{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:14:41Z","timestamp":1776057281038,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["156320\/2019-3"],"award-info":[{"award-number":["156320\/2019-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307829\/2021-9"],"award-info":[{"award-number":["307829\/2021-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/23139-2"],"award-info":[{"award-number":["2016\/23139-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/24028-8"],"award-info":[{"award-number":["2019\/24028-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/21834-8"],"award-info":[{"award-number":["2017\/21834-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s12640-022-00601-8","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T08:10:54Z","timestamp":1667808654000},"page":"1653-1663","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neurotoxicity Assessment of 1-[(2,3-Dihydro-1-Benzofuran-2-yl)Methyl]Piperazine (LINS01 Series) Derivatives and their Protective Effect on Cocaine-Induced Neurotoxicity Model in SH-SY5Y Cell Culture"],"prefix":"10.1007","volume":"40","author":[{"given":"La\u00edsa Aliandro","family":"dos Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela Salles","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Ariel Borges","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle Fidelis","family":"Corr\u00eaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Aparecida","family":"de Faria Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliam","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Marcourakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Paulo S.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael Caio Tamborelli","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"issue":"2","key":"601_CR1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/0014-2999(93)90435-k","volume":"249","author":"ML Albuquerque","year":"1993","unstructured":"Albuquerque ML, Kurth CD (1993) Cocaine constricts immature cerebral arterioles by a local anesthetic mechanism. Eur\u00a0J\u00a0Pharmacol 249(2):215\u2013220. https:\/\/doi.org\/10.1016\/0014-2999(93)90435-k","journal-title":"Eur\u00a0J\u00a0Pharmacol"},{"key":"601_CR2","doi-asserted-by":"crossref","unstructured":"Beauvais G, Atwell K, Jayanthi S, Ladenheim B, Cadet JL (2011) Involvement of dopamine receptors in binge methamphetamine-induced activation of endoplasmic reticulum and mitochondrial stress pathways. PloS One 6(12)","DOI":"10.1371\/journal.pone.0028946"},{"key":"601_CR3","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/1471-2202-14-76","volume":"14","author":"Y Chen","year":"2013","unstructured":"Chen Y, Ni YY, Liu J, Lu JW, Wang F, Wu XL, Gu MM, Lu ZY, Wang ZG, Ren ZH (2013) Dopamine receptor 3 might be an essential molecule in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. BMC Neurosci 14:76. https:\/\/doi.org\/10.1186\/1471-2202-14-76","journal-title":"BMC Neurosci"},{"key":"601_CR4","doi-asserted-by":"crossref","unstructured":"Corr\u00eaa MF, Balico-Silva AL, Kiss DJ, Fernandes G, Maraschin JC, Parreiras-E-Silva LT, Varela MT, Sim\u00f5es SC, Bouvier M, Keser\u0171 GM, Costa-Neto CM, Fernandes JPS (2021) Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands - functional characterization and modeling studies on H3 and H4 receptors. Bioorg\u00a0Med\u00a0Chem 30","DOI":"10.1016\/j.bmc.2020.115924"},{"key":"601_CR5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s12039-019-1694-6","volume":"132","author":"MF Corr\u00eaa","year":"2020","unstructured":"Corr\u00eaa MF, Reiner D, Fernandes GAB, Varela MT, Aranha CMSQ, Stark H, Fernandes JPS (2020) Profiling of LINS01 compounds at human dopamine D2 and D3 receptors. Chem\u00a0Sci\u00a0J 132:5. https:\/\/doi.org\/10.1007\/s12039-019-1694-6","journal-title":"Chem\u00a0Sci\u00a0J"},{"key":"601_CR6","doi-asserted-by":"publisher","unstructured":"Corr\u00eaa MF, Varela MT, Balbino AM, Torrecilhas AC, Landgraf RG, Troncone L, Fernandes JPS (2017) 1-[(2,3-Dihydro-1-benzofuran-2-yl) methyl]piperazines as novel anti-inflammatory compounds: synthesis and evaluation on H3 R\/H4 