{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:32:13Z","timestamp":1793302333063,"version":"4.5.0"},"reference-count":197,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Science and Engineering Research Board, Department of Science and Technology, Government of India","award":["POWER grant SPG\/2021\/002880"],"award-info":[{"award-number":["POWER grant SPG\/2021\/002880"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurotox Res"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s12640-026-00827-w","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:31:57Z","timestamp":1789183917000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetics of \u03b1-Synuclein: The Prime Pathological Player of Parkinson\u2019s Disease"],"prefix":"10.1007","volume":"44","author":[{"given":"Tanveera Rounaque","family":"Sarhadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atchaya","family":"Raveendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janhavee Shirish","family":"Panse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6101-8966","authenticated-orcid":false,"given":"Shirisha","family":"Nagotu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"827_CR1","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1038\/466S6a","volume":"466","author":"A Abbott","year":"2010","unstructured":"Abbott A (2010) Levodopa: the story so far. Nature 466:S6\u2013S7. https:\/\/doi.org\/10.1038\/466S6a","journal-title":"Nature"},{"key":"827_CR2","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1021\/acschemneuro.8b00448","volume":"10","author":"DL Abeyawardhane","year":"2019","unstructured":"Abeyawardhane DL, Heitger DR, Fern\u00e1ndez RD, Forney AK, Lucas HR (2019) C-Terminal CuII Coordination to \u03b1-synuclein Enhances Aggregation. ACS Chem Neurosci 10:1402\u20131410. https:\/\/doi.org\/10.1021\/acschemneuro.8b00448","journal-title":"ACS Chem Neurosci"},{"key":"827_CR3","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1021\/acs.jcim.1c00034","volume":"61","author":"L Aggarwal","year":"2021","unstructured":"Aggarwal L, Biswas P (2021) Hydration Thermodynamics of Familial Parkinson\u2019s Disease-Linked Mutants of \u03b1-synuclein. J Chem Inf Model 61:1850\u20131858. https:\/\/doi.org\/10.1021\/acs.jcim.1c00034","journal-title":"J Chem Inf Model"},{"key":"827_CR4","doi-asserted-by":"publisher","DOI":"10.1101\/2025.02.07.25321793","author":"M Al-Azzani","year":"2025","unstructured":"Al-Azzani M, Weber S, Ramalingam N, Ram\u00f3n M, Shvachiy L, Mestre G, Zech M, Sicking K, Ib\u00e1\u00f1ez de Opakua A, Jayanthi V, Amaral L, Agarwal A, Chandran A, Chaves SR, Winkelmann J, Trenkwalder C, Schwager M, Pauli S, Dettmer U, Fern\u00e1ndez CO, Lautenschl\u00e4ger J, Zweckstetter M, Busnadiego RF, Mollenhauer B, Outeiro TF (2025) A novel alpha-synuclein p.K58N missense variant in a patient with Parkinson\u2019s disease. medRxiv. https:\/\/doi.org\/10.1101\/2025.02.07.25321793","journal-title":"medRxiv"},{"key":"827_CR5","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1080\/08927022.2020.1786084","volume":"46","author":"H Al\u0131c\u0131","year":"2020","unstructured":"Al\u0131c\u0131 H (2020) In silico analysis: structural insights about inter-protofilaments interactions for \u03b1-synuclein (50\u201357) fibrils and its familial mutation. Mol Simul 46:867\u2013878. https:\/\/doi.org\/10.1080\/08927022.2020.1786084","journal-title":"Mol Simul"},{"issue":"8","key":"827_CR6","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.5409","volume":"11","author":"A Anwar","year":"2019","unstructured":"Anwar A, Saleem S, Akhtar A, Ashraf S, Ahmed MF (2019) Juvenile Parkinson disease. Cureus 11(8):e5409. https:\/\/doi.org\/10.7759\/cureus.5409","journal-title":"Cureus"},{"key":"827_CR7","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1002\/mds.29736","volume":"39","author":"M Avenali","year":"2024","unstructured":"Avenali M, Cerri S, Palmieri I, Ongari G, Stiuso R, Buongarzone G, Tassorelli C, Biagini T, Valente M, Cereda C, Mazza T, Gana S, Pacchetti C, Valente EM (2024) Functional Study of SNCA p.p.V15A Variant: Further Linking \u03b1-synuclein and Glucocerebrosidase. Mov Disord 39:1060\u20131065. https:\/\/doi.org\/10.1002\/mds.29736","journal-title":"Mov Disord"},{"issue":"7","key":"827_CR8","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1089\/ars.2011.4429","volume":"18","author":"E-J Bae","year":"2013","unstructured":"Bae E-J, Ho D-H, Park E, Jung JW, Cho K, Hong JH, Lee H-J, Kim KP, Lee S-J (2013) Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of \u03b1-synuclein. Antioxid Redox Signal 18(7):770\u2013783. https:\/\/doi.org\/10.1089\/ars.2011.4429","journal-title":"Antioxid Redox Signal"},{"key":"827_CR9","doi-asserted-by":"publisher","first-page":"3592","DOI":"10.1073\/pnas.1917914117","volume":"117","author":"DR Boyer","year":"2020","unstructured":"Boyer DR, Li B, Sun C, Fan W, Zhou K, Hughes MP, Sawaya MR, Jiang L, Eisenberg DS (2020) The \u03b1-synuclein hereditary mutation p.E46K unlocks a more stable, pathogenic fibril structure. Proc Natl Acad Sci USA 117:3592\u20133602. https:\/\/doi.org\/10.1073\/pnas.1917914117","journal-title":"Proc Natl Acad Sci USA"},{"key":"827_CR10","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","volume":"24","author":"H Braak","year":"2003","unstructured":"Braak H, Del Tredici C, Rueb U, De Vos RA, Steur ENJ, Braak E (2003) Staging of brain pathology related to sporadic Parkinson\u2019s disease. Neurobiol Aging 24:197\u2013211. https:\/\/doi.org\/10.1016\/S0197-4580(02)00065-9","journal-title":"Neurobiol Aging"},{"key":"827_CR11","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.bbadis.2011.10.002","volume":"1822","author":"L Breydo","year":"2012","unstructured":"Breydo L, Wu JW, Uversky VN (2012) \u03b1-synuclein misfolding and Parkinson\u2019s disease. Biochim Biophys Acta 1822:261\u2013285. https:\/\/doi.org\/10.1016\/j.bbadis.2011.10.002","journal-title":"Biochim Biophys Acta"},{"key":"827_CR12","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/cbic.200800581","volume":"10","author":"M Brucale","year":"2009","unstructured":"Brucale M, Sandal M, Di Maio S, Rampioni A, Tessari I, Tosatto L, Bisaglia M, Bubacco L, Samor\u00ec B (2009) Pathogenic Mutations Shift the Equilibria of \u03b1-synuclein Single Molecules towards Structured Conformers. ChemBioChem 10:176\u2013183. https:\/\/doi.org\/10.1002\/cbic.200800581","journal-title":"ChemBioChem"},{"key":"827_CR13","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13024-025-00889-y","volume":"20","author":"C Br\u00fccke","year":"2025","unstructured":"Br\u00fccke C, Al-Azzani M, Ramalingam N, Ram\u00f3n M, Sousa RL, Buratti F, Zech M, Sicking K, Amaral L, Gelpi E, Chandran A, Agarwal A, Chaves SR, Fern\u00e1ndez CO, Dettmer U, Lautenschl\u00e4ger J, Zweckstetter M, Fern\u00e1ndez-Busnadiego R, Zimprich A, Outeiro TF (2025) A novel alpha-synuclein p.G14R missense variant is associated with atypical neuropathological features. Mol Neurodegener 20:98. https:\/\/doi.org\/10.1186\/s13024-025-00889-y","journal-title":"Mol Neurodegener"},{"key":"827_CR14","doi-asserted-by":"publisher","first-page":"e4693","DOI":"10.1002\/pro.4693","volume":"32","author":"FA Buratti","year":"2023","unstructured":"Buratti FA, Fern\u00e1ndez CO, Zweckstetter M (2023) Parkinson\u2019s disease-linked p.V15A mutation facilitates \u03b1-synuclein aggregation by reducing membrane affinity. Protein Sci 32:e4693. https:\/\/doi.org\/10.1002\/pro.4693","journal-title":"Protein Sci"},{"key":"827_CR15","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a024091","volume":"8","author":"J Burr\u00e9","year":"2018","unstructured":"Burr\u00e9 J, Sharma M, S\u00fcdhof TC (2018) Cell biology and pathophysiology of \u03b1-synuclein. Cold Spring Harb Perspect Med 8:a024091. https:\/\/doi.org\/10.1101\/cshperspect.a024091","journal-title":"Cold Spring Harb Perspect Med"},{"key":"827_CR16","doi-asserted-by":"publisher","first-page":"4318416","DOI":"10.1155\/2017\/4318416","volume":"2017","author":"CLDC Camp\u00ealo","year":"2017","unstructured":"Camp\u00ealo CLDC, Silva RH (2017) Genetic variants in SNCA and the risk of sporadic Parkinson\u2019s disease and clinical outcomes: a review. Parkinson\u2019s disease 2017:4318416. https:\/\/doi.org\/10.1155\/2017\/4318416","journal-title":"Parkinson\u2019s disease"},{"key":"827_CR17","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.expneurol.2012.11.007","volume":"240","author":"JR Cannon","year":"2013","unstructured":"Cannon JR, Geghman KD, Tapias V, Sew T, Dail MK, Li C, Greenamyre JT (2013) Expression of human p.E46K-mutated \u03b1-synuclein in BAC-transgenic rats replicates early-stage Parkinson\u2019s disease features and enhances vulnerability to mitochondrial impairment. Exp Neurol 240:44\u201356. https:\/\/doi.org\/10.1016\/j.expneurol.2012.11.007","journal-title":"Exp Neurol"},{"key":"827_CR18","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.parkreldis.2019.05.038","volume":"65","author":"M Carmona-Abellan","year":"2019","unstructured":"Carmona-Abellan M, Gabilondo I, Murueta-Goyena A, Khurana V, Tijero B, Luquin MR, Acera M, Del Pino R, Gardeazabal J, Mart\u00ednez-Valbuena I, Sanchez-Pernaute R, G\u00f3mez-Esteban JC (2019) Small fiber neuropathy and phosphorylated alpha-synuclein in the skin of p.E46K-SNCA mutation carriers. Parkinsonism Relat Disord 65:139\u2013145. https:\/\/doi.org\/10.1016\/j.parkreldis.2019.05.038","journal-title":"Parkinsonism Relat Disord"},{"key":"827_CR19","doi-asserted-by":"publisher","unstructured":"Cevallos J, Eubanks E, Jung S, Huang Y, Guadagno E, Suvvari NR, Doshi A, Ravinutala N, Mosera A, Ramalingam N, Tripathi A, Bartels T, Dettmer U, Kara E (2025) Lipid droplets promote the aberrant liquid-liquid phase separation of alpha-synuclein leading to impaired energy