{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:17:22Z","timestamp":1787905042410,"version":"build-2784847793"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s12640-026-00807-0","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:44:17Z","timestamp":1783129457000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["EGF and GHRP6 Co-Administration Attenuates Cognitive Decline in Preclinical Models: Behavioral and Molecular Evidences"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6784-2446","authenticated-orcid":false,"given":"Daniela","family":"Risco-Acevedo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4024-7759","authenticated-orcid":false,"given":"Nelvys","family":"Subir\u00f3s-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8668-034X","authenticated-orcid":false,"given":"Hanlet","family":"Camacho-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2345-1923","authenticated-orcid":false,"given":"Jeney","family":"Ram\u00edrez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1794-8694","authenticated-orcid":false,"given":"Yaima","family":"Rodr\u00edguez-Virulich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Yansi","family":"Etchegoyen-Amoros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Hern\u00e1ndez-Estrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8916-4620","authenticated-orcid":false,"given":"Maylin","family":"Wong-Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9436-235X","authenticated-orcid":false,"given":"Yanay","family":"Montano-Peguero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9297-0911","authenticated-orcid":false,"given":"Thalia","family":"Estrada-Olivares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1970-5580","authenticated-orcid":false,"given":"Dasha","family":"Fuentes-Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9631-8336","authenticated-orcid":false,"given":"Daniel","family":"Palenzuela-Gard\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-4308","authenticated-orcid":false,"given":"H\u00e9ctor","family":"P\u00e9rez-Saad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-4518","authenticated-orcid":false,"given":"Yanier","family":"N\u00fa\u00f1ez-Figueredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5515-8272","authenticated-orcid":false,"given":"Li","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3098-0970","authenticated-orcid":false,"given":"Gerardo E.","family":"Guill\u00e9n-Nieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3654-490X","authenticated-orcid":false,"given":"Diana","family":"Garc\u00eda-del-Barco-Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"807_CR1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1159\/000262529","volume":"17","author":"D \u00c5berg","year":"2010","unstructured":"\u00c5berg D (2010) Role of the growth hormone\/insulin-like growth factor 1 axis in neurogenesis. Endocr Dev 17:63\u201376. https:\/\/doi.org\/10.1159\/000262529","journal-title":"Endocr Dev"},{"key":"807_CR2","doi-asserted-by":"publisher","first-page":"102210","DOI":"10.1016\/j.jchemneu.2022.102210","volume":"128","author":"L Aguilar-Hernandez","year":"2023","unstructured":"Aguilar-Hernandez L, Alejandre R, Morales-Medina JC, Iannitti T, Flores G (2023) Cellular mechanisms in brain aging: Focus on physiological and pathological aging. J Chem Neuroanat 128:102210. https:\/\/doi.org\/10.1016\/j.jchemneu.2022.102210","journal-title":"J Chem Neuroanat"},{"issue":"8","key":"807_CR3","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1038\/nn1938","volume":"10","author":"A Aguirre","year":"2007","unstructured":"Aguirre A, Dupree JL, Mangin JM, Gallo V (2007) A functional role for EGFR signaling in myelination and remyelination. Nat Neurosci 10(8):990\u20131002. https:\/\/doi.org\/10.1038\/nn1938","journal-title":"Nat Neurosci"},{"issue":"15","key":"807_CR4","doi-asserted-by":"publisher","first-page":"5245","DOI":"10.1158\/0008-5472.CAN-04-0496","volume":"64","author":"CL Andersen","year":"2004","unstructured":"Andersen CL, Jensen JL, \u00d8rntoft TF (2004) Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res 64(15):5245\u20135250. https:\/\/doi.org\/10.1158\/0008-5472.CAN-04-0496","journal-title":"Cancer Res"},{"key":"807_CR5","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s12035-009-8081-0","volume":"40","author":"A Annenkov","year":"2009","unstructured":"Annenkov A (2009) The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis. Mol Neurobiol 40:195\u2013215. https:\/\/doi.org\/10.1007\/s12035-009-8081-0","journal-title":"Mol Neurobiol"},{"issue":"2","key":"807_CR6","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","volume":"13","author":"M Antunes","year":"2012","unstructured":"Antunes M, Biala G (2012) The novel object recognition memory: neurobiology, test procedure, and its modifications. Cogn Process 13(2):93\u2013110. https:\/\/doi.org\/10.1007\/s10339-011-0430-z","journal-title":"Cogn Process"},{"issue":"5704","key":"807_CR7","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1126\/science.1103709","volume":"306","author":"HA Arnett","year":"2004","unstructured":"Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD (2004) bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science 306(5704):2111\u20132115. https:\/\/doi.org\/10.1126\/science.1103709","journal-title":"Science"},{"issue":"2","key":"807_CR8","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.brainres.2005.07.035","volume":"1056","author":"K Baldauf","year":"2005","unstructured":"Baldauf K, Reymann KG (2005) Influence of EGF\/bFGF treatment on proliferation, early neurogenesis and infarct volume after transient focal ischemia. Brain Res 1056(2):158\u2013167. https:\/\/doi.org\/10.1016\/j.brainres.2005.07.035","journal-title":"Brain Res"},{"key":"807_CR9","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3389\/fnagi.2017.00347","volume":"9","author":"J Bao","year":"2017","unstructured":"Bao J, Mahaman YA, Liu R, Wang J-Z, Zhang Z, Zhang B, Wang X (2017) Sex differences in the cognitive and hippocampal effects of streptozotocin in an animal model of sporadic AD. Front Aging Neurosci 9:347. https:\/\/doi.org\/10.3389\/fnagi.2017.00347","journal-title":"Front Aging Neurosci"},{"key":"807_CR10","doi-asserted-by":"publisher","first-page":"1476909","DOI":"10.3389\/fnagi.2024.1476909","volume":"16","author":"FJ Barrantes","year":"2024","unstructured":"Barrantes FJ (2024) Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders. Front Aging Neurosci 16:1476909. https:\/\/doi.org\/10.3389\/fnagi.2024.1476909","journal-title":"Front Aging Neurosci"},{"issue":"4","key":"807_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11064-025-04467-y","volume":"50","author":"A Bavafa","year":"2025","unstructured":"Bavafa A, Meftahi GH, Pirzad Jahromi G (2025) Multidimensional evaluation of the streptozotocin-induced Alzheimer\u2019s model: integrating molecular, histopathological, and behavioral correlates over time. Neurochem Res 50(4):1\u201314. https:\/\/doi.org\/10.1007\/s11064-025-04467-y","journal-title":"Neurochem Res"},{"issue":"7","key":"807_CR12","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.tips.2020.04.008","volume":"41","author":"O Benek","year":"2020","unstructured":"Benek O, Korabecny J, Soukup O (2020) A perspective on multi-target drugs for Alzheimer\u2019s disease. Trends Pharmacol Sci 41(7):434\u2013445. https:\/\/doi.org\/10.1016\/j.tips.2020.04.008","journal-title":"Trends Pharmacol Sci"},{"issue":"2","key":"807_CR13","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.neuroscience.2005.08.029","volume":"137","author":"TS Benice","year":"2006","unstructured":"Benice TS, Rizk A, Kohama S, Pfankuch T, Raber J (2006) Sex-differences in age-related cognitive decline in C57BL\/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivity. Neuroscience 137(2):413\u2013423. https:\/\/doi.org\/10.1016\/j.neuroscience.2005.08.029","journal-title":"Neuroscience"},{"issue":"4","key":"807_CR14","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.ymeth.2010.01.009","volume":"50","author":"A Bergkvist","year":"2010","unstructured":"Bergkvist A, Rusnakova V, Sindelka R, Garda JMA, Sj\u00f6green B, Lindh D et al (2010) Gene expression profiling\u2013clusters of possibilities. Methods 50(4):323\u2013335. https:\/\/doi.org\/10.1016\/j.ymeth.2010.01.009","journal-title":"Methods"},{"key":"807_CR15","doi-asserted-by":"publisher","first-page":"1402138","DOI":"10.3389\/fphar.2024.1402138","volume":"15","author":"J Berlanga-Acosta","year":"2024","unstructured":"Berlanga-Acosta J, Cibrian D, Valiente-Mustelier J, Su\u00e1rez-Alba J, Garc\u00eda-Ojalvo A, Falc\u00f3n-Cama V et al (2024) Growth hormone releasing peptide-6 (GHRP-6) prevents doxorubicin-induced myocardial and extra-myocardial damages by activating prosurvival mechanisms. Front Pharmacol 15:1402138. https:\/\/doi.org\/10.3389\/fphar.2024.1402138","journal-title":"Front Pharmacol"},{"issue":"5","key":"807_CR16","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1007\/s10787-024-01502-2","volume":"32","author":"S Bhardwaj","year":"2024","unstructured":"Bhardwaj S, Grewal AK, Singh S, Dhankar V, Jindal A (2024) An insight into the concept of neuroinflammation and neurodegeneration in Alzheimer\u2019s disease: targeting molecular approach Nrf2, NF-\u03baB, and CREB. Inflammopharmacology 32(5):2943\u20132960. https:\/\/doi.org\/10.1007\/s10787-024-01502-2","journal-title":"Inflammopharmacology"},{"key":"807_CR17","doi-asserted-by":"publisher","first-page":"102795","DOI":"10.1016\/j.redox.2023.102795","volume":"64","author":"K