{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T08:22:05Z","timestamp":1772180525747,"version":"3.50.1"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["22KD1002"],"award-info":[{"award-number":["22KD1002"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s12640-025-00777-9","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T03:42:53Z","timestamp":1766547773000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Neurite Outgrowth and Synaptic Plasticity-related Genes Showing Sustained Hypermethylation of Promoter Region in the Hippocampal Dentate Gyrus of Rats Exposed Maternally To Neurotoxicants To Induce Persistent Disruption of Hippocampal Neurogenesis"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4480-5252","authenticated-orcid":false,"given":"Ryota","family":"Ojiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8369-9798","authenticated-orcid":false,"given":"Qian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Sakamaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momoka","family":"Shobudani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-9319","authenticated-orcid":false,"given":"Xinyu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mio","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Ebizuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-9634","authenticated-orcid":false,"given":"Tetsuhito","family":"Kigata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3417-9697","authenticated-orcid":false,"given":"Makoto","family":"Shibutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"777_CR1","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1093\/toxsci\/kft092","volume":"134","author":"H Akane","year":"2013","unstructured":"Akane H, Shiraki A, Imatanaka N, Akahori Y, Itahashi M, Ohishi T, Mitsumori K, Shibutani M (2013a) Glycidol induces axonopathy by adult-stage exposure and aberration of hippocampal neurogenesis affecting late-stage differentiation by developmental exposure in rats. Toxicol Sci 134:140\u2013154. https:\/\/doi.org\/10.1093\/toxsci\/kft092","journal-title":"Toxicol Sci"},{"key":"777_CR2","doi-asserted-by":"publisher","first-page":"431","DOI":"10.2131\/jts.38.431","volume":"38","author":"H Akane","year":"2013","unstructured":"Akane H, Saito F, Yamanaka H, Shiraki A, Imatanaka N, Akahori Y, Morita R, Mitsumori K, Shibutani M (2013b) Methacarn as a whole brain fixative for gene and protein expression analyses of specific brain regions in rats. J Toxicol Sci 38:431\u2013443. https:\/\/doi.org\/10.2131\/jts.38.431","journal-title":"J Toxicol Sci"},{"key":"777_CR3","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.toxlet.2013.10.026","volume":"224","author":"H Akane","year":"2014","unstructured":"Akane H, Shiraki A, Imatanaka N, Akahori Y, Itahashi M, Abe H, Shibutani M (2014) Glycidol induces axonopathy and aberrations of hippocampal neurogenesis affecting late-stage differentiation by exposure to rats in a framework of 28-day toxicity study. Toxicol Lett 224:424\u2013432. https:\/\/doi.org\/10.1016\/j.toxlet.2013.10.026","journal-title":"Toxicol Lett"},{"key":"777_CR4","doi-asserted-by":"publisher","first-page":"218","DOI":"10.55782\/ane-2024-2587","volume":"84","author":"A Basiri","year":"2024","unstructured":"Basiri A, Izadi S, Kakhki S, Alikahni V, Askarian S, Beheshti F (2024) N-acetylcysteine prevents hypothyroidism-induced impairment of learning and memory in adolescent male rats via affecting oxidative status, inflammatory response and BDNF in hippocampal tissues. Acta Neurobiol Exp (Wars) 84:218\u2013229. https:\/\/doi.org\/10.55782\/ane-2024-2587","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"777_CR5","unstructured":"Bernal J Thyroid Hormones in Brain Development and Function. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, Dartmouth S (2022) 2000-. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK285549\/. Accessed 1 June 2025"},{"key":"777_CR6","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1517\/14728222.12.9.1191","volume":"12","author":"WJ Brackenbury","year":"2008","unstructured":"Brackenbury WJ, Isom LL (2008) Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets. Expert Opin Ther Targets 12:1191\u20131203. https:\/\/doi.org\/10.1517\/14728222.12.9.1191","journal-title":"Expert Opin Ther Targets"},{"key":"777_CR7","doi-asserted-by":"publisher","first-page":"3246","DOI":"10.1523\/JNEUROSCI.5446-07.2008","volume":"28","author":"WJ Brackenbury","year":"2008","unstructured":"Brackenbury WJ, Davis TH, Chen C, Slat EA, Detrow MJ, Dickendesher TL, Ranscht B, Isom LL (2008) Voltage-Gated Na+ channel \u03b21 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo. J Neurosci 