homeostasis. bioRxiv. https:\/\/doi.org\/10.1101\/2025.11.20.689615","DOI":"10.1101\/2025.11.20.689615"},{"key":"827_CR20","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S1474-4422(06)70373-8","volume":"5","author":"KR Chaudhuri","year":"2006","unstructured":"Chaudhuri KR, Healy DG, Schapira AH (2006) Non-motor symptoms of Parkinson\u2019s disease: diagnosis and management. Lancet Neurol 5:235\u2013245. https:\/\/doi.org\/10.1016\/S1474-4422(06)70373-8","journal-title":"Lancet Neurol"},{"key":"827_CR21","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1111\/gbb.12172","volume":"13","author":"AY Chen","year":"2014","unstructured":"Chen AY, Wilburn P, Hao X, Tully T (2014) Walking deficits and centrophobism in an \u03b1-synuclein fly model of Parkinson\u2019s disease. Genes Brain Behav 13:812\u2013820. https:\/\/doi.org\/10.1111\/gbb.12172","journal-title":"Genes Brain Behav"},{"key":"827_CR22","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1523\/jneurosci.0089-14.2015","volume":"5","author":"L Chen","year":"2015","unstructured":"Chen L, Xie Z, Turkson S, Zhuang X (2015) p.A53T human \u03b1-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration. J Neurosci 5:890\u2013905. https:\/\/doi.org\/10.1523\/jneurosci.0089-14.2015","journal-title":"J Neurosci"},{"key":"827_CR23","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1002\/mds.28191","volume":"35","author":"Y Chen","year":"2020","unstructured":"Chen Y, Gu X, Ou R, Zhang L, Hou Y, Liu K, Cao B, Wei Q, Li C, Song W, Zhao B, Wu Y, Cheng J, Shang H (2020) Evaluating the Role of SNCA, LRRK2, and GBA in Chinese Patients With Early-Onset Parkinson\u2019s Disease. Mov Disord 35:2046\u20132055. https:\/\/doi.org\/10.1002\/mds.28191","journal-title":"Mov Disord"},{"key":"827_CR24","doi-asserted-by":"publisher","first-page":"15474","DOI":"10.1074\/jbc.M113.544049","volume":"289","author":"Y-C Chi","year":"2014","unstructured":"Chi Y-C, Armstrong GS, Jones DNM, Eisenmesser EZ, Liu C-W (2014) Residue Histidine 50 Plays a Key Role in Protecting \u03b1-synuclein from Aggregation at Physiological pH*. J Biol Chem 289:15474\u201315481. https:\/\/doi.org\/10.1074\/jbc.M113.544049","journal-title":"J Biol Chem"},{"key":"827_CR25","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.febslet.2004.09.038","volume":"576","author":"W Choi","year":"2004","unstructured":"Choi W, Zibaee S, Jakes R, Serpell LC, Davletov B, Anthony Crowther R, Goedert M (2004) Mutation p.E46K increases phospholipid binding and assembly into filaments of human \u03b1-synuclein. FEBS Lett 576:363\u2013368. https:\/\/doi.org\/10.1016\/j.febslet.2004.09.038","journal-title":"FEBS Lett"},{"key":"827_CR26","doi-asserted-by":"publisher","first-page":"6344","DOI":"10.1074\/jbc.m108414200","volume":"277","author":"NB Cole","year":"2002","unstructured":"Cole NB, Murphy DD, Grider T, Rueter S, Brasaemle D, Nussbaum RL (2002) Lipid droplet binding and oligomerization properties of the Parkinson\u2019s disease protein \u03b1-synuclein. J Biol Chem 277:6344\u20136352. https:\/\/doi.org\/10.1074\/jbc.m108414200","journal-title":"J Biol Chem"},{"key":"827_CR27","doi-asserted-by":"publisher","first-page":"3306","DOI":"10.1523\/jneurosci.5367-11.2012","volume":"32","author":"E Colla","year":"2012","unstructured":"Colla E, Coune P, Liu Y, Pletnikova O, Troncoso JC, Iwatsubo T, Schneider BL, Lee MK (2012) Endoplasmic reticulum stress is important for the manifestations of \u03b1-synucleinopathy in vivo. J Neurosci 32:3306\u20133320. https:\/\/doi.org\/10.1523\/jneurosci.5367-11.2012","journal-title":"J Neurosci"},{"key":"827_CR28","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/3311","volume":"4","author":"KA Conway","year":"1998","unstructured":"Conway KA, Harper JD, Lansbury PT (1998) Accelerated in vitro fibril formation by a mutant \u03b1-synuclein linked to early-onset Parkinson disease. Nat Med 4:1318\u20131320. https:\/\/doi.org\/10.1038\/3311","journal-title":"Nat Med"},{"key":"827_CR29","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1126\/science.1129462","volume":"313","author":"AA Cooper","year":"2006","unstructured":"Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Marsischky G, Kolodner RD, LaBaer J, Rochet J-C, Bonini NM, Lindquist S (2006) Alpha-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson\u2019s Models. Science 313:324\u2013328. https:\/\/doi.org\/10.1126\/science.1129462","journal-title":"Science"},{"key":"827_CR30","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1126\/science.1101738","volume":"305","author":"AM Cuervo","year":"2004","unstructured":"Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D (2004) Impaired Degradation of Mutant \u03b1-synuclein by Chaperone-Mediated Autophagy. Science 305:1292\u20131295. https:\/\/doi.org\/10.1126\/science.1101738","journal-title":"Science"},{"key":"827_CR31","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1002\/mds.29162","volume":"37","author":"K Daida","year":"2022","unstructured":"Daida K, Shimonaka S, Shiba-Fukushima K, Ogata J, Yoshino H, Okuzumi A, Hatano T, Motoi Y, Hirunagi T, Katsuno M, Shindou H, Funayama M, Nishioka K, Hattori N, Imai Y (2022) \u03b1-synuclein p.V15A Variant in Familial Parkinson\u2019s Disease Exhibits a Weaker Lipid-Binding Property. Mov Disord 37:2075\u20132085. https:\/\/doi.org\/10.1002\/mds.29162","journal-title":"Mov Disord"},{"key":"827_CR32","doi-asserted-by":"publisher","first-page":"14702","DOI":"10.1080\/07391102.2023.2193997","volume":"41","author":"D Das","year":"2023","unstructured":"Das D, Mattaparthi VSK (2023) Conformational dynamics of p.A30G \u03b1-synuclein that causes familial Parkinson disease. J Biomol Struct Dyn 41:14702\u201314714. https:\/\/doi.org\/10.1080\/07391102.2023.2193997","journal-title":"J Biomol Struct Dyn"},{"key":"827_CR33","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","volume":"5","author":"LML de Lau","year":"2006","unstructured":"de Lau LML, Breteler MMB (2006) Epidemiology of Parkinson\u2019s disease. Lancet Neurol 5:525\u2013535. https:\/\/doi.org\/10.1016\/S1474-4422(06)70471-9","journal-title":"Lancet Neurol"},{"key":"827_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0598-9","volume":"2","author":"GAP de Oliveira","year":"2019","unstructured":"de Oliveira GAP, Silva JL (2019) Alpha-synuclein stepwise aggregation reveals features of an early onset mutation in Parkinson\u2019s disease. Commun Biol 2:374. https:\/\/doi.org\/10.1038\/s42003-019-0598-9","journal-title":"Commun Biol"},{"key":"827_CR35","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/s41531-023-00584-z","volume":"9","author":"SH Diaw","year":"2023","unstructured":"Diaw SH, Borsche M, Streubel-Gallasch L, Dulovic-Mahlow M, Hermes J, Lenz I, Seibler P, Klein C, Br\u00fcggemann N, Vos M, Lohmann K (2023) Characterization of the pathogenic \u03b1-synuclein Variant p.V15A in Parkinson\u00b4s disease. NPJ Parkinsons Dis 9:148. https:\/\/doi.org\/10.1038\/s41531-023-00584-z","journal-title":"NPJ Parkinsons Dis"},{"key":"827_CR36","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1534\/genetics.104.035493","volume":"170","author":"C Dixon","year":"2005","unstructured":"Dixon C, Mathias N, Zweig RM, Davis DA, Gross DS (2005) \u03b1-synuclein Targets the Plasma Membrane via the Secretory Pathway and Induces Toxicity in Yeast. Genetics 170:47\u201359. https:\/\/doi.org\/10.1534\/genetics.104.035493","journal-title":"Genetics"},{"key":"827_CR37","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1021\/bi101912q","volume":"50","author":"CG Dudzik","year":"2011","unstructured":"Dudzik CG, Walter ED, Millhauser GL (2011) Coordination Features and Affinity of the Cu2\u2009+\u2009Site in the \u03b1-synuclein Protein of Parkinson\u2019s Disease. Biochemistry 50:1771\u20131777. https:\/\/doi.org\/10.1021\/bi101912q","journal-title":"Biochemistry"},{"key":"827_CR38","doi-asserted-by":"publisher","first-page":"e00915","DOI":"10.1002\/brb3.915","volume":"8","author":"S Ekmark-Lew\u00e9n","year":"2018","unstructured":"Ekmark-Lew\u00e9n S, Lindstr\u00f6m V, Gumucio A, Ihse E, Behere A, Kahle PJ, Nordstr\u00f6m E, Eriksson M, Erlandsson A, Bergstr\u00f6m J, Ingelsson M (2018) Early fine motor impairment and behavioral dysfunction in (Thy-1)-h[p.A30P] alpha-synuclein mice. Brain Behav 8:e00915. https:\/\/doi.org\/10.1002\/brb3.915","journal-title":"Brain Behav"},{"key":"827_CR39","doi-asserted-by":"crossref","unstructured":"Elhadi SA, Congdon-Loeffler J, Harrosch E, Khatib D, Naamneh L, Schechter M, Eliassaf A, Shalev O, Sharon R (2025) \u03b1-synuclein Activates the PI3K\/AKT Pathway to Drive Lipid Droplets Accumulation: Implications for Parkinson\u2019s Disease. bioRxiv doi https:\/\/doi.org\/10.1101\/2025.03.27.645689%J","DOI":"10.1101\/2025.03.27.645689"},{"key":"827_CR40","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4103\/1735-1995.181989","volume":"21","author":"FN Emamzadeh","year":"2016","unstructured":"Emamzadeh FN (2016) Alpha-synuclein structure, functions, and interactions. J Res Med Sci 21:29. https:\/\/doi.org\/10.4103\/1735-1995.181989","journal-title":"J Res Med Sci"},{"key":"827_CR41","doi-asserted-by":"publisher","first-page":"865","DOI":"10.3390\/biom5020865","volume":"5","author":"M Emanuele","year":"2015","unstructured":"Emanuele M, Chieregatti E (2015) Mechanisms of Alpha-Synuclein Action on Neurotransmission: Cell-Autonomous and Non-Cell Autonomous Role. Biomolecules 5:865\u2013892. https:\/\/doi.org\/10.3390\/biom5020865","journal-title":"Biomolecules"},{"key":"827_CR42","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.molmed.2005.01.001","volume":"11","author":"JL Eriksen","year":"2005","unstructured":"Eriksen JL, Przedborski S, Petrucelli L (2005) Gene dosage and pathogenesis of Parkinson\u2019s disease. Trends Mol Med 11:91\u201396. https:\/\/doi.org\/10.1016\/j.molmed.2005.01.001","journal-title":"Trends Mol