{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:19:02Z","timestamp":1793837942750,"version":"4.6.1"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH-D-111089"],"award-info":[{"award-number":["TSGH-D-111089"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["CMU-109-S-20"],"award-info":[{"award-number":["CMU-109-S-20"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR-109-163"],"award-info":[{"award-number":["DMR-109-163"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022298","name":"Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation","doi-asserted-by":"publisher","award":["IMAR-110-01-15"],"award-info":[{"award-number":["IMAR-110-01-15"]}],"id":[{"id":"10.13039\/501100022298","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s12640-023-00666-z","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T14:08:52Z","timestamp":1694700532000},"page":"648-659","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer\u2019s Disease mice via IGF1R\/PI3K\/AKT and SIRT1\/AMPK Pathways"],"prefix":"10.1007","volume":"41","author":[{"given":"Da-Tong","family":"Ju","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rwei-Fen S.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce Chi-Kang","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chen","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Ling","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Ming","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Vijaya","family":"Padma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Jung","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hsu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Wen","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"666_CR1","doi-asserted-by":"publisher","unstructured":"Achudhan D, Li-Yun Chang S, Liu SC, Lin YY, Huang WC, Wu YC, Huang CC, Tsai CH, Ko CY, Kuo YH, Tang CH (2022) Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts. Food Nutr Res 66. https:\/\/doi.org\/10.29219\/fnr.v66.8645","DOI":"10.29219\/fnr.v66.8645"},{"issue":"1","key":"666_CR2","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s00401-009-0522-3","volume":"118","author":"RD Bell","year":"2009","unstructured":"Bell RD, Zlokovic BV (2009) Neurovascular mechanisms and blood\u2013brain barrier disorder in Alzheimer\u2019s disease. Acta Neuropathol 118(1):103\u2013113. https:\/\/doi.org\/10.1007\/s00401-009-0522-3","journal-title":"Acta Neuropathol"},{"issue":"11","key":"666_CR3","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.3390\/ijms18112441","volume":"18","author":"VE Bianchi","year":"2017","unstructured":"Bianchi VE, Locatelli V, Rizzi L (2017) Neurotrophic and Neuroregenerative Effects of GH\/IGF1. Int J Mol Sci 18(11):2441. https:\/\/doi.org\/10.3390\/ijms18112441","journal-title":"Int J Mol Sci"},{"issue":"3","key":"666_CR4","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/s0749-3797(03)00197-1","volume":"25","author":"EM Castillo","year":"2003","unstructured":"Castillo EM, Goodman-Gruen D, Kritz-Silverstein D, Morton DJ, Wingard DL, Barrett-Connor E (2003) Sarcopenia in elderly men and women: the Rancho Bernardo study. Am J Prev Med 25(3):226\u2013231. https:\/\/doi.org\/10.1016\/s0749-3797(03)00197-1","journal-title":"Am J Prev Med"},{"key":"666_CR5","doi-asserted-by":"publisher","unstructured":"Chang WS, Tsai CW, Yang JS, Hsu YM, Shih LC, Chiu HY, Bau DT, Tsai FJ (2021) Resveratrol inhibited the metastatic behaviors of cisplatin-resistant human oral cancer cells via phosphorylation of ERK\/p-38 and suppression of MMP-2\/9. J Food Biochem 