{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:58:15Z","timestamp":1781643495051,"version":"3.54.5"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer\u2019s disease (AD) is the leading cause of dementia and evidence suggests that alcohol, the most commonly used addictive substance, may increase AD risk. Locus coeruleus (LC) neurons are the primary source of norepinephrine in the brain and these neurons degenerate early in AD. In rodent models, lesioning the LC increases amyloid beta (A\u03b2) pathology suggesting that LC integrity and norepinephrine signaling obstruct A\u03b2 pathogenesis. We recently reported a decrease in the number of LC norepinephrine neurons and increased A\u03b2 pathology when measured after protracted abstinence from chronic intermittent alcohol consumption in female APP\/PS1 mice. Clinically, female subjects are at a higher risk for AD; additionally, female mice consume more alcohol than male mice making it unclear as to whether alcohol consumption would produce similar adverse outcomes in male subjects. To address this gap, male APP\/PS1 and non-transgenic mice underwent chronic intermittent access (IA) to alcohol followed by protracted abstinence with water drinking controls run in parallel, consistent with our prior study. In contrast to our previous results with female mice, the number of LC norepinephrine neurons was unchanged in male APP\/PS1 mice that had IA to alcohol; however, the length of LC axons was decreased and A\u03b2 pathology was increased in male APP\/PS1 mice that consumed alcohol. These data demonstrate that alcohol consumption during early adulthood results in negative consequences in male APP\/PS1 mice, although the effect may not be as severe as previously observed in female mice.<\/jats:p>","DOI":"10.1007\/s12640-026-00794-2","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T07:16:19Z","timestamp":1774250179000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decreased Length of Locus Coeruleus Norepinephrine Axons and Increased Amyloid Beta Pathology in Male APP\/PS1 Mice During Protracted Abstinence From Alcohol"],"prefix":"10.1007","volume":"44","author":[{"given":"Ivy J. Z.","family":"Garland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaydel","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Scalf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichole R.","family":"Payne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Graves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"issue":"12","key":"794_CR1","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/0024-3205(80)90025-9","volume":"27","author":"R Adolfsson","year":"1980","unstructured":"Adolfsson R, Gottfries CG, Oreland L, Wiberg A, Winblad B (1980) Increased activity of brain and platelet monoamine oxidase in dementia of Alzheimer type. Life Sci 27(12):1029\u20131034. https:\/\/doi.org\/10.1016\/0024-3205(80)90025-9","journal-title":"Life Sci"},{"key":"794_CR2","doi-asserted-by":"publisher","unstructured":"Alzheimer's disease (2024) 2024 Alzheimer's disease facts and figures. Alzheimers Dement 20(5):3708\u20133821 https:\/\/doi.org\/10.1002\/alz.13809","DOI":"10.1002\/alz.13809"},{"issue":"1","key":"794_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0006-8993(94)90199-6","volume":"650","author":"V Arango","year":"1994","unstructured":"Arango V, Underwood MD, Mann JJ (1994) Fewer pigmented neurons in the locus coeruleus of uncomplicated alcoholics. Brain Res 650(1):1\u20138. https:\/\/doi.org\/10.1016\/0006-8993(94)90199-6","journal-title":"Brain Res"},{"key":"794_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci7100139","author":"EA Barton","year":"2017","unstructured":"Barton EA, Baker C, Leasure JL (2017) Investigation of sex differences in the microglial response to binge ethanol and exercise. Brain Sci. https:\/\/doi.org\/10.3390\/brainsci7100139","journal-title":"Brain Sci"},{"issue":"4","key":"794_CR5","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.3233\/JAD-180141","volume":"64","author":"CR Beam","year":"2018","unstructured":"Beam CR, Kaneshiro C, Jang JY, Reynolds CA, Pedersen NL, Gatz M (2018) Differences between women and men in incidence rates of dementia and Alzheimer\u2019s disease. J Alzheimers Dis 64(4):1077\u20131083. https:\/\/doi.org\/10.3233\/JAD-180141","journal-title":"J Alzheimers Dis"},{"issue":"12","key":"794_CR6","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1016\/j.neurobiolaging.2014.06.011","volume":"35","author":"C Branca","year":"2014","unstructured":"Branca C, Wisely EV, Hartman LK, Caccamo A, Oddo S (2014) Administration of a selective beta2 adrenergic receptor antagonist exacerbates neuropathology and cognitive deficits in a mouse model of Alzheimer\u2019s disease. Neurobiol Aging 35(12):2726\u20132735. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.06.011","journal-title":"Neurobiol Aging"},{"issue":"2","key":"794_CR7","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/s0006-8993(98)01211-6","volume":"816","author":"WJ Burke","year":"1999","unstructured":"Burke WJ, Li SW, Schmitt CA, Xia P, Chung HD, Gillespie KN (1999) Accumulation of 3,4-dihydroxyphenylglycolaldehyde, the neurotoxic monoamine oxidase A metabolite of norepinephrine, in locus ceruleus cell bodies in Alzheimer\u2019s disease: mechanism of neuron death. Brain Res 816(2):633\u2013637. https:\/\/doi.org\/10.1016\/s0006-8993(98)01211-6","journal-title":"Brain Res"},{"issue":"1","key":"794_CR8","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1523\/JNEUROSCI.1483-17.2017","volume":"38","author":"T Chalermpalanupap","year":"2018","unstructured":"Chalermpalanupap T, Schroeder JP, Rorabaugh JM, Liles LC, Lah JJ, Levey AI, Weinshenker D (2018) Locus coeruleus ablation exacerbates cognitive deficits, neuropathology, and lethality in P301S tau transgenic mice. J Neurosci 38(1):74\u201392. https:\/\/doi.org\/10.1523\/JNEUROSCI.1483-17.2017","journal-title":"J Neurosci"},{"issue":"4","key":"794_CR9","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/S1474-4422(24)00038-3","volume":"23","author":"GBDNSD Collaborators","year":"2024","unstructured":"Collaborators GBDNSD (2024) Global, regional, and national burden of disorders affecting the nervous system, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol 23(4):344\u2013381. https:\/\/doi.org\/10.1016\/S1474-4422(24)00038-3","journal-title":"Lancet Neurol"},{"issue":"3","key":"794_CR10","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/j.1471-4159.2010.06622.x","volume":"113","author":"SE Counts","year":"2010","unstructured":"Counts SE, Mufson EJ (2010) Noradrenaline activation of neurotrophic pathways protects against neuronal amyloid toxicity. J Neurochem 113(3):649\u2013660. https:\/\/doi.org\/10.1111\/j.1471-4159.2010.06622.x","journal-title":"J Neurochem"},{"key":"794_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2019.09.006","author":"MC DeBaker","year":"2019","unstructured":"DeBaker MC, Robinson JM, Moen JK, Wickman K, Lee AM (2019) Differential patterns of alcohol and nicotine intake: combined alcohol and nicotine binge consumption behaviors in mice. Alcohol. https:\/\/doi.org\/10.1016\/j.alcohol.2019.09.006","journal-title":"Alcohol"},{"key":"794_CR12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.alcohol.2019.09.006","volume":"85","author":"MC DeBaker","year":"2020","unstructured":"DeBaker MC, Robinson JM, Moen JK, Wickman K, Lee AM (2020) Differential patterns of alcohol and nicotine intake: combined alcohol and nicotine binge consumption behaviors in mice. Alcohol 85:57\u201364. https:\/\/doi.org\/10.1016\/j.alcohol.2019.09.006","journal-title":"Alcohol"},{"key":"794_CR13","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jneumeth.2018.07.012","volume":"310","author":"OG Deniz","year":"2018","unstructured":"Deniz OG, Altun G, Kaplan AA, Yurt KK, von Bartheld CS, Kaplan S (2018) A concise review of optical, physical and isotropic fractionator techniques in neuroscience studies, including recent developments. J Neurosci Methods 310:45\u201353. https:\/\/doi.org\/10.1016\/j.jneumeth.2018.07.012","journal-title":"J Neurosci Methods"},{"issue":"1","key":"794_CR14","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","volume":"14","author":"MA DeTure","year":"2019","unstructured":"DeTure MA, Dickson DW (2019) The neuropathological diagnosis of Alzheimer\u2019s disease. Mol Neurodegener 14(1):32. https:\/\/doi.org\/10.1186\/s13024-019-0333-5","journal-title":"Mol Neurodegener"},{"key":"794_CR15","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.alcohol.2022.08.008","volume":"107","author":"AM Downs","year":"2023","unstructured":"Downs AM, Catavero CM, Kasten MR, McElligott ZA (2023) Tauopathy and alcohol consumption interact to alter locus coeruleus excitatory transmission and excitability in male and female mice. Alcohol 107:97\u2013107. https:\/\/doi.org\/10.1016\/j.alcohol.2022.08.008","journal-title":"Alcohol"},{"key":"794_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108817","volume":"200","author":"Y Du","year":"2021","unstructured":"Du Y, Lee YB, Graves SM (2021) Chronic methamphetamine-induced neurodegeneration: differential vulnerability of ventral tegmental area and substantia nigra pars compacta dopamine neurons. Neuropharmacology 200:108817. https:\/\/doi.org\/10.1016\/j.neuropharm.2021.108817","journal-title":"Neuropharmacology"},{"key":"794_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.949923","volume":"16","author":"Y Du","year":"2022","unstructured":"Du Y, Choi S, Pilski A, Graves SM (2022) Differential vulnerability of locus coeruleus and dorsal