{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:14:53Z","timestamp":1768083293809,"version":"3.49.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CAPES\/PVE 052\/2012 - CAPES-FCT 2014"],"award-info":[{"award-number":["CAPES\/PVE 052\/2012 - CAPES-FCT 2014"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CAPES\/PVE 052\/2012 - CAPES-FCT 2014"],"award-info":[{"award-number":["CAPES\/PVE 052\/2012 - CAPES-FCT 2014"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["Strategic Project 2015-UID\/NEU\/04539\/2013"],"award-info":[{"award-number":["Strategic Project 2015-UID\/NEU\/04539\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centro 2020 Regional Operational Programmes","award":["CENTRO-01-0145-FEDER-000012: HealthyAging2020 and CENTRO-01-0145-FEDER-000008: BrainHealth 2020"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-000012: HealthyAging2020 and CENTRO-01-0145-FEDER-000008: BrainHealth 2020"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["INCT for Excitotoxicity and Neuroprotection"],"award-info":[{"award-number":["INCT for Excitotoxicity and Neuroprotection"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s12640-022-00607-2","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T09:08:54Z","timestamp":1669626534000},"page":"1924-1936","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neonatal Isoflurane Exposure in Rats Impairs Short-Term Memory, Cell Viability, and Glutamate Uptake in Slices of the Frontal Cerebral Cortex, But Not the Hippocampus, in Adulthood"],"prefix":"10.1007","volume":"40","author":[{"given":"La\u00edse Figueiredo","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela Godoy","family":"Poluceno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuane Bazanella","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandra Celso","family":"Constantino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wagner Carbolin","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tharine","family":"Dal-Cim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Andrin\u00e9ia","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana Kalyne","family":"Ludka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui Daniel","family":"Prediger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederico C.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla In\u00eas","family":"Tasca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"issue":"3","key":"607_CR1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neulet.2003.11.049","volume":"356","author":"H Abe","year":"2004","unstructured":"Abe H, Ishida Y, Iwasaki T (2004) Perirhinal N-methyl-D-aspartate and muscarinic systems participate in object recognition in rats. Neurosci Lett 356(3):191\u2013194. https:\/\/doi.org\/10.1016\/j.neulet.2003.11.049","journal-title":"Neurosci Lett"},{"issue":"38","key":"607_CR2","doi-asserted-by":"publisher","first-page":"11959","DOI":"10.1073\/pnas.1500525112","volume":"112","author":"JP Baumgart","year":"2015","unstructured":"Baumgart JP, Zhou ZY, Hara M, Cook DC, Hoppa MB, Ryan TA, Hemmings HC Jr (2015) Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca2+ influx, not Ca2+-exocytosis coupling. Proc Natl Acad Sci USA 112(38):11959\u201311964. https:\/\/doi.org\/10.1073\/pnas.1500525112","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"607_CR3","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1097\/ALN.0b013e3181d049cd","volume":"112","author":"AM Brambrink","year":"2010","unstructured":"Brambrink AM, Evers AS, Avidan MS et al (2010) Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain. Anesthesiology 112(4):834\u2013841. https:\/\/doi.org\/10.1097\/ALN.0b013e3181d049cd","journal-title":"Anesthesiology"},{"issue":"3","key":"607_CR4","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1097\/ALN.0b013e3181cd7942","volume":"112","author":"A