45(6):e13666. https:\/\/doi.org\/10.1111\/jfbc.13666","DOI":"10.1111\/jfbc.13666"},{"issue":"5","key":"666_CR6","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1007\/s12640-022-00544-0","volume":"40","author":"M-S Chen","year":"2022","unstructured":"Chen M-S, Tsai BC-K, Sitorus MA, Kuo C-H, Kuo W-W, Chen T-S, Fu C-Y, Ho T-J, Huang C-Y, Ju D-T (2022) Epigallocatechin-3-gallate pretreatment improves autologous adipose-derived stem cells against rheumatoid arthritis-induced neuroinflammation in the brain of collagen-induced rats. Neurotox Res 40(5):1223\u20131234. https:\/\/doi.org\/10.1007\/s12640-022-00544-0","journal-title":"Neurotox Res"},{"key":"666_CR7","doi-asserted-by":"publisher","unstructured":"Chen MY, Tsai BC, Kuo WW, Kuo CH, Lin YM, Hsieh DJ, Pai PY, Liao SC, Huang SE, Lee SD, Huang CY (2023) Diosgenin Attenuates Myocardial Cell Apoptosis Triggered by Oxidative Stress through Estrogen Receptor to Activate the PI3K\/Akt and ERK Axes. Am J Chin Med 1\u201322. https:\/\/doi.org\/10.1142\/s0192415x23500556","DOI":"10.1142\/s0192415x23500556"},{"issue":"2","key":"666_CR8","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.ijcard.2012.01.031","volume":"167","author":"SM Cheng","year":"2013","unstructured":"Cheng SM, Ho TJ, Yang AL, Chen IJ, Kao CL, Wu FN, Lin JA, Kuo CH, Ou HC, Huang CY, Lee SD (2013) Exercise training enhances cardiac IGFI-R\/PI3K\/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats. Int J Cardiol 167(2):478\u2013485. https:\/\/doi.org\/10.1016\/j.ijcard.2012.01.031","journal-title":"Int J Cardiol"},{"issue":"6","key":"666_CR9","doi-asserted-by":"publisher","first-page":"744","DOI":"10.4103\/2230-8210.167553","volume":"19","author":"F Chentli","year":"2015","unstructured":"Chentli F, Azzoug S, Mahgoun S (2015) Diabetes mellitus in elderly. Indian J Endocrinol Metab 19(6):744\u2013752. https:\/\/doi.org\/10.4103\/2230-8210.167553","journal-title":"Indian J Endocrinol Metab"},{"issue":"1","key":"666_CR10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2217\/fca.11.76","volume":"8","author":"ZZ Chong","year":"2012","unstructured":"Chong ZZ, Wang S, Shang YC, Maiese K (2012) Targeting cardiovascular disease with novel SIRT1 pathways. Future Cardiol 8(1):89\u2013100. https:\/\/doi.org\/10.2217\/fca.11.76","journal-title":"Future Cardiol"},{"key":"666_CR11","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1155\/JBB.2005.189","volume":"2","author":"EH Corder","year":"2005","unstructured":"Corder EH, Ervin JF, Lockhart E, Szymanski MH, Schmechel DE (2005) Hulette CM (2005) Cardiovascular damage in Alzheimer disease: autopsy findings from the Bryan ADRC. J Biomed Biotechnol 2:189\u2013197. https:\/\/doi.org\/10.1155\/JBB.2005.189","journal-title":"J Biomed Biotechnol"},{"issue":"1","key":"666_CR12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.jalz.2005.06.001","volume":"1","author":"MM Corrada","year":"2005","unstructured":"Corrada MM, Kawas CH, Hallfrisch J, Muller D, Brookmeyer R (2005) Reduced risk of Alzheimer\u2019s disease with high folate intake: the Baltimore Longitudinal Study of Aging. Alzheimers Dement 1(1):11\u201318. https:\/\/doi.org\/10.1016\/j.jalz.2005.06.001","journal-title":"Alzheimers Dement"},{"key":"666_CR13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.redox.2018.08.005","volume":"19","author":"S Cui","year":"2018","unstructured":"Cui S, Lv X, Li W, Li Z, Liu H, Gao Y, Huang G (2018) Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro. Redox Biol 19:81\u201391. https:\/\/doi.org\/10.1016\/j.redox.2018.08.005","journal-title":"Redox Biol"},{"key":"666_CR14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cbi.2013.11.017","volume":"209","author":"JS Deng","year":"2014","unstructured":"Deng JS, Lee SD, Kuo WW, Fan MJ, Lin YM, Hu WS, Huang