{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T08:19:56Z","timestamp":1772180396652,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s12640-026-00783-5","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:58:20Z","timestamp":1770703100000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Effects of Arsenic Poisoning during Infancy Due to Contaminated Milk Powder: A Systematic Review"],"prefix":"10.1007","volume":"44","author":[{"given":"Khaled","family":"Saad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramez M.","family":"Odat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Elbataa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulhalim A","family":"Kikhia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saddik","family":"Haddad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Z","family":"Kouta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed G","family":"Nada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lama","family":"Alessawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romany Rezk","family":"Melad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anas H.","family":"Heiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimaa Elwardany","family":"Aly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zakaria M.","family":"Abdel-Sadek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wesam M","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibraheem","family":"Altamimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad-Hani","family":"Temsah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anas","family":"Elgenidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"783_CR1","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/oxfordjournals.aje.a117467","volume":"141","author":"MN Bates","year":"1995","unstructured":"Bates MN, Smith AH, Cantor KP (1995) Case-control study of bladder cancer and arsenic in drinking water. Am J Epidemiol 141:523\u2013530","journal-title":"Am J Epidemiol"},{"key":"783_CR2","first-page":"5470","volume":"50","author":"CJ Chen","year":"1990","unstructured":"Chen CJ, Wang CJ (1990) Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms. Cancer Res 50:5470\u20135474","journal-title":"Cancer Res"},{"key":"783_CR3","first-page":"1296","volume":"55","author":"HY Chiou","year":"1995","unstructured":"Chiou HY, Hsueh YM, Liaw KF et al (1995) Incidence of internal cancers and ingested inorganic arsenic: a seven-year follow-up study in Taiwan. Cancer Res 55:1296\u20131300","journal-title":"Cancer Res"},{"key":"783_CR4","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1093\/oxfordjournals.aje.a116514","volume":"136","author":"J Cuzick","year":"1992","unstructured":"Cuzick J, Sasieni P, Evans S (1992) Ingested arsenic, keratoses, and bladder cancer. Am J Epidemiol 136:417\u2013421","journal-title":"Am J Epidemiol"},{"issue":"6","key":"783_CR5","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/jhbp.1428","volume":"31","author":"A Elgenidy","year":"2024","unstructured":"Elgenidy A, Odat RM, Al-Ghorbany HA, Shahin HN, Abdel-Bary IS, AbdulHamid RA, Dhahab A, Salem M, Negm YA, El Attar NM, Abdelfattah AA, Khaliel MM, Moawad SM, Afifi AM (2024) Arsenic\u2019s shadowy influence: A systematic review of its carcinogenic role in gallbladder cancer. J Hepatobiliary Pancreat Sci 31(6):363\u2013375","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"1","key":"783_CR6","first-page":"6380","volume":"19","author":"European Food Safety Authority","year":"2021","unstructured":"European Food Safety Authority (2021) Chronic dietary exposure to inorganic arsenic. EFSA J 19(1):6380","journal-title":"EFSA J"},{"key":"783_CR7","unstructured":"FAO\/WHO (2011) Joint Expert Committee on Food Additives, WHO Expert Committee on Food Additives. Seventy-second report of the Joint FAO\/ WHO Technical Report Series, No. 959. WHO, Geneva"},{"key":"783_CR8","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1097\/00001648-199709000-00012","volume":"8","author":"HR Guo","year":"1997","unstructured":"Guo HR, Chiang HS, Hu H, Lipsitz SR, Monson RR (1997) Arsenic in drinking water and incidence of urinary cancers. Epidemiology 8:545\u2013550","journal-title":"Epidemiology"},{"key":"783_CR9","volume-title":"Report of arsenic poisoning incident due to powdered milk in Okayama Prefecture","year":"1957","unstructured":"Hamamoto E (ed) (1957) Report of arsenic poisoning incident due to powdered milk in Okayama Prefecture. Okayama Prefectural Government, Okayama"},{"key":"783_CR10","unstructured":"Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (eds) (n.d.) Cochrane Handbook for Systematic Reviews of Interventions version 6.4"},{"key":"783_CR11","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1097\/00001648-199603000-00003","volume":"7","author":"C Hopenhayn-Rich","year":"1996","unstructured":"Hopenhayn-Rich C, Biggs ML, Fuchs A et al (1996) Bladder cancer mortality associated with arsenic in drinking water in Argentina. Epidemiology 7:117\u2013124","journal-title":"Epidemiology"},{"key":"783_CR12","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/ije\/27.4.561","volume":"27","author":"C Hopenhayn-Rich","year":"1998","unstructured":"Hopenhayn-Rich C, Biggs ML, Smith AH (1998) Lung and kidney cancer mortality associated with arsenic in drinking water in Cordoba, Argentina. Int J Epidemiol 27:561\u2013569","journal-title":"Int J Epidemiol"},{"issue":"6","key":"783_CR13","first-page":"649","volume":"41","author":"TA Kawatsu","year":"1999","unstructured":"Kawatsu TA (1999) Follow-up study on punctate hypomelanosis and Palmo-Plantar keratotic papules associated with accidental mass arsenic poisoning during infancy. Skin Res 41(6):649\u2013654","journal-title":"Skin Res"},{"issue":"2","key":"783_CR14","doi-asserted-by":"publisher","first-page":"69","DOI":"10.5834\/jdh.27.69","volume":"27","author":"K Konishi","year":"1977","unstructured":"Konishi K, Hara