Med"},{"key":"827_CR43","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1002\/jnr.24092","volume":"96","author":"AG Erustes","year":"2018","unstructured":"Erustes AG, Stefani FY, Terashima JY, Stilhano RS, Monteforte PT, da Silva Pereira GJ, Han SW, Calgarotto AK, Hsu Y-T, Ureshino RP, Bincoletto C, Smaili SS (2018) Overexpression of \u03b1-synuclein in an astrocyte cell line promotes autophagy inhibition and apoptosis. J Neurosci Res 96:160\u2013171. https:\/\/doi.org\/10.1002\/jnr.24092","journal-title":"J Neurosci Res"},{"key":"827_CR44","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.028092","author":"V Evsyukov","year":"2017","unstructured":"Evsyukov V, Domanskyi A, Bierhoff H, Gispert S, Mustafa R, Schlaudraff F, Liss B, Parlato R (2017) Genetic mutations linked to Parkinson\u2019s disease differentially control nucleolar activity in pre-symptomatic mouse models. Dis Model Mech. https:\/\/doi.org\/10.1242\/dmm.028092","journal-title":"Dis Model Mech"},{"key":"827_CR45","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1021\/acschemneuro.1c00646","volume":"13","author":"H-F Fan","year":"2022","unstructured":"Fan H-F, Chen W-L, Chen Y-Z, Huang J-W, Shen Y-X (2022) Change in the Oligomeric State of \u03b1-synuclein Variants in Living Cells. ACS Chem Neurosci 13:1143\u20131164. https:\/\/doi.org\/10.1021\/acschemneuro.1c00646","journal-title":"ACS Chem Neurosci"},{"key":"827_CR46","doi-asserted-by":"publisher","first-page":"4491","DOI":"10.1093\/hmg\/ddu165","volume":"23","author":"M-B Fares","year":"2014","unstructured":"Fares M-B, Ait-Bouziad N, Dikiy I, Mbefo MK, Jovi\u010di\u0107 A, Kiely A, Holton JL, Lee S-J, Gitler AD, Eliezer D, Lashuel HA (2014) The novel Parkinson\u2019s disease linked mutation p.G51D attenuates in vitro aggregation and membrane binding of \u03b1-synuclein, and enhances its secretion and nuclear localization in cells. Hum Mol Genet 23:4491\u20134509. https:\/\/doi.org\/10.1093\/hmg\/ddu165","journal-title":"Hum Mol Genet"},{"key":"827_CR47","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/35006074","volume":"404","author":"MB Feany","year":"2000","unstructured":"Feany MB, Bender WW (2000) A Drosophila model of Parkinson\u2019s disease. Nature 404:394\u2013398. https:\/\/doi.org\/10.1038\/35006074","journal-title":"Nature"},{"key":"827_CR48","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23071531","volume":"23","author":"C Fecchio","year":"2018","unstructured":"Fecchio C, Palazzi L, Polverino de Laureto P (2018) \u03b1-synuclein and polyunsaturated fatty acids: molecular basis of the interaction and implication in neurodegeneration. Molecules 23:1531. https:\/\/doi.org\/10.3390\/molecules23071531","journal-title":"Molecules"},{"key":"827_CR49","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.parkreldis.2021.06.023","volume":"89","author":"C Fevga","year":"2021","unstructured":"Fevga C, Park Y, Lohmann E, Kievit AJ, Breedveld GJ, Ferraro F, de Boer L, van Minkelen R, Hanagasi H, Boon A, Wang W, Petsko GA, Hoang QQ, Emre M, Bonifati V (2021) A new alpha-synuclein missense variant (Thr72Met) in two Turkish families with Parkinson\u2019s disease. Parkinsonism Relat Disord 89:63\u201372. https:\/\/doi.org\/10.1016\/j.parkreldis.2021.06.023","journal-title":"Parkinsonism Relat Disord"},{"key":"827_CR50","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/392180","author":"M Fiske","year":"2011","unstructured":"Fiske M, Valtierra S, Solvang K, Zorniak M, White M, Herrera S, Konnikova A, Brezinsky R, DebBurman S (2011) Contribution of Alanine-76 and Serine phosphorylation in \u03b1-synuclein membrane association and aggregation in yeasts. Parkinsons Dis. https:\/\/doi.org\/10.4061\/2011\/392180","journal-title":"Parkinsons Dis"},{"key":"827_CR51","doi-asserted-by":"publisher","first-page":"10328","DOI":"10.1073\/pnas.1604645113","volume":"113","author":"P Flagmeier","year":"2016","unstructured":"Flagmeier P, Meisl G, Vendruscolo M, Knowles TPJ, Dobson CM, Buell AK, Galvagnion C (2016) Mutations associated with familial Parkinson\u2019s disease alter the initiation and amplification steps of \u03b1-synuclein aggregation. Proc Natl Acad Sci USA 113:10328\u201310333. https:\/\/doi.org\/10.1073\/pnas.1604645113","journal-title":"Proc Natl Acad Sci USA"},{"key":"827_CR52","doi-asserted-by":"publisher","first-page":"7107","DOI":"10.1021\/bi7000246","volume":"46","author":"RA Fredenburg","year":"2007","unstructured":"Fredenburg RA, Rospigliosi C, Meray RK, Kessler JC, Lashuel HA, Eliezer D, Lansbury PT (2007) The Impact of the p.E46K Mutation on the Properties of \u03b1-synuclein in Its Monomeric and Oligomeric States. Biochemistry 46:7107\u20137118. https:\/\/doi.org\/10.1021\/bi7000246","journal-title":"Biochemistry"},{"key":"827_CR53","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/ncb748","volume":"4","author":"H Fujiwara","year":"2002","unstructured":"Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T (2002) \u03b1-synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4:160\u2013164. https:\/\/doi.org\/10.1038\/ncb748","journal-title":"Nat Cell Biol"},{"key":"827_CR54","doi-asserted-by":"publisher","first-page":"S343","DOI":"10.1002\/mds.21676","volume":"22","author":"T Gasser","year":"2007","unstructured":"Gasser T (2007) Update on the genetics of Parkinson\u2019s disease. Mov Disord 22:S343\u2013S350. https:\/\/doi.org\/10.1002\/mds.21676","journal-title":"Mov Disord"},{"key":"827_CR55","doi-asserted-by":"publisher","first-page":"6925","DOI":"10.1021\/bi400999d","volume":"52","author":"D Ghosh","year":"2013","unstructured":"Ghosh D, Mondal M, Mohite GM, Singh PK, Ranjan P, Anoop A, Ghosh S, Jha NN, Kumar A, Maji SK (2013) The Parkinson\u2019s Disease-Associated p.H50Q Mutation Accelerates \u03b1-synuclein Aggregation in Vitro. Biochemistry 52:6925\u20136927. https:\/\/doi.org\/10.1021\/bi400999d","journal-title":"Biochemistry"},{"key":"827_CR56","doi-asserted-by":"publisher","first-page":"6419","DOI":"10.1021\/bi5010365","volume":"53","author":"D Ghosh","year":"2014","unstructured":"Ghosh D, Sahay S, Ranjan P, Salot S, Mohite GM, Singh PK, Dwivedi S, Carvalho E, Banerjee R, Kumar A, Maji SK (2014) The Newly Discovered Parkinson\u2019s Disease Associated Finnish Mutation (p.A53E) Attenuates \u03b1-synuclein Aggregation and Membrane Binding. Biochemistry 53:6419\u20136421. https:\/\/doi.org\/10.1021\/bi5010365","journal-title":"Biochemistry"},{"key":"827_CR57","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0896-6273(02)00682-7","volume":"34","author":"BI Giasson","year":"2002","unstructured":"Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VMY (2002) Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing p.A53T human alpha-synuclein. Neuron 34:521\u2013533. https:\/\/doi.org\/10.1016\/S0896-6273(02)00682-7","journal-title":"Neuron"},{"key":"827_CR58","doi-asserted-by":"publisher","first-page":"e1009921","DOI":"10.1371\/journal.pgen.1009921","volume":"17","author":"V Girard","year":"2021","unstructured":"Girard V, Jollivet F, Knittelfelder O, Celle M, Arsac J-N, Chatelain G, Van den Brink DM, Baron T, Shevchenko A, K\u00fchnlein RP, Davoust N, Mollereau B (2021) Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson\u2019s disease. PLoS Genet 17:e1009921. https:\/\/doi.org\/10.1371\/journal.pgen.1009921","journal-title":"PLoS Genet"},{"key":"827_CR59","doi-asserted-by":"publisher","first-page":"a008862","DOI":"10.1101\/cshperspect.a008862","volume":"1","author":"CG Goetz","year":"2011","unstructured":"Goetz CG (2011) The history of Parkinson\u2019s disease: early clinical descriptions and neurological therapies. Cold Spring Harb Perspect Med 1:a008862. https:\/\/doi.org\/10.1101\/cshperspect.a008862","journal-title":"Cold Spring Harb Perspect Med"},{"key":"827_CR60","doi-asserted-by":"publisher","first-page":"7800","DOI":"10.1074\/jbc.M411638200","volume":"280","author":"EA Greenbaum","year":"2005","unstructured":"Greenbaum EA, Graves CL, Mishizen-Eberz AJ, Lupoli MA, Lynch DR, Englander SW, Axelsen PH, Giasson BI (2005) The p.E46K Mutation in \u03b1-synuclein Increases Amyloid Fibril Formation*. J Biol Chem 280:7800\u20137807. https:\/\/doi.org\/10.1074\/jbc.M411638200","journal-title":"J Biol Chem"},{"key":"827_CR61","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2026.10037","author":"IJH Grimwade","year":"2026","unstructured":"Grimwade IJH, Enticknap G, Fernandez EDP, Croft CL (2026) \u03b1-Synuclein in Lewy body diseases: progress, remaining challenges and future perspectives. Expert Rev Mol Med. https:\/\/doi.org\/10.1017\/erm.2026.10037","journal-title":"Expert Rev Mol Med"},{"key":"827_CR62","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3389\/fncel.2020.00159","volume":"14","author":"Y Guan","year":"2020","unstructured":"Guan Y, Zhao X, Liu F, Yan S, Wang Y, Du C, Cui X, Li R, Zhang CX (2020) Pathogenic Mutations Differentially Regulate Cell-to-Cell Transmission of \u03b1-synuclein. Front Cell Neurosci 14:159. https:\/\/doi.org\/10.3389\/fncel.2020.00159","journal-title":"Front Cell Neurosci"},{"key":"827_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2019.114874","volume":"388","author":"C Gui","year":"2020","unstructured":"Gui C, Ren Y, Chen J, Wu X, Mao K, Li H, Yu H, Zou F, Li W (2020) p38 MAPK-DRP1 signaling is involved in mitochondrial dysfunction and cell death in mutant p.A53T \u03b1-synuclein model of Parkinson\u2019s disease. Toxicol Appl Pharmacol 388:114874. https:\/\/doi.org\/10.1016\/j.taap.2019.114874","journal-title":"Toxicol Appl Pharmacol"},{"key":"827_CR64","doi-asserted-by":"publisher","first-page":"648151doi","DOI":"10.3389\/fnagi.2021.648151","volume":"13","author":"Y Guo","year":"2021","unstructured":"Guo Y, Sun Y, Song Z, Zheng W, Xiong W, Yang Y, Yuan L, Deng H (2021) Genetic Analysis and Literature Review of SNCA Variants in Parkinson\u2019s Disease. Front Aging Neurosci 