Bode","year":"2023","unstructured":"Bode K, Hauri-Hohl M, Jaquet V, Weyd H (2023) Unlocking the power of NOX2: a comprehensive review on its role in immune regulation. Redox Biol 64:102795. https:\/\/doi.org\/10.1016\/j.redox.2023.102795","journal-title":"Redox Biol"},{"issue":"2","key":"807_CR18","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1007\/s12035-014-8657-1","volume":"50","author":"F Brosseron","year":"2014","unstructured":"Brosseron F, Krauthausen M, Kummer M, Heneka MT (2014) Body fluid cytokine levels in mild cognitive impairment and Alzheimer\u2019s disease: a comparative overview. Mol Neurobiol 50(2):534\u2013544. https:\/\/doi.org\/10.1007\/s12035-014-8657-1","journal-title":"Mol Neurobiol"},{"issue":"3","key":"807_CR19","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/bcp.12357","volume":"78","author":"S Cahill-Smith","year":"2014","unstructured":"Cahill-Smith S, Li JM (2014) Oxidative stress, redox signalling and endothelial dysfunction in ageing-related neurodegenerative diseases: a role of NADPH oxidase 2. B J Clin Pharmacol 78(3):441\u2013453. https:\/\/doi.org\/10.1111\/bcp.12357","journal-title":"B J Clin Pharmacol"},{"issue":"4","key":"807_CR20","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1002\/ana.22271","volume":"69","author":"AS Chen-Plotkin","year":"2011","unstructured":"Chen-Plotkin AS, Hu WT, Siderowf A, Weintraub D, Goldmann Gross R, Hurtig HI et al (2011) Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease. Ann Neurol 69(4):655\u2013663. https:\/\/doi.org\/10.1002\/ana.22271","journal-title":"Ann Neurol"},{"issue":"6","key":"807_CR21","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.ghir.2009.05.001","volume":"19","author":"LJ Christophidis","year":"2009","unstructured":"Christophidis LJ, Gorba T, Gustavsson M, Williams CE, Werther GA, Russo VC et al (2009) Growth hormone receptor immunoreactivity is increased in the subventricular zone of juvenile rat brain after focal ischemia: A potential role for growth hormone in injury-induced neurogenesis. Growth Horm IGF Res 19(6):497\u2013506. https:\/\/doi.org\/10.1016\/j.ghir.2009.05.001","journal-title":"Growth Horm IGF Res"},{"issue":"10","key":"807_CR22","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/s41593-018-0236-8","volume":"21","author":"TM Dawson","year":"2018","unstructured":"Dawson TM, Golde TE, Lagier-Tourenne C (2018) Animal models of neurodegenerative diseases. Nat Neurosci 21(10):1370\u20131379. https:\/\/doi.org\/10.1038\/s41593-018-0236-8","journal-title":"Nat Neurosci"},{"issue":"4","key":"807_CR23","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3233\/rnn-2011-0595","volume":"29","author":"DG del Barco","year":"2011","unstructured":"del Barco DG, Montero E, Coro-Antich RM, Brown E, Suarez-Alba J, Lopez L et al (2011a) Coadministration of epidermal growth factor and growth hormone releasing peptide-6 improves clinical recovery in experimental autoimmune encephalitis. Restor Neurol Neurosci 29(4):243\u2013252. https:\/\/doi.org\/10.3233\/rnn-2011-0595","journal-title":"Restor Neurol Neurosci"},{"issue":"1","key":"807_CR24","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s12640-010-9160-8","volume":"19","author":"DG del Barco","year":"2011","unstructured":"del Barco DG, P\u00e9rez-Saad H, Rodr\u00edguez V, Mar\u00edn J, Falc\u00f3n V, Mart\u00edn J et al (2011b) Therapeutic effect of the combined use of growth hormone releasing peptide-6 and epidermal growth factor in an axonopathy model. Neurotox Res 19(1):195\u2013209. https:\/\/doi.org\/10.1007\/s12640-010-9160-8","journal-title":"Neurotox Res"},{"key":"807_CR25","doi-asserted-by":"publisher","first-page":"1476971","DOI":"10.3389\/fnhum.2024.1476971","volume":"18","author":"F d'Oleire Uquillas","year":"2024","unstructured":"d\u2019Oleire Uquillas F, Falck RS, Oken BS (2024) The cognitive neuroscience of aging: where we are and where we are going. Front Hum Neurosci 18:1476971. https:\/\/doi.org\/10.3389\/fnhum.2024.1476971","journal-title":"Front Hum Neurosci"},{"issue":"4","key":"807_CR26","doi-asserted-by":"publisher","first-page":"3866","DOI":"10.3390\/ijms24043866","volume":"24","author":"Y El Ouaamari","year":"2023","unstructured":"El Ouaamari Y, Van den Bos J, Willekens B, Cools N, Wens I (2023) Neurotrophic factors as regenerative therapy for neurodegenerative diseases: current status, challenges and future perspectives. Int J Mol Sci 24(4):3866. https:\/\/doi.org\/10.3390\/ijms24043866","journal-title":"Int J Mol Sci"},{"issue":"1","key":"807_CR27","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","volume":"31","author":"A