YC, Velmurugan BK, Tsai FJ, Tsai CH, Huang CY (2014) Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts. Chem Biol Interact 209:77\u201384. https:\/\/doi.org\/10.1016\/j.cbi.2013.11.017","journal-title":"Chem Biol Interact"},{"issue":"2","key":"666_CR15","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1474-9726.2010.00548.x","volume":"9","author":"G Donmez","year":"2010","unstructured":"Donmez G, Guarente L (2010) Aging and disease: connections to sirtuins. Aging Cell 9(2):285\u2013290. https:\/\/doi.org\/10.1111\/j.1474-9726.2010.00548.x","journal-title":"Aging Cell"},{"issue":"6","key":"666_CR16","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1159\/000085063","volume":"1","author":"L Dupuis","year":"2004","unstructured":"Dupuis L, Gonzalez de Aguilar JL, Oudart H, de Tapia M, Barbeito L, Loeffler JP (2004) Mitochondria in amyotrophic lateral sclerosis: a trigger and a target. Neurodegener Dis 1(6):245\u2013254. https:\/\/doi.org\/10.1159\/000085063","journal-title":"Neurodegener Dis"},{"issue":"2","key":"666_CR17","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.ijcard.2012.10.046","volume":"168","author":"JA Finegold","year":"2013","unstructured":"Finegold JA, Asaria P, Francis DP (2013) Mortality from ischaemic heart disease by country, region, and age: statistics from World Health Organisation and United Nations. Int J Cardiol 168(2):934\u2013945. https:\/\/doi.org\/10.1016\/j.ijcard.2012.10.046","journal-title":"Int J Cardiol"},{"issue":"4","key":"666_CR18","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.cell.2011.10.033","volume":"147","author":"Y Fuchs","year":"2011","unstructured":"Fuchs Y, Steller H (2011) Programmed cell death in animal development and disease. Cell 147(4):742\u2013758. https:\/\/doi.org\/10.1016\/j.cell.2011.10.033","journal-title":"Cell"},{"key":"666_CR19","doi-asserted-by":"publisher","first-page":"629","DOI":"10.3389\/fnins.2019.00629","volume":"13","author":"S Gabbouj","year":"2019","unstructured":"Gabbouj S, Ryh\u00e4nen S, Marttinen M, Wittrahm R, Takalo M, Kemppainen S, Martiskainen H, Tanila H, Haapasalo A, Hiltunen M, Natunen T (2019) Altered Insulin Signaling in Alzheimer\u2019s Disease Brain - Special Emphasis on PI3K-Akt Pathway. Front Neurosci 13:629. https:\/\/doi.org\/10.3389\/fnins.2019.00629","journal-title":"Front Neurosci"},{"issue":"6","key":"666_CR20","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.tem.2013.01.010","volume":"24","author":"JL Gueant","year":"2013","unstructured":"Gueant JL, Namour F, Gueant-Rodriguez RM, Daval JL (2013) Folate and fetal programming: a play in epigenomics? Trends Endocrinol Metab 24(6):279\u2013289. https:\/\/doi.org\/10.1016\/j.tem.2013.01.010","journal-title":"Trends Endocrinol Metab"},{"issue":"11","key":"666_CR21","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/ncpneuro0924","volume":"4","author":"C Henchcliffe","year":"2008","unstructured":"Henchcliffe C, Beal MF (2008) Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neurol 4(11):600\u2013609. https:\/\/doi.org\/10.1038\/ncpneuro0924","journal-title":"Nat Clin Pract Neurol"},{"issue":"8","key":"666_CR22","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3390\/md16080263","volume":"16","author":"YL Hsieh","year":"2018","unstructured":"Hsieh YL, Teng HJ, Yeh YH, Hsieh CH, Huang CY (2018) The Protective Effects of Clams on Hypercholesterolemia in Late-Stage Triple-Transgenic Alzheimer\u2019s Diseased Mice Hearts. Mar Drugs 16(8):263. https:\/\/doi.org\/10.3390\/md16080263","journal-title":"Mar Drugs"},{"issue":"8","key":"666_CR23","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1038\/cdd.2014.46","volume":"21","author":"CY