13:648151doi. https:\/\/doi.org\/10.3389\/fnagi.2021.648151","journal-title":"Front Aging Neurosci"},{"key":"827_CR65","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1002\/mds.27887","volume":"35","author":"H Hayakawa","year":"2020","unstructured":"Hayakawa H, Nakatani R, Ikenaka K, Aguirre C, Choong C-J, Tsuda H, Nagano S, Koike M, Ikeuchi T, Hasegawa M, Papa SM, Nagai Y, Mochizuki H, Baba K (2020) Structurally Distinct \u03b1-synuclein Fibrils Induce Robust Parkinsonian Pathology. Mov Disord 35:256\u2013267. https:\/\/doi.org\/10.1002\/mds.27887","journal-title":"Mov Disord"},{"key":"827_CR66","doi-asserted-by":"publisher","first-page":"151491","DOI":"10.1016\/j.ijbiomac.2026.151491","volume":"355","author":"M Herrera","year":"2024","unstructured":"Herrera M (2024) Alpha-synuclein aggregation in the presence of mitochondrial lipid membranes: implications for Parkinson\u2019s disease. Int J Biol Macromol 355:151491. https:\/\/doi.org\/10.1016\/j.ijbiomac.2026.151491","journal-title":"Int J Biol Macromol"},{"key":"827_CR67","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1093\/ageing\/afp223","volume":"39","author":"JV Hindle","year":"2010","unstructured":"Hindle JV (2010) Ageing, neurodegeneration and Parkinson\u2019s disease. Age Ageing 39:156\u2013161. https:\/\/doi.org\/10.1093\/ageing\/afp223","journal-title":"Age Ageing"},{"key":"827_CR68","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/j.parkreldis.2013.07.011","volume":"19","author":"D Hoffman-Zacharska","year":"2013","unstructured":"Hoffman-Zacharska D, Koziorowski D, Ross OA, Milewski M, Pozna\u0144ski J, Jurek M, Wszolek ZK, Soto-Ortolaza A, S\u0142awek J, Janik P, Jamrozik Z, Potulska-Chromik A, Jasi\u0144ska-Myga B, Opala G, Krygowska-Wajs A, Czy\u017cewski K, Dickson DW, Bal J, Friedman A (2013) Novel p.A18T and pp.A29S substitutions in \u03b1-synuclein may be associated with sporadic Parkinson\u2019s disease. Parkinsonism Relat Disord 19:1057\u20131060. https:\/\/doi.org\/10.1016\/j.parkreldis.2013.07.011","journal-title":"Parkinsonism Relat Disord"},{"key":"827_CR69","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.849462","volume":"14","author":"P Hua","year":"2022","unstructured":"Hua P, Zhao Y, Zeng Q, Li L, Ren J, Guo J, Tang B, Liu W (2022) Genetic analysis of patients with early-onset Parkinson\u2019s disease in Eastern China. Front Aging Neurosci 14:849462. https:\/\/doi.org\/10.3389\/fnagi.2022.849462","journal-title":"Front Aging Neurosci"},{"key":"827_CR70","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/S0140-6736(04)17104-3","volume":"364","author":"P Ib\u00e1\u00f1ez","year":"2004","unstructured":"Ib\u00e1\u00f1ez P, Bonnet AM, D\u00e9barges B, Lohmann E, Tison F, Agid Y, D\u00fcrr A, Brice A, Pollak P (2004) Causal relation between alpha-synuclein gene duplication and familial Parkinson\u2019s disease. Lancet 364:1169\u20131171. https:\/\/doi.org\/10.1016\/S0140-6736(04)17104-3","journal-title":"Lancet"},{"key":"827_CR71","doi-asserted-by":"publisher","first-page":"E8274","DOI":"10.1073\/pnas.1703420114","volume":"114","author":"I \u00cd\u00f1igo-Marco","year":"2017","unstructured":"\u00cd\u00f1igo-Marco I, Valencia M, Larrea L, Bugallo R, Mart\u00ednez-Goikoetxea M, Zuriguel I, Arrasate M (2017) p.E46K \u03b1-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation. Proc Natl Acad Sci USA 114:E8274\u2013E8283. https:\/\/doi.org\/10.1073\/pnas.1703420114","journal-title":"Proc Natl Acad Sci USA"},{"key":"827_CR72","doi-asserted-by":"publisher","first-page":"10139","DOI":"10.1021\/bi00032a006","volume":"34","author":"A Iwai","year":"1995","unstructured":"Iwai A, Yoshimoto M, Masliah E, Saitoh T (1995) Non-A beta component of Alzheimer\u2019s disease amyloid (NAC) is amyloidogenic. Biochemistry 34:10139\u201310145. https:\/\/doi.org\/10.1021\/bi00032a006","journal-title":"Biochemistry"},{"key":"827_CR73","doi-asserted-by":"publisher","unstructured":"Jacob RS, Dema A, Ch\u00e9rot H, Dumesnil C, Cohen S, Shalom HS, Rimon N, Sibony-Nevo O, Beck G, Ainbinder E, Wolinski H, Athenstaedt K, Theillet F-X, Thiam AR, Selenko P (2024) \u03b1-synuclein acts as a cholesteryl-ester sensor on lipid droplets regulating organelle size and abundance. https:\/\/doi.org\/10.1101\/2024.06.19.599670. bioRxiv","DOI":"10.1101\/2024.06.19.599670"},{"key":"827_CR74","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3390\/diseases8020024","volume":"8","author":"N Joshi","year":"2020","unstructured":"Joshi N, Raveendran A, Nagotu S (2020) Chaperones and proteostasis: Role in Parkinson\u2019s Disease. Diseases 8:24. https:\/\/doi.org\/10.3390\/diseases8020024","journal-title":"Diseases"},{"key":"827_CR75","doi-asserted-by":"publisher","first-page":"5547","DOI":"10.1007\/s11033-023-08457-7","volume":"50","author":"N Joshi","year":"2023","unstructured":"Joshi N, Sarhadi TR, Raveendran A, Nagotu S (2023) Sporadic SNCA mutations p.A18T and p.A29S exhibit variable effects on protein aggregation, cell viability and oxidative stress. Mol Biol Rep 50:5547\u20135556. https:\/\/doi.org\/10.1007\/s11033-023-08457-7","journal-title":"Mol Biol Rep"},{"key":"827_CR76","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1080\/17386357.2006.9647291","volume":"10","author":"SJ Kang","year":"2006","unstructured":"Kang SJ, Shin KS, Kwon YK (2006) \u03b1-Synuclein induces unfolded protein response via distinct signaling pathway independent of er\u2010membrane kinases. Integr Biosci 10:115\u2013120. https:\/\/doi.org\/10.1080\/17386357.2006.9647291","journal-title":"Integr Biosci"},{"key":"827_CR77","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1111\/neup.12687","volume":"40","author":"A Kapasi","year":"2020","unstructured":"Kapasi A, Brosch JR, Nudelman KN, Agrawal S, Foroud TM, Schneider JA (2020) A novel SNCA p.E83Q mutation in a case of dementia with Lewy bodies and atypical frontotemporal lobar degeneration. Neuropathology 40:620\u2013626. https:\/\/doi.org\/10.1111\/neup.12687","journal-title":"Neuropathology"},{"key":"827_CR78","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/PL00007419","volume":"99","author":"M Kawashima","year":"2000","unstructured":"Kawashima M, Suzuki SO, Doh-ura K, Iwaki T (2000) \u03b1-synuclein is expressed in a variety of brain tumors showing neuronal differentiation. Acta Neuropathol 99:154\u2013160. https:\/\/doi.org\/10.1007\/PL00007419","journal-title":"Acta Neuropathol"},{"key":"827_CR79","doi-asserted-by":"publisher","first-page":"21856","DOI":"10.1074\/jbc.M114.553297","volume":"289","author":"O Khalaf","year":"2014","unstructured":"Khalaf O, Fauvet B, Oueslati A, Dikiy I, Mahul-Mellier A-L, Ruggeri FS, Mbefo MK, Vercruysse F, Dietler G, Lee S-J, Eliezer D, Lashuel HA (2014) The p.H50Q Mutation Enhances \u03b1-synuclein Aggregation, Secretion, and Toxicity*. J Biol Chem 289:21856\u201321876. https:\/\/doi.org\/10.1074\/jbc.M114.553297","journal-title":"J Biol Chem"},{"key":"827_CR80","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1111\/j.1399-0004.2007.00781.x","volume":"71","author":"C-S Ki","year":"2007","unstructured":"Ki C-S, Stavrou E, Davanos N, Lee W, Chung E, Kim J-Y, Athanassiadou A (2007) The Ala53Thr mutation in the \u03b1-synuclein gene in a Korean family with Parkinson disease. Clin Genet 71:471\u2013473. https:\/\/doi.org\/10.1111\/j.1399-0004.2007.00781.x","journal-title":"Clin Genet"},{"key":"827_CR81","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s00401-013-1096-7","volume":"125","author":"AP Kiely","year":"2013","unstructured":"Kiely AP, Asi YT, Kara E, Limousin P, Ling H, Lewis P, Proukakis C, Quinn N, Lees AJ, Hardy J, Revesz T, Houlden H, Holton JL (2013) \u03b1-synucleinopathy associated with p.G51D SNCA mutation: a link between Parkinson\u2019s disease and multiple system atrophy? Acta Neuropathol 125:753\u2013769. https:\/\/doi.org\/10.1007\/s00401-013-1096-7","journal-title":"Acta Neuropathol"},{"key":"827_CR82","doi-asserted-by":"publisher","first-page":"17382","DOI":"10.1038\/s41598-019-54034-z","volume":"9","author":"T Kilpel\u00e4inen","year":"2019","unstructured":"Kilpel\u00e4inen T, Julku UH, Svarcbahs R, My\u00f6h\u00e4nen TT (2019) Behavioural and dopaminergic changes in double mutated human p.A30P*p.A53T alpha-synuclein transgenic mouse model of Parkinson\u00b4s disease. Sci Rep 9:17382. https:\/\/doi.org\/10.1038\/s41598-019-54034-z","journal-title":"Sci Rep"},{"key":"827_CR83","doi-asserted-by":"publisher","first-page":"e1811","DOI":"10.1038\/cddis.2015.169","volume":"6","author":"JC Koch","year":"2015","unstructured":"Koch JC, Bitow F, Haack J, d\u2019Hedouville Z, Zhang JN, T\u00f6nges L, Michel U, Oliveira LMA, Jovin TM, Liman J, Tatenhorst L, B\u00e4hr M, Lingor P (2015) Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons. Cell Death Dis 6:e1811\u2013e1811. https:\/\/doi.org\/10.1038\/cddis.2015.169","journal-title":"Cell Death Dis"},{"key":"827_CR84","doi-asserted-by":"publisher","DOI":"10.15586\/codonpublications.parkinsonsdisease.2018.ch1","volume-title":"Parkinson\u2019s disease: pathogenesis and clinical aspects","author":"A Kouli","year":"2018","unstructured":"Kouli A, Torsney KM, Kuan WL (2018) Parkinson\u2019s disease: etiology, neuropathology, and pathogenesis. In: Stoker TB, Greenland JC (eds) Parkinson\u2019s disease: pathogenesis and clinical aspects. Codon, Brisbane. doi:https:\/\/doi.org\/10.15586\/codonpublications.parkinsonsdisease.2018.ch1"},{"key":"827_CR85","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1002\/ana.25687","volume":"87","author":"L Krohn","year":"2020","unstructured":"Krohn L, Wu RY, Heilbron K, Ruskey JA, Laurent SB, Blauwendraat et al (2020) Fine-mapping of SNCA in rapid eye movement sleep behavior disorder and overt Synucleinopathies. Ann Neurol 87:84\u2013598. https:\/\/doi.org\/10.1002\/ana.25687","journal-title":"Ann Neurol"},{"key":"827_CR86","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/ng0298-106","volume":"18","author":"R