{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:20:29Z","timestamp":1793074829583,"version":"4.5.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s12640-023-00670-3","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T05:03:13Z","timestamp":1697518993000},"page":"698-707","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["BIN1 in the Pursuit of Ousting the Alzheimer\u2019s Reign: Impact on Amyloid and Tau Neuropathology"],"prefix":"10.1007","volume":"41","author":[{"given":"Ishnoor","family":"Kaur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapan","family":"Behl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sundararajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Panneerselvam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"Vijayakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. P.","family":"Senthilkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Venkatachalam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmender","family":"Jaglan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivam","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Anwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj Kumar","family":"Fuloria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aayush","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Gulati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridevi","family":"Chigurupati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"670_CR1","doi-asserted-by":"publisher","unstructured":"Adams SL et al (2016) Subcellular changes in bridging integrator 1 protein expression in the cerebral cortex during the progression of Alzheimer disease pathology. J Neuropathol Exp Neurol 75(8):779\u2013790. https:\/\/doi.org\/10.1093\/jnen\/nlw056","DOI":"10.1093\/jnen\/nlw056"},{"key":"670_CR2","doi-asserted-by":"publisher","first-page":"4277","DOI":"10.1523\/JNEUROSCI.5078-05.2006","volume":"26","author":"CG Almeida","year":"2006","unstructured":"Almeida CG, Takahashi RH, Gouras GK (2006) Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system. J Neurosci 26:4277\u20134288","journal-title":"J Neurosci"},{"key":"670_CR3","unstructured":"Alzheimer\u2019s Gene BIN1 Promotes Synaptic Transmission | ALZFORUM [Internet]. www.alzforum.org. 2020 [cited 2023 Oct 11]. Available from: https:\/\/www.alzforum.org\/news\/research-news\/alzheimers-gene-bin1-promotes-synaptic-transmission"},{"key":"670_CR4","doi-asserted-by":"publisher","first-page":"4477","DOI":"10.1074\/jbc.RA118.006379","volume":"294","author":"RJ Andrew","year":"2019","unstructured":"Andrew RJ, De Rossi P, Nguyen P et al (2019) Reduction of the expression of the late-onset Alzheimer\u2019s disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model. J Biol Chem 294:4477\u20134487","journal-title":"J Biol Chem"},{"key":"670_CR5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ng1934","volume":"39","author":"L Bertram","year":"2007","unstructured":"Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE (2007) Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 39:17\u201323","journal-title":"Nat Genet"},{"key":"670_CR6","doi-asserted-by":"crossref","unstructured":"Betts MJ, Russell RB (2003) In: Barnes MR, Gray IC, eds. Bioinformatics for geneticists, John Wiley & Sons, Ltd, Chichester, UK: 289\u2013316","DOI":"10.1002\/0470867302.ch14"},{"key":"670_CR7","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1083\/jcb.137.6.1355","volume":"137","author":"MH Butler","year":"1997","unstructured":"Butler MH, David C, Ochoa GC et al (1997) Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin\/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of Ranvier in brain and around T tubules in skeletal muscle. J Cell Biol 137:1355\u20131367","journal-title":"J Cell Biol"},{"key":"670_CR8","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.celrep.2016.09.063","volume":"17","author":"S Calafate","year":"2016","unstructured":"Calafate S, Flavin W, Verstreken P, Moechars D (2016) Loss of bin1 promotes the propagation of tau pathology. Cell Rep 17:931\u2013940","journal-title":"Cell Rep"},{"key":"670_CR9","doi-asserted-by":"publisher","first-page":"12917","DOI":"10.1021\/bi060717k","volume":"45","author":"E