Ennaceur","year":"1988","unstructured":"Ennaceur A, Delacour J (1988) A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data. Beh Brain Res 31(1):47\u201359. https:\/\/doi.org\/10.1016\/0166-4328(88)90157-X","journal-title":"Beh Brain Res"},{"issue":"4","key":"807_CR28","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.3390\/ijms24043739","volume":"24","author":"M Fields","year":"2023","unstructured":"Fields M, Marcuzzi A, Gonelli A, Celeghini C, Maximova N, Rimondi E (2023) Mitochondria-targeted antioxidants, an innovative class of antioxidant compounds for neurodegenerative diseases: perspectives and limitations. Int J Mol Sci 24(4):3739. https:\/\/doi.org\/10.3390\/ijms24043739","journal-title":"Int J Mol Sci"},{"issue":"3","key":"807_CR29","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1515\/revneuro.2010.21.3.187","volume":"21","author":"AM Fjell","year":"2010","unstructured":"Fjell AM, Walhovd KB (2010) Structural brain changes in aging: courses, causes and cognitive consequences. Rev Neurosci 21(3):187\u2013222. https:\/\/doi.org\/10.1515\/revneuro.2010.21.3.187","journal-title":"Rev Neurosci"},{"key":"807_CR30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.brainres.2010.11.040","volume":"1376","author":"K Gampe","year":"2011","unstructured":"Gampe K, Brill MS, Momma S, G\u00f6tz M, Zimmermann H (2011) EGF induces CREB and ERK activation at the wall of the mouse lateral ventricles. Brain Res 1376:31\u201341. https:\/\/doi.org\/10.1016\/j.brainres.2010.11.040","journal-title":"Brain Res"},{"issue":"2","key":"807_CR31","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3233\/rnn-120262","volume":"31","author":"D Garc\u00eda Del Barco-Herrera","year":"2013","unstructured":"Garc\u00eda Del Barco-Herrera D, Mart\u00ednez NS, Coro-Antich RM, Machado JM, Alba JS, Salgueiro SR et al (2013) Epidermal growth factor and growth hormone-releasing peptide-6: combined therapeutic approach in experimental stroke. Restor Neurol Neurosci 31(2):213\u2013223. https:\/\/doi.org\/10.3233\/rnn-120262","journal-title":"Restor Neurol Neurosci"},{"issue":"1","key":"807_CR32","doi-asserted-by":"publisher","first-page":"T171","DOI":"10.1530\/JME-18-0093","volume":"61","author":"S Gubbi","year":"2018","unstructured":"Gubbi S, Quipildor GF, Barzilai N, Huffman DM, Milman S (2018) 40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain. J Mol Endocrinol 61(1):T171\u2013T185. https:\/\/doi.org\/10.1530\/JME-18-0093","journal-title":"J Mol Endocrinol"},{"issue":"9","key":"807_CR33","doi-asserted-by":"publisher","first-page":"e13083","DOI":"10.1371\/journal.pone.0013083","volume":"5","author":"X Guo","year":"2010","unstructured":"Guo X, Harada C, Namekata K, Mitamura Y, Yoshida H, Matsumoto Y et al (2010) Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice. PLoS ONE 5(9):e13083. https:\/\/doi.org\/10.1371\/journal.pone.0013083","journal-title":"PLoS ONE"},{"issue":"2","key":"807_CR34","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2307\/1164588","volume":"6","author":"LV Hedges","year":"1981","unstructured":"Hedges LV (1981) Distribution theory for Glass\u2019s estimator of effect size and related estimators. J Educ Stat 6(2):107\u2013128. https:\/\/doi.org\/10.2307\/1164588","journal-title":"J Educ Stat"},{"key":"807_CR35","doi-asserted-by":"publisher","first-page":"113649","DOI":"10.1016\/j.bbr.2021.113649","volume":"418","author":"JO Hendrickx","year":"2022","unstructured":"Hendrickx JO, De Moudt S, Calus E, De Deyn PP, Van Dam D, De Meyer GR (2022) Age-related cognitive decline in spatial learning and memory of C57BL\/6J mice. Behav Brain Res 418:113649. https:\/\/doi.org\/10.1016\/j.bbr.2021.113649","journal-title":"Behav Brain Res"},{"issue":"4","key":"807_CR36","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","volume":"14","author":"MT Heneka","year":"2015","unstructured":"Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL et al (2015) Neuroinflammation in Alzheimer\u2019s disease. Lancet Neurol 14(4):388\u2013405. https:\/\/doi.org\/10.1016\/S1474-4422(15)70016-5","journal-title":"Lancet Neurol"},{"key":"807_CR37","doi-asserted-by":"publisher","first-page":"1303402","DOI":"10.3389\/fneur.2024.1303402","volume":"15","author":"F Hern\u00e1ndez-Bernal","year":"2024","unstructured":"Hern\u00e1ndez-Bernal F, Estenoz-Garc\u00eda D, Guti\u00e9rrez-Ronquillo JH, Mart\u00edn-Bauta Y, Catas\u00fas-\u00c1lvarez K, Guti\u00e9rrez-Castillo M et al (2024) Combination therapy of Epidermal Growth Factor and Growth Hormone-Releasing Hexapeptide in acute ischemic stroke: a phase I\/II non-blinded, randomized clinical trial. Front Neurol 15:1303402. https:\/\/doi.org\/10.3389\/fneur.2024.1303402","journal-title":"Front