Kr\u00fcger","year":"1998","unstructured":"Kr\u00fcger R, Kuhn W, M\u00fcller T, Woitalla D, Graeber M, K\u00f6sel S, Przuntek H, Epplen JT, Schols L, Riess O (1998) AlaSOPro mutation in the gene encoding \u03b1-synuclein in Parkinson\u2019s disease. Nat Genet 18:106\u2013108. https:\/\/doi.org\/10.1038\/ng0298-106","journal-title":"Nat Genet"},{"key":"827_CR87","doi-asserted-by":"publisher","unstructured":"Kr\u00fcger R, Kuhn W, Leenders KL, Sprengelmeyer R, M\u00fcller T, Woitalla D, Portman AT, Maguire RP, Veenma L, Schr\u00f6der U, Sch\u00f6ls L, Epplen JT, Riess O, Przuntek H (2001) Familial parkinsonism with synuclein pathology. Clinical and PET studies of p.A30P mutation carriers. Neurology 56: 1355\u20131362 https:\/\/doi.org\/10.1212\/WNL.56.10.1355\/J Neurology","DOI":"10.1212\/WNL.56.10.1355\/J"},{"key":"827_CR88","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1021\/acschemneuro.6b00430","volume":"9","author":"S Kumar","year":"2018","unstructured":"Kumar S, Jangir DK, Kumar R, Kumari M, Bhavesh NS, Maiti TK (2018) Role of Sporadic Parkinson Disease Associated Mutations p.A18T and p.A29S in Enhanced \u03b1-synuclein Fibrillation and Cytotoxicity. ACS Chem Neurosci 9:230\u2013240. https:\/\/doi.org\/10.1021\/acschemneuro.6b00430","journal-title":"ACS Chem Neurosci"},{"key":"827_CR89","doi-asserted-by":"publisher","first-page":"eabn0044","DOI":"10.1126\/sciadv.abn0044","volume":"8","author":"ST Kumar","year":"2022","unstructured":"Kumar ST, Mahul-Mellier A-L, Hegde RN, Rivi\u00e8re G, Moons R, Ib\u00e1\u00f1ez de Opakua A, Magalh\u00e3es P, Rostami I, Donzelli S, Sobott F, Zweckstetter M, Lashuel HA (2022) A NAC domain mutation (p.E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity. Sci Adv 8:eabn0044. https:\/\/doi.org\/10.1126\/sciadv.abn0044","journal-title":"Sci Adv"},{"key":"827_CR90","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1074\/jbc.M504860200","volume":"281","author":"T Kuwahara","year":"2006","unstructured":"Kuwahara T, Koyama A, Gengyo-Ando K, Masuda M, Kowa H, Tsunoda M, Mitani S, Iwatsubo T (2006) Familial Parkinson Mutant \u03b1-synuclein Causes Dopamine Neuron Dysfunction in Transgenic Caenorhabditis elegans*. J Biol Chem 281:334\u2013340. https:\/\/doi.org\/10.1074\/jbc.M504860200","journal-title":"J Biol Chem"},{"key":"827_CR91","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s40478-016-0402-8","volume":"4","author":"DF L\u00e1zaro","year":"2016","unstructured":"L\u00e1zaro DF, Dias MC, Carija A, Navarro S, Madaleno CS, Tenreiro S, Ventura S, Outeiro TF (2016) The effects of the novel p.A53E alpha-synuclein mutation on its oligomerization and aggregation. Acta Neuropathol Commun 4:128. https:\/\/doi.org\/10.1186\/s40478-016-0402-8","journal-title":"Acta Neuropathol Commun"},{"key":"827_CR92","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41419-019-1364-0","volume":"10","author":"Z Lei","year":"2019","unstructured":"Lei Z, Cao G, Wei G (2019) p.A30P mutant \u03b1-synuclein impairs autophagic flux by inactivating JNK signaling to enhance ZKSCAN3 activity in midbrain dopaminergic neurons. Cell Death Dis 10:133. https:\/\/doi.org\/10.1038\/s41419-019-1364-0","journal-title":"Cell Death Dis"},{"key":"827_CR93","doi-asserted-by":"publisher","first-page":"11526","DOI":"10.1074\/jbc.M111.306902","volume":"287","author":"LR Lemkau","year":"2012","unstructured":"Lemkau LR, Comellas G, Kloepper KD, Woods WS, George JM, Rienstra CM (2012) Mutant Protein p.A30P \u03b1-synuclein Adopts Wild-type Fibril Structure, Despite Slower Fibrillation Kinetics*. J Biol Chem 287:11526\u201311532. https:\/\/doi.org\/10.1074\/jbc.M111.306902","journal-title":"J Biol Chem"},{"key":"827_CR94","doi-asserted-by":"publisher","first-page":"e49750","DOI":"10.1371\/journal.pone.0049750","volume":"8","author":"LR Lemkau","year":"2013","unstructured":"Lemkau LR, Comellas G, Lee SW, Rikardsen LK, Woods WS, George JM, Rienstra CM (2013) Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson\u2019s disease associated mutations p.A53T and p.E46K. PLoS ONE 8:e49750. https:\/\/doi.org\/10.1371\/journal.pone.0049750","journal-title":"PLoS ONE"},{"key":"827_CR95","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/ana.23894","volume":"73","author":"S Lesage","year":"2013","unstructured":"Lesage S, Anheim M, Letournel F, Bousset L, Honor\u00e9 A, Rozas N, Pieri L, Madiona K, D\u00fcrr A, Melki R, Verny C, Brice A, Group FPDGS (2013) p.G51D \u03b1-synuclein mutation causes a novel Parkinsonian\u2013pyramidal syndrome. Ann Neurol 73:459\u2013471. https:\/\/doi.org\/10.1002\/ana.23894","journal-title":"Ann Neurol"},{"key":"827_CR96","doi-asserted-by":"publisher","first-page":"11604","DOI":"10.1021\/bi010616g","volume":"40","author":"J Li","year":"2001","unstructured":"Li J, Uversky VN, Fink AL (2001) Effect of familial Parkinson\u2019s disease point mutations p.A30P and p.A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein. Biochemistry 40:11604\u201311613. https:\/\/doi.org\/10.1021\/bi010616g","journal-title":"Biochemistry"},{"key":"827_CR97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085815","volume":"8","author":"L Li","year":"2014","unstructured":"Li L, Nadanaciva S, Berger Z, Shen W, Paumier K, Schwartz J, Mou K, Loos P, Milici AJ, Dunlop J, Hirst WD (2014) Human p.A53T \u03b1-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons. PLoS One 8:e85815. https:\/\/doi.org\/10.1371\/journal.pone.0085815","journal-title":"PLoS One"},{"key":"827_CR98","doi-asserted-by":"publisher","first-page":"6480","DOI":"10.1039\/c9nr00023b","volume":"11","author":"X Li","year":"2019","unstructured":"Li X, Tong X, Lu W, Yu D, Diao J, Zhao Q (2019) Label-free detection of early oligomerization of \u03b1-synuclein and its mutants p.A30P\/p.E46K through solid-state nanopores. Nanoscale 11:6480\u20136488. https:\/\/doi.org\/10.1039\/c9nr00023b","journal-title":"Nanoscale"},{"key":"827_CR99","doi-asserted-by":"publisher","first-page":"322","DOI":"10.3892\/mmr.2018.9002","volume":"18","author":"M Liu","year":"2018","unstructured":"Liu M, Qin L, Wang L, Tan J, Zhang H, Tang J, Shen X, Tan L, Wang C (2018) \u03b1\u2013synuclein induces apoptosis of astrocytes by causing dysfunction of the endoplasmic reticulum\u2013Golgi compartment. Mol Med Rep 18:322\u2013332. https:\/\/doi.org\/10.3892\/mmr.2018.9002","journal-title":"Mol Med Rep"},{"key":"827_CR100","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1002\/mds.28534","volume":"36","author":"H Liu","year":"2021","unstructured":"Liu H, Koros C, Stroh\u00e4ker T, Schulte C, Bozi M, Varvaresos S, Ib\u00e1\u00f1ez de Opakua A, Simitsi AM, Bougea A, Voumvourakis K, Maniati M, Papageorgiou SG, Hauser A-K, Becker S, Zweckstetter M, Stefanis L, Gasser T (2021) A Novel SNCA p.A30G Mutation Causes Familial Parkinson\u02bcs Disease. Mov Disord 36:1624\u20131633. https:\/\/doi.org\/10.1002\/mds.28534","journal-title":"Mov Disord"},{"key":"827_CR101","doi-asserted-by":"publisher","first-page":"e2012435118","DOI":"10.1073\/pnas.2012435118","volume":"118","author":"H Long","year":"2021","unstructured":"Long H, Zheng W, Liu Y, Sun Y, Zhao K, Liu Z, Xia W, Lv S, Liu Z, Li D, He K-W, Liu C (2021) Wild-type \u03b1-synuclein inherits the structure and exacerbated neuropathology of p.E46K mutant fibril strain by cross-seeding. Proc Natl Acad Sci USA 118:e2012435118. https:\/\/doi.org\/10.1073\/pnas.2012435118","journal-title":"Proc Natl Acad Sci USA"},{"key":"827_CR102","doi-asserted-by":"publisher","first-page":"10510","DOI":"10.1523\/jneurosci.1659-16.2016","volume":"36","author":"MHR Ludtmann","year":"2016","unstructured":"Ludtmann MHR, Angelova PR, Ninkina NN, Gandhi S, Buchman VL, Abramov AY (2016) Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase. J Neurosci 36:10510\u201310521. https:\/\/doi.org\/10.1523\/jneurosci.1659-16.2016","journal-title":"J Neurosci"},{"key":"827_CR103","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.1212\/NXG.0000000000000027","volume":"1","author":"MH Martikainen","year":"2015","unstructured":"Martikainen MH, P\u00e4iv\u00e4rinta M, Hietala M, Kaasinen V (2015) Clinical and imaging findings in Parkinson disease associated with the p.A53E SNCA mutation. Neurol Genet 1:e27. https:\/\/doi.org\/10.1212\/NXG.0000000000000027","journal-title":"Neurol Genet"},{"key":"827_CR104","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1523\/jneurosci.4308-05.2006","volume":"26","author":"LJ Martin","year":"2006","unstructured":"Martin LJ, Pan Y, Price AC, Sterling W, Copeland NG, Jenkins NA, Price DL, Lee MK (2006) Parkinson\u2019s Disease \u03b1-synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death. J Neurosci 26:41\u201350. https:\/\/doi.org\/10.1523\/jneurosci.4308-05.2006","journal-title":"J Neurosci"},{"key":"827_CR105","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1073\/pnas.1520335113","volume":"113","author":"JR Mazzulli","year":"2016","unstructured":"Mazzulli JR, Zunke F, Isacson O, Studer L, Krainc D (2016) \u03b1-synuclein\u2013induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models. Proc Natl Acad Sci USA 113:1931\u20131936. https:\/\/doi.org\/10.1073\/pnas.1520335113","journal-title":"Proc Natl Acad Sci USA"},{"key":"827_CR106","doi-asserted-by":"publisher","first-page":"9412","DOI":"10.1074\/jbc.M114.610774","volume":"290","author":"MK Mbefo","year":"2015","unstructured":"Mbefo MK, Fares M-B, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA (2015) Parkinson Disease Mutant p.E46K Enhances \u03b1-synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, and in Vivo*. J Biol Chem 290:9412\u20139427. https:\/\/doi.org\/10.1074\/jbc.M114.610774","journal-title":"J Biol Chem"},{"key":"827_CR107","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","volume":"65","author":"IG McKeith","year":"2005","unstructured":"McKeith