Casal","year":"2006","unstructured":"Casal E, Federici L, Zhang W et al (2006) The crystal structure of the BAR domain from human Bin1\/ amphiphysin II and its implications for molecular recognition. Biochemistry 45:12917\u201312928","journal-title":"Biochemistry"},{"key":"670_CR10","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0002-9440(10)64538-5","volume":"157","author":"AM Cataldo","year":"2000","unstructured":"Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA (2000) Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer\u2019s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol 157:277\u2013286","journal-title":"Am J Pathol"},{"key":"670_CR11","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1038\/mp.2013.1","volume":"18","author":"J Chapuis","year":"2013","unstructured":"Chapuis J, Hansmannel F, Gistelinck M, Mounier A, Van Cauwenberghe C, Kolen KV et al (2013a) Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry 18:1225\u20131234. https:\/\/doi.org\/10.1038\/mp.2013.1","journal-title":"Mol Psychiatry"},{"key":"670_CR12","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1038\/mp.2013.1","volume":"18","author":"J Chapuis","year":"2013","unstructured":"Chapuis J, Hansmannel F, Gistelinck M, Mounier A et al (2013b) Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry 18:1225\u20131234","journal-title":"Mol Psychiatry"},{"key":"670_CR13","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1038\/mp.2013.1","volume":"18","author":"J Chapuis","year":"2013","unstructured":"Chapuis J et al (2013c) Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry 18:1225\u20131234","journal-title":"Mol Psychiatry"},{"key":"670_CR14","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1111\/tra.12088","volume":"14","author":"PZC Chia","year":"2013","unstructured":"Chia PZC, Toh WH, Sharples R, Gasnereau I, Hill AF, Gleeson PA (2013) Intracellular itinerary of internalised \u03b2-secretase, BACE1, and its potential impact on \u03b2-amyloid peptide biogenesis. Traffic 14:997\u20131013","journal-title":"Traffic"},{"key":"670_CR15","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuron.2008.02.003","volume":"58","author":"JR Cirrito","year":"2008","unstructured":"Cirrito JR, Kang JE, Lee J et al (2008) Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron 58:42\u201351","journal-title":"Neuron"},{"key":"670_CR16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13024-016-0124-1","volume":"11","author":"P De Rossi","year":"2016","unstructured":"De Rossi P, Buggia-Pr\u00e9vot V et al (2016) Predominant expression of Alzheimer\u2019s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts. Mol Neurodegener 11:59","journal-title":"Mol Neurodegener"},{"key":"670_CR17","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13024-016-0124-1","volume":"11","author":"P De Rossi","year":"2016","unstructured":"De Rossi P, Buggia-Pr\u00e9vot V, Clayton BLL et al (2016) Predominant expression of Alzheimer\u2019s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts. Mol Neurodegener 11:59","journal-title":"Mol Neurodegener"},{"key":"670_CR18","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1111\/bpa.12687","volume":"29","author":"P De Rossi","year":"2019","unstructured":"De Rossi P, Andrew RJ, Musial TF et al (2019) Aberrant accrual of BIN1 near Alzheimer\u2019s disease amyloid deposits in transgenic models. Brain Pathol 29:485\u2013501","journal-title":"Brain Pathol"},{"key":"670_CR19","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1111\/j.1398-9219.2004.00198.x","volume":"5","author":"E Evergren","year":"2004","unstructured":"Evergren E, Marcucci M et al (2004) Amphiphysin is a component of clathrin coats formed during synaptic vesicle recycling at the lamprey giant synapse. Traffic 5:514\u2013528","journal-title":"Traffic"},{"key":"670_CR20","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1001\/archpsyc.63.2.168","volume":"63","author":"M Gatz","year":"2006","unstructured":"Gatz M, Reynolds CA, Fratiglioni L, Johansson B, Mortimer JA, Berg S et al (2006a) Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry 63:168\u2013174. https:\/\/doi.org\/10.1001\/archpsyc.63.2.168","journal-title":"Arch