Neurol"},{"issue":"4","key":"807_CR38","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1073\/pnas.94.4.1500","volume":"94","author":"CJ Heyser","year":"1997","unstructured":"Heyser CJ, Masliah E, Samimi A, Campbell IL, Gold LH (1997) Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain. Proc Natl Acad Sci 94(4):1500\u20131505. https:\/\/doi.org\/10.1073\/pnas.94.4.1500","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"807_CR39","doi-asserted-by":"publisher","first-page":"fcad356","DOI":"10.1093\/braincomms\/fcad356","volume":"6","author":"A Houldsworth","year":"2024","unstructured":"Houldsworth A (2024) Role of oxidative stress in neurodegenerative disorders: a review of reactive oxygen species and prevention by antioxidants. Brain Commun 6(1):fcad356. https:\/\/doi.org\/10.1093\/braincomms\/fcad356","journal-title":"Brain Commun"},{"issue":"6","key":"807_CR40","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1007\/BF00571510","volume":"89","author":"M Huell","year":"1995","unstructured":"Huell M, Strauss S, Volk B, Berger M, Bauer J (1995) Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer\u2019s disease patients. Acta Neuropathol 89(6):544\u2013551. https:\/\/doi.org\/10.1007\/BF00571510","journal-title":"Acta Neuropathol"},{"issue":"1","key":"807_CR41","doi-asserted-by":"publisher","first-page":"pyae038","DOI":"10.1093\/ijnp\/pyae038","volume":"28","author":"D Jin","year":"2025","unstructured":"Jin D, Zhang M, Shi L, Liu H (2025) Investigating the impact of IL-6 and CXCL8 on neurodegeneration and cognitive decline in Alzheimer disease. Int J Neuropsychopharmacol 28(1):pyae038. https:\/\/doi.org\/10.1093\/ijnp\/pyae038","journal-title":"Int J Neuropsychopharmacol"},{"issue":"7","key":"807_CR42","doi-asserted-by":"publisher","first-page":"4548","DOI":"10.1007\/s12035-015-9384-y","volume":"53","author":"PK Kamat","year":"2016","unstructured":"Kamat PK, Kalani A, Rai S, Tota SK, Kumar A, Ahmad AS (2016) Streptozotocin intracerebroventricular-induced neurotoxicity and brain insulin resistance: a therapeutic intervention for treatment of sporadic Alzheimer\u2019s disease (sAD)-like pathology. Mol Neurobiol 53(7):4548\u20134562. https:\/\/doi.org\/10.1007\/s12035-015-9384-y","journal-title":"Mol Neurobiol"},{"key":"807_CR43","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.peptides.2015.07.005","volume":"71","author":"S Kang","year":"2015","unstructured":"Kang S, Moon NR, Kim DS, Kim SH, Park S (2015) Central acylated ghrelin improves memory function and hippocampal AMPK activation and partly reverses the impairment of energy and glucose metabolism in rats infused with \u03b2-amyloid. Peptides 71:84\u201393. https:\/\/doi.org\/10.1016\/j.peptides.2015.07.005","journal-title":"Peptides"},{"key":"807_CR44","doi-asserted-by":"publisher","first-page":"1400533","DOI":"10.3389\/fimmu.2024.1400533","volume":"15","author":"I Kerkis","year":"2024","unstructured":"Kerkis I, Silva \u00c1Pd, Araldi RP (2024) The impact of interleukin-6 (IL-6) and mesenchymal stem cell-derived IL-6 on neurological conditions. Front Immunol 15:1400533. https:\/\/doi.org\/10.3389\/fimmu.2024.1400533","journal-title":"Front Immunol"},{"issue":"4","key":"807_CR45","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.exger.2006.10.011","volume":"42","author":"K-H Krause","year":"2007","unstructured":"Krause K-H (2007) Aging: a revisited theory based on free radicals generated by NOX family NADPH oxidases. Exp Gerontol 42(4):256\u2013262. https:\/\/doi.org\/10.1016\/j.exger.2006.10.011","journal-title":"Exp Gerontol"},{"key":"807_CR46","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/0031-9384(90)90364-A","volume":"47","author":"Y Lamberty","year":"1990","unstructured":"Lamberty Y, Gower AJ (1990) Age-related changes in spontaneous behavior and learning in NMRI mice from maturity to middle age. Physiol Behav 47:1137\u20131144. https:\/\/doi.org\/10.1016\/0031-9384(90)90364-A","journal-title":"Physiol Behav"},{"issue":"12","key":"807_CR47","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1038\/nprot.2013.155","volume":"8","author":"M Leger","year":"2013","unstructured":"Leger M, Quiedeville A, Bouet V, Haelewyn B, Boulouard M, Schumann-Bard P et al (2013) Object recognition test in mice. Nat Protoc 8(12):2531\u20132537. https:\/\/doi.org\/10.1038\/nprot.2013.155","journal-title":"Nat Protoc"},{"key":"807_CR48","doi-asserted-by":"publisher","first-page":"1453772","DOI":"10.3389\/fnagi.2024.1453772","volume":"16","author":"J Li","year":"2024","unstructured":"Li J, Wang Y, Xiong K, Gao C (2024) Neuroinflammation and cognitive impairment. Front Aging Neurosci 16:1453772. https:\/\/doi.org\/10.3389\/fnagi.2024.1453772","journal-title":"Front Aging