raphe neurons to chronic methamphetamine-induced degeneration. Front Cell Neurosci 16:949923. https:\/\/doi.org\/10.3389\/fncel.2022.949923","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"794_CR18","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/s0304-3940(02)00307-5","volume":"326","author":"L Emilsson","year":"2002","unstructured":"Emilsson L, Saetre P, Balciuniene J, Castensson A, Cairns N, Jazin EE (2002) Increased monoamine oxidase messenger RNA expression levels in frontal cortex of Alzheimer\u2019s disease patients. Neurosci Lett 326(1):56\u201360. https:\/\/doi.org\/10.1016\/s0304-3940(02)00307-5","journal-title":"Neurosci Lett"},{"key":"794_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2025.05.004","author":"S Engel","year":"2025","unstructured":"Engel S, Dillerud M, Scalf M, Dobbelmann R, Du Y, Lee AM, Graves SM (2025) Alcohol consumption during early adulthood increases the vulnerability of locus coeruleus neurons and amyloid beta pathology in female APP\/PS1 mice. Alcohol. https:\/\/doi.org\/10.1016\/j.alcohol.2025.05.004","journal-title":"Alcohol"},{"key":"794_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105089","volume":"146","author":"AK Evans","year":"2020","unstructured":"Evans AK, Ardestani PM, Yi B, Park HH, Lam RK, Shamloo M (2020) Beta-adrenergic receptor antagonism is proinflammatory and exacerbates neuroinflammation in a mouse model of Alzheimer\u2019s disease. Neurobiol Dis 146:105089. https:\/\/doi.org\/10.1016\/j.nbd.2020.105089","journal-title":"Neurobiol Dis"},{"issue":"3","key":"794_CR21","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.nbd.2006.08.017","volume":"24","author":"M Garcia-Alloza","year":"2006","unstructured":"Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP (2006) Characterization of amyloid deposition in the APPswe\/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis 24(3):516\u2013524. https:\/\/doi.org\/10.1016\/j.nbd.2006.08.017","journal-title":"Neurobiol Dis"},{"key":"794_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112105","volume":"151","author":"YS Gong","year":"2021","unstructured":"Gong YS, Hou FL, Guo J, Lin L, Zhu FY (2021) Effects of alcohol intake on cognitive function and beta-amyloid protein in APP\/PS1 transgenic mice. Food Chem Toxicol 151:112105. https:\/\/doi.org\/10.1016\/j.fct.2021.112105","journal-title":"Food Chem Toxicol"},{"key":"794_CR23","doi-asserted-by":"publisher","unstructured":"Gong J, Harris K, Lipnicki DM, Castro-Costa E, Lima-Costa MF, Diniz BS, Xiao S, Lipton RB, Katz MJ, Wang C, Preux PM, Guerchet M, Gbessemehlan A, Ritchie K, Ancelin ML, Skoog I, Najar J, Sterner TR, Scarmeas N, Yannakoulia M, Kosmidis MH, Guaita A, Rolandi E, Davin A, Gureje O, Trompet S, Gussekloo J, Riedel-Heller S, Pabst A, Rohr S, Shahar S, Singh DKA, Rivan NFM, Boxtel MV, Kohler S, Ganguli M, Chang CC, Jacobsen E, Haan M, Ding D, Zhao Q, Xiao Z, Narazaki K, Chen T, Chen S, Ng TP, Gwee X, Numbers K, Mather KA, Scazufca M, Lobo A, De-la-Camara C, Lobo E, Sachdev PS, Brodaty H, Hackett ML, Peters SAE, Woodward M, Cohort Studies of Memory in an International C (2023) Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium. Alzheimers Dement 19(8):3365\u20133378 https:\/\/doi.org\/10.1002\/alz.12962","DOI":"10.1002\/alz.12962"},{"issue":"1","key":"794_CR24","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41593-019-0556-3","volume":"23","author":"SM Graves","year":"2020","unstructured":"Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ (2020) Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. Nat Neurosci 23(1):15\u201320. https:\/\/doi.org\/10.1038\/s41593-019-0556-3","journal-title":"Nat Neurosci"},{"key":"794_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105409","volume":"156","author":"SM Graves","year":"2021","unstructured":"Graves SM, Schwarzschild SE, Tai RA, Chen Y, Surmeier DJ (2021) Mitochondrial oxidant stress mediates methamphetamine neurotoxicity in substantia nigra dopaminergic neurons. Neurobiol Dis 156:105409. https:\/\/doi.org\/10.1016\/j.nbd.2021.105409","journal-title":"Neurobiol Dis"},{"issue":"3","key":"794_CR26","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.neurobiolaging.2006.02.007","volume":"28","author":"A Grudzien","year":"2007","unstructured":"Grudzien A, Shaw P, Weintraub S, Bigio E, Mash DC, Mesulam MM (2007) Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer\u2019s disease. Neurobiol Aging 28(3):327\u2013335. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2006.02.007","journal-title":"Neurobiol Aging"},{"issue":"1","key":"794_CR27","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1038\/s42003-021-02259-y","volume":"4","author":"MV Guillot-Sestier","year":"2021","unstructured":"Guillot-Sestier MV, Araiz AR, Mela V, Gaban AS, O\u2019Neill E, Joshi L, Chouchani ET, Mills EL, Lynch MA (2021) Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer\u2019s disease. Commun Biol 4(1):711. https:\/\/doi.org\/10.1038\/s42003-021-02259-y","journal-title":"Commun Biol"},{"issue":"2","key":"794_CR28","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/alz.12694","volume":"19","author":"A Gustavsson","year":"2023","unstructured":"Gustavsson A, Norton N, Fast T, Frolich L, Georges J, Holzapfel D, Kirabali T, Krolak-Salmon P, Rossini PM, Ferretti MT, Lanman L, Chadha AS, van der Flier WM (2023) Global estimates on the number of persons across the Alzheimer\u2019s disease continuum. Alzheimers Dement 19(2):658\u2013670. https:\/\/doi.org\/10.1002\/alz.12694","journal-title":"Alzheimers Dement"},{"key":"794_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2025.115632","volume":"398","author":"E Hegnet","year":"2025","unstructured":"Hegnet E, Hakli S, Koivisto H, Miettinen PO, Jin N, Gureviciene I, Tanila H (2025) Age and sex dependent hippocampal neuronal hyperactivity in Alzheimer model mice. Exp Neurol 398:115632. https:\/\/doi.org\/10.1016\/j.expneurol.2025.115632","journal-title":"Exp Neurol"},{"issue":"7","key":"794_CR30","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1523\/JNEUROSCI.22-07-02434.2002","volume":"22","author":"MT Heneka","year":"2002","unstructured":"Heneka MT, Galea E, Gavriluyk V, Dumitrescu-Ozimek L, Daeschner J, O\u2019Banion MK, Weinberg G, Klockgether T, Feinstein DL (2002) Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer\u2019s disease. J Neurosci 22(7):2434\u20132442. https:\/\/doi.org\/10.1523\/JNEUROSCI.22-07-02434.2002","journal-title":"J Neurosci"},{"issue":"5","key":"794_CR31","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1523\/JNEUROSCI.4236-05.2006","volume":"26","author":"MT Heneka","year":"2006","unstructured":"Heneka MT, Ramanathan M, Jacobs AH, Dumitrescu-Ozimek L, Bilkei-Gorzo A, Debeir T, Sastre M, Galldiks N, Zimmer A, Hoehn M, Heiss WD, Klockgether T, Staufenbiel M (2006) Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice. J Neurosci 26(5):1343\u20131354. https:\/\/doi.org\/10.1523\/JNEUROSCI.4236-05.2006","journal-title":"J Neurosci"},{"issue":"13","key":"794_CR32","doi-asserted-by":"publisher","first-page":"6058","DOI":"10.1073\/pnas.0909586107","volume":"107","author":"MT Heneka","year":"2010","unstructured":"Heneka MT, Nadrigny F, Regen T, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch UK, Kummer MP (2010) Locus ceruleus controls Alzheimer\u2019s disease pathology by modulating microglial functions through norepinephrine. Proc Natl Acad Sci U S A 107(13):6058\u20136063. https:\/\/doi.org\/10.1073\/pnas.0909586107","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"794_CR33","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nm0198-097","volume":"4","author":"L Holcomb","year":"1998","unstructured":"Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O\u2019Campo K, Hardy J, Prada CM, Eckman C, Younkin S, Hsiao K, Duff K (1998) Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 4(1):97\u2013100. https:\/\/doi.org\/10.1038\/nm0198-097","journal-title":"Nat Med"},{"key":"794_CR34","unstructured":"Howard CVR, MG (1998) Unbiased Stereology, Three-Dimensional Measurement in Microscopy. BIOS Scientific Publishers, Milton Park, England, pp 170\u2013172"},{"issue":"41","key":"794_CR35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2204306119","volume":"119","author":"Y Huang","year":"2022","unstructured":"Huang Y, Lemke G (2022) Early death in a mouse model of Alzheimer\u2019s disease exacerbated by microglial loss of TAM receptor signaling. Proc Natl Acad Sci U S A 119(41):e2204306119. https:\/\/doi.org\/10.1073\/pnas.2204306119","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"794_CR36","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1111\/j.1530-0277.2011.01545.x","volume":"35","author":"LS Hwa","year":"2011","unstructured":"Hwa LS, Chu A, Levinson SA, Kayyali TM, DeBold JF, Miczek KA (2011) Persistent escalation of alcohol drinking in C57BL\/6J mice with intermittent access to 20% ethanol. Alcohol Clin Exp Res 35(11):1938\u20131947. https:\/\/doi.org\/10.1111\/j.1530-0277.2011.01545.x","journal-title":"Alcohol Clin Exp Res"},{"issue":"2","key":"794_CR37","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/s0741-8329(03)00002-8","volume":"29","author":"P Jaatinen","year":"2003","unstructured":"Jaatinen P, Riikonen J, Riihioja P, Kajander O, Hervonen A (2003) Interaction of aging and intermittent ethanol exposure on brain cytochrome c oxidase activity levels. Alcohol 29(2):91\u2013100. https:\/\/doi.org\/10.1016\/s0741-8329(03)00002-8","journal-title":"Alcohol"},{"issue":"6","key":"794_CR38","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/s1389-0344(01)00067-3","volume":"17","author":"JL