574_CR19","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1097\/01.WCB.0000138665.25305.7C","volume":"24","author":"JH Fowler","year":"2004","unstructured":"Fowler JH, Whalley K, Murray T, O\u2019neill MJ, McCulloch J (2004) The AMPA receptor potentiator LY404187 increases cerebral glucose utilization and c-fos expression in the rat. J Cereb Blood Flow Metab 24:1098\u20131109. https:\/\/doi.org\/10.1097\/01.WCB.0000138665.25305.7C","journal-title":"J Cereb Blood Flow Metab"},{"key":"574_CR20","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1002\/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I","volume":"6","author":"TF Freund","year":"1996","unstructured":"Freund TF, Buzs\u00e1ki G (1996) Interneurons of the hippocampus. Hippocampus 6:347\u2013470. https:\/\/doi.org\/10.1002\/(SICI)1098-1063(1996)6:4%3c347::AID-HIPO1%3e3.0.CO;2-I","journal-title":"Hippocampus"},{"key":"574_CR21","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.tox.2013.01.002","volume":"305","author":"Y Fujii","year":"2013","unstructured":"Fujii Y, Kimura M, Ishii Y, Yamamoto R, Morita R, Hayashi SM, Suzuki K, Shibutani M (2013) Effect of enzymatically modified isoquercitrin on preneoplastic liver cell lesions induced by thioacetamide promotion in a two-stage hepatocarcinogenesis model using rats. Toxicology 305:30\u201340. https:\/\/doi.org\/10.1016\/j.tox.2013.01.002","journal-title":"Toxicology"},{"key":"574_CR22","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.jep.2010.12.026","volume":"134","author":"A Gasparotto Junior","year":"2011","unstructured":"Gasparotto Junior A, Gasparotto FM, Louren\u00e7o EL, Crestani S, Stefanello ME, Salvador MJ, da Silva-Santos JE, Marques MC, Kassuya CA (2011) Antihypertensive effects of isoquercitrin and extracts from Tropaeolum majus L.: evidence for the inhibition of angiotensin converting enzyme. J Ethnopharmacol 134:363\u2013372. https:\/\/doi.org\/10.1016\/j.jep.2010.12.026","journal-title":"J Ethnopharmacol"},{"key":"574_CR23","doi-asserted-by":"publisher","first-page":"3576","DOI":"10.3390\/ijms21103576","volume":"21","author":"M G\u0105ssowska-Dobrowolska","year":"2020","unstructured":"G\u0105ssowska-Dobrowolska M, Cie\u015blik M, Czapski GA, J\u0119\u015bko H, Frontczak-Baniewicz M, Gewartowska M, Dominiak A, Polowy R, Filipkowski RK, Babiec L, Adamczyk A (2020) Prenatal exposure to valproic acid affects microglia and synaptic ultrastructure in a brain-region-specific manner in young-adult male rats: relevance to autism spectrum disorders. Int J Mol Sci 21:3576. https:\/\/doi.org\/10.3390\/ijms21103576","journal-title":"Int J Mol Sci"},{"key":"574_CR24","doi-asserted-by":"publisher","unstructured":"Ghowsi M, Khazali H, Sisakhtnezhad S (2018) Evaluation of\u00a0TNF-\u03b1\u00a0and\u00a0IL-6\u00a0mRNAs expressions in visceral and subcutaneous adipose tissues of polycystic ovarian rats and effects of resveratrol. Iran J Basic Med Sci 21:165\u2013174. https:\/\/doi.org\/10.22038\/ijbms.2017.24801.6167","DOI":"10.22038\/ijbms.2017.24801.6167"},{"key":"574_CR25","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.neuropharm.2012.07.028","volume":"63","author":"HS Go","year":"2012","unstructured":"Go HS, Kim KC, Choi CS, Jeon SJ, Kwon KJ, Han SH, Lee J, Cheong JH, Ryu JH, Kim CH, Ko KH, Shin CY (2012) Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3\u03b2\/\u03b2-catenin pathway. Neuropharmacology 63:1028\u20131041. https:\/\/doi.org\/10.1016\/j.neuropharm.2012.07.028","journal-title":"Neuropharmacology"},{"key":"574_CR26","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.cell.2016.10.021","volume":"167","author":"JT