28:3246\u20133256. https:\/\/doi.org\/10.1523\/JNEUROSCI.5446-07.2008","journal-title":"J Neurosci"},{"key":"777_CR8","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1073\/pnas.1208767110","volume":"110","author":"WJ Brackenbury","year":"2013","unstructured":"Brackenbury WJ, Yuan Y, O\u2019Malley HA, Parent JM, Isom LL (2013) Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability. Proc Natl Acad Sci U S A 110:1089\u20131094. https:\/\/doi.org\/10.1073\/pnas.1208767110","journal-title":"Proc Natl Acad Sci U S A"},{"key":"777_CR9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.fct.2018.10.050","volume":"123","author":"SK Bunker","year":"2019","unstructured":"Bunker SK, Dutta A, Pradhan J, Dandapat J, Chainy GBN (2019) Curcumin restores hepatic epigenetic changes in propylthiouracil (PTU)-induced hypothyroid male rats: a study on DNMTs, MBDs, GADD45a, C\/EBP-\u03b2 and PCNA. Food Chem Toxicol 123:169\u2013180. https:\/\/doi.org\/10.1016\/j.fct.2018.10.050","journal-title":"Food Chem Toxicol"},{"key":"777_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2024.112267","volume":"590","author":"F Campo Verde Arbocco","year":"2024","unstructured":"Campo Verde Arbocco F, Pascual LI, Garc\u00eda D, Ortiz I, Gamarra-Luques C, Car\u00f3n RW, Hapon MB (2024) Epigenetic impact of hypothyroidism on the functional differentiation of the mammary gland in rats. Mol Cell Endocrinol 590:112267. https:\/\/doi.org\/10.1016\/j.mce.2024.112267","journal-title":"Mol Cell Endocrinol"},{"key":"777_CR11","doi-asserted-by":"publisher","first-page":"3787","DOI":"10.1523\/JNEUROSCI.5312-04.2005","volume":"25","author":"X Chen","year":"2005","unstructured":"Chen X, Johnston D (2005) Constitutively active G-protein-gated inwardly rectifying K+ channels in dendrites of hippocampal CA1 pyramidal neurons. J Neurosci 25:3787\u20133792. https:\/\/doi.org\/10.1523\/JNEUROSCI.5312-04.2005","journal-title":"J Neurosci"},{"key":"777_CR12","doi-asserted-by":"publisher","first-page":"4030","DOI":"10.1523\/JNEUROSCI.4139-03.2004","volume":"24","author":"C Chen","year":"2004","unstructured":"Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O\u2019Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, Shrager P, Catterall WA, Isom LL (2004) Mice lacking sodium channel \u03b21 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci 24:4030\u20134042. https:\/\/doi.org\/10.1523\/JNEUROSCI.4139-03.2004","journal-title":"J Neurosci"},{"key":"777_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.637480","volume":"12","author":"XJ Chen","year":"2021","unstructured":"Chen XJ, Zhang H, Yang F, Liu Y, Chen G (2021) DNA methylation sustains \u201cinflamed\u201d memory of peripheral immune cells aggravating kidney inflammatory response in chronic kidney disease. Front Physiol 12:637480. https:\/\/doi.org\/10.3389\/fphys.2021.637480","journal-title":"Front Physiol"},{"key":"777_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2025.117282","volume":"498","author":"N Clavel Rolland","year":"2025","unstructured":"Clavel Rolland N, Kiehr B, Zhu M, Chen C, Gao P, Pourcher T, Blanck O (2025) Toxicokinetic insights into distinct mechanisms of action of two thyroid toxicants: Propylthiouracil and pregnenolone 16\u03b1-carbonitrile. Toxicol Appl Pharmacol 498:117282. https:\/\/doi.org\/10.1016\/j.taap.2025.117282","journal-title":"Toxicol Appl Pharmacol"},{"key":"777_CR15","doi-asserted-by":"publisher","first-page":"51424","DOI":"10.1074\/jbc.M410830200","volume":"279","author":"TH Davis","year":"2004","unstructured":"Davis TH, Chen C, Isom LL (2004) Sodium channel \u03b21 subunits promote neurite outgrowth in cerebellar granule neurons. J Biol Chem 279:51424\u201351432. https:\/\/doi.org\/10.1074\/jbc.M410830200","journal-title":"J Biol Chem"},{"key":"777_CR16","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1159\/000504668","volume":"8","author":"BA Demeneix","year":"2019","unstructured":"Demeneix BA (2019) Evidence for prenatal exposure to thyroid disruptors and adverse effects on brain development. Eur Thyroid J 8:283\u2013292. https:\/\/doi.org\/10.1159\/000504668","journal-title":"Eur Thyroid J"},{"key":"777_CR17","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s12031-011-9492-8","volume":"44","author":"GF Deng","year":"2011","unstructured":"Deng GF, Qin JM, Sun XS, Kuang ZY, Su T, Zhao QH, Shi YW, Liu XR, Yu MJ, Yi YH, Liao WP, Long YS (2011) Promoter analysis of mouse Scn3a gene and regulation of the promoter activity by GC box and CpG methylation. J Mol Neurosci 44:115\u2013121. https:\/\/doi.org\/10.1007\/s12031-011-9492-8","journal-title":"J Mol Neurosci"},{"key":"777_CR18","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3389\/fncir.2012.00113","volume":"6","author":"CV