IG, Dickson DW, Lowe J, Emre M, O\u2019Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VMY, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M (2005) Diagnosis and management of dementia with Lewy bodies. Neurology 65:1863\u20131872. https:\/\/doi.org\/10.1212\/01.wnl.0000187889.17253.b1","journal-title":"Neurology"},{"key":"827_CR108","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13024-019-0329-1","volume":"14","author":"RM Meade","year":"2019","unstructured":"Meade RM, Fairlie DP, Mason JM (2019) Alpha-synuclein structure and Parkinson\u2019s disease \u2013 lessons and emerging principles. Mol Neurodegener 14:29. https:\/\/doi.org\/10.1186\/s13024-019-0329-1","journal-title":"Mol Neurodegener"},{"key":"827_CR109","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2025.107852","volume":"135","author":"R Mehanna","year":"2025","unstructured":"Mehanna R, Marras C, Fleisher J, Post B, Kumar KR, Noyce A, Alcalay R, Morris HR, Hatano T, Salari M, Smilowska K, Wu YR, Zhang B, Tan E-K, Savica R (2025) Diagnostic work up when suspecting early onset Parkinson disease (EOPD). Recommendations from the MDS EOPD study group. Parkinsonism Relat Disord 135:107852. https:\/\/doi.org\/10.1016\/j.parkreldis.2025.107852","journal-title":"Parkinsonism Relat Disord"},{"key":"827_CR110","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1007\/s00221-016-4836-9","volume":"235","author":"TQ Melo","year":"2017","unstructured":"Melo TQ, van Zomeren KC, Ferrari MFR, Boddeke HWGM, Copray JCVM (2017) Impairment of mitochondria dynamics by human p.A53T \u03b1-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson\u2019s disease. Exp Brain Res 235:731\u2013742. https:\/\/doi.org\/10.1007\/s00221-016-4836-9","journal-title":"Exp Brain Res"},{"key":"827_CR111","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/sj.mp.4000446","volume":"3","author":"E Mezey","year":"1998","unstructured":"Mezey E, Dehejia AM, Harta G, Suchy SF, Nussbaum RL, Brownstein MJ, Polymeropoulos MH (1998) Alpha synuclein is present in Lewy bodies in sporadic Parkinson\u2019s disease. Mol Psychiatry 3:493\u2013499. https:\/\/doi.org\/10.1038\/sj.mp.4000446","journal-title":"Mol Psychiatry"},{"key":"827_CR112","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.neuron.2016.03.038","volume":"90","author":"PP Michel","year":"2016","unstructured":"Michel PP, Hirsch EC, Hunot S (2016) Understanding dopaminergic cell death pathways in Parkinson disease. Neuron 90:675\u2013691. https:\/\/doi.org\/10.1016\/j.neuron.2016.03.038","journal-title":"Neuron"},{"key":"827_CR113","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1136\/jnnp.2004.046425","volume":"76","author":"AW Michell","year":"2005","unstructured":"Michell AW, Barker RA, Raha SK, Raha-Chowdhury R (2005) A case of late onset sporadic Parkinson\u2019s disease with an A53T mutation in alpha-synuclein. J Neurol Neurosurg Psychiatry 76:596\u2013597. https:\/\/doi.org\/10.1136\/jnnp.2004.046425","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"827_CR114","unstructured":"Minafra B, Buongarzone G, Gana S, Valente ML, Palmieri I, Biagini T et al (2020) A novel likely pathogenic SNCA variant associated with Parkinson\u2019s disease. Mov Disord 35. doi: https:\/\/www.mdsabstracts.org\/abstract\/a-novel-likely-pathogenic-snca-variant-associated-with-parkinsons-disease\/"},{"key":"827_CR115","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1021\/acschemneuro.8b00107","volume":"9","author":"GM Mohite","year":"2018","unstructured":"Mohite GM, Dwivedi S, Das S, Kumar R, Paluri S, Mehra S, Ruhela N, S A, Jha NN, Maji SK (2018a) Parkinson\u2019s disease associated \u03b1-synuclein familial mutants promote dopaminergic neuronal death in Drosophila melanogaster. ACS Chem Neurosci 9:2628\u20132638. https:\/\/doi.org\/10.1021\/acschemneuro.8b00107","journal-title":"ACS Chem Neurosci"},{"key":"827_CR116","doi-asserted-by":"publisher","first-page":"5183","DOI":"10.1021\/acs.biochem.8b00314","volume":"57","author":"GM Mohite","year":"2018","unstructured":"Mohite GM, Kumar R, Panigrahi R, Navalkar A, Singh N, Datta D, Mehra S, Ray S, Gadhe LG, Das S, Singh N, Chatterjee D, Kumar A, Maji SK (2018b) Comparison of kinetics, toxicity, oligomer formation, and membrane binding capacity of \u03b1-synuclein familial mutations at the A53 site, including the newly discovered p.A53V mutation. Biochemistry 57:5183\u20135187. https:\/\/doi.org\/10.1021\/acs.biochem.8b00314","journal-title":"Biochemistry"},{"key":"827_CR117","doi-asserted-by":"publisher","first-page":"5014","DOI":"10.1021\/acs.biochem.8b00321","volume":"57","author":"GM Mohite","year":"2018","unstructured":"Mohite GM, Navalkar A, Kumar R, Mehra S, Das S, Gadhe LG, Ghosh D, Alias B, Chandrawanshi V, Ramakrishnan A, Mehra S, Maji SK (2018c) The familial \u03b1-synuclein p.A53E mutation enhances cell death in response to environmental toxins due to a larger population of oligomers. Biochemistry 57:5014\u20135028. https:\/\/doi.org\/10.1021\/acs.biochem.8b00321","journal-title":"Biochemistry"},{"key":"827_CR119","doi-asserted-by":"publisher","first-page":"5265","DOI":"10.1021\/acs.jcim.0c00807","volume":"60","author":"P Moretti","year":"2020","unstructured":"Moretti P, Mariani P, Ortore MG, Plotegher N, Bubacco L, Beltramini M, Spinozzi F (2020) Comprehensive Structural and Thermodynamic Analysis of Prefibrillar WT \u03b1-synuclein and Its p.G51D, p.E46K, and p.A53T Mutants by a Combination of Small-Angle X-ray Scattering and Variational Bayesian Weighting. J Chem Inf Model 60:5265\u20135281. https:\/\/doi.org\/10.1021\/acs.jcim.0c00807","journal-title":"J Chem Inf Model"},{"key":"827_CR120","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/S1474-4422(19)30320-5","volume":"8","author":"MA Nalls","year":"2019","unstructured":"Nalls MA, Blauwendraat C, Vallerga CL, Heilbron K, Bandres-Ciga S, Chang D, Tan M, Kia DA, Noyce AJ et al (2019) Identification of novel risk loci, causal insights, and heritable risk for Parkinson\u2019s disease: a meta-analysis of genome-wide association studies. Lancet Neurol 8:1091\u20131102. https:\/\/doi.org\/10.1016\/S1474-4422(19)30320-5","journal-title":"Lancet Neurol"},{"key":"827_CR121","doi-asserted-by":"publisher","first-page":"9843","DOI":"10.1074\/jbc.274.14.9843","volume":"274","author":"L Narhi","year":"1999","unstructured":"Narhi L, Wood SJ, Steavenson S, Jiang Y, Wu GM, Anafi D, Kaufman SA, Martin F, Sitney K, Denis P, Louis J-C, Wypych J, Biere AL, Citron M (1999) Both Familial Parkinson\u2019s Disease Mutations Accelerate \u03b1-synuclein Aggregation*. J Biol Chem 274:9843\u20139846. https:\/\/doi.org\/10.1074\/jbc.274.14.9843","journal-title":"J Biol Chem"},{"key":"827_CR122","doi-asserted-by":"publisher","first-page":"3931","DOI":"10.1038\/srep03931","volume":"4","author":"J Neuner","year":"2014","unstructured":"Neuner J, Filser S, Michalakis S, Biel M, Herms J (2014) p.A30P \u03b1-synuclein interferes with the stable integration of adult-born neurons into the olfactory network. Sci Rep 4:3931. https:\/\/doi.org\/10.1038\/srep03931","journal-title":"Sci Rep"},{"key":"827_CR123","doi-asserted-by":"publisher","first-page":"e67713","DOI":"10.1371\/journal.pone.0067713","volume":"8","author":"SB Nielsen","year":"2013","unstructured":"Nielsen SB, Macchi F, Raccosta S, Langkilde AE, Giehm L, Kyrsting A, Svane ASP, Manno M, Christiansen G, Nielsen NC (2013) Wildtype and p.A30P mutant alpha-synuclein form different fibril structures. PLoS ONE 8:e67713. https:\/\/doi.org\/10.1371\/journal.pone.0067713","journal-title":"PLoS ONE"},{"key":"827_CR124","doi-asserted-by":"publisher","first-page":"34885","DOI":"10.1074\/jbc.M110.148460","volume":"285","author":"T Nonaka","year":"2010","unstructured":"Nonaka T, Watanabe ST, Iwatsubo T, Hasegawa M (2010) Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases. J Biol Chem 285:34885\u201334898. https:\/\/doi.org\/10.1074\/jbc.M110.148460","journal-title":"J Biol Chem"},{"key":"827_CR125","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.neuron.2017.11.036","volume":"97","author":"DG Ordonez","year":"2018","unstructured":"Ordonez DG, Lee MK, Feany MB (2018) \u03b1-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton. Neuron 97:108\u2013124e106. https:\/\/doi.org\/10.1016\/j.neuron.2017.11.036","journal-title":"Neuron"},{"key":"827_CR126","doi-asserted-by":"publisher","first-page":"6048","DOI":"10.1523\/jneurosci.20-16-06048.2000","volume":"20","author":"N Ostrerova-Golts","year":"2000","unstructured":"Ostrerova-Golts N, Petrucelli L, Hardy J, Lee JM, Farer M, Wolozin B (2000) The p.A53T \u03b1-synuclein Mutation Increases Iron-Dependent Aggregation and Toxicity. J Neurosci 20:6048\u20136054. https:\/\/doi.org\/10.1523\/jneurosci.20-16-06048.2000","journal-title":"J Neurosci"},{"key":"827_CR127","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3233\/jpd-160779","volume":"6","author":"A Oueslati","year":"2016","unstructured":"Oueslati A (2016) Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade? J Parkinsons Dis 6:39\u201351. https:\/\/doi.org\/10.3233\/jpd-160779","journal-title":"J Parkinsons Dis"},{"key":"827_CR128","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1126\/science.1090439","volume":"302","author":"TF Outeiro","year":"2003","unstructured":"Outeiro TF, Lindquist S (2003) Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science 302:1772\u20131775. https:\/\/doi.org\/10.1126\/science.1090439","journal-title":"Science"},{"key":"827_CR129","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.nbd.2018.08.001","volume":"119","author":"I Paiva","year":"2018","unstructured":"Paiva I, Jain G, L\u00e1zaro DF, Jer\u010di\u0107 KG, Hentrich T, Kerimoglu C, Pinho R, Szeg\u0151 \u00c8M, Burkhardt S, Capece V, Halder R, Islam R, Xylaki M, Caldi Gomes LA, Roser A-E, Lingor P, Schulze-Hentrich JM, Borove\u010dki F, Fischer