Briner","year":"2010","unstructured":"Briner A, De Roo M, Dayer A, Muller D, Habre W, Vutskits L (2010) Volatile anesthetics rapidly increase dendritic spine density in the rat medial prefrontal cortex during synaptogenesis. Anesthesiology 112(3):546\u2013556. https:\/\/doi.org\/10.1097\/ALN.0b013e3181cd7942","journal-title":"Anesthesiology"},{"issue":"1","key":"607_CR5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1101\/lm.1650110","volume":"17","author":"NJ Broadbent","year":"2010","unstructured":"Broadbent NJ, Gaskin S, Squire LR, Clark RE (2010) Object recognition memory and the rodent hippocampus. Learn Mem 17(1):5\u201311. https:\/\/doi.org\/10.1101\/lm.1650110","journal-title":"Learn Mem"},{"issue":"1","key":"607_CR6","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/ALN.0000000000001383","volume":"126","author":"K Coleman","year":"2017","unstructured":"Coleman K, Robertson ND, Dissen GA et al (2017) Isoflurane anesthesia has long-term consequences on motor and behavioral development in infant rhesus macaques. Anesthesiology 126(1):74\u201384. https:\/\/doi.org\/10.1097\/ALN.0000000000001383","journal-title":"Anesthesiology"},{"issue":"Suppl 1","key":"607_CR7","doi-asserted-by":"publisher","first-page":"i29","DOI":"10.1093\/bja\/aet173","volume":"110","author":"C Creeley","year":"2013","unstructured":"Creeley C, Dikranian K, Dissen G, Martin L, Olney J, Brambrink A (2013) Propofol-induced apoptosis of neurones and oligodendrocytes in fetal and neonatal rhesus macaque brain. Br J Anaesth 110(Suppl 1):i29-38. https:\/\/doi.org\/10.1093\/bja\/aet173","journal-title":"Br J Anaesth"},{"issue":"4","key":"607_CR8","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/jnc.12324","volume":"126","author":"T Dal-Cim","year":"2013","unstructured":"Dal-Cim T, Ludka FK, Martins WC et al (2013) Guanosine controls inflammatory pathways to afford neuroprotection of hippocampal slices under oxygen and glucose deprivation conditions. J Neurochem 126(4):437\u2013450. https:\/\/doi.org\/10.1111\/jnc.12324","journal-title":"J Neurochem"},{"issue":"4","key":"607_CR9","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s11302-019-09679-w","volume":"15","author":"T Dal-Cim","year":"2019","unstructured":"Dal-Cim T, Poluceno GG, Lanznaster D, de Oliveira KA, Nedel CB, Tasca CI (2019) Guanosine prevents oxidative damage and glutamate uptake impairment induced by oxygen\/glucose deprivation in cortical astrocyte cultures: involvement of A1 and A2A adenosine receptors and PI3K, MEK, and PKC pathways. Purinergic Signal 15(4):465\u2013476. https:\/\/doi.org\/10.1007\/s11302-019-09679-w","journal-title":"Purinergic Signal"},{"issue":"7","key":"607_CR10","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1111\/j.1460-9592.2010.03506.x","volume":"21","author":"AJ Davidson","year":"2011","unstructured":"Davidson AJ (2011) Anesthesia and neurotoxicity to the developing brain: the clinical relevance. Paediatr Anaesth 21(7):716\u2013721. https:\/\/doi.org\/10.1111\/j.1460-9592.2010.03506.x","journal-title":"Paediatr Anaesth"},{"issue":"9","key":"607_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007043","volume":"4","author":"M De Roo","year":"2009","unstructured":"De Roo M, Klauser P, Briner A et al (2009) Anesthetics rapidly promote synaptogenesis during a critical period of brain development. PLoS ONE 4(9):e7043. https:\/\/doi.org\/10.1371\/journal.pone.0007043","journal-title":"PLoS ONE"},{"issue":"5","key":"607_CR12","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1002\/hipo.20077","volume":"15","author":"TC Dumas","year":"2005","unstructured":"Dumas TC (2005) Late postnatal maturation of excitatory synaptic transmission permits adult-like expression of hippocampal-dependent behaviors. Hippocampus 