Dieni","year":"2013","unstructured":"Dieni CV, Chancey JH, Overstreet-Wadiche LS (2013) Dynamic functions of GABA signaling during granule cell maturation. Front Neural Circuits 6:113. https:\/\/doi.org\/10.3389\/fncir.2012.00113","journal-title":"Front Neural Circuits"},{"key":"777_CR19","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1111\/jne.12169","volume":"26","author":"ME Gilbert","year":"2014","unstructured":"Gilbert ME, Ramos RL, McCloskey DP, Goodman JH (2014) Subcortical band heterotopia in rat offspring following maternal hypothyroxinaemia: structural and functional characteristics. J Neuroendocrinol 26:528\u2013541. https:\/\/doi.org\/10.1111\/jne.12169","journal-title":"J Neuroendocrinol"},{"key":"777_CR20","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1002\/cne.20844","volume":"494","author":"C Harashima","year":"2006","unstructured":"Harashima C, Jacobowitz DM, Witta J, Borke RC, Best TK, Siarey RJ, Galdzicki Z (2006) Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia Nigra of Ts65Dn mouse: a model of down syndrome. J Comp Neurol 494:815\u2013833. https:\/\/doi.org\/10.1002\/cne.20844","journal-title":"J Comp Neurol"},{"key":"777_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nar\/gkn923","volume":"37","author":"DW Huang","year":"2009","unstructured":"Huang DW, Sherman BT, Lempicki RA (2009a) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37:1\u201313. https:\/\/academic.oup.com\/nar\/article-abstract\/37\/1\/1\/1026684","journal-title":"Nucleic Acids Res"},{"key":"777_CR22","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"DW Huang","year":"2009","unstructured":"Huang DW, Sherman BT, Lempicki RA (2009b) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44\u201357. https:\/\/doi.org\/10.1038\/nprot.2008.211","journal-title":"Nat Protoc"},{"key":"777_CR23","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1093\/toxsci\/kfy081","volume":"164","author":"M Inohana","year":"2018","unstructured":"Inohana M, Eguchi A, Nakamura M, Nagahara R, Onda N, Nakajima K, Saegusa Y, Yoshida T, Shibutani M (2018) Developmental exposure to aluminum chloride irreversibly affects postnatal hippocampal neurogenesis involving multiple functions in mice. Toxicol Sci 164:264\u2013277. https:\/\/doi.org\/10.1093\/toxsci\/kfy081","journal-title":"Toxicol Sci"},{"key":"777_CR26","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s10072-015-2199-9","volume":"36","author":"S Jena","year":"2015","unstructured":"Jena S (2015) Effect of persistent and transient hypothyroidism on histoarchitecture and antioxidant defence system in rat brain. Neurol Sci 36:953\u2013959. https:\/\/doi.org\/10.1007\/s10072-015-2199-9","journal-title":"Neurol Sci"},{"key":"777_CR27","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ygcen.2012.03.012","volume":"178","author":"S Jena","year":"2012","unstructured":"Jena S, Chainy GB, Dandapat J (2012) Hypothyroidism modulates renal antioxidant gene expression during postnatal development and maturation in rat. Gen Comp Endocrinol 178:8\u201318. https:\/\/doi.org\/10.1016\/j.ygcen.2012.03.012","journal-title":"Gen Comp Endocrinol"},{"key":"777_CR28","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1089\/thy.2017.0331","volume":"28","author":"K Kawahori","year":"2018","unstructured":"Kawahori K, Hashimoto K, Yuan X, Tsujimoto K, Hanzawa N, Hamaguchi M, Kase S, Fujita K, Tagawa K, Okazawa H, Nakajima Y, Shibusawa N, Yamada M, Ogawa Y (2018) Mild maternal hypothyroxinemia during pregnancy induces persistent DNA hypermethylation in the hippocampal Brain-Derived neurotrophic factor gene in mouse offspring. Thyroid 28:395\u2013406. https:\/\/doi.org\/10.1089\/thy.2017.0331","journal-title":"Thyroid"},{"key":"777_CR29","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.tins.2004.05.013","volume":"27","author":"G Kempermann","year":"2004","unstructured":"Kempermann G, Jessberger S, Steiner B, Kronenberg G (2004) Milestones of neuronal development in the adult hippocampus. Trends Neurosci 27:447\u2013452. https:\/\/doi.org\/10.1016\/j.tins.2004.05.013","journal-title":"Trends Neurosci"},{"key":"777_CR30","doi-asserted-by":"publisher","first-page":"a018812","DOI":"10.1101\/cshperspect.a018812","volume":"7","author":"G Kempermann","year":"2015","unstructured":"Kempermann G, Song H, Gage FH (2015) Neurogenesis in the adult hippocampus. Cold Spring Harb Perspect Biol 7:a018812. https:\/\/doi.org\/10.1101\/cshperspect.a018812","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"777_CR31","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1203\/01.PDR.0000065736.69214.20","volume":"54","author":"JY Khan","year":"2003","unstructured":"Khan JY, Black SM (2003) Developmental