Gon\u00e7alves","year":"2016","unstructured":"Gon\u00e7alves JT, Schafer ST, Gage FH (2016) Adult neurogenesis in the hippocampus: from stem cells to behavior. Cell 167:897\u2013914. https:\/\/doi.org\/10.1016\/j.cell.2016.10.021","journal-title":"Cell"},{"key":"574_CR27","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1523\/JNEUROSCI.16-10-03397.1996","volume":"16","author":"AI Guly\u00e1s","year":"1996","unstructured":"Guly\u00e1s AI, H\u00e1jos N, Freund TF (1996) Interneurons containing calretinin are specialized to control other interneurons in the rat hippocampus. J Neurosci 16:3397\u20133411. https:\/\/doi.org\/10.1523\/JNEUROSCI.16-10-03397.1996","journal-title":"J Neurosci"},{"key":"574_CR28","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1001\/archgenpsychiatry.2011.76","volume":"68","author":"J Hallmayer","year":"2011","unstructured":"Hallmayer J, Cleveland S, Torres A, Phillips J, Cohen B, Torigoe T, Miller J, Fedele A, Collins J, Smith K, Lotspeich L, Croen LA, Ozonoff S, Lajonchere C, Grether JK, Risch N (2011) Genetic heritability and shared environmental factors among twin pairs with autism. Arch Gen Psychiatry 68:1095\u20131102. https:\/\/doi.org\/10.1001\/archgenpsychiatry.2011.76","journal-title":"Arch Gen Psychiatry"},{"key":"574_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/2058738418785514","volume":"32","author":"MA Hamzawy","year":"2018","unstructured":"Hamzawy MA, El-Ghandour YB, Abdel-Aziem SH, Ali ZH (2018) Leptin and camel milk abate oxidative stress status, genotoxicity induced in valproic acid rat model of autism. Int J Immunopathol Pharmacol 32:1\u201311. https:\/\/doi.org\/10.1177\/2058738418785514","journal-title":"Int J Immunopathol Pharmacol"},{"key":"574_CR30","doi-asserted-by":"publisher","first-page":"15886","DOI":"10.1523\/JNEUROSCI.4505-11.2012","volume":"32","author":"H He","year":"2012","unstructured":"He H, Mahnke AH, Doyle S, Fan N, Wang CC, Hall BJ, Tang YP, Inglis FM, Chen C, Erickson JD (2012) Neurodevelopmental role for VGLUT2 in pyramidal neuron plasticity, dendritic refinement, and in spatial learning. J Neurosci 32:15886\u201315901. https:\/\/doi.org\/10.1523\/JNEUROSCI.4505-11.2012","journal-title":"J Neurosci"},{"key":"574_CR31","doi-asserted-by":"publisher","first-page":"3707","DOI":"10.1523\/JNEUROSCI.4280-07.2008","volume":"28","author":"RD Hodge","year":"2008","unstructured":"Hodge RD, Kowalczyk TD, Wolf SA, Encinas JM, Rippey C, Enikolopov G, Kempermann G, Hevner RF (2008) Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output. J Neurosci 28:3707\u20133717. https:\/\/doi.org\/10.1523\/JNEUROSCI.4280-07.2008","journal-title":"J Neurosci"},{"key":"574_CR32","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.brainres.2015.11.010","volume":"1631","author":"A Hu","year":"2016","unstructured":"Hu A, Yuan H, Wu L, Chen R, Chen Q, Zhang T, Wang Z, Liu P, Zhu X (2016) The effect of constitutive over-expression of insulin-like growth factor 1 on the cognitive function in aged mice. Brain Res 1631:204\u2013213. https:\/\/doi.org\/10.1016\/j.brainres.2015.11.010","journal-title":"Brain Res"},{"key":"574_CR33","doi-asserted-by":"publisher","first-page":"287","DOI":"10.21307\/ane-2018-027","volume":"78","author":"J Jaworski","year":"2018","unstructured":"Jaworski J, Kalita K, Knapska E (2018) c-Fos and neuronal plasticity: the aftermath of Kaczmarek\u2019s theory. Acta Neurobiol Exp (wars) 