15(5):562\u2013578. https:\/\/doi.org\/10.1002\/hipo.20077","journal-title":"Hippocampus"},{"issue":"5","key":"607_CR13","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1001\/archpedi.1953.02050080600004","volume":"86","author":"JE Eckenhoff","year":"1953","unstructured":"Eckenhoff JE (1953) Relationship of anesthesia to postoperative personality changes in children. AMA Am J Dis Child 86(5):587\u2013591. https:\/\/doi.org\/10.1001\/archpedi.1953.02050080600004","journal-title":"AMA Am J Dis Child"},{"issue":"2","key":"607_CR14","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1213\/00000539-199202000-00012","volume":"74","author":"EJ Frink Jr","year":"1992","unstructured":"Frink EJ Jr, Malan TP, Atlas M, Dominguez LM, DiNardo JA, Brown BR Jr (1992) Clinical comparison of sevoflurane and isoflurane in healthy patients. Anesth Analg 74(2):241\u2013245. https:\/\/doi.org\/10.1213\/00000539-199202000-00012","journal-title":"Anesth Analg"},{"issue":"2","key":"607_CR15","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1097\/00000542-200402000-00019","volume":"100","author":"CD Futterer","year":"2004","unstructured":"Futterer CD, Maurer MH, Schmitt A, Feldmann RE Jr, Kuschinsky W, Waschke KF (2004) Alterations in rat brain proteins after desflurane anesthesia. Anesthesiology 100(2):302\u2013308. https:\/\/doi.org\/10.1097\/00000542-200402000-00019","journal-title":"Anesthesiology"},{"issue":"2","key":"607_CR16","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2344\/0003-3006-64.2.57","volume":"64","author":"S Ganzberg","year":"2017","unstructured":"Ganzberg S (2017) The FDA warning on anesthesia drugs. Anesth Prog 64(2):57\u201358. https:\/\/doi.org\/10.2344\/0003-3006-64.2.57","journal-title":"Anesth Prog"},{"issue":"1","key":"607_CR17","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2174\/157015910790909502","volume":"8","author":"PS Garcia","year":"2010","unstructured":"Garcia PS, Kolesky SE, Jenkins A (2010) General anesthetic actions on GABA(A) receptors. Curr Neuropharmacol 8(1):2\u20139. https:\/\/doi.org\/10.2174\/157015910790909502","journal-title":"Curr Neuropharmacol"},{"issue":"3","key":"607_CR18","first-page":"177","volume":"88","author":"A Gupta","year":"2020","unstructured":"Gupta A, Datta PK (2020) Sevoflurane consumption during inhalational induction in children: a randomized comparison of minute ventilation-based techniques with standard fixed fresh gas flow technique. AANA J 88(3):177\u2013182","journal-title":"AANA J"},{"issue":"6380","key":"607_CR19","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/357686a0","volume":"357","author":"S Hestrin","year":"1992","unstructured":"Hestrin S (1992) Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse. Nature 357(6380):686\u2013689. https:\/\/doi.org\/10.1038\/357686a0","journal-title":"Nature"},{"issue":"2","key":"607_CR20","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1097\/00000542-200402000-00003","volume":"100","author":"K Hogan","year":"2004","unstructured":"Hogan K (2004) Long-lasting changes in brain protein expression after exposure to an anesthetic. Anesthesiology 100(2):209\u2013212. https:\/\/doi.org\/10.1097\/00000542-200402000-00003","journal-title":"Anesthesiology"},{"issue":"2","key":"607_CR21","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/00002826-200403000-00004","volume":"27","author":"C Jiang","year":"2004","unstructured":"Jiang C, Wan X, Jankovic J et al (2004) Dopaminergic properties and experimental anti-parkinsonian effects of IPX750 in rodent models of Parkinson disease. Clin Neuropharmacol 27(2):63\u201373. https:\/\/doi.org\/10.1097\/00002826-200403000-00004","journal-title":"Clin Neuropharmacol"},{"key":"607_CR22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.brainres.2016.01.052","volume":"1636","author":"GH Kim","year":"2016","unstructured":"Kim GH, Lee JJ, Lee SH, Chung YH, Cho HS, Kim JA, Kim MK (2016) Exposure of isoflurane-treated cells to hyperoxia decreases cell viability