R. Chem\u00a0Biol\u00a0Drug Des 90(2):317\u2013322. https:\/\/doi.org\/10.1111\/cbdd.12947","DOI":"10.1111\/cbdd.12947"},{"issue":"1","key":"601_CR7","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.brainres.2006.03.061","volume":"1089","author":"T Cunha-Oliveira","year":"2006","unstructured":"Cunha-Oliveira T, Rego AC, Cardoso SM, Borges F, Swerdlow RH, Macedo T, de Oliveira CR (2006) Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine. Brain Res 1089(1):44\u201354. https:\/\/doi.org\/10.1016\/j.brainres.2006.03.061","journal-title":"Brain Res"},{"issue":"1","key":"601_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.tox.2010.06.009","volume":"276","author":"T Cunha-Oliveira","year":"2010","unstructured":"Cunha-Oliveira T, Rego AC, Garrido J, Borges F, Macedo T, Oliveira CR (2010) Neurotoxicity of heroin-cocaine combinations in rat cortical neurons. Toxicology 276(1):11\u201317. https:\/\/doi.org\/10.1016\/j.tox.2010.06.009","journal-title":"Toxicology"},{"issue":"11","key":"601_CR9","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1002\/cmdc.201600182","volume":"11","author":"A Daina","year":"2016","unstructured":"Daina A, Zoete V (2016) A BOILED-Egg to predict gastrointestinal absorption and brain penetration of small molecules. Chem Med Chem 11(11):1117\u20131121. https:\/\/doi.org\/10.1002\/cmdc.201600182","journal-title":"Chem Med Chem"},{"issue":"1","key":"601_CR10","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ejphar.2006.06.024","volume":"545","author":"M Di Filippo","year":"2006","unstructured":"Di Filippo M, Picconi B, Costa C, Bagetta V, Tantucci M, Parnetti L, Calabresi P (2006) Pathways of neurodegeneration and experimental models of basal ganglia disorders: downstream effects of mitochondrial inhibition. Eur\u00a0J\u00a0Pharmacol 545(1):65\u201372. https:\/\/doi.org\/10.1016\/j.ejphar.2006.06.024","journal-title":"Eur\u00a0J\u00a0Pharmacol"},{"key":"601_CR11","doi-asserted-by":"publisher","unstructured":"Ellenbroek BA (2013)\u00a0Histamine H3 receptors, the complex interaction with dopamine and its implications for addiction.\u00a0Br\u00a0J\u00a0Pharmacol\u00a0170(1):46\u201357.\u00a0https:\/\/doi.org\/10.1111\/bph.12221","DOI":"10.1111\/bph.12221"},{"issue":"2","key":"601_CR12","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0197-0186(94)00105-4","volume":"26","author":"L Erinoff","year":"1995","unstructured":"Erinoff L (1995) General considerations in assessing neurotoxicity using neuroanatomical methods. Neurochem\u00a0Int 26(2):111\u2013114. https:\/\/doi.org\/10.1016\/0197-0186(94)00105-4","journal-title":"Neurochem\u00a0Int"},{"key":"601_CR13","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/j.toxrep.2019.11.001","volume":"6","author":"R Garcia","year":"2019","unstructured":"Garcia R, Torres LL, Dati L, Loureiro A, Afeche SC, Sandoval M, Marcourakis T (2019) Anhydroecgonine methyl ester (AEME), a cocaine pyrolysis product, impairs glutathione-related enzymes response and increases lipid peroxidation in the hippocampal cell culture. Toxicol\u00a0Rep 6:1223\u20131229. https:\/\/doi.org\/10.1016\/j.toxrep.2019.11.001","journal-title":"Toxicol\u00a0Rep"},{"issue":"1","key":"601_CR14","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1093\/toxsci\/kfs140","volume":"128","author":"RC Garcia","year":"2012","unstructured":"Garcia RC, Dati LM, Fukuda S, Torres LH, Moura S, de Carvalho ND, Carrettiero DC, Camarini R, Levada-Pires AC, Yonamine M, Negrini-Neto O, Abdalla FM, Sandoval MR, Afeche SC, Marcourakis T (2012) Neurotoxicity of anhydroecgonine methyl ester, a crack cocaine pyrolysis product. Toxicol\u00a0Sci 128(1):223\u2013234. https:\/\/doi.org\/10.1093\/toxsci\/kfs140","journal-title":"Toxicol\u00a0Sci"},{"key":"601_CR15","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.tox.2016.04.009","volume":"376","author":"RC Garcia","year":"2017","unstructured":"Garcia RC, Torres LH, Balestrin NT, Andrioli TC, Fl\u00f3rio JC, de Oliveira CD, da Costa JL, Yonamine M, Sandoval MR, Camarini R, Marcourakis T (2017) Anhydroecgonine methyl ester, a cocaine pyrolysis product, may contribute to cocaine