A, Outeiro TF (2018) Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function. Neurobiol Dis 119:121\u2013135. https:\/\/doi.org\/10.1016\/j.nbd.2018.08.001","journal-title":"Neurobiol Dis"},{"key":"827_CR130","doi-asserted-by":"publisher","first-page":"16895","DOI":"10.1074\/jbc.M800747200","volume":"283","author":"KE Paleologou","year":"2008","unstructured":"Paleologou KE, Schmid AW, Rospigliosi CC, Kim HY, Lamberto GR, Fredenburg RA, Lansbury PT Jr., Fernandez CO, Eliezer D, Zweckstetter M, Lashuel HA (2008) Phosphorylation at Ser-129 but not the phosphomimics S129E\/D inhibits the fibrillation of alpha-synuclein. J Biol Chem 283:16895\u201316905. https:\/\/doi.org\/10.1074\/jbc.M800747200","journal-title":"J Biol Chem"},{"key":"827_CR131","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1212\/wnl.52.3.651","volume":"52","author":"A Papadimitriou","year":"1999","unstructured":"Papadimitriou A, Veletza V, Hadjigeorgiou G, Patrikiou A, Hirano M, Anastasopoulos I (1999) Mutated \u03b1-synuclein gene in two Greek kindreds with familial PD: incomplete penetrance? Neurology 52:651\u2013651. https:\/\/doi.org\/10.1212\/wnl.52.3.651","journal-title":"Neurology"},{"key":"827_CR132","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1176\/jnp.14.2.223","volume":"14","author":"J Parkinson","year":"2002","unstructured":"Parkinson J (2002) An essay on the shaking palsy. J Neuropsychiatry Clin Neurosci 14:223\u2013236. https:\/\/doi.org\/10.1176\/jnp.14.2.223","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"827_CR133","doi-asserted-by":"publisher","first-page":"2180.e2181","DOI":"10.1016\/j.neurobiolaging.2014.03.024","volume":"35","author":"P Pasanen","year":"2014","unstructured":"Pasanen P, Myllykangas L, Siitonen M, Raunio A, Kaakkola S, Lyytinen J, Tienari PJ, P\u00f6yh\u00f6nen M, Paetau A (2014) A novel \u03b1-synuclein mutation p.A53E associated with atypical multiple system atrophy and Parkinson\u2019s disease-type pathology. Neurobiol Aging 35:2180.e2181-2180.e2185. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.03.024","journal-title":"Neurobiol Aging"},{"key":"827_CR134","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2505240122","volume":"122","author":"C Paschou","year":"2025","unstructured":"Paschou C, Apokotou O, Charmpi K, Kollias A, Dede S, Samiotaki M, Koutsoudaki PN, Havaki S, Palese F, Dimoula K, Emmanouilidou E, Gorgoulis VG, Taoufik E, Zurzolo C, Matsas R, Papastefanaki F (2025) Dysregulated proteostasis in p.p.A53T-\u03b1-synuclein astrocytes aggravates Lewy-like neuropathology in a Parkinson\u2019s disease iPSC model. Proc Natl Acad Sci U S A 122:e2505240122. https:\/\/doi.org\/10.1073\/pnas.2505240122","journal-title":"Proc Natl Acad Sci U S A"},{"key":"827_CR135","doi-asserted-by":"publisher","first-page":"7177","DOI":"10.1074\/jbc.M808895200","volume":"284","author":"JD Perlmutter","year":"2009","unstructured":"Perlmutter JD, Braun AR, Sachs JN (2009) Curvature Dynamics of \u03b1-synuclein Familial Parkinson Disease Mutants*. J Biol Chem 284:7177\u20137189. https:\/\/doi.org\/10.1074\/jbc.M808895200","journal-title":"J Biol Chem"},{"key":"827_CR136","doi-asserted-by":"publisher","first-page":"552549","DOI":"10.3389\/fcell.2021.552549","volume":"9","author":"M Perni","year":"2021","unstructured":"Perni M, van der Goot A, Limbocker R, van Ham TJ, Aprile FA, Xu CK, Flagmeier P, Thijssen K, Sormanni P, Fusco G, Chen SW, Challa PK, Kirkegaard JB, Laine RF, Ma KY, M\u00fcller MBD, Sinnige T, Kumita JR, Cohen SIA, Seinstra R, Kaminski Schierle GS, Kaminski CF, Barbut D, De Simone A, Knowles TPJ, Zasloff M, Nollen EAA, Vendruscolo M, Dobson CM (2021) Comparative Studies in the p.A30P and p.A53T \u03b1-synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson\u2019s Disease. Front Cell Dev Biol 9:552549. https:\/\/doi.org\/10.3389\/fcell.2021.552549","journal-title":"Front Cell Dev Biol"},{"key":"827_CR137","doi-asserted-by":"publisher","first-page":"27567","DOI":"10.1074\/jbc.M112.361865","volume":"287","author":"D Petroi","year":"2012","unstructured":"Petroi D, Popova B, Taheri-Talesh N, Irniger S, Shahpasandzadeh H, Zweckstetter M, Outeiro TF, Braus GH (2012) Aggregate clearance of \u03b1-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome. J Biol Chem 287:27567\u201327579. https:\/\/doi.org\/10.1074\/jbc.M112.361865","journal-title":"J Biol Chem"},{"key":"827_CR138","first-page":"205","volume":"59","author":"M Plaas","year":"2008","unstructured":"Plaas M, Karis A, Innos J, Rebane E, Baekelandt V, Vaarmann A, Luuk H, Vasar E, Koks S (2008) Alpha-synuclein p.A30P point-mutation generates age-dependent nigrostriatal deficiency in mice. J Physiol Pharmacol 59:205","journal-title":"J Physiol Pharmacol"},{"key":"827_CR139","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","volume":"276","author":"MH Polymeropoulos","year":"1997","unstructured":"Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson\u2019s disease. Science 276:2045\u20132047. https:\/\/doi.org\/10.1126\/science.276.5321.2045","journal-title":"Science"},{"key":"827_CR140","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1002\/mds.24962","volume":"27","author":"M Poulopoulos","year":"2012","unstructured":"Poulopoulos M, Levy OA, Alcalay RN (2012) The neuropathology of genetic Parkinson\u2019s disease. Mov Disord 27:831\u2013842. https:\/\/doi.org\/10.1002\/mds.24962","journal-title":"Mov Disord"},{"key":"827_CR141","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/mds.21782","volume":"23","author":"KM Powers","year":"2008","unstructured":"Powers KM, Kay DM, Factor SA, Zabetian CP, Higgins DS, Samii A, Nutt JG, Griffith A, Leis B, Roberts JW, Martinez ED, Montimurro JS, Checkoway H, Payami H (2008) Combined effects of smoking, coffee, and NSAIDs on Parkinson\u2019s disease risk. Mov Disord 23:88\u201395. https:\/\/doi.org\/10.1002\/mds.21782","journal-title":"Mov Disord"},{"key":"827_CR142","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1083\/jcb.201011118","volume":"194","author":"IM Pranke","year":"2011","unstructured":"Pranke IM, Morello V, Bigay J, Gibson K, Verbavatz J-M, Antonny B, Jackson CL (2011) \u03b1-synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding. J Biol Chem 194:89\u2013103. https:\/\/doi.org\/10.1083\/jcb.201011118","journal-title":"J Biol Chem"},{"key":"827_CR143","doi-asserted-by":"publisher","first-page":"26515","DOI":"10.1074\/jbc.M003542200","volume":"275","author":"AN Pronin","year":"2000","unstructured":"Pronin AN, Morris AJ, Surguchov A, Benovic JL (2000) Synucleins are a novel class of substrates for G protein-coupled receptor kinases *. J Biol Chem 275:26515\u201326522. https:\/\/doi.org\/10.1074\/jbc.M003542200","journal-title":"J Biol Chem"},{"key":"827_CR144","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1212\/WNL.0b013e31828727ba","volume":"80","author":"C Proukakis","year":"2013","unstructured":"Proukakis C, Dudzik CG, Brier T, MacKay DS, Cooper JM, Millhauser GL, Houlden H, Schapira AH (2013) A novel \u03b1-synuclein missense mutation in Parkinson disease. Neurology 80:1062\u20131064. https:\/\/doi.org\/10.1212\/WNL.0b013e31828727ba","journal-title":"Neurology"},{"key":"827_CR145","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.parkreldis.2009.06.007","volume":"15","author":"A Puschmann","year":"2009","unstructured":"Puschmann A, Ross OA, Vilari\u00f1o-G\u00fcell C, Lincoln SJ, Kachergus JM, Cobb SA, Lindquist SG, Nielsen JE, Wszolek ZK, Farrer M, Widner H, van Westen D, H\u00e4gerstr\u00f6m D, Markopoulou K, Chase BA, Nilsson K, Reimer J, Nilsson C (2009) A Swedish family with de novo \u03b1-synuclein p.A53T mutation: Evidence for early cortical dysfunction. Parkinsonism Relat Disord 15:627\u2013632. https:\/\/doi.org\/10.1016\/j.parkreldis.2009.06.007","journal-title":"Parkinsonism Relat Disord"},{"key":"827_CR146","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41531-023-00444-w","volume":"9","author":"N Ramalingam","year":"2023","unstructured":"Ramalingam N, Jin S-X, Moors TE, Fonseca-Ornelas L, Shimanaka K, Lei S, Cam HP, Watson AH, Brontesi L, Ding L, Hacibaloglu DY, Jiang H, Choi SJ, Kanter E, Liu L, Bartels T, Nuber S, Sulzer D, Mosharov EV, Chen WV, Li S, Selkoe DJ, Dettmer U (2023) Dynamic physiological \u03b1-synuclein S129 phosphorylation is driven by neuronal activity. NPJ Parkinsons Dis 9:4. https:\/\/doi.org\/10.1038\/s41531-023-00444-w","journal-title":"NPJ Parkinsons Dis"},{"key":"827_CR147","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1021\/acs.biochem.6b00280","volume":"55","author":"P Ranjan","year":"2016","unstructured":"Ranjan P, Kumar A (2016) The Involvement of His50 during Protein Disulfide Isomerase Binding Is Essential for Inhibiting \u03b1-synuclein Fibril Formation. Biochemistry 55:2677\u20132680. https:\/\/doi.org\/10.1021\/acs.biochem.6b00280","journal-title":"Biochemistry"},{"key":"827_CR148","doi-asserted-by":"publisher","first-page":"6621507","DOI":"10.1155\/2021\/6621507","volume":"2021","author":"S Reiszadeh Jahromi","year":"2021","unstructured":"Reiszadeh Jahromi S, Ramesh SR, Finkelstein DI, Haddadi M (2021) \u03b1-synuclein p.E46K Mutation and Involvement of Oxidative Stress in a Drosophila Model of Parkinson\u2019s Disease. Parkinsons Dis 2021:6621507. https:\/\/doi.org\/10.1155\/2021\/6621507","journal-title":"Parkinsons Dis"},{"key":"827_CR149","doi-asserted-by":"publisher","first-page":"19366","DOI":"10.1021\/ja2029848","volume":"133","author":"NP Reynolds","year":"2011","unstructured":"Reynolds NP, Soragni A, Rabe M, Verdes D, Liverani E, Handschin S, Riek R, Seeger S (2011) Mechanism of Membrane Interaction and Disruption by \u03b1-synuclein. J Am Chem Soc 133:19366\u201319375. https:\/\/doi.org\/10.1021\/ja2029848","journal-title":"J Am Chem Soc"},{"key":"827_CR150","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1007\/s00018-012-1198-8","volume":"70","author":"G