Huang","year":"2014","unstructured":"Huang CY, Kuo WW, Yeh YL, Ho TJ, Lin JY, Lin DY, Chu CH, Tsai FJ, Tsai CH, Huang CY (2014) ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation. Cell Death Differ 21(8):1262\u20131274. https:\/\/doi.org\/10.1038\/cdd.2014.46","journal-title":"Cell Death Differ"},{"issue":"7","key":"666_CR24","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1002\/tox.23521","volume":"37","author":"CY Huang","year":"2022","unstructured":"Huang CY, Su YC, Lu CY, Chiu PL, Chang YM, Ju DT, Chen RJ, Yang LY, Ho TJ, Kao HC (2022) Edible folic acid and medicinal folinic acid produce cardioprotective effects in late-stage triple-transgenic Alzheimer\u2019s disease model mice by suppressing cardiac hypertrophy and fibrosis. Environ Toxicol 37(7):1740\u20131749. https:\/\/doi.org\/10.1002\/tox.23521","journal-title":"Environ Toxicol"},{"key":"666_CR25","doi-asserted-by":"publisher","unstructured":"Huang CY, Yang AL, Lin YM, Wu FN, Lin JA, Chan YS, Tsai FJ, Tsai CH, Kuo CH, Lee SD (2012) Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts. J Appl Physiol (1985) 112(5):883\u2013891. https:\/\/doi.org\/10.1152\/japplphysiol.00605.2011","DOI":"10.1152\/japplphysiol.00605.2011"},{"issue":"17","key":"666_CR26","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1056\/NEJM199910213411706","volume":"341","author":"JJ Hunter","year":"1999","unstructured":"Hunter JJ, Chien KR (1999) Signaling pathways for cardiac hypertrophy and failure. N Engl J Med 341(17):1276\u20131283. https:\/\/doi.org\/10.1056\/NEJM199910213411706","journal-title":"N Engl J Med"},{"issue":"7\u20138","key":"666_CR27","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.mad.2008.04.001","volume":"129","author":"JC Jeyapalan","year":"2008","unstructured":"Jeyapalan JC, Sedivy JM (2008) Cellular senescence and organismal aging. Mech Ageing Dev 129(7\u20138):467\u2013474. https:\/\/doi.org\/10.1016\/j.mad.2008.04.001","journal-title":"Mech Ageing Dev"},{"key":"666_CR28","doi-asserted-by":"publisher","unstructured":"Kim JY, Mondaca-Ruff D, Singh S, Wang Y (2022) SIRT1 and Autophagy: Implications in Endocrine Disorders. Front Endocrinol (Lausanne) 13:930919. https:\/\/doi.org\/10.3389\/fendo.2022.930919","DOI":"10.3389\/fendo.2022.930919"},{"issue":"5","key":"666_CR29","doi-asserted-by":"publisher","first-page":"315","DOI":"10.4093\/dmj.2013.37.5.315","volume":"37","author":"M Kitada","year":"2013","unstructured":"Kitada M, Koya D (2013) SIRT1 in type 2 diabetes: mechanisms and therapeutic potential. Diabetes Metab J 37(5):315\u2013325. https:\/\/doi.org\/10.4093\/dmj.2013.37.5.315","journal-title":"Diabetes Metab J"},{"key":"666_CR30","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1146\/annurev.pharmtox.44.101802.121851","volume":"44","author":"JE Klaunig","year":"2004","unstructured":"Klaunig JE, Kamendulis LM (2004) The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol 44:239\u2013267. https:\/\/doi.org\/10.1146\/annurev.pharmtox.44.101802.121851","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"4","key":"666_CR31","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1007\/s12602-021-09745-z","volume":"13","author":"K-P Koay","year":"2021","unstructured":"Koay K-P, Tsai BC-K, Kuo C-H, Kuo W-W, Luk H-N, Day CH, Chen R-J, Chen MY-C, Padma VV, Huang C-Y (2021) Hyperglycemia-Induced Cardiac Damage Is Alleviated by Heat-Inactivated Lactobacillus reuteri GMNL-263 via Activation of the IGF1R Survival Pathway. Probiotics Antimicrob Proteins 13(4):1044\u20131053. https:\/\/doi.org\/10.1007\/s12602-021-09745-z","journal-title":"Probiotics Antimicrob Proteins"},{"key":"666_CR32","doi-asserted-by":"publisher","unstructured":"Kumar