behavioral sensitization. Toxicology 376:44\u201350. https:\/\/doi.org\/10.1016\/j.tox.2016.04.009","journal-title":"Toxicology"},{"issue":"3","key":"601_CR16","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.nbd.2011.01.033","volume":"42","author":"N Granado","year":"2011","unstructured":"Granado N, Ares-Santos S, Oliva I, O\u2019Shea E, Martin ED, Colado MI, Moratalla R (2011) Dopamine D2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA. Neurobiol\u00a0Dis 42(3):391\u2013403. https:\/\/doi.org\/10.1016\/j.nbd.2011.01.033","journal-title":"Neurobiol\u00a0Dis"},{"issue":"5","key":"601_CR17","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/ejn.13499","volume":"45","author":"JM Hernandez-Martinez","year":"2017","unstructured":"Hernandez-Martinez JM, Forrest CM, Darlington LG, Smith RA, Stone TW (2017) Quinolinic acid induces neuritogenesis in SH-SY5Y neuroblastoma cells independently of NMDA receptor activation. Eur\u00a0J\u00a0Neurosci 45(5):700\u2013711. https:\/\/doi.org\/10.1111\/ejn.13499","journal-title":"Eur\u00a0J\u00a0Neurosci"},{"key":"601_CR18","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1111\/j.1749-6632.2005.tb00058.x","volume":"1053","author":"SZ Imam","year":"2005","unstructured":"Imam SZ, Duhart HM, Skinner JT, Ali SF (2005) Cocaine induces a differential dose-dependent alteration in the expression profile of immediate early genes, transcription factors, and caspases in PC12 cells: a possible mechanism of neurotoxic damage in cocaine addiction. Ann\u00a0N Y Acad\u00a0Sci 1053:482\u2013490. https:\/\/doi.org\/10.1111\/j.1749-6632.2005.tb00058.x","journal-title":"Ann\u00a0N Y Acad\u00a0Sci"},{"issue":"7","key":"601_CR19","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/0166-2236(91)90141-g","volume":"14","author":"MJ Kuhar","year":"1991","unstructured":"Kuhar MJ, Ritz MC, Boja JW (1991) The dopamine hypothesis of the reinforcing properties of cocaine. Trends Neurosci 14(7):299\u2013302. https:\/\/doi.org\/10.1016\/0166-2236(91)90141-g","journal-title":"Trends Neurosci"},{"key":"601_CR20","doi-asserted-by":"publisher","unstructured":"Kovalevich J, Langford D (2013) Considerations for the use of SH-SY5Y neuroblastoma cells in neurobiology.\u00a0Methods Mol\u00a0Biol\u00a0(Clifton, N.J.) 1078:9\u201321. https:\/\/doi.org\/10.1007\/978-1-62703-640-5_2","DOI":"10.1007\/978-1-62703-640-5_2"},{"issue":"2","key":"601_CR21","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.mehy.2004.06.028","volume":"64","author":"P Kovacic","year":"2005","unstructured":"Kovacic P (2005) Role of oxidative metabolites of cocaine in toxicity and addiction: oxidative stress and electron transfer. Med\u00a0Hypotheses 64(2):350\u2013356. https:\/\/doi.org\/10.1016\/j.mehy.2004.06.028","journal-title":"Med\u00a0Hypotheses"},{"key":"601_CR22","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1756-6606-2-3","volume":"2","author":"LB Lepsch","year":"2009","unstructured":"Lepsch LB, Munhoz CD, Kawamoto EM, Yshii LM, Lima LS, Curi-Boaventura MF, Salgado TM, Curi R, Planeta CS, Scavone C (2009) Cocaine induces cell death and activates the transcription nuclear factor kappa-B in PC12 cells. Mol Brain 2:3. https:\/\/doi.org\/10.1186\/1756-6606-2-3","journal-title":"Mol Brain"},{"issue":"2","key":"601_CR23","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1046\/j.1471-4159.1997.69020581.x","volume":"69","author":"Y Liu","year":"1997","unstructured":"Liu Y, Peterson DA, Kimura H, Schubert D (1997) Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction. J\u00a0Neurochem 69(2):581\u2013593. https:\/\/doi.org\/10.1046\/j.1471-4159.1997.69020581.x","journal-title":"J\u00a0Neurochem"},{"issue":"2","key":"601_CR24","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/cbdd.13866","volume":"98","author":"FB Lopes","year":"2021","unstructured":"Lopes FB, Aranha C, Fernandes JPS (2021) Histamine H3 receptor and cholinesterases as synergistic targets for cognitive decline: strategies to the rational design of multitarget ligands. Chem\u00a0Biol\u00a0Drug Des 98(2):212\u2013225. https:\/\/doi.org\/10.1111\/cbdd.13866","journal-title":"Chem\u00a0Biol\u00a0Drug