78:287\u2013296","journal-title":"Acta Neurobiol Exp (wars)"},{"key":"574_CR34","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3389\/fncel.2020.00198","volume":"14","author":"AM Jurga","year":"2020","unstructured":"Jurga AM, Paleczna M, Kuter KZ (2020) Overview of general and discriminating markers of differential microglia phenotypes. Front Cell Neurosci 14:198. https:\/\/doi.org\/10.3389\/fncel.2020.00198","journal-title":"Front Cell Neurosci"},{"key":"574_CR35","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.etp.2016.12.004","volume":"69","author":"Y Kangawa","year":"2017","unstructured":"Kangawa Y, Yoshida T, Abe H, Seto Y, Miyashita T, Nakamura M, Kihara T, Hayashi SM, Shibutani M (2017) Anti-inflammatory effects of the selective phosphodiesterase 3 inhibitor, cilostazol, and antioxidants, enzymatically-modified isoquercitrin and \u03b1-lipoic acid, reduce dextran sulphate sodium-induced colorectal mucosal injury in mice. Exp Toxicol Pathol 69:179\u2013186. https:\/\/doi.org\/10.1016\/j.etp.2016.12.004","journal-title":"Exp Toxicol Pathol"},{"key":"574_CR36","doi-asserted-by":"publisher","first-page":"a018812","DOI":"10.1101\/cshperspect.a018812","volume":"7","author":"G Kempermann","year":"2015","unstructured":"Kempermann G, Song H, Gage FH (2015) Neurogenesis in the adult hippocampus. Cold Spring Harb Perspect Biol 7:a018812. https:\/\/doi.org\/10.1101\/cshperspect.a018812","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"574_CR37","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.ijdevneu.2018.06.009","volume":"69","author":"R Khalaj","year":"2018","unstructured":"Khalaj R, Hajizadeh Moghaddam A, Zare M (2018) Hesperetin and it nanocrystals ameliorate social behavior deficits and oxido-inflammatory stress in rat model of autism. Int J Dev Neurosci 69:80\u201387. https:\/\/doi.org\/10.1016\/j.ijdevneu.2018.06.009","journal-title":"Int J Dev Neurosci"},{"key":"574_CR38","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/mp.2017.87","volume":"23","author":"M Kondo","year":"2018","unstructured":"Kondo M, Koyama Y, Nakamura Y, Shimada S (2018) A novel 5HT3 receptor-IGF1 mechanism distinct from SSRI-induced antidepressant effects. Mol Psychiatry 23:833\u2013842. https:\/\/doi.org\/10.1038\/mp.2017.87","journal-title":"Mol Psychiatry"},{"key":"574_CR39","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jneuroim.2016.03.014","volume":"294","author":"D Lian","year":"2016","unstructured":"Lian D, He D, Wu J, Liu Y, Zhu M, Sun J, Chen F, Li L (2016) Exogenous BDNF increases neurogenesis in the hippocampus in experimental Streptococcus pneumoniae meningitis. J Neuroimmunol 294:46\u201355. https:\/\/doi.org\/10.1016\/j.jneuroim.2016.03.014","journal-title":"J Neuroimmunol"},{"key":"574_CR40","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT Method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"574_CR41","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1152\/physrev.00013.2009","volume":"89","author":"S Loebrich","year":"2009","unstructured":"Loebrich S, Nedivi E (2009) The function of activity-regulated genes in the nervous system. Physiol Rev 89:1079\u20131103. https:\/\/doi.org\/10.1152\/physrev.00013.2009","journal-title":"Physiol Rev"},{"key":"574_CR42","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s11418-013-0760-5","volume":"67","author":"T Makino","year":"2013","unstructured":"Makino T, Kanemaru M, Okuyama S, Shimizu R, Tanaka H, Mizukami H (2013) Anti-allergic effects of enzymatically modified isoquercitrin (\u03b1-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, \u03b1-oligoglucosyl rutin, and quercetin, when administered orally to mice. J Nat Med 67:881\u2013886. https:\/\/doi.org\/10.1007\/s11418-013-0760-5","journal-title":"J Nat Med"},{"key":"574_CR43","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s12035-011-8207-z","volume":"44","author":"I Masiulis","year":"2011","unstructured":"Masiulis I, Yun S, Eisch AJ (2011) The interesting interplay between interneurons and adult hippocampal neurogenesis. Mol Neurobiol 44:287\u2013302. https:\/\/doi.org\/10.1007\/s12035-011-8207-z","journal-title":"Mol Neurobiol"},{"key":"574_CR44","doi-asserted-by":"publisher","first-page":"107975","DOI":"10.1016\/j.neuropharm.2020.107975","volume":"168","author":"K Matsuo","year":"2020","unstructured":"Matsuo K, Yabuki Y, Fukunaga K (2020) 5-aminolevulinic acid inhibits oxidative stress and ameliorates autistic-like behaviors in prenatal valproic acid-exposed rats. Neuropharmacology 168:107975. https:\/\/doi.org\/10.1016\/j.neuropharm.2020.107975","journal-title":"Neuropharmacology"},{"key":"574_CR45","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.brainresbull.2019.02.003","volume":"147","author":"R Mirza","year":"2019","unstructured":"Mirza R, Sharma B (2019) Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats. Brain Res Bull 147:36\u201346. https:\/\/doi.org\/10.1016\/j.brainresbull.2019.02.003","journal-title":"Brain Res Bull"},{"key":"574_CR46","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1634\/stemcells.2008-0234","volume":"27","author":"S M\u00fcller","year":"2009","unstructured":"M\u00fcller S, Chakrapani BP, Schwegler H, Hofmann HD, Kirsch M (2009) Neurogenesis in the dentate gyrus depends on ciliary neurotrophic factor and signal transducer and activator of transcription 3 signaling. Stem Cells 27:431\u2013441. https:\/\/doi.org\/10.1634\/stemcells.2008-0234","journal-title":"Stem Cells"},{"key":"574_CR47","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1007\/s00429-014-0778-9","volume":"220","author":"K Nordenankar","year":"2015","unstructured":"Nordenankar K, Smith-Anttila CJ, Schweizer N, Viereckel T, Birgner C, Mejia-Toiber J, Morales M, Leao RN, Wall\u00e9n-Mackenzie \u00c5 (2015) Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity. Brain Struct Funct 220:2171\u20132190. https:\/\/doi.org\/10.1007\/s00429-014-0778-9","journal-title":"Brain Struct Funct"},{"key":"574_CR48","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.jff.2019.02.024","volume":"55","author":"R Okada","year":"2019","unstructured":"Okada R, Masubuchi Y, Tanaka T, Nakajima K, Masuda S, Nakamura K, Maronpot RR, Yoshida T, Koyanagi M, Hayashi SM, Shibutani M (2019) Continuous exposure to \u03b1-glycosyl isoquercitrin from developmental stage facilitates fear extinction learning in rats. J Funct Foods 55:312\u2013324. https:\/\/doi.org\/10.1016\/j.jff.2019.02.024","journal-title":"J Funct Foods"},{"key":"574_CR49","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.3390\/antiox9121186","volume":"9","author":"L Pangrazzi","year":"2020","unstructured":"Pangrazzi L, Balasco L, Bozzi Y (2020) Natural antioxidants: a novel therapeutic approach to autism spectrum disorders? Antioxidants (Basel) 9:1186. https:\/\/doi.org\/10.3390\/antiox9121186","journal-title":"Antioxidants (basel)"},{"key":"574_CR50","doi-asserted-by":"publisher","first-page":"4636","DOI":"10.1523\/JNEUROSCI.5284-09.2010","volume":"30","author":"L Pujadas","year":"2010","unstructured":"Pujadas L, Gruart A, Bosch