R, Chaterjee P, Sharma PK, Singh AK, Gupta A, Gill K, Tripathi M, Dey AB, Dey S (2013) Sirtuin1: a promising serum protein marker for early detection of Alzheimer's disease. PloS one 8(4):e61560. https:\/\/doi.org\/10.1371\/journal.pone.0061560","DOI":"10.1371\/journal.pone.0061560"},{"issue":"3","key":"666_CR33","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1002\/tox.23717","volume":"38","author":"CH Lai","year":"2022","unstructured":"Lai CH, Van Thao D, Tsai BCK, Hsieh DJY, Chen MYC, Kuo WW, Kuo CH, Lu SY, Liao SC, Lin KH (2022) Insulin-like growth factor II receptor alpha overexpression in heart aggravates hyperglycemia-induced cardiac inflammation and myocardial necrosis. Environ Toxicol 38(3):676\u2013684. https:\/\/doi.org\/10.1002\/tox.23717","journal-title":"Environ Toxicol"},{"issue":"2","key":"666_CR34","doi-asserted-by":"publisher","first-page":"152","DOI":"10.2174\/1570159x18666200729093724","volume":"19","author":"J Leszek","year":"2021","unstructured":"Leszek J, Mikhaylenko EV, Belousov DM, Koutsouraki E, Szczechowiak K, Kobusiak-Prokopowicz M, Mysiak A, Diniz BS, Somasundaram SG, Kirkland CE, Aliev G (2021) The Links between Cardiovascular Diseases and Alzheimer\u2019s Disease. Curr Neuropharmacol 19(2):152\u2013169. https:\/\/doi.org\/10.2174\/1570159x18666200729093724","journal-title":"Curr Neuropharmacol"},{"key":"666_CR35","doi-asserted-by":"publisher","first-page":"757","DOI":"10.2147\/cia.S158513","volume":"13","author":"I Liguori","year":"2018","unstructured":"Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P (2018) Oxidative stress, aging, and diseases. Clin Interv Aging 13:757\u2013772. https:\/\/doi.org\/10.2147\/cia.S158513","journal-title":"Clin Interv Aging"},{"key":"666_CR36","doi-asserted-by":"publisher","unstructured":"Liu G, Yao L, Liu J, Jiang Y, Ma G,\u00a0Genetic, Environmental Risk for Alzheimer's disease C, Chen Z, Zhao B, Li K, (2014) Cardiovascular disease contributes to Alzheimer\u2019s disease: evidence from large-scale genome-wide association studies. Neurobiol Aging 35(4):786\u2013792. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2013.10.084","DOI":"10.1016\/j.neurobiolaging.2013.10.084"},{"key":"666_CR37","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12986-020-0432-x","volume":"17","author":"SP Liu","year":"2020","unstructured":"Liu SP, Shibu MA, Tsai FJ, Hsu YM, Tsai CH, Chung JG, Yang JS, Tang CH, Wang S, Li Q, Huang CY (2020) Tetramethylpyrazine reverses high-glucose induced hypoxic effects by negatively regulating HIF-1alpha induced BNIP3 expression to ameliorate H9c2 cardiomyoblast apoptosis. Nutr Metab (lond) 17:12. https:\/\/doi.org\/10.1186\/s12986-020-0432-x","journal-title":"Nutr Metab (lond)"},{"key":"666_CR38","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.molmet.2018.01.013","volume":"9","author":"S Logan","year":"2018","unstructured":"Logan S, Pharaoh GA, Marlin MC, Masser DR, Matsuzaki S, Wronowski B, Yeganeh A, Parks EE, Premkumar P, Farley JA, Owen DB, Humphries KM, Kinter M, Freeman WM, Szweda LI, Van Remmen H, Sonntag WE (2018) Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-\u03b2 uptake in astrocytes. Mol Metab 9:141\u2013155. https:\/\/doi.org\/10.1016\/j.molmet.2018.01.013","journal-title":"Mol Metab"},{"issue":"12","key":"666_CR39","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1097\/HJH.0000000000003285","volume":"40","author":"S-Y Lu","year":"2022","unstructured":"Lu S-Y, Hong W-Z, Tsai BC-K, Chang Y-C, Kuo C-H, Mhone TG, Chen R-J, Kuo W-W, Huang C-Y (2022) Angiotensin II prompts heart cell apoptosis via AT1 receptor-augmented phosphatase and tensin homolog and miR-320-3p functions to enhance