and activates the mitochondrial apoptotic pathway. Brain Res 1636:13\u201320. https:\/\/doi.org\/10.1016\/j.brainres.2016.01.052","journal-title":"Brain Res"},{"issue":"9","key":"607_CR23","first-page":"5828","volume":"7","author":"J Liu","year":"2014","unstructured":"Liu J, Wang P, Zhang X, Zhang W, Gu G (2014) Effects of different concentration and duration time of isoflurane on acute and long-term neurocognitive function of young adult C57BL\/6 mouse. Int J Clin Exp Pathol 7(9):5828\u20135836","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"607_CR24","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193(1):265\u2013275","journal-title":"J Biol Chem"},{"issue":"5","key":"607_CR25","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1007\/s12035-016-9882-6","volume":"54","author":"FK Ludka","year":"2017","unstructured":"Ludka FK, Dal-Cim T, Binder LB, Constantino LC, Massari C, Tasca CI (2017) Atorvastatin and fluoxetine prevent oxidative stress and mitochondrial dysfunction evoked by glutamate toxicity in hippocampal slices. Mol Neurobiol 54(5):3149\u20133161. https:\/\/doi.org\/10.1007\/s12035-016-9882-6","journal-title":"Mol Neurobiol"},{"key":"607_CR26","doi-asserted-by":"publisher","unstructured":"Lueptow LM (2017) Novel object recognition test for the investigation of learning and memory in mice. J Vis Exp (126). https:\/\/doi.org\/10.3791\/55718","DOI":"10.3791\/55718"},{"key":"607_CR27","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6459","volume":"367","author":"ME McCann","year":"2019","unstructured":"McCann ME, Soriano SG (2019) Does general anesthesia affect neurodevelopment in infants and children? BMJ 367:l6459. https:\/\/doi.org\/10.1136\/bmj.l6459","journal-title":"BMJ"},{"issue":"1","key":"607_CR28","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s11064-007-9402-1","volume":"33","author":"S Molz","year":"2008","unstructured":"Molz S, Decker H, Dal-Cim T, Cremonez C, Cordova FM, Leal RB, Tasca CI (2008) Glutamate-induced toxicity in hippocampal slices involves apoptotic features and p38 MAPK signaling. Neurochem Res 33(1):27\u201336. https:\/\/doi.org\/10.1007\/s11064-007-9402-1","journal-title":"Neurochem Res"},{"issue":"7","key":"607_CR29","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.neuint.2009.06.015","volume":"55","author":"S Molz","year":"2009","unstructured":"Molz S, Dal-Cim T, Tasca CI (2009) Guanosine-5\u2019-monophosphate induces cell death in rat hippocampal slices via ionotropic glutamate receptors activation and glutamate uptake inhibition. Neurochem Int 55(7):703\u2013709. https:\/\/doi.org\/10.1016\/j.neuint.2009.06.015","journal-title":"Neurochem Int"},{"issue":"9","key":"607_CR30","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1002\/jnr.22681","volume":"89","author":"S Molz","year":"2011","unstructured":"Molz S, Dal-Cim T, Budni J et al (2011) Neuroprotective effect of guanosine against glutamate-induced cell death in rat hippocampal slices is mediated by the phosphatidylinositol-3 kinase\/Akt\/ glycogen synthase kinase 3beta pathway activation and inducible nitric oxide synthase inhibition. J Neurosci Res 89(9):1400\u20131408. https:\/\/doi.org\/10.1002\/jnr.22681","journal-title":"J Neurosci Res"},{"issue":"1\u20132","key":"607_CR31","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65(1\u20132):55\u201363. https:\/\/doi.org\/10.1016\/0022-1759(83)90303-4","journal-title":"J Immunol Methods"},{"key":"607_CR32","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3389\/fneur.2013.00087","volume":"4","author":"KL Murphy","year":"2013","unstructured":"Murphy KL, Baxter MG (2013) Long-term effects of neonatal single or multiple isoflurane exposures on spatial memory in rats. Front Neurol 4:87. https:\/\/doi.org\/10.3389\/fneur.2013.00087","journal-title":"Front Neurol"},{"key":"607_CR33","doi-asserted-by":"publisher","unstructured":"National