Neurosci"},{"issue":"5","key":"807_CR49","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1002\/acn3.299","volume":"3","author":"NS Lim","year":"2016","unstructured":"Lim NS, Swanson CR, Cherng HR, Unger TL, Xie SX, Weintraub D et al (2016) Plasma EGF and cognitive decline in Parkinson\u2019s disease and Alzheimer\u2019s disease. Ann Clin Transl Neurol 3(5):346\u2013355. https:\/\/doi.org\/10.1002\/acn3.299","journal-title":"Ann Clin Transl Neurol"},{"issue":"10","key":"807_CR50","doi-asserted-by":"publisher","first-page":"e3329","DOI":"10.1371\/journal.pone.0003329","volume":"3","author":"PM Loerch","year":"2008","unstructured":"Loerch PM, Lu T, Dakin KA, Vann JM, Isaacs A, Geula C et al (2008) Evolution of the aging brain transcriptome and synaptic regulation. PLoS ONE 3(10):e3329. https:\/\/doi.org\/10.1371\/journal.pone.0003329","journal-title":"PLoS ONE"},{"issue":"4","key":"807_CR51","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1097\/WAD.0b013e31820ce536","volume":"25","author":"L-y Ma","year":"2011","unstructured":"Ma L-y, Zhang D-m, Tang Y, Lu Y, Zhang Y, Gao Y et al (2011) Ghrelin-attenuated cognitive dysfunction in streptozotocin-induced diabetic rats. Alzheimer Dis Assoc Disord 25(4):352\u2013363. https:\/\/doi.org\/10.1097\/WAD.0b013e31820ce536","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"9","key":"807_CR52","doi-asserted-by":"publisher","first-page":"e22508","DOI":"10.1096\/fj.202200634R","volume":"36","author":"Y Ma","year":"2022","unstructured":"Ma Y, Zhang H, Guo W, Yu L (2022) Potential role of ghrelin in the regulation of inflammation. FASEB J 36(9):e22508. https:\/\/doi.org\/10.1096\/fj.202200634R","journal-title":"FASEB J"},{"issue":"1","key":"807_CR53","doi-asserted-by":"publisher","first-page":"33","DOI":"10.4449\/aib.v151i1.1461","volume":"151","author":"V Paramanik","year":"2013","unstructured":"Paramanik V, Thakur MK (2013) Role of CREB signaling in aging brain. Arch Ital Biol 151(1):33\u201342. https:\/\/doi.org\/10.4449\/aib.v151i1.1461","journal-title":"Arch Ital Biol"},{"issue":"1","key":"807_CR54","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.yexcr.2004.01.002","volume":"295","author":"RA Quintanilla","year":"2004","unstructured":"Quintanilla RA, Orellana DI, Gonz\u00e1lez-Billault C, Maccioni RB (2004) Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5\/p35 pathway. Exp Cell Res 295(1):245\u2013257. https:\/\/doi.org\/10.1016\/j.yexcr.2004.01.002","journal-title":"Exp Cell Res"},{"key":"807_CR55","doi-asserted-by":"publisher","first-page":"102358","DOI":"10.1016\/j.ceca.2021.102358","volume":"94","author":"CI Radulescu","year":"2021","unstructured":"Radulescu CI, Cerar V, Haslehurst P, Kopanitsa M, Barnes SJ (2021) The aging mouse brain: cognition, connectivity and calcium. Cell Calcium 94:102358. https:\/\/doi.org\/10.1016\/j.ceca.2021.102358","journal-title":"Cell Calcium"},{"issue":"18","key":"807_CR56","doi-asserted-by":"publisher","first-page":"10087","DOI":"10.3390\/ijms221810087","volume":"22","author":"L Regner-Nelke","year":"2021","unstructured":"Regner-Nelke L, Nelke C, Schroeter CB, Dziewas R, Warnecke T, Ruck T, Meuth SG (2021) Enjoy carefully: the multifaceted role of vitamin E in neuro-nutrition. Int J Mol Sci 22(18):10087. https:\/\/doi.org\/10.3390\/ijms221810087","journal-title":"Int J Mol Sci"},{"issue":"12","key":"807_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00221-025-07183-9","volume":"243","author":"D Risco-Acevedo","year":"2025","unstructured":"Risco-Acevedo D, Subir\u00f3s-Mart\u00ednez N, Camacho-Rodr\u00edguez H, Ram\u00edrez-S\u00e1nchez J, Rodr\u00edguez-Virulich Y, Etchegoyen-Amoros A et al (2025) The impact of aging on cognitive and motor functions: a molecular and behavioral study in female C57BL\/6 mice. Exp Brain Res 243(12):1\u201313. https:\/\/doi.org\/10.1007\/s00221-025-07183-9","journal-title":"Exp Brain Res"},{"key":"807_CR58","doi-asserted-by":"crossref","unstructured":"Romano R, Bucci C (2020) Role of EGFR in the Nervous System. Cells 9(8):1887. https:\/\/www.mdpi.com\/2073-4409\/9\/8\/1887","DOI":"10.3390\/cells9081887"},{"issue":"4","key":"807_CR59","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3390\/biom8040124","volume":"8","author":"B Salehi","year":"2018","unstructured":"Salehi B, Martorell M, Arbiser JL, Sureda A, Martins N, Maurya PK et al (2018) Antioxidants: positive or negative actors? Biomolecules 8(4):124. https:\/\/doi.org\/10.3390\/biom8040124","journal-title":"Biomolecules"},{"issue":"17","key":"807_CR60","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1002\/1873-3468.14995","volume":"598","author":"DF Santos","year":"2024","unstructured":"Santos DF, Sim\u00e3o S, N\u00f3brega C, Bragan\u00e7a J, Castelo-Branco