suppression of the IGF1R-PI3K-AKT survival pathway. J Hypertens 40(12):2502\u20132512. https:\/\/doi.org\/10.1097\/HJH.0000000000003285","journal-title":"J Hypertens"},{"issue":"5","key":"666_CR40","doi-asserted-by":"publisher","first-page":"4329","DOI":"10.1007\/s11033-023-08327-2","volume":"50","author":"SY Lu","year":"2023","unstructured":"Lu SY, Tsai BC, Van Thao D, Lai CH, Chen MY, Kuo WW, Kuo CH, Lin KH, Hsieh DJ, Huang CY (2023) Cardiac-specific overexpression of insulin-like growth factor II receptor-\u03b1 interferes with the regulation of calcium homeostasis in the heart under hyperglycemic conditions. Mol Biol Rep 50(5):4329\u20134338. https:\/\/doi.org\/10.1007\/s11033-023-08327-2","journal-title":"Mol Biol Rep"},{"key":"666_CR41","doi-asserted-by":"publisher","first-page":"5323","DOI":"10.2741\/3084","volume":"13","author":"E Lubos","year":"2008","unstructured":"Lubos E, Handy DE, Loscalzo J (2008) Role of oxidative stress and nitric oxide in atherothrombosis. Front Biosci 13:5323\u20135344. https:\/\/doi.org\/10.2741\/3084","journal-title":"Front Biosci"},{"key":"666_CR42","doi-asserted-by":"publisher","unstructured":"Mangiola A, Vigo V, Anile C, De Bonis P, Marziali G, Lofrese G (2015) Role and Importance of IGF-1 in Traumatic Brain Injuries. Biomed Res Int 2015:736104. https:\/\/doi.org\/10.1155\/2015\/736104","DOI":"10.1155\/2015\/736104"},{"key":"666_CR43","doi-asserted-by":"publisher","unstructured":"Mayeux R, Stern Y (2012) Epidemiology of Alzheimer disease. Cold Spring Harb Perspect Med 2(8):a006239. https:\/\/doi.org\/10.1101\/cshperspect.a006239","DOI":"10.1101\/cshperspect.a006239"},{"issue":"5","key":"666_CR44","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.3892\/etm.2017.4259","volume":"13","author":"Y Meng","year":"2017","unstructured":"Meng Y, Wang W, Kang J, Wang X, Sun L (2017) Role of the PI3K\/AKT signalling pathway in apoptotic cell death in the cerebral cortex of streptozotocin-induced diabetic rats. Exp Ther Med 13(5):2417\u20132422. https:\/\/doi.org\/10.3892\/etm.2017.4259","journal-title":"Exp Ther Med"},{"issue":"7","key":"666_CR45","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.2174\/1570159X18666200729111744","volume":"19","author":"P Mishra","year":"2021","unstructured":"Mishra P, Mittal AK, Kalonia H, Madan S, Ghosh S, Sinha JK, Rajput SK (2021) SIRT1 promotes neuronal fortification in neurodegenerative diseases through attenuation of pathological hallmarks and enhancement of cellular lifespan. Curr Neuropharmacol 19(7):1019\u20131037. https:\/\/doi.org\/10.2174\/1570159X18666200729111744","journal-title":"Curr Neuropharmacol"},{"issue":"10","key":"666_CR46","doi-asserted-by":"publisher","first-page":"3104","DOI":"10.1002\/art.20516","volume":"50","author":"SL Morgan","year":"2004","unstructured":"Morgan SL, Oster RA, Lee JY, Alarcon GS, Baggott JE (2004) The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis. Arthritis Rheum 50(10):3104\u20133111. https:\/\/doi.org\/10.1002\/art.20516","journal-title":"Arthritis Rheum"},{"issue":"8","key":"666_CR47","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/s41580-020-0241-0","volume":"21","author":"H Nakatogawa","year":"2020","unstructured":"Nakatogawa H (2020) Mechanisms governing autophagosome biogenesis. Nat Rev Mol Cell Biol 21(8):439\u2013458. https:\/\/doi.org\/10.1038\/s41580-020-0241-0","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"666_CR48","doi-asserted-by":"publisher","first-page":"156","DOI":"10.2174\/157489008786263989","volume":"3","author":"S Pillarisetti","year":"2008","unstructured":"Pillarisetti S (2008) A review of Sirt1 and Sirt1 modulators in cardiovascular and metabolic