changes in murine brain antioxidant enzymes. Pediatr Res 54:77\u201382. https:\/\/doi.org\/10.1203\/01.PDR.0000065736.69214.20","journal-title":"Pediatr Res"},{"issue":"Suppl.","key":"777_CR32","doi-asserted-by":"publisher","DOI":"10.14869\/toxpt.47.1.0_P-183","volume":"45","author":"S Kikuchi","year":"2020","unstructured":"Kikuchi S, Okano H, Takahashi Y, Takashima K, Yamashita R, Kobayashi M, Yoshida T, Shibutani M (2020) Developmental exposure effect of aluminum chloride on hippocampal neurogenesis in rats. J Toxicol Sci 45(Suppl.):S318. https:\/\/doi.org\/10.14869\/toxpt.47.1.0_P-183","journal-title":"J Toxicol Sci"},{"key":"777_CR33","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1002\/jat.4089","volume":"41","author":"S Kikuchi","year":"2021","unstructured":"Kikuchi S, Takahashi Y, Ojiro R, Takashima K, Okano H, Tang Q, Woo GH, Yoshida T, Shibutani M (2021) Identification of gene targets of developmental neurotoxicity focusing on DNA hypermethylation involved in irreversible disruption of hippocampal neurogenesis in rats. J Appl Toxicol 41:1021\u20131037. https:\/\/doi.org\/10.1002\/jat.4089","journal-title":"J Appl Toxicol"},{"key":"777_CR34","doi-asserted-by":"publisher","first-page":"e06414","DOI":"10.7554\/eLife.06414","volume":"4","author":"Y Kim","year":"2015","unstructured":"Kim Y, Hsu CL, Cembrowski MS, Mensh BD, Spruston N (2015) Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons. Elife 4:e06414. https:\/\/doi.org\/10.7554\/eLife.06414","journal-title":"Elife"},{"key":"777_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nbd.2017.03.009","volume":"103","author":"AM Kleschevnikov","year":"2017","unstructured":"Kleschevnikov AM, Yu J, Kim J, Lysenko LV, Zeng Z, Yu YE, Mobley WC (2017) Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis 103:1\u201310. https:\/\/doi.org\/10.1016\/j.nbd.2017.03.009","journal-title":"Neurobiol Dis"},{"key":"777_CR36","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a029264","volume":"8","author":"LC Kruger","year":"2016","unstructured":"Kruger LC, Isom LL (2016) Voltage-gated Na<Superscript>+<\/Superscript> channels: not just for conduction. Cold Spring Harb Perspect Biol 8:a029264. https:\/\/doi.org\/10.1101\/cshperspect.a029264","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"777_CR37","doi-asserted-by":"publisher","first-page":"4289","DOI":"10.1523\/JNEUROSCI.4178-05.2006","volume":"26","author":"A Kulik","year":"2006","unstructured":"Kulik A, Vida I, Fukazawa Y, Guetg N, Kasugai Y, Marker CL, Rigato F, Bettler B, Wickman K, Frotscher M, Shigemoto R (2006) Compartment-dependent colocalization of Kir3.2-containing K<Superscript>+<\/Superscript> channels and GABA<Subscript>B<\/Subscript> receptors in hippocampal pyramidal cells. J Neurosci 26:4289\u20134297. https:\/\/doi.org\/10.1523\/JNEUROSCI.4178-05.2006","journal-title":"J Neurosci"},{"key":"777_CR38","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.bbrc.2018.05.173","volume":"502","author":"P Kumar","year":"2018","unstructured":"Kumar P, Godbole NM, Chaturvedi CP, Singh RS, George N, Upadhyay A, Anjum B, Godbole MM, Sinha RA (2018) Mechanisms involved in epigenetic down-regulation of Gfap under maternal hypothyroidism. Biochem Biophys Res Commun 502:375\u2013381. https:\/\/doi.org\/10.1016\/j.bbrc.2018.05.173","journal-title":"Biochem Biophys Res Commun"},{"key":"777_CR39","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.molmed.2014.02.004","volume":"20","author":"AP Landstrom","year":"2014","unstructured":"Landstrom AP, Beavers DL, Wehrens XHT (2014) The Junctophilin family of proteins: from bench to bedside. Trends Mol Med 20:353\u2013362. https:\/\/doi.org\/10.1016\/j.molmed.2014.02.004","journal-title":"Trends Mol Med"},{"key":"777_CR40","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.1161\/01.CIR.0000147187.78162.AC","volume":"110","author":"S Le Bouter","year":"2004","unstructured":"Le Bouter S, El Harchi A, Marionneau C, Bellocq C, Chambellan A, van Veen T, Boixel C, Gavillet B, Abriel H, Le Quang K, Chevalier JC, Lande G, L\u00e9ger JJ, Charpentier F, Escande D, Demolombe S (2004) Long-term Amiodarone administration remodels expression of ion channel transcripts in the mouse heart. Circulation 110:3028\u20133035. https:\/\/doi.org\/10.1161\/01.CIR.0000147187.78162.AC","journal-title":"Circulation"},{"key":"777_CR41","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1016\/0006-2952(88)90574-6","volume":"37","author":"E Lee","year":"1988","unstructured":"Lee E, Hirouchi M, Hosokawa M, Sayo H, Kohno M, Kariya K (1988) Inactivation of peroxidases of rat bone marrow by repeated administration of propylthiouracil is accompanied by a change in the Heme structure. Biochem