{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:30:32Z","timestamp":1790814632865,"version":"4.1.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T00:00:00Z","timestamp":1681516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T00:00:00Z","timestamp":1681516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s12640-023-00645-4","type":"journal-article","created":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T06:02:16Z","timestamp":1681538536000},"page":"398-407","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["NRF2 Antagonizes HIV-1 Tat and Methamphetamine-Induced BV2 Cell Ferroptosis by Regulating SLC7A11"],"prefix":"10.1007","volume":"41","author":[{"given":"Shucheng","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genmeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Kwan","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,15]]},"reference":[{"key":"645_CR1","doi-asserted-by":"publisher","first-page":"466","DOI":"10.3389\/fnins.2018.00466","volume":"12","author":"M Abdalkader","year":"2018","unstructured":"Abdalkader M, Lampinen R, Kanninen KM, Malm TM, Liddell JR (2018) Targeting Nrf2 to suppress ferroptosis and mitochondrial dysfunction in neurodegeneration. Front Neurosci 12:466. https:\/\/doi.org\/10.3389\/fnins.2018.00466","journal-title":"Front Neurosci"},{"key":"645_CR2","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.pharmthera.2015.11.003","volume":"157","author":"I Buendia","year":"2016","unstructured":"Buendia I, Michalska P, Navarro E, Gameiro I, Egea J, Leon R (2016) Nrf2-ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacol Ther 157:84\u2013104. https:\/\/doi.org\/10.1016\/j.pharmthera.2015.11.003","journal-title":"Pharmacol Ther"},{"key":"645_CR3","doi-asserted-by":"publisher","unstructured":"Chen X, Yu C, Kang R, Tang D (2020) Iron metabolism in ferroptosis. Front Cell Dev Biol 8:590226.\u00a0https:\/\/doi.org\/10.3389\/fcell.2020.590226","DOI":"10.3389\/fcell.2020.590226"},{"key":"645_CR4","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","volume":"35","author":"M Colonna","year":"2017","unstructured":"Colonna M, Butovsky O (2017) Microglia function in the central nervous system during health and neurodegeneration. Annu Rev Immunol 35:441\u2013468. https:\/\/doi.org\/10.1146\/annurev-immunol-051116-052358","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"645_CR5","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1186\/s12974-021-02231-x","volume":"18","author":"Y Cui","year":"2021","unstructured":"Cui Y, Zhang Z, Zhou X, Zhao Z, Zhao R, Xu X, Kong X, Ren J, Yao X, Wen Q, Guo F, Gao S, Sun J, Wan Q (2021) Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression. J Neuroinflammation 18(1):249. https:\/\/doi.org\/10.1186\/s12974-021-02231-x","journal-title":"J Neuroinflammation"},{"issue":"5","key":"645_CR6","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060\u20131072. https:\/\/doi.org\/10.1016\/j.cell.2012.03.042","journal-title":"Cell"},{"key":"645_CR7","doi-asserted-by":"publisher","unstructured":"Dong H, Qiang Z, Chai D, Peng J, Xia Y, Hu R, Jiang H (2020) Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1. Aging (Albany NY) 12(13):12943\u201312959.\u00a0https:\/\/doi.org\/10.18632\/aging.103378","DOI":"10.18632\/aging.103378"},{"key":"645_CR8","doi-asserted-by":"publisher","unstructured":"Fan Z, Wirth AK, Chen D, Wruck CJ, Rauh M, Buchfelder M, Savaskan N (2017) Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis. Oncogenesis 6(8):e371.\u00a0https:\/\/doi.org\/10.1038\/oncsis.2017.65","DOI":"10.1038\/oncsis.2017.65"},{"key":"645_CR9","doi-asserted-by":"publisher","unstructured":"Fattakhov N, Torices S, Stangis M, Park M, Toborek M (2021) Synergistic impairment of the neurovascular unit by HIV-1 infection and methamphetamine use: implications for HIV-1-associated neurocognitive disorders. Viruses 13(9).\u00a0https:\/\/doi.org\/10.3390\/v13091883","DOI":"10.3390\/v13091883"},{"issue":"1","key":"645_CR10","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1186\/s12967-021-03042-7","volume":"19","author":"L Feng","year":"2021","unstructured":"Feng L, Zhao K, Sun L, Yin X, Zhang J, Liu C, Li B (2021a) SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis. J Transl Med 19(1):367. https:\/\/doi.org\/10.1186\/s12967-021-03042-7","journal-title":"J Transl Med"},{"key":"645_CR11","doi-asserted-by":"publisher","unstructured":"Feng Z, Min L, Chen H, Deng W, Tan M, Liu H, Hou J (2021b) Iron overload in the motor cortex induces neuronal ferroptosis following spinal cord injury. Redox Biol 43:101984.