diseases. Recent Pat Cardiovasc Drug Discov 3(3):156\u2013164. https:\/\/doi.org\/10.2174\/157489008786263989","journal-title":"Recent Pat Cardiovasc Drug Discov"},{"key":"666_CR49","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1196\/annals.1427.010","volume":"1147","author":"D Pratico","year":"2008","unstructured":"Pratico D (2008) Evidence of oxidative stress in Alzheimer\u2019s disease brain and antioxidant therapy: lights and shadows. Ann N Y Acad Sci 1147:70\u201378. https:\/\/doi.org\/10.1196\/annals.1427.010","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"666_CR50","doi-asserted-by":"publisher","first-page":"975","DOI":"10.3233\/jad-160612","volume":"57","author":"R Rajmohan","year":"2017","unstructured":"Rajmohan R, Reddy PH (2017) Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer\u2019s disease Neurons. J Alzheimers Dis 57(4):975\u2013999. https:\/\/doi.org\/10.3233\/jad-160612","journal-title":"J Alzheimers Dis"},{"issue":"6","key":"666_CR51","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1007\/s12192-021-01231-3","volume":"26","author":"E Razani","year":"2021","unstructured":"Razani E, Pourbagheri-Sigaroodi A, Safaroghli-Azar A, Zoghi A, Shanaki-Bavarsad M, Bashash D (2021) The PI3K\/Akt signaling axis in Alzheimer\u2019s disease: a valuable target to stimulate or suppress? Cell Stress Chaperones 26(6):871\u2013887. https:\/\/doi.org\/10.1007\/s12192-021-01231-3","journal-title":"Cell Stress Chaperones"},{"key":"666_CR52","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.dadm.2017.01.005","volume":"7","author":"CY Santos","year":"2017","unstructured":"Santos CY, Snyder PJ, Wu WC, Zhang M, Echeverria A, Alber J (2017) Pathophysiologic relationship between Alzheimer\u2019s disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis. Alzheimers Dement (amst) 7:69\u201387. https:\/\/doi.org\/10.1016\/j.dadm.2017.01.005","journal-title":"Alzheimers Dement (amst)"},{"key":"666_CR53","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.fct.2013.08.011","volume":"60","author":"S Suman","year":"2013","unstructured":"Suman S, Datta K, Chakraborty K, Kulkarni SS, Doiron K, Fornace AJ Jr, Sree Kumar K, Hauer-Jensen M, Ghosh SP (2013) Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival. Food Chem Toxicol 60:488\u2013496. https:\/\/doi.org\/10.1016\/j.fct.2013.08.011","journal-title":"Food Chem Toxicol"},{"key":"666_CR54","doi-asserted-by":"publisher","unstructured":"Tang BL (2016) Sirt1 and the Mitochondria. Mol Cells 39(2):87\u201395. https:\/\/doi.org\/10.14348\/molcells.2016.2318","DOI":"10.14348\/molcells.2016.2318"},{"issue":"7","key":"666_CR55","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1002\/art.1780310712","volume":"31","author":"M Tishler","year":"1988","unstructured":"Tishler M, Caspi D, Fishel B, Yaron M (1988) The effects of leucovorin (folinic acid) on methotrexate therapy in rheumatoid arthritis patients. Arthritis Rheum 31(7):906\u2013908. https:\/\/doi.org\/10.1002\/art.1780310712","journal-title":"Arthritis Rheum"},{"issue":"2","key":"666_CR56","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ijcard.2013.10.065","volume":"170","author":"AM Tolppanen","year":"2013","unstructured":"Tolppanen AM, Kettunen R, Ahonen R, Soininen H, Hartikainen S (2013) Incident ischaemic heart disease in persons with Alzheimer\u2019s disease in a Finnish nationwide exposure-matched cohort. Int J Cardiol 170(2):195\u2013201. https:\/\/doi.org\/10.1016\/j.ijcard.2013.10.065","journal-title":"Int J Cardiol"},{"issue":"22","key":"666_CR57","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1016\/j.jacc.2016.08.073","volume":"68","author":"L Troncone","year":"2016","unstructured":"Troncone