Pharmacol 37:2151\u20132153. https:\/\/doi.org\/10.1016\/0006-2952(88)90574-6","journal-title":"Biochem Pharmacol"},{"key":"777_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbagrm.2014.11.004","volume":"1849","author":"HJ Li","year":"2015","unstructured":"Li HJ, Wan RP, Tang LJ, Liu SJ, Zhao QH, Gao MM, Yi YH, Liao WP, Sun XF, Long YS (2015) Alteration of Scn3a expression is mediated via CpG methylation and MBD2 in mouse hippocampus during postnatal development and seizure condition. Biochim Biophys Acta 1849:1\u20139. https:\/\/doi.org\/10.1016\/j.bbagrm.2014.11.004","journal-title":"Biochim Biophys Acta"},{"key":"777_CR43","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2<Superscript>\u2212\u0394\u0394C<\/Superscript><Subscript>T<\/Subscript> method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"777_CR44","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1007\/s12640-022-00577-5","volume":"40","author":"N Maeda","year":"2022","unstructured":"Maeda N, Shimizu S, Takahashi Y, Kubota R, Uomoto S, Takesue K, Takashima K, Okano H, Ojiro R, Ozawa S, Tang Q, Jin M, Ikarashi Y, Yoshida T, Shibutani M (2022) Oral exposure to lead acetate for 28 days reduces the number of neural progenitor cells but increases the number and synaptic plasticity of newborn granule cells in adult hippocampal neurogenesis of young-adult rats. Neurotox Res 40:2203\u20132220. https:\/\/doi.org\/10.1007\/s12640-022-00577-5","journal-title":"Neurotox Res"},{"key":"777_CR45","doi-asserted-by":"publisher","first-page":"654","DOI":"10.3389\/fcell.2020.00654","volume":"8","author":"S Mart\u00edn-Su\u00e1rez","year":"2020","unstructured":"Mart\u00edn-Su\u00e1rez S, Abiega O, Ricobaraza A, Hernandez-Alcoceba R, Encinas JM (2020) Alterations of the hippocampal neurogenic niche in a mouse model of Dravet syndrome. Front Cell Dev Biol 8:654. https:\/\/doi.org\/10.3389\/fcell.2020.00654","journal-title":"Front Cell Dev Biol"},{"key":"777_CR46","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12929-017-0397-x","volume":"24","author":"H Matsumura","year":"2017","unstructured":"Matsumura H, Nakano Y, Ochi H, Onohara Y, Sairaku A, Tokuyama T, Tomomori S, Motoda C, Amioka M, Hironobe N, Toshishige M, Takahashi S, Imai K, Sueda T, Chayama K, Kihara Y (2017) H558R, a common SCN5A polymorphism, modifies the clinical phenotype of Brugada syndrome by modulating DNA methylation of SCN5A promoters. J Biomed Sci 24:91. https:\/\/doi.org\/10.1186\/s12929-017-0397-x","journal-title":"J Biomed Sci"},{"key":"777_CR47","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.pneurobio.2008.10.001","volume":"86","author":"MF Mehler","year":"2008","unstructured":"Mehler MF (2008) Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog Neurobiol 86:305\u2013341. https:\/\/doi.org\/10.1016\/j.pneurobio.2008.10.001","journal-title":"Prog Neurobiol"},{"key":"777_CR48","doi-asserted-by":"publisher","first-page":"10811","DOI":"10.1073\/pnas.0509863103","volume":"103","author":"S Moriguchi","year":"2006","unstructured":"Moriguchi S, Nishi M, Komazaki S, Sakagami H, Miyazaki T, Masumiya H, Saito SY, Watanabe M, Kondo H, Yawo H, Fukunaga K, Takeshima H (2006) Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins. Proc Natl Acad Sci U S A 103:10811\u201310816. https:\/\/doi.org\/10.1073\/pnas.0509863103","journal-title":"Proc Natl Acad Sci U S A"},{"key":"777_CR49","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ntt.2015.10.001","volume":"52","author":"WR Mundy","year":"2015","unstructured":"Mundy WR, Padilla S, Breier JM, Crofton KM, Gilbert ME, Herr DW, Jensen KF, Radio NM, Raffaele KC, Schumacher K, Shafer TJ, Cowden J (2015) Expanding the test set: chemicals with potential to disrupt mammalian brain development. Neurotoxicol Teratol 52:25\u201335. https:\/\/doi.org\/10.1016\/j.ntt.2015.10.001","journal-title":"Neurotoxicol Teratol"},{"key":"777_CR50","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.4161\/cc.7.9.5791","volume":"7","author":"RK Ng","year":"2008","unstructured":"Ng RK, Gurdon JB (2008) Epigenetic inheritance of cell differentiation status. Cell Cycle 7:1173\u20131177. https:\/\/doi.org\/10.4161\/cc.7.9.5791","journal-title":"Cell Cycle"},{"key":"777_CR51","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3389\/fnana.2015.00053","volume":"9","author":"Z Nicola","year":"2015","unstructured":"Nicola Z, Fabel K, Kempermann G (2015) Development of the adult neurogenic niche in the hippocampus of mice. Front Neuroanat 9:53. https:\/\/doi.org\/10.3389\/fnana.2015.00053","journal-title":"Front Neuroanat"},{"key":"777_CR52","doi-asserted-by":"publisher","unstructured":"OECD (2007) Test No. 426: Developmental Neurotoxicity Study, OECD Guidelines for the Testing of Chemicals, Sect.\u00a04. https:\/\/doi.org\/10.1787\/9789264067394-en. Accessed 1 June 2025","DOI":"10.1787\/9789264067394-en"},{"key":"777_CR53","doi-asserted-by":"publisher","unstructured":"OECD (2008) Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents, OECD Guidelines for the Testing of Chemicals, Sect.\u00a04. https:\/\/doi.org\/10.1787\/9789264070684-en. Accessed 1 June 2025","DOI":"10.1787\/9789264070684-en"},{"key":"777_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01078-9","volume":"7","author":"J Park","year":"2022","unstructured":"Park J, Lee K, Kim K, Yi SJ (2022) The role of histone modifications: from neurodevelopment to neurodiseases. Signal Transduct Target Ther 7:217. https:\/\/doi.org\/10.1038\/s41392-022-01078-9","journal-title":"Signal Transduct Target Ther"},{"key":"777_CR55","doi-asserted-by":"publisher","first-page":"11613","DOI":"10.1038\/ncomms11613","volume":"7","author":"JR Reinhard","year":"2016","unstructured":"Reinhard JR, Kriz A, Galic M, Angliker N, Rajalu M, Vogt KE, Ruegg MA (2016) The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nat Commun 7:11613. https:\/\/doi.org\/10.1038\/ncomms11613","journal-title":"Nat Commun"},{"key":"777_CR56","doi-asserted-by":"publisher","first-page":"15591","DOI":"10.1038\/s41598-017-15529-9","volume":"7","author":"C Serrano-Nascimento","year":"2017","unstructured":"Serrano-Nascimento C, Salgueiro RB, Pantale\u00e3o T, Corr\u00eaa da Costa VM, Nunes MT (2017) Maternal exposure to iodine excess throughout pregnancy and lactation induces hypothyroidism in adult male rat offspring. Sci Rep 7:15591. https:\/\/doi.org\/10.1038\/s41598-017-15529-9","journal-title":"Sci Rep"},{"key":"777_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.14252\/foodsafetyfscj.2014038","volume":"3","author":"M Shibutani","year":"2015","unstructured":"Shibutani M (2015) Hippocampal neurogenesis as a critical target of neurotoxicants contained in foods. Food Saf 3:1\u201315. https:\/\/doi.org\/10.14252\/foodsafetyfscj.2014038","journal-title":"Food Saf"},{"key":"777_CR58","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.reprotox.2009.04.011","volume":"28","author":"M Shibutani","year":"2009","unstructured":"Shibutani M, Woo GH, Fujimoto H, Saegusa Y, Takahashi M, Inoue K, Hirose M, Nishikawa A (2009) Assessment of developmental effects of hypothyroidism in rats from in utero and lactation exposure to anti-thyroid agents. Reprod Toxicol 28:297\u2013307. https:\/\/doi.org\/10.1016\/j.reprotox.2009.04.011","journal-title":"Reprod Toxicol"},{"key":"777_CR59","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1002\/jat.4299","volume":"42","author":"S Shimizu","year":"2022","unstructured":"Shimizu S, Maeda N, Takahashi Y, Uomoto S, Takesue K, Ojiro R, Tang Q, Ozawa S, Okano H, Takashima K, Woo GH, Yoshida T, Shibutani M (2022) Oral exposure to aluminum chloride for 28 days suppresses neural stem cell proliferation and increases mature granule cells in adult hippocampal neurogenesis of young-adult rats. J Appl Toxicol 42:1337\u20131353. https:\/\/doi.org\/10.1002\/jat.4299","journal-title":"J Appl Toxicol"},{"key":"777_CR60","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.toxlet.2016.08.019","volume":"261","author":"A Shiraki","year":"2016","unstructured":"Shiraki A, Tanaka T, Watanabe Y, Saito F, Akahori Y, Imatanaka N, Yoshida T, Shibutani M (2016) Immunohistochemistry of aberrant neuronal development induced by 6-propyl-2-thiouracil in rats. Toxicol Lett 261:59\u201371. https:\/\/doi.org\/10.1016\/j.toxlet.2016.08.019","journal-title":"Toxicol Lett"},{"key":"777_CR61","doi-asserted-by":"publisher","first-page":"5497","DOI":"10.1007\/s12035-016-0072-3","volume":"54","author":"M Sibbe","year":"2017","unstructured":"Sibbe M, Kulik A (2017) Gabaergic regulation of adult hippocampal neurogenesis. Mol Neurobiol 54:5497\u20135510. https:\/\/doi.org\/10.1007\/s12035-016-0072-3","journal-title":"Mol Neurobiol"},{"key":"777_CR62","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1002\/glia.20407","volume":"54","author":"B Steiner","year":"2006","unstructured":"Steiner B, Klempin F, Wang L, Kott M, Kettenmann H, Kempermann G (2006) Type-2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis. Glia 54:805\u2013814. https:\/\/doi.org\/10.1002\/glia.20407","journal-title":"Glia"},{"key":"777_CR63","doi-asserted-by":"publisher","first-page":"152958","DOI":"10.1016\/j.tox.2021.152958","volume":"462","author":"Y Takahashi","year":"2021","unstructured":"Takahashi Y, Yamashita R, Okano H, Takashima K, Ogawa B, Ojiro R, Tang Q, Ozawa S, Woo GH, Yoshida T, Shibutani M (2021) Aberrant neurogenesis and late onset suppression of synaptic plasticity as well as