K, Kambara M, Waki T, Nihida H, Kuzushita Y, Hieda T, Oyazato Y (1977) Epidemiological Studies of Dental Diseases in the Arsenic Poisoning of Osaka Children Caused by Morinaga Dry Milk. J Dent Health 27(2):69\u201377","journal-title":"J Dent Health"},{"key":"783_CR15","first-page":"34","volume":"1641","author":"T Koyama","year":"1955","unstructured":"Koyama T (1955) Dry milk poisoning incident. Nihon Iji Shinpo 1641:34\u201338","journal-title":"Nihon Iji Shinpo"},{"key":"783_CR16","first-page":"1","volume":"00","author":"R Liu","year":"2020","unstructured":"Liu R, Tabuchi T, Kitamura T, Miyashiro I, Sobue T (2020) Long-term observational study on 6223 survivors of arsenic poisoning due to contaminated milk powder during infancy. Cancer Sci 00:1\u20139","journal-title":"Cancer Sci"},{"key":"783_CR17","first-page":"1","volume":"74","author":"Y Nakagawa","year":"1970","unstructured":"Nakagawa Y, Iibuchi Y (1970) Follow-up survey of Morinaga arsenic poisoning. Igaku No Ayumi 74:1\u20133","journal-title":"Igaku No Ayumi"},{"key":"783_CR18","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1265\/jjh.27.500","volume":"27","author":"M Ohira","year":"1973","unstructured":"Ohira M, Aoyama H (1973) Epidemiological studies on the Morinaga powdered milk poisoning incident, Nihon Eiseigaku Zasshi. Jpn J Hyg 27:500\u2013531","journal-title":"Jpn J Hyg"},{"key":"783_CR19","doi-asserted-by":"crossref","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372","DOI":"10.1136\/bmj.n71"},{"key":"783_CR20","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1093\/oxfordjournals.aje.a009507","volume":"147","author":"AH Smith","year":"1998","unstructured":"Smith AH, Goycolea M, Haque R, Biggs ML (1998) A marked increase in bladder and lung cancer mortality in a region of Northern Chile due to arsenic in drinking water. Am J Epidemiol 147:660\u2013669","journal-title":"Am J Epidemiol"},{"key":"783_CR21","doi-asserted-by":"publisher","first-page":"439","DOI":"10.2188\/jea.JE20090131","volume":"20","author":"H Tanaka","year":"2010","unstructured":"Tanaka H, Tsukuma H, Oshima A (2010) Long-term prospective study of 6104 survivors of arsenic poisoning during infancy due to contaminated milk powder in 1955. J Epidemiol 20:439\u2013445","journal-title":"J Epidemiol"},{"issue":"2","key":"783_CR22","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.yrtph.2003.12.002","volume":"39","author":"JS Tsuji","year":"2004","unstructured":"Tsuji JS, Benson R, Schoof RA, Hook GC (2004) Health effect levels for risk assessment of childhood exposure to arsenic. Regul Toxicol Pharmacol 39(2):99\u2013110","journal-title":"Regul Toxicol Pharmacol"},{"key":"783_CR23","volume-title":"Arsenic compounds hazard summary","author":"US Environmental Protection Agency","year":"2021","unstructured":"US Environmental Protection Agency (2021) Arsenic compounds hazard summary. EPA, Washington, DC"},{"issue":"3","key":"783_CR24","first-page":"8","volume":"78","author":"D Wilson","year":"2015","unstructured":"Wilson D (2015) Arsenic consumption in the united States. J Environ Health 78(3):8\u201315","journal-title":"J Environ Health"},{"key":"783_CR25","volume-title":"Exposure to arsenic: a major public health concern. WHO\/CED\/PHE\/EPE\/19.4.1","author":"World Health Organization","year":"2019","unstructured":"World Health Organization (2019) Exposure to arsenic: a major public health concern. WHO, Geneva."},{"key":"783_CR26","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1265\/jjh.27.364","volume":"27","author":"N Yamashita","year":"1972","unstructured":"Yamashita N, Doi M, Nishio M, Hojo H (1972) Tanaka.Recent observations of Kyoto children poisoned by arsenic-tainted Morinaga dry Milk, Nihon Eiseigaku Zasshi. Jpn J Hyg 27:364\u2013399","journal-title":"Jpn J Hyg"},{"key":"783_CR27","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ntt.2015.12.001","volume":"53","author":"T Yorifuji","year":"2016","unstructured":"Yorifuji T, Kato T, Ohta H, Bellinger DC, Matsuoka K, Grandjean P (2016) Neurological and neuropsychological functions in adults with a history of developmental arsenic poisoning from contaminated milk powder. Neurotoxicol Teratol 53:75\u201380","journal-title":"Neurotoxicol Teratol"},{"key":"783_CR28","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.envres.2017.02.002","volume":"155","author":"T Yorifuji","year":"2017","unstructured":"Yorifuji T, Matsuoka K, Grandjean P (2017) Height and blood chemistry in adults with a history of developmental arsenic poisoning from contaminated milk powder. Environ Res 155:86\u201391","journal-title":"Environ Res"},{"key":"783_CR29","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/s12199-010-0182-x","volume":"16","author":"T Yorifuji","year":"2011","unstructured":"Yorifuji T, Tsuda T, Doi H, Grandjean P (2011) Cancer excess after arsenic exposure from contaminated milk powder. Environ Health Prev Med 16:164\u2013170","journal-title":"Environ Health Prev Med"},{"key":"783_CR30","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.taap.2003.10.022","volume":"198","author":"T Yoshida","year":"2004","unstructured":"Yoshida T, Yamauchi H, Sun GF (2004) Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review. Toxicol Appl Pharmacol 198:243\u2013252","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-026-00783-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-026-00783-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-026-00783-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:56:41Z","timestamp":1772175401000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12640-026-00783-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["783"],"URL":"https:\/\/doi.org\/10.1007\/s12640-026-00783-5","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"22 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The study\u2019s execution did not require informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"8"}}