Research Council (2011) Guide for the Care and Use of Laboratory Animals: Eighth Edition. Washington, DC: The National Academies Press. https:\/\/doi.org\/10.17226\/12910","DOI":"10.17226\/12910"},{"issue":"2","key":"607_CR34","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.bja.2020.10.015","volume":"126","author":"V Neudecker","year":"2021","unstructured":"Neudecker V, Perez-Zoghbi JF, Coleman K et al (2021) Infant isoflurane exposure affects social behaviours, but does not impair specific cognitive domains in juvenile non-human primates. Br J Anaesth 126(2):486\u2013499. https:\/\/doi.org\/10.1016\/j.bja.2020.10.015","journal-title":"Br J Anaesth"},{"issue":"3","key":"607_CR35","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1093\/bja\/aex123","volume":"119","author":"KK Noguchi","year":"2017","unstructured":"Noguchi KK, Johnson SA, Dissen GA et al (2017) Isoflurane exposure for three hours triggers apoptotic cell death in neonatal macaque brain. Br J Anaesth 119(3):524\u2013531. https:\/\/doi.org\/10.1093\/bja\/aex123","journal-title":"Br J Anaesth"},{"issue":"3","key":"607_CR36","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1097\/00000542-200109000-00028","volume":"95","author":"G Orliaguet","year":"2001","unstructured":"Orliaguet G, Vivien B, Langeron O, Bouhemad B, Coriat P, Riou B (2001) Minimum alveolar concentration of volatile anesthetics in rats during postnatal maturation. Anesthesiology 95(3):734\u2013739. https:\/\/doi.org\/10.1097\/00000542-200109000-00028","journal-title":"Anesthesiology"},{"issue":"1","key":"607_CR37","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12993-017-0132-5","volume":"13","author":"A Palanisamy","year":"2017","unstructured":"Palanisamy A, Crosby G, Culley DJ (2017) Early gestational exposure to isoflurane causes persistent cell loss in the dentate gyrus of adult male rats. Behav Brain Funct 13(1):14. https:\/\/doi.org\/10.1186\/s12993-017-0132-5","journal-title":"Behav Brain Funct"},{"issue":"4","key":"607_CR38","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1097\/ALN.0b013e31819c42a4","volume":"110","author":"P Patel","year":"2009","unstructured":"Patel P, Sun L (2009) Update on neonatal anesthetic neurotoxicity: insight into molecular mechanisms and relevance to humans. Anesthesiology 110(4):703\u2013708. https:\/\/doi.org\/10.1097\/ALN.0b013e31819c42a4","journal-title":"Anesthesiology"},{"issue":"2","key":"607_CR39","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s12640-009-9057-6","volume":"16","author":"TC Piermartiri","year":"2009","unstructured":"Piermartiri TC, Vandresen-Filho S, de Araujo HB et al (2009) Atorvastatin prevents hippocampal cell death due to quinolinic acid-induced seizures in mice by increasing Akt phosphorylation and glutamate uptake. Neurotox Res 16(2):106\u2013115. https:\/\/doi.org\/10.1007\/s12640-009-9057-6","journal-title":"Neurotox Res"},{"issue":"1","key":"607_CR40","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11064-012-0889-8","volume":"38","author":"X Qu","year":"2013","unstructured":"Qu X, Xu C, Wang H et al (2013) Hippocampal glutamate level and glutamate aspartate transporter (GLAST) are up-regulated in senior rat associated with isoflurane-induced spatial learning\/memory impairment. Neurochem Res 38(1):59\u201373. https:\/\/doi.org\/10.1007\/s11064-012-0889-8","journal-title":"Neurochem Res"},{"key":"607_CR41","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.neuint.2016.03.014","volume":"98","author":"MB Robinson","year":"2016","unstructured":"Robinson MB, Jackson JG (2016) Astroglial glutamate transporters coordinate excitatory signaling and brain energetics. Neurochem Int 98:56\u201371. https:\/\/doi.org\/10.1016\/j.neuint.2016.03.014","journal-title":"Neurochem Int"},{"issue":"4","key":"607_CR42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175258","volume":"12","author":"M