sustained neuroinflammation in the hippocampal dentate gyrus after developmental exposure to ethanol in rats. Toxicology 462:152958. https:\/\/doi.org\/10.1016\/j.tox.2021.152958","journal-title":"Toxicology"},{"key":"777_CR64","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.toxlet.2022.02.006","volume":"360","author":"Y Takahashi","year":"2022","unstructured":"Takahashi Y, Okano H, Takashima K, Ojiro R, Tang Q, Ozawa S, Ogawa B, Woo GH, Yoshida T, Shibutani M (2022) Oral exposure to high-dose ethanol for 28 days in rats reduces neural stem cells and immediate nascent neural progenitor cells as well as FOS-expressing newborn granule cells in adult hippocampal neurogenesis. Toxicol Lett 360:20\u201332. https:\/\/doi.org\/10.1016\/j.toxlet.2022.02.006","journal-title":"Toxicol Lett"},{"key":"777_CR65","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.toxlet.2023.10.016","volume":"390","author":"Y Takahashi","year":"2023","unstructured":"Takahashi Y, Ojiro R, Yamashita R, Shimizu S, Maeda N, Zou X, Tang Q, Ozawa S, Woo GH, Yoshida T, Shibutani M (2023) Suppression of neurogranin expression by disruption of epigenetic DNA methylation in hippocampal mature granule cells after developmental exposure to neurotoxicants in rats. Toxicol Lett 390:33\u201345. https:\/\/doi.org\/10.1016\/j.toxlet.2023.10.016","journal-title":"Toxicol Lett"},{"key":"777_CR66","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1007\/s12035-016-9871-9","volume":"54","author":"NN Tan","year":"2017","unstructured":"Tan NN, Tang HL, Lin GW, Chen YH, Lu P, Li HJ, Gao MM, Zhao QH, Yi YH, Liao WP, Long YS (2017) Epigenetic downregulation of Scn3a expression by valproate: a possible role in its anticonvulsant activity. Mol Neurobiol 54:2831\u20132842. https:\/\/doi.org\/10.1007\/s12035-016-9871-9","journal-title":"Mol Neurobiol"},{"key":"777_CR67","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13040410","volume":"13","author":"S Terracina","year":"2024","unstructured":"Terracina S, Tarani L, Ceccanti M, Vitali M, Francati S, Lucarelli M, Venditti S, Verdone L, Ferraguti G, Fiore M (2024) The impact of oxidative stress on the epigenetics of fetal alcohol spectrum disorders. Antioxidants (Basel) 13:410. https:\/\/doi.org\/10.3390\/antiox13040410","journal-title":"Antioxidants (Basel)"},{"key":"777_CR68","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fnmol.2011.00012","volume":"4","author":"C Ufer","year":"2011","unstructured":"Ufer C, Wang CC (2011) The roles of glutathione peroxidases during embryo development. Front Mol Neurosci 4:12. https:\/\/doi.org\/10.3389\/fnmol.2011.00012","journal-title":"Front Mol Neurosci"},{"key":"777_CR69","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s00441-007-0432-4","volume":"329","author":"von Bohlen Und Halbach O","year":"2007","unstructured":"von Bohlen Und Halbach O (2007) Immunohistological markers for staging neurogenesis in adult hippocampus. Cell Tissue Res 329:409\u2013420. https:\/\/doi.org\/10.1007\/s00441-007-0432-4","journal-title":"Cell Tissue Res"},{"key":"777_CR70","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1080\/19336950.2017.1380758","volume":"11","author":"J Wang","year":"2017","unstructured":"Wang J, Ou SW, Wang YJ (2017) Distribution and function of voltage-gated sodium channels in the nervous system. Channels (Austin) 11:534\u2013554. https:\/\/doi.org\/10.1080\/19336950.2017.1380758","journal-title":"Channels (Austin)"},{"key":"777_CR71","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s12640-016-9660-2","volume":"31","author":"Y Watanabe","year":"2017","unstructured":"Watanabe Y, Murakami T, Kawashima M, Hasegawa-Baba Y, Mizukami S, Imatanaka N, Akahori Y, Yoshida T, Shibutani M (2017) Maternal exposure to valproic acid primarily targets interneurons followed by late effects on neurogenesis in the hippocampal dentate gyrus in rat offspring. Neurotox Res 31:46\u201362. https:\/\/doi.org\/10.1007\/s12640-016-9660-2","journal-title":"Neurotox Res"},{"key":"777_CR72","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.toxlet.2019.05.013","volume":"312","author":"Y Watanabe","year":"2019","unstructured":"Watanabe Y, Nakajima K, Ito Y, Akahori Y, Saito F, Woo GH, Yoshida T, Shibutani M (2019) Twenty-eight-day repeated oral doses of sodium valproic acid increases neural stem cells and suppresses differentiation of granule cell lineages in adult hippocampal neurogenesis of postpubertal rats. Toxicol Lett 312:195\u2013203. https:\/\/doi.org\/10.1016\/j.toxlet.2019.05.013","journal-title":"Toxicol Lett"},{"key":"777_CR73","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-1-54","volume":"1","author":"TK Wojdacz","year":"2008","unstructured":"Wojdacz TK, Hansen