\u00a0https:\/\/doi.org\/10.1016\/j.redox.2021.101984","DOI":"10.1016\/j.redox.2021.101984"},{"issue":"12","key":"645_CR12","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","volume":"16","author":"JP Friedmann Angeli","year":"2014","unstructured":"Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Radmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Forster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O\u2019Donnell VB, Kagan VE, Schick JA, Conrad M (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol 16(12):1180\u20131191. https:\/\/doi.org\/10.1038\/ncb3064","journal-title":"Nat Cell Biol"},{"issue":"3","key":"645_CR13","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","volume":"25","author":"L Galluzzi","year":"2018","unstructured":"Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D\u2019Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jaattela M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, Lopez-Otin C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Munoz-Pinedo C, Nagata S, Nunez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ 25(3):486\u2013541. https:\/\/doi.org\/10.1038\/s41418-017-0012-4","journal-title":"Cell Death Differ"},{"key":"645_CR14","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.bbadis.2013.12.011","volume":"8","author":"L Gan","year":"1842","unstructured":"Gan L,\u00a0Johnson JA (2014) Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases. Biochim Biophys Acta 8:1208\u20131218. https:\/\/doi.org\/10.1016\/j.bbadis.2013.12.011","journal-title":"Biochim Biophys Acta"},{"issue":"9","key":"645_CR15","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/cr.2016.95","volume":"26","author":"M Gao","year":"2016","unstructured":"Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X (2016) Ferroptosis is an autophagic cell death process. Cell Res 26(9):1021\u20131032. https:\/\/doi.org\/10.1038\/cr.2016.95","journal-title":"Cell Res"},{"issue":"12","key":"645_CR16","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1002\/glia.21229","volume":"59","author":"N Granado","year":"2011","unstructured":"Granado N, Lastres-Becker I, Ares-Santos S, Oliva I, Martin E, Cuadrado A, Moratalla R (2011) Nrf2 deficiency potentiates methamphetamine-induced dopaminergic axonal damage and gliosis in the striatum. Glia 59(12):1850\u20131863. https:\/\/doi.org\/10.1002\/glia.21229","journal-title":"Glia"},{"key":"645_CR17","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neuint.2017.01.004","volume":"104","author":"SJ Guiney","year":"2017","unstructured":"Guiney SJ, Adlard PA, Bush AI, Finkelstein DI, Ayton S (2017) Ferroptosis and cell death mechanisms in Parkinson\u2019s disease. Neurochem Int 104:34\u201348. https:\/\/doi.org\/10.1016\/j.neuint.2017.01.004","journal-title":"Neurochem Int"},{"key":"645_CR18","doi-asserted-by":"publisher","unstructured":"Guo D, Huang X, Xiong T, Wang X, Zhang J, Wang Y, Liang J (2022) Molecular mechanisms of programmed cell death in methamphetamine-induced neuronal damage. Front Pharmacol 13:980340 https:\/\/doi.org\/10.3389\/fphar.2022.980340","DOI":"10.3389\/fphar.2022.980340"},{"issue":"4","key":"645_CR19","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tibs.2014.02.002","volume":"39","author":"JD Hayes","year":"2014","unstructured":"Hayes JD, Dinkova-Kostova AT (2014) The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem Sci 39(4):199\u2013218. https:\/\/doi.org\/10.1016\/j.tibs.2014.02.002","journal-title":"Trends Biochem Sci"},{"key":"645_CR20","doi-asserted-by":"publisher","unstructured":"Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, Porto Freitas F, Seibt T, Mehr L, Aichler M, Walch A, Lamp D, Jastroch M, Miyamoto S, Wurst W, Ursini F, Arner ESJ, Fradejas-Villar N, Schweizer U, Zischka H, Friedmann Angeli JP, Conrad M (2018) Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis. Cell 172(3):409\u2013422 e421.\u00a0https:\/\/doi.org\/10.1016\/j.cell.2017.11.048","DOI":"10.1016\/j.cell.2017.11.048"},{"issue":"4","key":"645_CR21","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22(4):266\u2013282. https:\/\/doi.org\/10.1038\/s41580-020-00324-8","journal-title":"Nat Rev Mol Cell Biol"},{"key":"645_CR22","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.freeradbiomed.2018.05.074","volume":"133","author":"R Kang","year":"2019","unstructured":"Kang R, Kroemer G, Tang D (2019) The tumor suppressor protein p53 and the ferroptosis network. Free Radic Biol Med 133:162\u2013168. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.05.074","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"645_CR23","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/s41422-019-0263-3","volume":"30","author":"G Lei","year":"2020","unstructured":"Lei G, Zhang Y, Koppula P, Liu X, Zhang J, Lin SH, Ajani JA, Xiao Q, Liao Z, Wang H, Gan B (2020) The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression. Cell Res 30(2):146\u2013162. https:\/\/doi.org\/10.1038\/s41422-019-0263-3","journal-title":"Cell Res"},{"key":"645_CR24","doi-asserted-by":"publisher","unstructured":"Liu J, Xu P, Collins C, Liu H, Zhang J, Keblesh JP, Xiong H (2013) HIV-1 Tat protein increases microglial outward K(+) current and resultant neurotoxic activity. PLoS One 8(5):e64904.\u00a0https:\/\/doi.org\/10.1371\/journal.pone.0064904","DOI":"10.1371\/journal.pone.0064904"},{"issue":"5","key":"645_CR25","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1007\/s13365-018-0705-6","volume":"25","author":"KA McLaurin","year":"2019","unstructured":"McLaurin KA, Booze RM, Mactutus CF (2019) Diagnostic and prognostic biomarkers for HAND. J Neurovirol 25(5):686\u2013701. https:\/\/doi.org\/10.1007\/s13365-018-0705-6","journal-title":"J Neurovirol"},{"key":"645_CR26","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.3389\/fmicb.2015.01164","volume":"6","author":"S Mediouni","year":"2015","unstructured":"Mediouni S, Marcondes MC, Miller C, McLaughlin JP, Valente ST (2015) The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders. Front Microbiol 6:1164. https:\/\/doi.org\/10.3389\/fmicb.2015.01164","journal-title":"Front Microbiol"},{"issue":"2","key":"645_CR27","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s12017-018-8518-6","volume":"21","author":"Y Mi","year":"2019","unstructured":"Mi Y, Gao X, Xu H, Cui Y, Zhang Y, Gou X (2019) The emerging roles of ferroptosis in Huntington\u2019s disease. Neuromolecular Med 21(2):110\u2013119. https:\/\/doi.org\/10.1007\/s12017-018-8518-6","journal-title":"Neuromolecular Med"},{"issue":"3","key":"645_CR28","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s11904-019-00426-9","volume":"16","author":"R Paul","year":"2019","unstructured":"Paul R (2019) Neurocognitive phenotyping of HIV in the era of antiretroviral therapy. Curr HIV\/AIDS Rep 16(3):230\u2013235. https:\/\/doi.org\/10.1007\/s11904-019-00426-9","journal-title":"Curr HIV\/AIDS Rep"},{"key":"645_CR29","doi-asserted-by":"publisher","first-page":"639","DOI":"10.3389\/fphar.2017.00639","volume":"8","author":"X Qie","year":"2017","unstructured":"Qie X, Wen D, Guo H, Xu G, Liu S, Shen Q, Liu Y, Zhang W, Cong B, Ma C (2017) Endoplasmic reticulum stress mediates methamphetamine-induced blood-brain barrier damage. Front Pharmacol 8:639. https:\/\/doi.org\/10.3389\/fphar.2017.00639","journal-title":"Front Pharmacol"},{"issue":"5","key":"645_CR30","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.neuint.2011.06.011","volume":"61","author":"PV Reddy","year":"2012","unstructured":"Reddy PV, Gandhi N, Samikkannu T, Saiyed Z, Agudelo M, Yndart A, Khatavkar P, Nair MP (2012) HIV-1 gp120 induces antioxidant response element-mediated expression in primary astrocytes: role in HIV associated neurocognitive disorder. Neurochem Int 61(5):807\u2013814. https:\/\/doi.org\/10.1016\/j.neuint.2011.06.011","journal-title":"Neurochem Int"},{"key":"645_CR31","unstructured":"Report WD (2021) United Nations\u00a0: Office on Drugs and Crime. Retrieved September 28, 2022. www.unodc.org\/unodc\/en\/data-and-analysis\/wdr2021.html."},{"key":"645_CR32","doi-asserted-by":"publisher","unstructured":"Scutari R, Alteri C, Perno CF, Svicher V, Aquaro S (2017) The role of HIV infection in neurologic injury. Brain Sci 7(4). https:\/\/doi.org\/10.3390\/brainsci7040038","DOI":"10.3390\/brainsci7040038"},{"key":"645_CR33","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.freeradbiomed.2018.10.426","volume":"129","author":"D Shin","year":"2018","unstructured":"Shin D, Kim EH, Lee J, Roh JL (2018) Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med 129:454\u2013462. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.10.426","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"645_CR34","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1186\/s12974-020-02038-2","volume":"17","author":"E Sigfridsson","year":"2020","unstructured":"Sigfridsson E, Marangoni M, Hardingham GE, Horsburgh K, Fowler JH (2020) Deficiency of Nrf2 exacerbates white matter damage and microglia\/macrophage levels in a mouse model of vascular cognitive impairment. J Neuroinflammation 17(1):367. https:\/\/doi.org\/10.1186\/s12974-020-02038-2","journal-title":"J Neuroinflammation"},{"issue":"5","key":"645_CR35","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s13365-011-0043-4","volume":"17","author":"PS Silverstein","year":"2011","unstructured":"Silverstein PS, Shah A, Gupte R, Liu X, Piepho RW, Kumar S, Kumar A (2011) Methamphetamine toxicity and its implications during HIV-1 infection. J Neurovirol 17(5):401\u2013415. https:\/\/doi.org\/10.1007\/s13365-011-0043-4","journal-title":"J Neurovirol"},{"issue":"5","key":"645_CR36","doi-asserted-by":"publisher","first-page":"369","DOI":"10.2174\/157016212802138724","volume":"10","author":"PS Silverstein","year":"2012","unstructured":"Silverstein PS, Shah A, Weemhoff J, Kumar S, Singh DP, Kumar A (2012) HIV-1 gp120 and drugs of abuse: interactions in the central nervous system. Curr HIV Res 10(5):369\u2013383. https:\/\/doi.org\/10.2174\/157016212802138724","journal-title":"Curr HIV Res"},{"key":"645_CR37","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3389\/fnins.2020.00267","volume":"14","author":"X Song","year":"2020","unstructured":"Song X, Long D (2020) Nrf2 and ferroptosis: a new research direction for neurodegenerative diseases. Front Neurosci 14:267. https:\/\/doi.org\/10.3389\/fnins.2020.00267","journal-title":"Front Neurosci"},{"issue":"2","key":"645_CR38","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","volume":"31","author":"D Tang","year":"2021","unstructured":"Tang D, Chen X, Kang R, Kroemer G (2021) Ferroptosis: molecular mechanisms and health implications. Cell Res 31(2):107\u2013125. https:\/\/doi.org\/10.1038\/s41422-020-00441-1","journal-title":"Cell Res"},{"key":"645_CR39","doi-asserted-by":"publisher","unstructured":"Thangaraj A, Chivero ET, Tripathi A, Singh S, Niu F, Guo ML, Pillai P, Periyasamy P, Buch S (2021) HIV TAT-mediated microglial senescence: role of SIRT3-dependent mitochondrial oxidative stress. Redox Biol 40:101843. https:\/\/doi.org\/10.1016\/j.redox.2020.101843","DOI":"10.1016\/j.redox.2020.101843"},{"issue":"8","key":"645_CR40","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1038\/s41401-021-00814-1","volume":"43","author":"MP Wang","year":"2022","unstructured":"Wang MP, Joshua B, Jin NY, Du SW, Li C (2022) Ferroptosis in viral infection: the unexplored possibility. Acta Pharmacol Sin 43(8):1905\u20131915. https:\/\/doi.org\/10.1038\/s41401-021-00814-1","journal-title":"Acta Pharmacol Sin"},{"issue":"3","key":"645_CR41","first-page":"84","volume":"9","author":"E Xu","year":"2017","unstructured":"Xu E, Liu J, Liu H, Wang X, Xiong H (2017) Role of microglia in methamphetamine-induced neurotoxicity. Int J Physiol Pathophysiol Pharmacol 9(3):84\u2013100","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"645_CR42","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.toxlet.2018.09.009","volume":"299","author":"XF Zeng","year":"2018","unstructured":"Zeng XF, Li Q, Li J, Wong N, Li Z, Huang J, Yang G, Sham PC, Li SB, Lu G (2018) HIV-1 Tat and methamphetamine co-induced oxidative cellular injury is mitigated by N-acetylcysteine amide (NACA) through rectifying mTOR signaling. Toxicol Lett 299:159\u2013171. https:\/\/doi.org\/10.1016\/j.toxlet.2018.09.009","journal-title":"Toxicol Lett"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-023-00645-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-023-00645-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-023-00645-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T08:12:14Z","timestamp":1694592734000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12640-023-00645-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,15]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["645"],"URL":"https:\/\/doi.org\/10.1007\/s12640-023-00645-4","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,15]]},"assertion":[{"value":"4 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}