Des"},{"issue":"6","key":"601_CR25","doi-asserted-by":"publisher","first-page":"3756","DOI":"10.1074\/jbc.273.6.3756","volume":"273","author":"Y Luo","year":"1998","unstructured":"Luo Y, Umegaki H, Wang X, Abe R, Roth GS (1998) Dopamine induces apoptosis through an oxidation-involved SAPK\/JNK activation pathway. J Biol Chem 273(6):3756\u20133764. https:\/\/doi.org\/10.1074\/jbc.273.6.3756","journal-title":"J Biol Chem"},{"issue":"1","key":"601_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0014-2999(88)90581-x","volume":"153","author":"KM Merchant","year":"1988","unstructured":"Merchant KM, Letter AA, Gibb JW, Hanson GR (1988) Changes in the limbic neurotensin systems induced by dopaminergic drugs. Eur\u00a0J\u00a0Pharmacol 153(1):1\u20139. https:\/\/doi.org\/10.1016\/0014-2999(88)90581-x","journal-title":"Eur\u00a0J\u00a0Pharmacol"},{"key":"601_CR27","doi-asserted-by":"crossref","unstructured":"Mittleman RE, Wetli CV (1984) Death caused by recreational cocaine use an update. JAMA 252(14):1889\u20131893","DOI":"10.1001\/jama.252.14.1889"},{"issue":"1\u20132","key":"601_CR28","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J\u00a0Immunol\u00a0Methods 65(1\u20132):55\u201363. https:\/\/doi.org\/10.1016\/0022-1759(83)90303-4","journal-title":"J\u00a0Immunol\u00a0Methods"},{"issue":"5","key":"601_CR29","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.biopsych.2012.08.027","volume":"73","author":"AV McCormick","year":"2013","unstructured":"McCormick AV, Wheeler JM, Guthrie CR, Liachko NF, Kraemer BC (2013) Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity. Biol\u00a0Psychiatry 73(5):464\u2013471. https:\/\/doi.org\/10.1016\/j.biopsych.2012.08.027","journal-title":"Biol\u00a0Psychiatry"},{"issue":"9","key":"601_CR30","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1002\/bit.260440916","volume":"44","author":"S Mercille","year":"1994","unstructured":"Mercille S, Massie B (1994) Induction of apoptosis in nutrient-deprived cultures of hybridoma and myeloma cells. Biotechnol\u00a0Bioeng 44(9):1140\u20131154. https:\/\/doi.org\/10.1002\/bit.260440916","journal-title":"Biotechnol\u00a0Bioeng"},{"issue":"8","key":"601_CR31","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.euroneuro.2013.05.006","volume":"23","author":"S Nakajima","year":"2013","unstructured":"Nakajima S, Gerretsen P, Takeuchi H, Caravaggio F, Chow T, Le Foll B, Mulsant B, Pollock B, Graff-Guerrero A (2013) The potential role of dopamine D3 receptor neurotransmission in cognition. Eur Neuropsychopharmacol 23(8):799\u2013813. https:\/\/doi.org\/10.1016\/j.euroneuro.2013.05.006","journal-title":"Eur Neuropsychopharmacol"},{"issue":"5","key":"601_CR32","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1124\/mol.116.104752","volume":"90","author":"G Nieto-Alamilla","year":"2016","unstructured":"Nieto-Alamilla G, M\u00e1rquez-G\u00f3mez R, Garc\u00eda-G\u00e1lvez AM, Morales-Figueroa GE, Arias-Monta\u00f1o JA (2016) The histamine H3 receptor: structure, pharmacology, and function. Mol\u00a0Pharmacol 90(5):649\u2013673. https:\/\/doi.org\/10.1124\/mol.116.104752","journal-title":"Mol\u00a0Pharmacol"},{"issue":"1","key":"601_CR33","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ejphar.2010.10.024","volume":"650","author":"R Numa","year":"2011","unstructured":"Numa R, Baron M, Kohen R, Yaka R (2011) Tempol attenuates cocaine-induced death of PC12 cells through decreased oxidative damage. Eur\u00a0J\u00a0Pharmacol 650(1):157\u2013162. https:\/\/doi.org\/10.1016\/j.ejphar.2010.10.024","journal-title":"Eur\u00a0J\u00a0Pharmacol"},{"issue":"8","key":"601_CR34","doi-asserted-by":"publisher","first-page":"895","DOI":"10.3109\/15563658108990316","volume":"18","author":"GR Nakamura","year":"1981","unstructured":"Nakamura GR, Noguchi TT (1981) Fatalities from cocaine overdoses in Los Angeles County. Clin\u00a0Toxicol 18(8):895\u2013905. https:\/\/doi.org\/10.3109\/15563658108990316","journal-title":"Clin\u00a0Toxicol"},{"issue":"2","key":"601_CR35","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0379-0738(90)90105-8","volume":"48","author":"FJ Peretti","year":"1990","unstructured":"Peretti FJ, Isenschmid DS, Levine B, Caplan YH, Smialek JE (1990) Cocaine fatality: an unexplained blood concentration in a fatal overdose. Forensic Sci\u00a0Int 48(2):135\u2013138. https:\/\/doi.org\/10.1016\/0379-0738(90)90105-8","journal-title":"Forensic Sci\u00a0Int"},{"issue":"1","key":"601_CR36","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.neuint.2006.06.012","volume":"50","author":"HF Poon","year":"2007","unstructured":"Poon HF, Abdullah L, Mullan MA, Mullan MJ, Crawford FC (2007) Cocaine-induced oxidative stress precedes cell death in human neuronal progenitor cells. Neurochem\u00a0Int 50(1):69\u201373. https:\/\/doi.org\/10.1016\/j.neuint.2006.06.012","journal-title":"Neurochem\u00a0Int"},{"issue":"1\u20132","key":"601_CR37","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.autneu.2006.07.009","volume":"129","author":"GJ Sanger","year":"2006","unstructured":"Sanger GJ, Andrews PL (2006) Treatment of nausea and vomiting: gaps in our knowledge. Auton Neurosci 129(1\u20132):3\u201316. https:\/\/doi.org\/10.1016\/j.autneu.2006.07.009","journal-title":"Auton Neurosci"},{"key":"601_CR38","unstructured":"SwissADME online platform: www.swissadme.ch"},{"issue":"8","key":"601_CR39","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/s1471-4914(03)00117-5","volume":"9","author":"S Shimohama","year":"2003","unstructured":"Shimohama S, Sawada H, Kitamura Y, Taniguchi T (2003) Disease model: Parkinson\u2019s disease. Trends Mol\u00a0Med 9(8):360\u2013365. https:\/\/doi.org\/10.1016\/s1471-4914(03)00117-5","journal-title":"Trends Mol\u00a0Med"},{"key":"601_CR40","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.3389\/fphar.2019.01583","volume":"10","author":"N Wang","year":"2020","unstructured":"Wang N, Ma J, Liu J, Wang J, Liu C, Wang H, Liu Y, Yan H, Jiang S (2020) Histamine H3 receptor antagonist enhances neurogenesis and improves chronic cerebral hypoperfusion-induced cognitive impairments. Front\u00a0Pharmacol 10:1583. https:\/\/doi.org\/10.3389\/fphar.2019.01583","journal-title":"Front\u00a0Pharmacol"},{"issue":"5","key":"601_CR41","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1038\/npp.2013.341","volume":"39","author":"N Wang","year":"2014","unstructured":"Wang N, Su P, Zhang Y, Lu J, Xing B, Kang K, Li W, Wang Y (2014) Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses. Neuropsychopharmacol\u00a0Rep 39(5):1290\u20131301. https:\/\/doi.org\/10.1038\/npp.2013.341","journal-title":"Neuropsychopharmacol\u00a0Rep"},{"issue":"3","key":"601_CR42","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s00213-011-2291-7","volume":"217","author":"MC Yang","year":"2011","unstructured":"Yang MC, Lung FW (2011) Neuroprotection of paliperidone on SH-SY5Y cells against \u03b2-amyloid peptide(25\u201335), N-methyl-4-phenylpyridinium ion, and hydrogen peroxide-induced cell death. Psychopharmacology 217(3):397\u2013410. https:\/\/doi.org\/10.1007\/s00213-011-2291-7","journal-title":"Psychopharmacology"},{"issue":"2","key":"601_CR43","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1081\/dct-100100119","volume":"23","author":"C Yuan","year":"2000","unstructured":"Yuan C, Acosta D Jr (2000) Effect of cocaine on mitochondrial electron transport chain evaluated in primary cultures of neonatal rat myocardial cells and in isolated mitochondrial preparations. Drug Chem Toxicol 23(2):339\u2013348. https:\/\/doi.org\/10.1081\/dct-100100119","journal-title":"Drug Chem Toxicol"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-022-00601-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-022-00601-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-022-00601-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T04:38:33Z","timestamp":1672288713000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12640-022-00601-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,7]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["601"],"URL":"https:\/\/doi.org\/10.1007\/s12640-022-00601-8","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,7]]},"assertion":[{"value":"26 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}