Rosenholm","year":"2017","unstructured":"Rosenholm M, Paro E, Antila H, Voikar V, Rantamaki T (2017) Repeated brief isoflurane anesthesia during early postnatal development produces negligible changes on adult behavior in male mice. PLoS ONE 12(4):e0175258. https:\/\/doi.org\/10.1371\/journal.pone.0175258","journal-title":"PLoS ONE"},{"issue":"3","key":"607_CR43","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s12640-018-9927-x","volume":"34","author":"TB Sampaio","year":"2018","unstructured":"Sampaio TB, de Oliveira LF, Constantino LC et al (2018) Long-term neurobehavioral consequences of a single ketamine neonatal exposure in rats: effects on cellular viability and glutamate transport in frontal cortex and hippocampus. Neurotox Res 34(3):649\u2013659. https:\/\/doi.org\/10.1007\/s12640-018-9927-x","journal-title":"Neurotox Res"},{"issue":"4","key":"607_CR44","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1097\/ALN.0000000000003482","volume":"133","author":"ML Schaefer","year":"2020","unstructured":"Schaefer ML, Perez PJ, Wang M et al (2020) Neonatal isoflurane anesthesia or disruption of postsynaptic density-95 protein interactions change dendritic spine densities and cognitive function in juvenile mice. Anesthesiology 133(4):812\u2013823. https:\/\/doi.org\/10.1097\/ALN.0000000000003482","journal-title":"Anesthesiology"},{"key":"607_CR45","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.neuro.2013.08.007","volume":"39","author":"X Shen","year":"2013","unstructured":"Shen X, Liu Y, Xu S, Zhao Q, Guo X, Shen R, Wang F (2013) Early life exposure to sevoflurane impairs adulthood spatial memory in the rat. Neurotoxicology 39:45\u201356. https:\/\/doi.org\/10.1016\/j.neuro.2013.08.007","journal-title":"Neurotoxicology"},{"issue":"4","key":"607_CR46","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1097\/ALN.0b013e31819c463d","volume":"110","author":"G Stratmann","year":"2009","unstructured":"Stratmann G, Sall JW, May LD et al (2009a) Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats. Anesthesiology 110(4):834\u2013848. https:\/\/doi.org\/10.1097\/ALN.0b013e31819c463d","journal-title":"Anesthesiology"},{"issue":"4","key":"607_CR47","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1097\/ALN.0b013e31819c7140","volume":"110","author":"G Stratmann","year":"2009","unstructured":"Stratmann G, May LD, Sall JW et al (2009b) Effect of hypercarbia and isoflurane on brain cell death and neurocognitive dysfunction in 7-day-old rats. Anesthesiology 110(4):849\u2013861. https:\/\/doi.org\/10.1097\/ALN.0b013e31819c7140","journal-title":"Anesthesiology"},{"issue":"2","key":"607_CR48","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1213\/ANE.0b013e3181af8015","volume":"110","author":"G Stratmann","year":"2010","unstructured":"Stratmann G, Sall JW, May LD, Loepke AW, Lee MT (2010) Beyond anesthetic properties: the effects of isoflurane on brain cell death, neurogenesis, and long-term neurocognitive function. Anesth Analg 110(2):431\u2013437. https:\/\/doi.org\/10.1213\/ANE.0b013e3181af8015","journal-title":"Anesth Analg"},{"issue":"4","key":"607_CR49","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1538\/expanim.17-0037","volume":"66","author":"A Tsukamoto","year":"2017","unstructured":"Tsukamoto A, Konishi Y, Kawakami T, Koibuchi C, Sato R, Kanai E, Inomata T (2017) Pharmacological properties of various anesthetic protocols in 10-day-old neonatal rats. Exp Anim 66(4):397\u2013404. https:\/\/doi.org\/10.1538\/expanim.17-0037","journal-title":"Exp Anim"},{"issue":"3","key":"607_CR50","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1037\/0033-2909.83.3.482","volume":"83","author":"RN Walsh","year":"1976","unstructured":"Walsh RN, Cummins RA (1976) The open-field test: a critical review. Psychol Bull 83(3):482\u2013504","journal-title":"Psychol