C, Delgado L, Teixeira CM, Rossi D, de Lecea L, Mart\u00ednez A, Delgado-Garc\u00eda JM, Soriano E (2010) Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation. J Neurosci 30:4636\u20134649. https:\/\/doi.org\/10.1523\/JNEUROSCI.5284-09.2010","journal-title":"J Neurosci"},{"key":"574_CR51","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2","volume":"370","author":"PM Rodier","year":"1996","unstructured":"Rodier PM, Ingram JL, Tisdale B, Nelson S, Romano J (1996) Embryological origin for autism: developmental anomalies of the cranial nerve motor nuclei. J Comp Neurol 370:247\u2013261. https:\/\/doi.org\/10.1002\/(SICI)1096-9861(19960624)370:2%3c247::AID-CNE8%3e3.0.CO;2-2","journal-title":"J Comp Neurol"},{"key":"574_CR52","doi-asserted-by":"publisher","first-page":"4253","DOI":"10.1007\/s10803-021-04904-1","volume":"51","author":"NE Rosen","year":"2021","unstructured":"Rosen NE, Lord C, Volkmar FR (2021) The diagnosis of autism: from Kanner to DSM-III to DSM-5 and beyond. J Autism Dev Disord 51:4253\u20134270. https:\/\/doi.org\/10.1007\/s10803-021-04904-1","journal-title":"J Autism Dev Disord"},{"key":"574_CR53","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3389\/fphys.2014.00150","volume":"5","author":"DA Rossignol","year":"2014","unstructured":"Rossignol DA, Frye RE (2014) Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Front Physiol 5:150. https:\/\/doi.org\/10.3389\/fphys.2014.00150","journal-title":"Front Physiol"},{"key":"574_CR54","doi-asserted-by":"publisher","first-page":"e109824","DOI":"10.1371\/journal.pone.0109824","volume":"9","author":"MS Santos","year":"2014","unstructured":"Santos MS, Foss SM, Park CK, Voglmaier SM (2014) Protein interactions of the vesicular glutamate transporter VGLUT1. PLoS ONE 9:e109824. https:\/\/doi.org\/10.1371\/journal.pone.0109824","journal-title":"PLoS ONE"},{"key":"574_CR55","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.neuroscience.2008.02.037","volume":"158","author":"SD Santos","year":"2009","unstructured":"Santos SD, Carvalho AL, Caldeira MV, Duarte CB (2009) Regulation of AMPA receptors and synaptic plasticity. Neuroscience 158:105\u2013125. https:\/\/doi.org\/10.1016\/j.neuroscience.2008.02.037","journal-title":"Neuroscience"},{"key":"574_CR56","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.expneurol.2004.11.016","volume":"192","author":"H Scharfman","year":"2005","unstructured":"Scharfman H, Goodman J, Macleod A, Phani S, Antonelli C, Croll S (2005) Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats. Exp Neurol 192:348\u2013356. https:\/\/doi.org\/10.1016\/j.expneurol.2004.11.016","journal-title":"Exp Neurol"},{"key":"574_CR57","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13041-019-0442-7","volume":"12","author":"P Sheppard","year":"2019","unstructured":"Sheppard P, Choleris E, Galea L (2019) Structural plasticity of the hippocampus in response to estrogens in female rodents. Mol Brain 12:22. https:\/\/doi.org\/10.1186\/s13041-019-0442-7","journal-title":"Mol Brain"},{"key":"574_CR58","doi-asserted-by":"publisher","first-page":"e0119643","DOI":"10.1371\/journal.pone.0119643","volume":"10","author":"M Sibbe","year":"2015","unstructured":"Sibbe M, Kuner E, Althof D, Frotscher M (2015) Stem- and progenitor cell proliferation in the dentate gyrus of the reeler mouse. PLoS ONE 10:e0119643. https:\/\/doi.org\/10.1371\/journal.pone.0119643","journal-title":"PLoS ONE"},{"key":"574_CR59","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1017\/S0029665110000054","volume":"69","author":"JP