LL, Dobrovic A (2008) A new approach to primer design for the control of PCR bias in methylation studies. BMC Res Notes 1:54. https:\/\/doi.org\/10.1186\/1756-0500-1-54","journal-title":"BMC Res Notes"},{"key":"777_CR74","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s12031-015-0603-9","volume":"57","author":"Y Wu","year":"2015","unstructured":"Wu Y, Song H, Sun B, Xu M, Shi J (2015) DNA methylation of the EphA5 promoter is associated with rat congenital hypothyroidism. J Mol Neurosci 57:203\u2013210. https:\/\/doi.org\/10.1007\/s12031-015-0603-9","journal-title":"J Mol Neurosci"},{"key":"777_CR75","doi-asserted-by":"publisher","unstructured":"Yagi S, Eid RS, Qiu W, Duarte-Guterman P, Galea LAM (2020) Estrogenic Regulation of Hippocampal Neurogenesis Throughout the Lifespan. In: Frick KM (ed) Estrogens and Memory: Basic Research and Clinical Implications. Oxford Academic, New York, pp 253\u2013281. https:\/\/doi.org\/10.1093\/oso\/9780190645908.003.0016","DOI":"10.1093\/oso\/9780190645908.003.0016"},{"key":"777_CR76","doi-asserted-by":"publisher","first-page":"152782","DOI":"10.1016\/j.tox.2021.152782","volume":"456","author":"R Yamashita","year":"2021","unstructured":"Yamashita R, Takahashi Y, Takashima K, Okano H, Ojiro R, Tang Q, Kikuchi S, Kobayashi M, Ogawa B, Jin M, Kubota R, Ikarashi Y, Yoshida T, Shibutani M (2021) Induction of cellular senescence as a late effect and BDNF-TrkB signaling-mediated ameliorating effect on disruption of hippocampal neurogenesis after developmental exposure to lead acetate in rats. Toxicology 456:152782. https:\/\/doi.org\/10.1016\/j.tox.2021.152782","journal-title":"Toxicology"},{"key":"777_CR77","doi-asserted-by":"publisher","first-page":"659","DOI":"10.26402\/jpp.2022.5.09","volume":"73","author":"H Yang","year":"2022","unstructured":"Yang H, Jia W, Zhang DP, Xu YX, Wang F, Wang N, Zhu DF (2022) Long non-coding RNAs and small nucleolar RNA host gene 6 contribute to the depression-like behavior of hypothyroid mice by promoting methylation of the brain-derived neuropathic factor promoter that is mediated by DNA methyltransferase 1. J Physiol Pharmacol 73:659\u2013672. https:\/\/doi.org\/10.26402\/jpp.2022.5.09","journal-title":"J Physiol Pharmacol"},{"key":"777_CR78","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/nrn.2016.70","volume":"17","author":"B Yao","year":"2016","unstructured":"Yao B, Christian KM, He C, Jin P, Ming GL, Song H (2016) Epigenetic mechanisms in neurogenesis. Nat Rev Neurosci 17:537\u2013549. https:\/\/doi.org\/10.1038\/nrn.2016.70","journal-title":"Nat Rev Neurosci"},{"key":"777_CR79","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/gb-2003-4-3-207","volume":"4","author":"FH Yu","year":"2003","unstructured":"Yu FH, Catterall WA (2003) Overview of the voltage-gated sodium channel family. Genome Biol 4:207. https:\/\/doi.org\/10.1186\/gb-2003-4-3-207","journal-title":"Genome Biol"},{"key":"777_CR80","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.neuroscience.2025.04.042","volume":"576","author":"Z Zare","year":"2025","unstructured":"Zare Z, Zarbakhsh S, Mohammadi M (2025) Perinatal thyroid hormone deficiency leads to oxidative stress-induced neuronal damage and activation of astrocytes in rat hippocampus: neuroprotective effect of exercise. Neuroscience 576:96\u2013104. https:\/\/doi.org\/10.1016\/j.neuroscience.2025.04.042","journal-title":"Neuroscience"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-025-00777-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-025-00777-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-025-00777-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:56:38Z","timestamp":1772175398000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12640-025-00777-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["777"],"URL":"https:\/\/doi.org\/10.1007\/s12640-025-00777-9","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,24]]},"assertion":[{"value":"2 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"The experimental procedures of animal studies were conducted strictly following the Guide for the Care and Use of Laboratory Animals outlined by the National Academy of Sciences of the United States of America (NIH Publication No. 8023, revised 1978). The procedures were conducted in compliance with the approved experimental protocol by the Animal Care and Use Committee of the Tokyo University of Agriculture and Technology (Approved Nos. 30-60, 31-21, R02-81, and R202-80). In addition, the reporting of animal experiments followed the ARRIVE guidelines. Every possible measure was taken to minimize animal distress.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval Statement"}}],"article-number":"1"}}