Bull"},{"key":"607_CR51","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2147\/DDDT.S163197","volume":"13","author":"X Wang","year":"2019","unstructured":"Wang X, Shan Y, Tang Z, Gao L, Liu H (2019) Neuroprotective effects of dexmedetomidine against isoflurane-induced neuronal injury via glutamate regulation in neonatal rats. Drug Des Dev Ther 13:153\u2013160","journal-title":"Drug Des Dev Ther"},{"issue":"21","key":"607_CR52","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.1523\/JNEUROSCI.2946-19.2020","volume":"40","author":"HY Wang","year":"2020","unstructured":"Wang HY, Eguchi K, Yamashita T, Takahashi T (2020) Frequency-dependent block of excitatory neurotransmission by isoflurane via dual presynaptic mechanisms. J Neurosci 40(21):4103\u20134115. https:\/\/doi.org\/10.1523\/JNEUROSCI.2946-19.2020","journal-title":"J Neurosci"},{"issue":"1\u20133","key":"607_CR53","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ejphar.2013.04.056","volume":"719","author":"T Yuan","year":"2013","unstructured":"Yuan T, Bellone C (2013) Glutamatergic receptors at developing synapses: the role of GluN3A-containing NMDA receptors and GluA2-lacking AMPA receptors. Eur J Pharmacol 719(1\u20133):107\u2013111. https:\/\/doi.org\/10.1016\/j.ejphar.2013.04.056","journal-title":"Eur J Pharmacol"},{"issue":"17","key":"607_CR54","doi-asserted-by":"publisher","first-page":"4551","DOI":"10.1523\/JNEUROSCI.5694-07.2008","volume":"28","author":"G Zhang","year":"2008","unstructured":"Zhang G, Dong Y, Zhang B et al (2008) Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci 28(17):4551\u20134560. https:\/\/doi.org\/10.1523\/JNEUROSCI.5694-07.2008","journal-title":"J Neurosci"},{"key":"607_CR55","doi-asserted-by":"publisher","first-page":"26865","DOI":"10.1038\/srep26865","volume":"6","author":"T Zhao","year":"2016","unstructured":"Zhao T, Li C, Wei W, Zhang H, Ma D, Song X, Zhou L (2016) Prenatal ketamine exposure causes abnormal development of prefrontal cortex in rat. Sci Rep 6:26865. https:\/\/doi.org\/10.1038\/srep26865","journal-title":"Sci Rep"},{"issue":"4","key":"607_CR56","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.neuroscience.2007.12.013","volume":"151","author":"X Zou","year":"2008","unstructured":"Zou X, Sadovova N, Patterson TA et al (2008) The effects of L-carnitine on the combination of, inhalation anesthetic-induced developmental, neuronal apoptosis in the rat frontal cortex. Neuroscience 151(4):1053\u20131065. https:\/\/doi.org\/10.1016\/j.neuroscience.2007.12.013","journal-title":"Neuroscience"},{"issue":"5","key":"607_CR57","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1097\/00001756-200104170-00042","volume":"12","author":"Z Zuo","year":"2001","unstructured":"Zuo Z (2001) Isoflurane enhances glutamate uptake via glutamate transporters in rat glial cells. NeuroReport 12(5):1077\u20131080. https:\/\/doi.org\/10.1097\/00001756-200104170-00042","journal-title":"NeuroReport"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-022-00607-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-022-00607-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-022-00607-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T04:39:32Z","timestamp":1672288772000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12640-022-00607-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,28]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["607"],"URL":"https:\/\/doi.org\/10.1007\/s12640-022-00607-2","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,28]]},"assertion":[{"value":"31 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Experiments followed the \u201cPrinciples of Laboratory Animal Care\u201d (NIH 2011) and were approved by the Committee on the Ethics of Animal Experiments of the Federal University of Santa Catarina (CEUA\/UFSC PP955).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}