Jankowsky","year":"2001","unstructured":"Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Borchelt DR (2001) Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng 17(6):157\u2013165. https:\/\/doi.org\/10.1016\/s1389-0344(01)00067-3","journal-title":"Biomol Eng"},{"issue":"2","key":"794_CR39","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1093\/hmg\/ddh019","volume":"13","author":"JL Jankowsky","year":"2004","unstructured":"Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR (2004) Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet 13(2):159\u2013170. https:\/\/doi.org\/10.1093\/hmg\/ddh019","journal-title":"Hum Mol Genet"},{"issue":"4","key":"794_CR40","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.neuint.2010.02.001","volume":"57","author":"D Jardanhazi-Kurutz","year":"2010","unstructured":"Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Dyrks T, Thiele A, Heneka MT (2010) Induced LC degeneration in APP\/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits. Neurochem Int 57(4):375\u2013382. https:\/\/doi.org\/10.1016\/j.neuint.2010.02.001","journal-title":"Neurochem Int"},{"key":"794_CR41","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.neuroscience.2010.11.052","volume":"176","author":"D Jardanhazi-Kurutz","year":"2011","unstructured":"Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Thiele A, Heneka MT (2011) Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP\/PS1 transgenic mice. Neuroscience 176:396\u2013407. https:\/\/doi.org\/10.1016\/j.neuroscience.2010.11.052","journal-title":"Neuroscience"},{"issue":"2","key":"794_CR42","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1007\/s12640-015-9589-x","volume":"29","author":"SS Jiao","year":"2016","unstructured":"Jiao SS, Bu XL, Liu YH, Zhu C, Wang QH, Shen LL, Liu CH, Wang YR, Yao XQ, Wang YJ (2016) Sex dimorphism profile of Alzheimer\u2019s disease-type pathologies in an APP\/PS1 mouse model. Neurotox Res 29(2):256\u2013266. https:\/\/doi.org\/10.1007\/s12640-015-9589-x","journal-title":"Neurotox Res"},{"key":"794_CR43","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.neurobiolaging.2018.07.009","volume":"71","author":"N Jin","year":"2018","unstructured":"Jin N, Lipponen A, Koivisto H, Gurevicius K, Tanila H (2018) Increased cortical beta power and spike-wave discharges in middle-aged APP\/PS1 mice. Neurobiol Aging 71:127\u2013141. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2018.07.009","journal-title":"Neurobiol Aging"},{"issue":"8","key":"794_CR44","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1016\/j.neurobiolaging.2006.06.003","volume":"28","author":"S Kalinin","year":"2007","unstructured":"Kalinin S, Gavrilyuk V, Polak PE, Vasser R, Zhao J, Heneka MT, Feinstein DL (2007) Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer\u2019s disease. Neurobiol Aging 28(8):1206\u20131214. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2006.06.003","journal-title":"Neurobiol Aging"},{"issue":"1","key":"794_CR45","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-017-0411-2","volume":"5","author":"SC Kelly","year":"2017","unstructured":"Kelly SC, He B, Perez SE, Ginsberg SD, Mufson EJ, Counts SE (2017) Locus coeruleus cellular and molecular pathology during the progression of Alzheimer\u2019s disease. Acta Neuropathol Commun 5(1):8. https:\/\/doi.org\/10.1186\/s40478-017-0411-2","journal-title":"Acta Neuropathol Commun"},{"issue":"2","key":"794_CR46","doi-asserted-by":"publisher","first-page":"135","DOI":"10.5483\/BMBRep.2011.44.2.135","volume":"44","author":"SR Kim","year":"2011","unstructured":"Kim SR, Jeong HY, Yang S, Choi SP, Seo MY, Yun YK, Choi Y, Baik SH, Park JS, Gwon AR, Yang DK, Lee CH, Lee SM, Park KW, Jo DG (2011) Effects of chronic alcohol consumption on expression levels of APP and Abeta-producing enzymes. BMB Rep 44(2):135\u2013139. https:\/\/doi.org\/10.5483\/BMBRep.2011.44.2.135","journal-title":"BMB Rep"},{"issue":"2","key":"794_CR47","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/j.1530-0277.1993.tb00784.x","volume":"17","author":"C Kjellstrom","year":"1993","unstructured":"Kjellstrom C, Almstrom S, Conradi N (1993) Decreased synapse-to-neuron ratio in rat locus ceruleus following chronic ethanol feeding. Alcohol Clin Exp Res 17(2):406\u2013410. https:\/\/doi.org\/10.1111\/j.1530-0277.1993.tb00784.x","journal-title":"Alcohol Clin Exp Res"},{"issue":"2","key":"794_CR48","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.jhep.2012.08.018","volume":"58","author":"TM Leung","year":"2013","unstructured":"Leung TM, Nieto N (2013) CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease. J Hepatol 58(2):395\u2013398. https:\/\/doi.org\/10.1016\/j.jhep.2012.08.018","journal-title":"J Hepatol"},{"issue":"4","key":"794_CR49","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1177\/0023677215615269","volume":"50","author":"X