Spencer","year":"2010","unstructured":"Spencer JP (2010) Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain. Proc Nutr Soc 69:244\u2013260. https:\/\/doi.org\/10.1017\/S0029665110000054","journal-title":"Proc Nutr Soc"},{"key":"574_CR60","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/mp.2009.67","volume":"15","author":"D Taliaz","year":"2010","unstructured":"Taliaz D, Stall N, Dar DE, Zangen A (2010) Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Mol Psychiatry 15:80\u201392. https:\/\/doi.org\/10.1038\/mp.2009.67","journal-title":"Mol Psychiatry"},{"key":"574_CR61","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0079-6123(07)63016-7","volume":"163","author":"MK Tallent","year":"2007","unstructured":"Tallent MK (2007) Somatostatin in the dentate gyrus. Prog Brain Res 163:265\u2013284. https:\/\/doi.org\/10.1016\/S0079-6123(07)63016-7","journal-title":"Prog Brain Res"},{"key":"574_CR62","doi-asserted-by":"publisher","first-page":"12051","DOI":"10.1523\/JNEUROSCI.1857-12.2012","volume":"32","author":"CM Teixeira","year":"2012","unstructured":"Teixeira CM, Kron MM, Masachs N, Zhang H, Lagace DC, Martinez A, Reillo I, Duan X, Bosch C, Pujadas L, Brunso L, Song H, Eisch AJ, Borrell V, Howell BW, Parent JM, Soriano E (2012) Cell-autonomous inactivation of the reelin pathway impairs adult neurogenesis in the hippocampus. J Neurosci 32:12051\u201312065. https:\/\/doi.org\/10.1523\/JNEUROSCI.1857-12.2012","journal-title":"J Neurosci"},{"key":"574_CR63","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s00441-007-0432-4","volume":"329","author":"O von Bohlen und Halbach","year":"2007","unstructured":"von Bohlen und Halbach O (2007) Immunohistological markers for staging neurogenesis in adult hippocampus. Cell Tissue Res 329:409\u2013420. https:\/\/doi.org\/10.1007\/s00441-007-0432-4","journal-title":"Cell Tissue Res"},{"key":"574_CR64","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13195-015-0139-9","volume":"7","author":"DG Walker","year":"2015","unstructured":"Walker DG, Lue LF (2015) Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains. Alzheimers Res Ther 7:56. https:\/\/doi.org\/10.1186\/s13195-015-0139-9","journal-title":"Alzheimers Res Ther"},{"key":"574_CR65","doi-asserted-by":"publisher","first-page":"14318","DOI":"10.1523\/JNEUROSCI.0709-12.2012","volume":"32","author":"EG Waterhouse","year":"2012","unstructured":"Waterhouse EG, An JJ, Orefice LL, Baydyuk M, Liao GY, Zheng K, Lu B, Xu B (2012) BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission. J Neurosci 32:14318\u201314330. https:\/\/doi.org\/10.1523\/JNEUROSCI.0709-12.2012","journal-title":"J Neurosci"},{"key":"574_CR66","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s00401-010-0655-4","volume":"119","author":"J Wegiel","year":"2010","unstructured":"Wegiel J, Kuchna I, Nowicki K, Imaki H, Wegiel J, Marchi E, Ma SY, Chauhan A, Chauhan V, Bobrowicz TW, de Leon M, Louis LA, Cohen IL, London E, Brown WT, Wisniewski T (2010) The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes. Acta Neuropathol 119:755\u2013770. https:\/\/doi.org\/10.1007\/s00401-010-0655-4","journal-title":"Acta Neuropathol"},{"key":"574_CR67","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.freeradbiomed.2011.09.010","volume":"52","author":"RJ Williams","year":"2012","unstructured":"Williams RJ, Spencer JP (2012) Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease. Free Radic Biol Med 52:35\u201345. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2011.09.010","journal-title":"Free Radic Biol Med"},{"key":"574_CR68","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.lfs.2017.01.012","volume":"173","author":"H Wu","year":"2017","unstructured":"Wu H, Wang X, Gao J, Liang S, Hao Y, Sun C, Xia W, Cao Y, Wu L (2017) Fingolimod (FTY720) attenuates social deficits, learning and memory impairments, neuronal loss and neuroinflammation in the rat model of autism. Life Sci 173:43\u201354. https:\/\/doi.org\/10.1016\/j.lfs.2017.01.012","journal-title":"Life Sci"},{"key":"574_CR69","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/0896-6273(93)90192-t","volume":"11","author":"K Yamagata","year":"1993","unstructured":"Yamagata K, Andreasson KI, Kaufmann WE, Barnes CA, Worley PF (1993) Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11:371\u2013386. https:\/\/doi.org\/10.1016\/0896-6273(93)90192-t","journal-title":"Neuron"},{"key":"574_CR70","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1523\/JNEUROSCI.3574-07.2008","volume":"28","author":"P Yang","year":"2008","unstructured":"Yang P, Arnold SA, Habas A, Hetman M, Hagg T (2008) Ciliary neurotrophic factor mediates dopamine D2 receptor-induced CNS neurogenesis in adult mice. J Neurosci 28:2231\u20132241. https:\/\/doi.org\/10.1523\/JNEUROSCI.3574-07.2008","journal-title":"J Neurosci"},{"key":"574_CR71","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.neuroscience.2006.12.038","volume":"145","author":"AR Zavala","year":"2006","unstructured":"Zavala AR, Biswas S, Harlan RE, Neisewander JL (2006) Fos and glutamate AMPA receptor subunit coexpression associated with cue-elicited cocaine-seeking behavior in abstinent rats. Neuroscience 145:438\u2013452. https:\/\/doi.org\/10.1016\/j.neuroscience.2006.12.038","journal-title":"Neuroscience"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-022-00574-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-022-00574-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-022-00574-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T04:35:24Z","timestamp":1672288524000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12640-022-00574-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,12]]},"references-count":71,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["574"],"URL":"https:\/\/doi.org\/10.1007\/s12640-022-00574-8","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,12]]},"assertion":[{"value":"3 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal experiments in the present study were conducted in accordance with the National Institutes of Health guide for the care and use of laboratory animals (NIH Publications No. 8023, revised 1978), and all efforts were made to minimize animal suffering. The experimental procedures were approved by the Animal Care and Use Committee of the Tokyo University of Agriculture and Technology (Approved No.: R2-05 for main study; R03-162 for satellite study).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Mihoko Koyanagi is employed by a food additive manufacturer whose product lines include AGIQ. Robert R. Maronpot is a scientific consultant at the aforementioned food additive manufacturer. The views and opinions expressed in this article are those of the authors and not necessarily those of their respective employers. Kazumi Takashima, Hiromu Okano, Ryota Ojiro, Qian Tang, Yasunori Takahashi, Shunsuke Ozawa, Xinyu Zou, Toshinori Yoshida, and Makoto Shibutani declare that no conflicts of interest exist.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interest"}}]}}