Gen Psychiatry"},{"key":"670_CR21","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1001\/archpsyc.63.2.168","volume":"63","author":"M Gatz","year":"2006","unstructured":"Gatz M, Reynolds CA, Fratiglioni L, Johansson B, Mortimer JA, Berg S, Fiske A, Pedersen NL (2006b) Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry 63:168\u2013174","journal-title":"Arch Gen Psychiatry"},{"key":"670_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078806","volume":"8","author":"EBC Glennon","year":"2013","unstructured":"Glennon EBC, Whitehouse IJ, Miners JS, Kehoe PG, Love S, Kellett KAB et al (2013) BIN1 is decreased in sporadic but not familial Alzheimer\u2019s disease or in aging. PLoS ONE 8:e78806. https:\/\/doi.org\/10.1371\/journal.pone.0078806","journal-title":"PLoS ONE"},{"key":"670_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078806","volume":"8","author":"EBC Glennon","year":"2013","unstructured":"Glennon EBC, Whitehouse IJ et al (2013) BIN1 is decreased in sporadic but not familial Alzheimer\u2019s disease or in aging. PLoS ONE 8:e78806","journal-title":"PLoS ONE"},{"key":"670_CR24","doi-asserted-by":"crossref","unstructured":"Glennon EB, Lau DHW, Gabriele RMC et al (2020) Bridging integrator 1 protein loss in Alzheimer\u2019s disease promotes synaptic tau accumulation and disrupts tau release. Brain Commun 2:fcaa011","DOI":"10.1093\/braincomms\/fcaa011"},{"key":"670_CR25","doi-asserted-by":"crossref","unstructured":"Glennon EB, Lau DHW, Gabriele RMC et al (2020) Bridging integrator-1 protein loss in Alzheimer\u2019s disease promotes synaptic tau accumulation and disrupts tau release. Brain Commun 2:fcaa011","DOI":"10.1093\/braincomms\/fcaa011"},{"key":"670_CR26","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.lfs.2012.06.004","volume":"91","author":"GK Gouras","year":"2012","unstructured":"Gouras GK, Will\u00e9n K, Tampellini D (2012) Critical role of intraneuronal A\u03b2 in Alzheimer\u2019s disease: technical challenges in studying intracellular A\u03b2. Life Sci 91:1153\u20131158","journal-title":"Life Sci"},{"key":"670_CR27","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.3233\/JAD-132450","volume":"42","author":"CJ Holler","year":"2014","unstructured":"Holler CJ, Davis PR et al (2014) Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer\u2019s disease brain and correlates with neurofibrillary tangle pathology. J Alzheimers Dis 42:1221\u20131227","journal-title":"J Alzheimers Dis"},{"key":"670_CR28","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.3233\/JAD-132450","volume":"42","author":"CJ Holler","year":"2014","unstructured":"Holler CJ, Davis PR, Beckett TL, Platt TL, Webb RL, Head E et al (2014) Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer\u2019s disease brain and correlates with neurofibrillary tangle pathology. J Alzheimer\u2019s Dis 42:1221\u20131227. https:\/\/doi.org\/10.3233\/JAD-132450","journal-title":"J Alzheimer\u2019s Dis"},{"key":"670_CR29","doi-asserted-by":"crossref","unstructured":"Holtzman DM, Morris JC, Goate AM (2011) Alzheimer\u2019s disease: the challenge of the second century. Sci Transl Med 3:77sr71","DOI":"10.1126\/scitranslmed.3002369"},{"key":"670_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016616","volume":"6","author":"X Hu","year":"2011","unstructured":"Hu X, Pickering E, Liu YC, Hall S et al (2011) Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer\u2019s disease. PLoS ONE 6:e16616","journal-title":"PLoS ONE"},{"key":"670_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050976","volume":"7","author":"CM Karch","year":"2012","unstructured":"Karch CM, Jeng AT, Nowotny P et al (2012) Expression of novel Alzheimer\u2019s disease risk genes in control and Alzheimer\u2019s disease brains. PLoS ONE 7:e50976","journal-title":"PLoS ONE"},{"key":"670_CR32","doi-asserted-by":"publisher","unstructured":"Karch CM, Goate AM (2015) Alzheimer\u2019s disease risk genes and mechanisms of disease pathogenesis. Biol Psychiatry 77(1):43\u201351.