P, Ara\u00fajo IM et al (2024) Oxidative stress and aging: synergies for age related diseases. FEBS Lett 598(17):2074\u20132091. https:\/\/doi.org\/10.1002\/1873-3468.14995","journal-title":"FEBS Lett"},{"issue":"2","key":"807_CR61","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1515\/RNS.2011.018","volume":"22","author":"CA Saura","year":"2011","unstructured":"Saura CA, Valero J (2011) The role of CREB signaling in Alzheimer\u2019s disease and other cognitive disorders. Rev Neurosci 22(2):153\u2013169. https:\/\/doi.org\/10.1515\/RNS.2011.018","journal-title":"Rev Neurosci"},{"issue":"2","key":"807_CR62","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1021\/acs.chemrev.8b00138","volume":"119","author":"MG Savelieff","year":"2018","unstructured":"Savelieff MG, Nam G, Kang J, Lee HJ, Lee M, Lim MH (2018) Development of multifunctional molecules as potential therapeutic candidates for Alzheimer\u2019s disease, Parkinson\u2019s disease, and amyotrophic lateral sclerosis in the last decade. Chem Rev 119(2):1221\u20131322. https:\/\/doi.org\/10.1021\/acs.chemrev.8b00138","journal-title":"Chem Rev"},{"issue":"4","key":"807_CR63","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.arr.2004.05.002","volume":"3","author":"F Serrano","year":"2004","unstructured":"Serrano F, Klann E (2004) Reactive oxygen species and synaptic plasticity in the aging hippocampus. Ageing Res Rev 3(4):431\u2013443. https:\/\/doi.org\/10.1016\/j.arr.2004.05.002","journal-title":"Ageing Res Rev"},{"issue":"7","key":"807_CR64","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1080\/00207454.2016.1212854","volume":"127","author":"T Shabab","year":"2017","unstructured":"Shabab T, Khanabdali R, Moghadamtousi SZ, Kadir HA, Mohan G (2017) Neuroinflammation pathways: a general review. Int J Neurosci 127(7):624\u2013633. https:\/\/doi.org\/10.1080\/00207454.2016.1212854","journal-title":"Int J Neurosci"},{"issue":"4","key":"807_CR65","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1007\/s11064-023-04085-6","volume":"49","author":"C Shan","year":"2024","unstructured":"Shan C, Zhang C, Zhang C (2024) The role of IL-6 in neurodegenerative disorders. Neurochem Res 49(4):834\u2013846. https:\/\/doi.org\/10.1007\/s11064-023-04085-6","journal-title":"Neurochem Res"},{"issue":"14","key":"807_CR66","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.2174\/1567205018666210218152253","volume":"17","author":"VK Sharma","year":"2020","unstructured":"Sharma VK, Singh TG (2020) CREB: a multifaceted target for Alzheimer\u2019s disease. Curr Alzheimer Res 17(14):1280\u20131293. https:\/\/doi.org\/10.2174\/1567205018666210218152253","journal-title":"Curr Alzheimer Res"},{"issue":"1","key":"807_CR67","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.sxmr.2017.02.004","volume":"6","author":"JT Sigalos","year":"2018","unstructured":"Sigalos JT, Pastuszak AW (2018) The safety and efficacy of growth hormone secretagogues. Sex Med Rev 6(1):45\u201353. https:\/\/doi.org\/10.1016\/j.sxmr.2017.02.004","journal-title":"Sex Med Rev"},{"issue":"7","key":"807_CR68","doi-asserted-by":"publisher","first-page":"e70487","DOI":"10.1371\/journal.pone.0070487","volume":"8","author":"RK Sodhi","year":"2013","unstructured":"Sodhi RK, Singh N (2013) Defensive effect of lansoprazole in dementia of AD type in mice exposed to streptozotocin and cholesterol enriched diet. PLoS ONE 8(7):e70487. https:\/\/doi.org\/10.1371\/journal.pone.0070487","journal-title":"PLoS ONE"},{"issue":"5","key":"807_CR69","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/1873-3468.12902","volume":"592","author":"R Stefanatos","year":"2018","unstructured":"Stefanatos R, Sanz A (2018) The role of mitochondrial ROS in the aging brain. FEBS Lett 592(5):743\u2013758. https:\/\/doi.org\/10.1002\/1873-3468.12902","journal-title":"FEBS Lett"},{"issue":"1","key":"807_CR70","first-page":"21","volume":"1","author":"D Stott","year":"2006","unstructured":"Stott D (2006) Cognitive decline in ageing. AJGG 1(1):21\u201325","journal-title":"AJGG"},{"issue":"3","key":"807_CR71","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1179\/1743132815y.0000000089","volume":"38","author":"N Subir\u00f3s","year":"2016","unstructured":"Subir\u00f3s N, P\u00e9rez-Saad HM, Berlanga JA, Aldana L, Garc\u00eda-Illera G, Gibson CL et al (2016a) Assessment of dose-effect and therapeutic time window in preclinical studies of rhEGF and GHRP-6 coadministration for stroke therapy. Neurol Res 38(3):187\u2013195. https:\/\/doi.org\/10.1179\/1743132815y.0000000089","journal-title":"Neurol Res"},{"issue":"11","key":"807_CR72","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1080\/01616412.2016.1235249","volume":"38","author":"N Subir\u00f3s","year":"2016","unstructured":"Subir\u00f3s