Li","year":"2016","unstructured":"Li X, Feng Y, Wu W, Zhao J, Fu C, Li Y, Ding Y, Wu B, Gong Y, Yang G, Zhou X (2016) Sex differences between APPswePS1dE9 mice in A-beta accumulation and pancreatic islet function during the development of Alzheimer\u2019s disease. Lab Anim 50(4):275\u2013285. https:\/\/doi.org\/10.1177\/0023677215615269","journal-title":"Lab Anim"},{"issue":"51","key":"794_CR50","doi-asserted-by":"publisher","first-page":"13805","DOI":"10.1523\/JNEUROSCI.4218-08.2008","volume":"28","author":"Y Liu","year":"2008","unstructured":"Liu Y, Yoo MJ, Savonenko A, Stirling W, Price DL, Borchelt DR, Mamounas L, Lyons WE, Blue ME, Lee MK (2008) Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer\u2019s disease. J Neurosci 28(51):13805\u201313814. https:\/\/doi.org\/10.1523\/JNEUROSCI.4218-08.2008","journal-title":"J Neurosci"},{"issue":"24","key":"794_CR51","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.3969\/j.issn.1673-5374.2013.24.004","volume":"8","author":"L Liu","year":"2013","unstructured":"Liu L, Luo S, Zeng L, Wang W, Yuan L, Jian X (2013) Degenerative alterations in noradrenergic neurons of the locus coeruleus in Alzheimer\u2019s disease. Neural Regen Res 8(24):2249\u20132255. https:\/\/doi.org\/10.3969\/j.issn.1673-5374.2013.24.004","journal-title":"Neural Regen Res"},{"issue":"1","key":"794_CR52","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3233\/JAD-141062","volume":"44","author":"X Liu","year":"2015","unstructured":"Liu X, Ye K, Weinshenker D (2015) Norepinephrine protects against amyloid-beta toxicity via TrkB. J Alzheimers Dis 44(1):251\u2013260. https:\/\/doi.org\/10.3233\/JAD-141062","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"794_CR53","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","volume":"179","author":"JM Long","year":"2019","unstructured":"Long JM, Holtzman DM (2019) Alzheimer disease: an update on pathobiology and treatment strategies. Cell 179(2):312\u2013339. https:\/\/doi.org\/10.1016\/j.cell.2019.09.001","journal-title":"Cell"},{"issue":"4","key":"794_CR54","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1093\/oxfordjournals.alcalc.a008281","volume":"32","author":"W Lu","year":"1997","unstructured":"Lu W, Jaatinen P, Rintala J, Sarviharju M, Kiianmaa K, Hervonen A (1997) Effects of lifelong ethanol consumption on rat locus coeruleus. Alcohol Alcohol 32(4):463\u2013470. https:\/\/doi.org\/10.1093\/oxfordjournals.alcalc.a008281","journal-title":"Alcohol Alcohol"},{"issue":"10","key":"794_CR55","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.biopsych.2013.10.010","volume":"75","author":"BA Matthews","year":"2014","unstructured":"Matthews BA, Kish SJ, Xu X, Boileau I, Rusjan PM, Wilson AA, DiGiacomo D, Houle S, Meyer JH (2014) Greater monoamine oxidase a binding in alcohol dependence. Biol Psychiatry 75(10):756\u2013764. https:\/\/doi.org\/10.1016\/j.biopsych.2013.10.010","journal-title":"Biol Psychiatry"},{"key":"794_CR56","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.neurobiolaging.2021.01.018","volume":"101","author":"MA Mifflin","year":"2021","unstructured":"Mifflin MA, Winslow W, Surendra L, Tallino S, Vural A, Velazquez R (2021) Sex differences in the IntelliCage and the Morris water maze in the APP\/PS1 mouse model of amyloidosis. Neurobiol Aging 101:130\u2013140. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2021.01.018","journal-title":"Neurobiol Aging"},{"issue":"11","key":"794_CR57","doi-asserted-by":"publisher","first-page":"3453","DOI":"10.1523\/JNEUROSCI.5215-08.2009","volume":"29","author":"R Minkeviciene","year":"2009","unstructured":"Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fulop L, Penke B, Zilberter Y, Harkany T, Pitkanen A, Tanila H (2009) Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy. J Neurosci 29(11):3453\u20133462. https:\/\/doi.org\/10.1523\/JNEUROSCI.5215-08.2009","journal-title":"J Neurosci"},{"issue":"13","key":"794_CR58","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1212\/WNL.0000000000004425","volume":"89","author":"L Mosconi","year":"2017","unstructured":"Mosconi L, Berti V, Quinn C, McHugh P, Petrongolo G, Varsavsky I, Osorio RS, Pupi A, Vallabhajosula S, Isaacson RS, de Leon MJ, Brinton RD (2017) Sex differences in Alzheimer risk: brain imaging of endocrine vs chronologic aging. Neurology 89(13):1382\u20131390. https:\/\/doi.org\/10.1212\/WNL.0000000000004425","journal-title":"Neurology"},{"issue":"1","key":"794_CR59","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02870-2","volume":"20","author":"SR Ocanas","year":"2023","unstructured":"Ocanas SR, Pham KD, Cox JEJ, Keck AW, Ko S, Ampadu FA, Porter HL, Ansere VA, Kulpa A, Kellogg CM, Machalinski AH, Thomas MA, Wright Z, Chucair-Elliott AJ, Freeman WM (2023) Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer\u2019s disease. J Neuroinflammation 20(1):188. https:\/\/doi.org\/10.1186\/s12974-023-02870-2","journal-title":"J Neuroinflammation"},{"key":"794_CR60","doi-asserted-by":"publisher","DOI":"10.3389\/fgwh.2023.1324522","volume":"4","author":"MA O'Neal","year":"2023","unstructured":"O\u2019Neal MA (2023) Women and the risk of Alzheimer\u2019s disease. Front Glob Womens Health 4:1324522. https:\/\/doi.org\/10.3389\/fgwh.2023.1324522","journal-title":"Front Glob Womens Health"},{"key":"794_CR61","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.neuropharm.2016.06.023","volume":"109","author":"KY O'Rourke","year":"2016","unstructured":"O\u2019Rourke KY, Touchette JC, Hartell EC, Bade EJ, Lee AM (2016) Voluntary co-consumption of alcohol and nicotine: effects of abstinence, intermittency, and withdrawal in mice. Neuropharmacology 109:236\u2013246. https:\/\/doi.org\/10.1016\/j.neuropharm.2016.06.023","journal-title":"Neuropharmacology"},{"key":"794_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2024.115183","volume":"474","author":"W Peng","year":"2024","unstructured":"Peng W, Wang B, Jiang W, Wan Y, Li R, Jin S (2024) Effects of voluntary chronic intermittent access to ethanol on the behavioral performance in adult C57BL\/6\u202fJ mice. Behav Brain Res 474:115183. https:\/\/doi.org\/10.1016\/j.bbr.2024.115183","journal-title":"Behav Brain Res"},{"key":"794_CR63","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713039","author":"A Pilski","year":"2023","unstructured":"Pilski A, Graves SM (2023) Repeated methamphetamine administration results in axon loss prior to somatic loss of substantia nigra pars compacta and locus coeruleus neurons in male but not female mice. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms241713039","journal-title":"Int J Mol Sci"},{"issue":"3","key":"794_CR64","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/s0741-8329(98)00012-3","volume":"16","author":"J Rintala","year":"1998","unstructured":"Rintala J, Jaatinen P, Wei L, Sarviharju M, Eriksson P, Kiianmaa K, Hervonen A (1998) Lifelong ethanol consumption and loss of locus coeruleus neurons in AA and ANA rats. Alcohol 16(3):243\u2013248. https:\/\/doi.org\/10.1016\/s0741-8329(98)00012-3","journal-title":"Alcohol"},{"issue":"6","key":"794_CR65","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1038\/nn.3717","volume":"17","author":"J Sanchez-Padilla","year":"2014","unstructured":"Sanchez-Padilla J, Guzman JN, Ilijic E, Kondapalli J, Galtieri DJ, Yang B, Schieber S, Oertel W, Wokosin D, Schumacker PT, Surmeier DJ (2014) Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase. Nat Neurosci 17(6):832\u2013840. https:\/\/doi.org\/10.1038\/nn.3717","journal-title":"Nat Neurosci"},{"issue":"1","key":"794_CR66","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13195-017-0279-1","volume":"9","author":"S Schedin-Weiss","year":"2017","unstructured":"Schedin-Weiss S, Inoue M, Hromadkova L, Teranishi Y, Yamamoto NG, Wiehager B, Bogdanovic N, Winblad B, Sandebring-Matton A, Frykman S, Tjernberg LO (2017) Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with gamma-secretase and regulates neuronal amyloid beta-peptide levels. Alzheimers Res Ther 9(1):57. https:\/\/doi.org\/10.1186\/s13195-017-0279-1","journal-title":"Alzheimers Res Ther"},{"issue":"2","key":"794_CR67","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/acer.13923","volume":"43","author":"EA Sneddon","year":"2019","unstructured":"Sneddon EA, White RD, Radke AK (2019) Sex differences in binge-like and aversion-resistant alcohol drinking in C57BL\/6J mice. Alcohol Clin Exp Res 43(2):243\u2013249. https:\/\/doi.org\/10.1111\/acer.13923","journal-title":"Alcohol Clin Exp Res"},{"issue":"11","key":"794_CR68","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.jalz.2016.08.004","volume":"12","author":"HM Snyder","year":"2016","unstructured":"Snyder HM, Asthana S, Bain L, Brinton R, Craft S, Dubal DB, Espeland MA, Gatz M, Mielke MM, Raber J, Rapp PR, Yaffe K, Carrillo MC (2016) Sex biology contributions to vulnerability to Alzheimer\u2019s disease: a think tank convened by the Women\u2019s Alzheimer\u2019s Research Initiative. Alzheimers Dement 12(11):1186\u20131196. https:\/\/doi.org\/10.1016\/j.jalz.2016.08.004","journal-title":"Alzheimers Dement"},{"key":"794_CR69","unstructured":"Substance Abuse and Mental Health Services Administration (2024) Key substance use and mental health indicators in the United States: Results from the 2023 National Survey on Drug Use and Health (HHS Publication No. PEP24\u201307\u2013021, NSDUH Series H-59. . Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration"},{"key":"794_CR70","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310808","author":"AU Syed","year":"2023","unstructured":"Syed AU, Liang C, Patel KK, Mondal R, Kamalia VM, Moran TR, Ahmed ST, Mukherjee J (2023) Comparison of monoamine oxidase-A, A\u03b2 plaques, tau, and translocator protein levels in postmortem human Alzheimer\u2019s disease brain. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms241310808","journal-title":"Int J Mol Sci"},{"key":"794_CR71","doi-asserted-by":"publisher","first-page":"5541","DOI":"10.2147\/IJN.S200490","volume":"14","author":"S Tiwari","year":"2019","unstructured":"Tiwari S, Atluri V, Kaushik A, Yndart A, Nair M (2019) Alzheimer\u2019s disease: pathogenesis, diagnostics, and therapeutics. Int J Nanomedicine 14:5541\u20135554. https:\/\/doi.org\/10.2147\/IJN.S200490","journal-title":"Int J Nanomedicine"},{"issue":"36","key":"794_CR72","doi-asserted-by":"publisher","first-page":"9002","DOI":"10.1073\/pnas.1801802115","volume":"115","author":"TC Tzeng","year":"2018","unstructured":"Tzeng TC, Hasegawa Y, Iguchi R, Cheung A, Caffrey DR, Thatcher EJ, Mao W, Germain G, Tamburro ND, Okabe S, Heneka MT, Latz E, Futai K, Golenbock DT (2018) Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice. Proc Natl Acad Sci U S A 115(36):9002\u20139007. https:\/\/doi.org\/10.1073\/pnas.1801802115","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"794_CR73","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107510","volume":"300","author":"I Ulku","year":"2024","unstructured":"Ulku I, Leung R, Herre F, Walther L, Shobo A, Saftig P, Hancock MA, Liebsch F, Multhaup G (2024) Inhibition of BACE1 affected both its Abeta producing and degrading activities and increased Abeta42 and Abeta40 levels at high-level BACE1 expression. J Biol Chem 300(8):107510. https:\/\/doi.org\/10.1016\/j.jbc.2024.107510","journal-title":"J Biol Chem"},{"issue":"3","key":"794_CR74","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.nbd.2006.05.010","volume":"23","author":"T van Groen","year":"2006","unstructured":"van Groen T, Kiliaan AJ, Kadish I (2006) Deposition of mouse amyloid \u03b2 in human APP\/PS1 double and single AD model transgenic mice. Neurobiol Dis 23(3):653\u2013662. https:\/\/doi.org\/10.1016\/j.nbd.2006.05.010","journal-title":"Neurobiol Dis"},{"issue":"3","key":"794_CR75","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.nbd.2003.08.009","volume":"14","author":"J Wang","year":"2003","unstructured":"Wang J, Tanila H, Puolivali J, Kadish I, van Groen T (2003) Gender differences in the amount and deposition of amyloid\u03b2 in APPswe and PS1 double transgenic mice. Neurobiol Dis 14(3):318\u2013327. https:\/\/doi.org\/10.1016\/j.nbd.2003.08.009","journal-title":"Neurobiol Dis"},{"issue":"2","key":"794_CR76","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/ahe.12896","volume":"52","author":"AA Warille","year":"2023","unstructured":"Warille AA, Kocaman A, Elamin AA, Mohamed H, Elhaj AE, Altunkaynak BZ (2023) Applications of various stereological tools for estimation of biological tissues. Anat Histol Embryol 52(2):127\u2013134. https:\/\/doi.org\/10.1111\/ahe.12896","journal-title":"Anat Histol Embryol"},{"key":"794_CR77","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2018.00049","volume":"12","author":"MJ West","year":"2018","unstructured":"West MJ (2018) Space balls revisited: stereological estimates of length with virtual isotropic surface probes. Front Neuroanat 12:49. https:\/\/doi.org\/10.3389\/fnana.2018.00049","journal-title":"Front Neuroanat"},{"issue":"5","key":"794_CR78","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1007\/s12264-018-0268-9","volume":"34","author":"JT Yang","year":"2018","unstructured":"Yang JT, Wang ZJ, Cai HY, Yuan L, Hu MM, Wu MN, Qi JS (2018) Sex differences in neuropathology and cognitive behavior in APP\/PS1\/tau triple-transgenic mouse model of Alzheimer\u2019s disease. Neurosci Bull 34(5):736\u2013746. https:\/\/doi.org\/10.1007\/s12264-018-0268-9","journal-title":"Neurosci Bull"},{"issue":"4","key":"794_CR79","first-page":"245","volume":"29","author":"S Zakhari","year":"2006","unstructured":"Zakhari S (2006) Overview: how is alcohol metabolized by the body? Alcohol Res Health 29(4):245\u2013254","journal-title":"Alcohol Res Health"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-026-00794-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-026-00794-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-026-00794-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:41:07Z","timestamp":1781642467000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12640-026-00794-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":79,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["794"],"URL":"https:\/\/doi.org\/10.1007\/s12640-026-00794-2","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"30 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14"}}