\u00a0https:\/\/doi.org\/10.1016\/j.biopsych.2014.05.006","DOI":"10.1016\/j.biopsych.2014.05.006"},{"key":"670_CR33","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13195-016-0232-8","volume":"9","author":"NY Kim","year":"2017","unstructured":"Kim NY, Cho MH et al (2017) Sorting nexin-4 regulates \u03b2-amyloid production by modulating \u03b2-site-activating cleavage enzyme-1. Alzheimers Res Ther 9:4","journal-title":"Alzheimers Res Ther"},{"key":"670_CR34","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.neurobiolaging.2006.06.019","volume":"28","author":"M Knobloch","year":"2007","unstructured":"Knobloch M, Konietzko U, Krebs DC, Nitsch RM (2007) Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice. Neurobiol Aging 28:1297\u20131306","journal-title":"Neurobiol Aging"},{"key":"670_CR35","doi-asserted-by":"publisher","first-page":"17386","DOI":"10.1016\/S0021-9258(17)32449-3","volume":"269","author":"EH Koo","year":"1994","unstructured":"Koo EH, Squazzo SL (1994) Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J Biol Chem 269:17386\u201317389","journal-title":"J Biol Chem"},{"key":"670_CR36","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1038\/ng.2802","volume":"45","author":"JC Lambert","year":"2013","unstructured":"Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC et al (2013) Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2019s disease. Nat Genet 45:1452\u20131458","journal-title":"Nat Genet"},{"key":"670_CR37","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1242\/jcs.00403","volume":"116","author":"C Leprince","year":"2003","unstructured":"Leprince C, Le Scolan E et al (2003) Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. J Cell Sci 116:1937\u20131948","journal-title":"J Cell Sci"},{"key":"670_CR38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.neulet.2013.02.075","volume":"544","author":"G Liu","year":"2013","unstructured":"Liu G, Zhang S, Cai Z, Li Y, Cui L, Ma G, Jiang Y, Zhang L, Feng R, Liao M, Chen Z, Zhao B, Li K (2013) BIN1 gene rs744373 polymorphism contributes to Alzheimer\u2019s disease in East Asian population. Neurosci Lett 544:47\u201351","journal-title":"Neurosci Lett"},{"key":"670_CR39","doi-asserted-by":"publisher","unstructured":"Marques-Coelho D, Iohan L da CC, Melo de Farias AR, Flaig A, Letournel F, Martin-N\u00e9grier ML et al (2021) Differential transcript usage unravels gene expression alterations in Alzheimer\u2019s disease human brains. NPJ Aging Mech Dis 7.\u00a0https:\/\/doi.org\/10.1038\/s41514-020-00052-5","DOI":"10.1038\/s41514-020-00052-5"},{"key":"670_CR40","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm1315","volume":"5","author":"FR Maxfield","year":"2004","unstructured":"Maxfield FR, McGraw TE (2004) Endocytic recycling. Nat Rev Mol Cell Biol 5:121\u2013132","journal-title":"Nat Rev Mol Cell Biol"},{"key":"670_CR41","doi-asserted-by":"crossref","unstructured":"Mayer BJ, Eck MJ (1995) SH3 domains. Minding your p\u2019s and q\u2019s. Curr Biol 5:364\u2013367","DOI":"10.1016\/S0960-9822(95)00073-X"},{"key":"670_CR42","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.febslet.2008.01.003","volume":"582","author":"VA Morais","year":"2008","unstructured":"Morais VA, Leight S, Pijak DS et al (2008) Cellular localization of nicastrin affects amyloid beta species production. FEBS Lett 582:427\u2013433","journal-title":"FEBS Lett"},{"key":"670_CR43","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/ng.801","volume":"43","author":"AC Naj","year":"2011","unstructured":"Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN et al (2011) Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer\u2019s disease. Nat Genet 43:436\u2013441","journal-title":"Nat Genet"},{"key":"670_CR44","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1038\/ng2086","volume":"39","author":"AS Nicot","year":"2007","unstructured":"Nicot AS, Toussaint A, Tosch V et al (2007) Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy. Nat Genet 39:1134\u20131139","journal-title":"Nat Genet"},{"key":"670_CR45","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1038\/ncb1986","volume":"11","author":"S Pant","year":"2009","unstructured":"Pant S, Sharma M, Patel K et al (2009) AMPH-1\/amphiphysin\/Bin1 functions with RME-1\/Ehd1 in endocytic recycling. Nat Cell Biol 11:1399\u20131410","journal-title":"Nat Cell