N, P\u00e9rez-Saad H, Aldana L, Gibson CL, Borgnakke WS, Garcia-Del-Barco D (2016b) Neuroprotective effect of epidermal growth factor plus growth hormone-releasing peptide-6 resembles hypothermia in experimental stroke. Neurol Res 38(11):950\u2013958. https:\/\/doi.org\/10.1080\/01616412.2016.1235249","journal-title":"Neurol Res"},{"issue":"10","key":"807_CR73","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.biopsych.2010.06.012","volume":"68","author":"W Swardfager","year":"2010","unstructured":"Swardfager W, Lanct\u00f4t K, Rothenburg L, Wong A, Cappell J, Herrmann N (2010) A meta-analysis of cytokines in Alzheimer\u2019s disease. Biol Psychiatry 68(10):930\u2013941. https:\/\/doi.org\/10.1016\/j.biopsych.2010.06.012","journal-title":"Biol Psychiatry"},{"issue":"1","key":"807_CR74","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s13311-014-0327-5","volume":"12","author":"AF Teich","year":"2015","unstructured":"Teich AF, Nicholls RE, Puzzo D, Fiorito J, Purgatorio R, Arancio O (2015) Synaptic therapy in Alzheimer\u2019s disease: a CREB-centric approach. Neurotherapeutics 12(1):29\u201341. https:\/\/doi.org\/10.1007\/s13311-014-0327-5","journal-title":"Neurotherapeutics"},{"issue":"2","key":"807_CR75","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s11596-010-0210-5","volume":"30","author":"C Tian","year":"2010","unstructured":"Tian C, Ye F, Xu T, Wang S, Wang X, Wang H et al (2010) GHRP-6 induces CREB phosphorylation and growth hormone secretion via a protein kinase C\u03c3-dependent pathway in GH3 cells. J Huazhong Univ Sci Technolog Med Sci 30(2):183\u2013187. https:\/\/doi.org\/10.1007\/s11596-010-0210-5","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"issue":"1","key":"807_CR76","doi-asserted-by":"publisher","first-page":"e0147733","DOI":"10.1371\/journal.pone.0147733","volume":"11","author":"A Wolf","year":"2016","unstructured":"Wolf A, Bauer B, Abner EL, Ashkenazy-Frolinger T, Hartz AM (2016) A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6\/Tg2576 Mice. PLoS ONE 11(1):e0147733. https:\/\/doi.org\/10.1371\/journal.pone.0147733","journal-title":"PLoS ONE"},{"key":"807_CR77","doi-asserted-by":"publisher","first-page":"115385","DOI":"10.1016\/j.bbr.2024.115385","volume":"480","author":"M Wong-Guerra","year":"2025","unstructured":"Wong-Guerra M, Montano-Peguero Y, Hernandez-Ensenat D, Ram\u00edrez-S\u00e1nchez J, Mondelo-Rodriguez A, Padr\u00f3n-Yaquis AS et al (2025) Mitochondrial protective properties exerted by JM-20 in a dementia model induced by intracerebroventricular administration of streptozotocin in mice. Behav Brain Res 480:115385. https:\/\/doi.org\/10.1016\/j.bbr.2024.115385","journal-title":"Behav Brain Res"},{"issue":"8","key":"807_CR78","doi-asserted-by":"publisher","first-page":"3905","DOI":"10.3390\/ijms26083905","volume":"26","author":"H Xing","year":"2025","unstructured":"Xing H, Yue S, Qin R, Du X, Wu Y, Zhangsun D, Luo S (2025) Recent advances in drug development for Alzheimer\u2019s disease: a comprehensive review. Int J Mol Sci 26(8):3905. https:\/\/doi.org\/10.3390\/ijms26083905","journal-title":"Int J Mol Sci"},{"issue":"5","key":"807_CR79","doi-asserted-by":"publisher","first-page":"e03919","DOI":"10.1016\/j.heliyon.2020.e03919","volume":"6","author":"S Zaldua","year":"2020","unstructured":"Zaldua S, Damen FC, Pisharody R, Thomas R, Fan KD, Ekkurthi GK et al (2020) Epidermal growth factor treatment of female mice that express APOE4 at an age of advanced pathology mitigates behavioral and cerebrovascular dysfunction. Heliyon 6(5):e03919. https:\/\/doi.org\/10.1016\/j.heliyon.2020.e03919","journal-title":"Heliyon"},{"issue":"12","key":"807_CR80","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1002\/mrd.23285","volume":"86","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Yang J, Yang J, Li J, Zhang M (2019) CREB activity is required for epidermal growth factor-induced mouse cumulus expansion. Mol Reprod Dev 86(12):1887\u20131900. https:\/\/doi.org\/10.1002\/mrd.23285","journal-title":"Mol Reprod Dev"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-026-00807-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-026-00807-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-026-00807-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:24:29Z","timestamp":1787901869000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12640-026-00807-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":80,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["807"],"URL":"https:\/\/doi.org\/10.1007\/s12640-026-00807-0","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]},"assertion":[{"value":"31 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"31"}}