L, Luciani M, Coggins M, Wilker EH, Ho CY, Codispoti KE, Frosch MP, Kayed R, Del Monte F (2016) A\u03b2 Amyloid Pathology Affects the Hearts of Patients With Alzheimer\u2019s Disease: Mind the Heart. J Am Coll Cardiol 68(22):2395\u20132407. https:\/\/doi.org\/10.1016\/j.jacc.2016.08.073","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"666_CR58","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1017\/S0007114507777140","volume":"98","author":"AJ Wright","year":"2007","unstructured":"Wright AJ, Dainty JR, Finglas PM (2007) Folic acid metabolism in human subjects revisited: potential implications for proposed mandatory folic acid fortification in the UK. Br J Nutr 98(4):667\u2013675. https:\/\/doi.org\/10.1017\/S0007114507777140","journal-title":"Br J Nutr"},{"key":"666_CR59","doi-asserted-by":"publisher","unstructured":"Yang Y, Liu Y, Wang Y, Chao Y, Zhang J, Jia Y, Tie J, Hu D (2022) Regulation of SIRT1 and Its Roles in Inflammation. Front Immunol 13:831168. https:\/\/doi.org\/10.3389\/fimmu.2022.831168","DOI":"10.3389\/fimmu.2022.831168"},{"key":"666_CR60","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mad.2016.02.003","volume":"155","author":"Y Yuan","year":"2016","unstructured":"Yuan Y, Cruzat VF, Newsholme P, Cheng J, Chen Y, Lu Y (2016) Regulation of SIRT1 in aging: roles in mitochondrial function and biogenesis. Mech Ageing Dev 155:10\u201321. https:\/\/doi.org\/10.1016\/j.mad.2016.02.003","journal-title":"Mech Ageing Dev"},{"issue":"2","key":"666_CR61","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.3892\/etm.2018.6336","volume":"16","author":"M Zhang","year":"2018","unstructured":"Zhang M, Liu J, Li M, Zhang S, Lu Y, Liang Y, Zhao K, Li Y (2018) Insulin-like growth factor 1\/insulin-like growth factor 1 receptor signaling protects against cell apoptosis through the PI3K\/AKT pathway in glioblastoma cells. Exp Ther Med 16(2):1477\u20131482. https:\/\/doi.org\/10.3892\/etm.2018.6336","journal-title":"Exp Ther Med"},{"key":"666_CR62","doi-asserted-by":"publisher","unstructured":"Zhao L, Cao J, Hu K, He X, Yun D, Tong T, Han L (2020) Sirtuins and their biological relevance in aging and age-related diseases. Aging Dis 11(4):927\u2013945. https:\/\/doi.org\/10.14336\/AD.2019.0820","DOI":"10.14336\/AD.2019.0820"},{"issue":"8","key":"666_CR63","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.clineuro.2008.05.002","volume":"110","author":"R Zulli","year":"2008","unstructured":"Zulli R, Nicosia F, Borroni B, Agosti C, Prometti P, Donati P, De Vecchi M, Turini D, Romanelli G, Grassi V, Padovani A (2008) Increased prevalence of silent myocardial ischaemia and severe ventricular arrhythmias in untreated patients with Alzheimer\u2019s disease and mild cognitive impairment without overt coronary artery disease. Clin Neurol Neurosurg 110(8):791\u2013796. https:\/\/doi.org\/10.1016\/j.clineuro.2008.05.002","journal-title":"Clin Neurol Neurosurg"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-023-00666-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-023-00666-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-023-00666-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T01:11:21Z","timestamp":1701133881000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12640-023-00666-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,14]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["666"],"URL":"https:\/\/doi.org\/10.1007\/s12640-023-00666-z","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,14]]},"assertion":[{"value":"25 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing interest in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interest"}}]}}