Biol"},{"key":"670_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101056","volume":"297","author":"C Perdig\u00e3o","year":"2021","unstructured":"Perdig\u00e3o C, Barata MA et al (2021) Alzheimer\u2019s disease BIN1 coding variants increase intracellular A\u03b2 levels by interfering with BACE1 recycling. J Biol Chem 297:101056","journal-title":"J Biol Chem"},{"key":"670_CR47","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1126\/science.1092586","volume":"303","author":"BJ Peter","year":"2004","unstructured":"Peter BJ, Kent HM, Mills IG et al (2004) BAR domains as sensors of membrane curvature: the amphiphysin BAR structure. Science 303:495\u2013499","journal-title":"Science"},{"key":"670_CR48","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3390\/membranes2010091","volume":"2","author":"F Safari","year":"2012","unstructured":"Safari F, Suetsugu S (2012) The BAR domain superfamily proteins from subcellular structures to human diseases. Membranes (basel) 2:91\u2013117","journal-title":"Membranes (basel)"},{"key":"670_CR49","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/ng0996-69","volume":"14","author":"D Sakamuro","year":"1996","unstructured":"Sakamuro D, Elliott KJ, Wechsler-Reya R, Prendergast GC (1996) BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat Genet 14:69\u201377. https:\/\/doi.org\/10.1038\/ng0996-69","journal-title":"Nat Genet"},{"key":"670_CR50","doi-asserted-by":"publisher","first-page":"E559","DOI":"10.1073\/pnas.1100745108","volume":"108","author":"R Sannerud","year":"2011","unstructured":"Sannerud R, Declerck I, Peric A, Raemaekers T et al (2011) ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proc Natl Acad Sci USA 108:E559\u2013E568","journal-title":"Proc Natl Acad Sci USA"},{"key":"670_CR51","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.cell.2016.05.020","volume":"166","author":"R Sannerud","year":"2016","unstructured":"Sannerud R, Esselens C, Ejsmont P et al (2016) Restricted location of PSEN2\/\u03b3-secretase determines substrate specificity and generates an intracellular A\u03b2 pool. Cell 166:193\u2013208","journal-title":"Cell"},{"key":"670_CR52","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00401-019-02017-9","volume":"138","author":"M Sartori","year":"2019","unstructured":"Sartori M, Mendes T, Desai S et al (2019) BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with tau through Thr348 phosphorylation. Acta Neuropathol 138:631\u2013652","journal-title":"Acta Neuropathol"},{"key":"670_CR53","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1001\/jama.2010.574","volume":"303","author":"S Seshadri","year":"2010","unstructured":"Seshadri S, Fitzpatrick AL, Ikram MA et al (2010) Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 303:1832\u20131840","journal-title":"JAMA"},{"key":"670_CR54","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s40478-015-0237-8","volume":"3","author":"Y Sottejeau","year":"2015","unstructured":"Sottejeau Y, Bretteville A, Cantrelle FX et al (2015) Tau phosphorylation regulates the interaction between BIN1\u2019s SH3 domain and tau\u2019s proline-rich domain. Acta Neuropathol Commun 3:58","journal-title":"Acta Neuropathol Commun"},{"key":"670_CR55","doi-asserted-by":"publisher","first-page":"3592","DOI":"10.1523\/JNEUROSCI.5167-03.2004","volume":"24","author":"RH Takahashi","year":"2004","unstructured":"Takahashi RH, Almeida CG, Kearney PF et al (2004) Oligomerization of Alzheimer\u2019s beta-amyloid within processes and synapses of cultured neurons and brain. J Neurosci 24:3592\u20133599","journal-title":"J Neurosci"},{"issue":"1781","key":"670_CR56","first-page":"e1781","volume":"35","author":"MS Tan","year":"2014","unstructured":"Tan MS, Yu JT, Jiang T, Zhu XC, Guan HS, Tan L (2014a) Genetic variation in BIN1 gene and Alzheimer\u2019s disease risk in Han Chinese individuals. Neurobiol Aging 35(1781):e1781-1788","journal-title":"Neurobiol Aging"},{"key":"670_CR57","doi-asserted-by":"publisher","first-page":"1781.e1","DOI":"10.1016\/j.neurobiolaging.2014.01.151","volume":"35","author":"MS Tan","year":"2014","unstructured":"Tan MS, Yu JT, Jiang T et al (2014b) Genetic variation in BIN1 gene and Alzheimer\u2019s disease risk in Han Chinese individuals. Neurobiol Aging 35:1781.e1-1781.e8","journal-title":"Neurobiol Aging"},{"key":"670_CR58","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.molmed.2013.06.004","volume":"19","author":"MS Tan","year":"2013","unstructured":"Tan MS, Yu JT, Tan L (2013) Bridging integrator 1 (BIN1): form, function, and Alzheimer\u2019s disease. Trends Mol Med 19:594\u2013603","journal-title":"Trends Mol Med"},{"key":"670_CR59","doi-asserted-by":"publisher","first-page":"102","DOI":"10.15252\/embr.201642738","volume":"18","author":"F Ubelmann","year":"2017","unstructured":"Ubelmann F, Burrinha T, Salavessa L et al (2017) Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep 18:102\u2013122","journal-title":"EMBO Rep"},{"key":"670_CR60","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/ana.24466","volume":"78","author":"BN Vardarajan","year":"2015","unstructured":"Vardarajan BN, Ghani M, Kahn A et al (2015) Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci. Ann Neurol 78:487\u2013498","journal-title":"Ann Neurol"},{"key":"670_CR61","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1126\/science.286.5440.735","volume":"286","author":"R Vassar","year":"1999","unstructured":"Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA et al (1999) Beta-secretase cleavage of Alzheimer\u2019s amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286:735\u2013741","journal-title":"Science"},{"key":"670_CR62","doi-asserted-by":"publisher","unstructured":"Voskobiynyk Y, Roth JR, Cochran JN et al (2020) Alzheimer\u2019s disease risk gene BIN1 induces Tau-dependent network hyperexcitability. BioRxiv.\u00a0https:\/\/doi.org\/10.7554\/eLife.57354","DOI":"10.7554\/eLife.57354"},{"key":"670_CR63","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1091\/mbc.8.10.2003","volume":"8","author":"P Wigge","year":"1997","unstructured":"Wigge P, K\u00f6hler K et al (1997) Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis. Mol Biol Cell 8:2003\u20132015","journal-title":"Mol Biol Cell"},{"key":"670_CR64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001308","volume":"7","author":"EM Wijsman","year":"2011","unstructured":"Wijsman EM, Pankratz ND, Choi Y, Rothstein JH et al (2011) Genome-wide association of familial late-onset Alzheimer\u2019s disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. PLoS Genet 7:e1001308","journal-title":"PLoS Genet"},{"key":"670_CR65","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11064-018-2511-1","volume":"44","author":"MS Wolfe","year":"2019","unstructured":"Wolfe MS (2019) Dysfunctional \u03b3-secretase in familial Alzheimer\u2019s disease. Neurochem Res 44:5\u201311","journal-title":"Neurochem Res"},{"key":"670_CR66","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0969-2126(01)00151-4","volume":"3","author":"X Wu","year":"1995","unstructured":"Wu X, Knudsen B, Feller SM, Zheng J, Sali A, Cowburn D et al (1995) Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure 3:215\u2013226","journal-title":"Structure"},{"key":"670_CR67","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1111\/j.1600-0854.2008.00819.x","volume":"9","author":"Y Zhao","year":"2008","unstructured":"Zhao Y, Keen JH (2008) Gyrating clathrin: highly dynamic clathrin structures involved in rapid receptor recycling. Traffic 9:2253\u20132264","journal-title":"Traffic"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-023-00670-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-023-00670-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-023-00670-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T13:25:54Z","timestamp":1701177954000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12640-023-00670-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,17]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["670"],"URL":"https:\/\/doi.org\/10.1007\/s12640-023-00670-3","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,17]]},"assertion":[{"value":"13 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"All the authors have given approval for publication of the current manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"None.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}