Rodriguez-Araujo","year":"2013","unstructured":"Rodriguez-Araujo G, Nakagami H, Hayashi H, Mori M, Shiuchi T, Minokoshi Y, Nakaoka Y, Takami Y, Komuro I, Morishita R, Kaneda Y (2013) Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1\/PI3K\/Akt transduction pathway. Cell Mol Life Sci 70:1123\u20131133. https:\/\/doi.org\/10.1007\/s00018-012-1198-8","journal-title":"Cell Mol Life Sci"},{"key":"827_CR151","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1021\/acschemneuro.8b00579","volume":"10","author":"VC Ruf","year":"2019","unstructured":"Ruf VC, N\u00fcbling GS, Willikens S, Shi S, Schmidt F, Levin J, B\u00f6tzel K, Kamp F, Giese A (2019) Different Effects of \u03b1-synuclein Mutants on Lipid Binding and Aggregation Detected by Single Molecule Fluorescence Spectroscopy and ThT Fluorescence-Based Measurements. ACS Chem Neurosci 10:1649\u20131659. https:\/\/doi.org\/10.1021\/acschemneuro.8b00579","journal-title":"ACS Chem Neurosci"},{"key":"827_CR152","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.neulet.2015.04.022","volume":"597","author":"NJ Rutherford","year":"2015","unstructured":"Rutherford NJ, Giasson BI (2015) The p.A53E \u03b1-synuclein pathological mutation demonstrates reduced aggregation propensity in vitro and in cell culture. Neurosci Lett 597:43\u201348. https:\/\/doi.org\/10.1016\/j.neulet.2015.04.022","journal-title":"Neurosci Lett"},{"key":"827_CR153","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1111\/jnc.12806","volume":"131","author":"NJ Rutherford","year":"2014","unstructured":"Rutherford NJ, Moore BD, Golde TE, Giasson BI (2014) Divergent effects of the p.H50Q and p.G51D SNCA mutations on the aggregation of \u03b1-synuclein. J Neurochem 131:859\u2013867. https:\/\/doi.org\/10.1111\/jnc.12806","journal-title":"J Neurochem"},{"key":"827_CR154","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.cell.2013.11.009","volume":"155","author":"D Ryan Scott","year":"2013","unstructured":"Ryan SD, Dolatabadi N, Chan SF, Zhang X, Akhtar MW, Parker J, Soldner F, Sunico CR, Nagar S, Talantova M, Lee B, Lopez K, Nutter A, Shan B, Molokanova E, Zhang Y, Han X, Nakamura T, Masliah E, Yates JR III, Nakanishi N, Andreyev AY, Okamoto S-i, Jaenisch R, Ambasudhan R, Lipton SA (2013) Isogenic Human iPSC Parkinson\u2019s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1\u03b1 Transcription. Cell 155:1351\u20131364. https:\/\/doi.org\/10.1016\/j.cell.2013.11.009","journal-title":"Cell"},{"key":"827_CR155","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218261","volume":"14","author":"R Sakai","year":"2019","unstructured":"Sakai R, Suzuki M, Ueyama M, Takeuchi T, Minakawa EN, Hayakawa H, Baba K, Mochizuki H, Nagai Y (2019) P.E46K mutant \u03b1-synuclein is more degradation resistant and exhibits greater toxic effects than wild-type \u03b1-synuclein in Drosophila models of Parkinson\u2019s disease. PLoS One 14:e0218261. https:\/\/doi.org\/10.1371\/journal.pone.0218261","journal-title":"PLoS One"},{"key":"827_CR156","doi-asserted-by":"publisher","first-page":"4374","DOI":"10.1074\/jbc.M115.705095","volume":"291","author":"F Samuel","year":"2016","unstructured":"Samuel F, Flavin WP, Iqbal S, Pacelli C, Sri Renganathan SD, Trudeau LE, Campbell EM, Fraser PE, Tandon A (2016) Effects of Serine 129 Phosphorylation on \u03b1-synuclein Aggregation, Membrane Association, and Internalization. J Biol Chem 291:4374\u20134385. https:\/\/doi.org\/10.1074\/jbc.M115.705095","journal-title":"J Biol Chem"},{"key":"827_CR157","doi-asserted-by":"publisher","DOI":"10.1002\/pro.70195","volume":"34","author":"DQ SanGiovanni","year":"2025","unstructured":"SanGiovanni DQ, McGlinchey RP, Lee JC (2025) Amyloid formation of alternatively spliced variants of \u03b1-synuclein. Protein Sci 34:e70195. https:\/\/doi.org\/10.1002\/pro.70195","journal-title":"Protein Sci"},{"key":"827_CR158","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1080\/07391102.2017.1347060","volume":"36","author":"A Sanjeev","year":"2018","unstructured":"Sanjeev A, Mattaparthi VSK (2018) Computational investigation on the effects of p.H50Q and p.G51D mutations on the \u03b1-synuclein aggregation propensity. J Biomol Struct Dynamics 36:2224\u20132236. https:\/\/doi.org\/10.1080\/07391102.2017.1347060","journal-title":"J Biomol Struct Dynamics"},{"key":"827_CR159","doi-asserted-by":"publisher","first-page":"15779","DOI":"10.1007\/s12035-025-05236-2","volume":"62","author":"TR Sarhadi","year":"2025","unstructured":"Sarhadi TR, Joshi N, Nagotu S (2025) The Yeast Parkinson\u2019s Disease Model Exhibits An Increase in Peroxisome Number Independent of the Division Proteins Vps1 and Dnm1. Mol Neurobiol 62:15779\u201315797. https:\/\/doi.org\/10.1007\/s12035-025-05236-2","journal-title":"Mol Neurobiol"},{"key":"827_CR160","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nrn.2017.62","volume":"18","author":"AHV Schapira","year":"2017","unstructured":"Schapira AHV, Chaudhuri KR, Jenner P (2017) Non-motor features of Parkinson disease. Nat Rev Neurosci 18:435\u2013450. https:\/\/doi.org\/10.1038\/nrn.2017.62","journal-title":"Nat Rev Neurosci"},{"key":"827_CR161","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s40478-020-01026-0","volume":"8","author":"AJ Schaser","year":"2020","unstructured":"Schaser AJ, Stackhouse TL, Weston LJ, Kerstein PC, Osterberg VR, L\u00f3pez CS, Dickson DW, Luk KC, Meshul CK, Woltjer RL, Unni VK (2020) Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo p.A53T alpha-synuclein mouse model of synucleinopathy. Acta Neuropathol Commun 8:150. https:\/\/doi.org\/10.1186\/s40478-020-01026-0","journal-title":"Acta Neuropathol Commun"},{"key":"827_CR162","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1002\/mds.27193","volume":"32","author":"SA Schneider","year":"2017","unstructured":"Schneider SA, Alcalay RN (2017) Neuropathology of genetic synucleinopathies with parkinsonism: review of the literature. Mov Disord 32:1504\u20131523. https:\/\/doi.org\/10.1002\/mds.27193","journal-title":"Mov Disord"},{"key":"827_CR163","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1002\/ana.21966","volume":"67","author":"K Seidel","year":"2010","unstructured":"Seidel K, Sch\u00f6ls L, Nuber S, Petrasch-Parwez E, Gierga K, Wszolek Z, Dickson D, Gai WP, Bornemann A, Riess O, Rami A, Den Dunnen WFA, Deller T, R\u00fcb U, Kr\u00fcger R (2010) First appraisal of brain pathology owing to p.A30P mutant alpha-synuclein. Ann Neurol 67:684\u2013689. https:\/\/doi.org\/10.1002\/ana.21966","journal-title":"Ann Neurol"},{"key":"827_CR164","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1002\/mds.23313","volume":"25","author":"T Sekine","year":"2010","unstructured":"Sekine T, Kagaya H, Funayama M, Li Y, Yoshino H, Tomiyama H, Hattori N (2010) Clinical course of the first Asian family with Parkinsonism related to SNCA triplication. Mov Disord 25:2871\u20132875. https:\/\/doi.org\/10.1002\/mds.23313","journal-title":"Mov Disord"},{"key":"827_CR165","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00415-024-12836-w","volume":"272","author":"AM Simitsi","year":"2025","unstructured":"Simitsi AM, Sfikas E, Koros C, Papagiannakis N, Beratis I, Papadimitriou D, Antonellou R, Fragiadaki S, Kontaxopoulou D, Picillo M, Pachi I, Alefanti I, Stamelou M, Barone P, Stefanis L (2025) Motor and nonmotor features of p.p.A53T alpha-synuclein PD vs idiopathic PD: longitudinal data from the PPMI study. J Neurol 272:203. https:\/\/doi.org\/10.1007\/s00415-024-12836-w","journal-title":"J Neurol"},{"key":"827_CR166","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1038\/ng.487","volume":"41","author":"J Sim\u00f3n-S\u00e1nchez","year":"2009","unstructured":"Sim\u00f3n-S\u00e1nchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Kr\u00fcger R, Federoff M, Klein C, Goate A, Perlmutter J, Bonin M, Nalls MA, Illig T, Gieger C, Houlden H, Steffens M, Okun MS, Racette BA, Cookson MR, Foote KD, Fernandez HH, Traynor BJ, Schreiber S, Arepalli S, Zonozi R, Gwinn K, van der Brug M, Lopez G, Chanock SJ, Schatzkin A, Park Y, Hollenbeck A, Gao J, Huang X, Wood NW, Lorenz D, Deuschl G, Chen H, Riess O, Hardy JA, Singleton AB, Gasser T (2009) Genome-wide association study reveals genetic risk underlying Parkinson\u2019s disease. Nat Genet 41:1308\u201312. https:\/\/doi.org\/10.1038\/ng.487","journal-title":"Nat Genet"},{"key":"827_CR167","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1126\/science.1090278","volume":"302","author":"AB Singleton","year":"2003","unstructured":"Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, Lincoln S, Crawley A, Hanson M, Maraganore D, Adler C, Cookson MR, Muenter M, Baptista M, Miller D, Blancato J, Hardy J, Gwinn-Hardy K (2003) alpha-Synuclein locus triplication causes Parkinson\u2019s disease. Science 302:841. https:\/\/doi.org\/10.1126\/science.1090278","journal-title":"Science"},{"key":"827_CR168","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.1093\/hmg\/ddi396","volume":"14","author":"WW Smith","year":"2005","unstructured":"Smith WW, Jiang H, Pei Z, Tanaka Y, Morita H, Sawa A, Dawson VL, Dawson TM, Ross CA (2005) Endoplasmic reticulum stress and mitochondrial cell death pathways mediate p.A53T mutant alpha-synuclein-induced toxicity. Hum Mol Genet 14:3801\u20133811. https:\/\/doi.org\/10.1093\/hmg\/ddi396","journal-title":"Hum Mol Genet"},{"key":"827_CR169","doi-asserted-by":"publisher","first-page":"3725","DOI":"10.1091\/mbc.e08-03-0302","volume":"20","author":"VL Sousa","year":"2009","unstructured":"Sousa VL, Bellani S, Giannandrea M, Yousuf M, Valtorta F, Meldolesi J, Chieregatti E (2009) \u03b1-synuclein and Its p.A30P Mutant Affect Actin Cytoskeletal Structure and Dynamics. Mol Biol Cell 20:3725\u20133739. https:\/\/doi.org\/10.1091\/mbc.e08-03-0302","journal-title":"Mol Biol Cell"},{"key":"827_CR170","doi-asserted-by":"publisher","first-page":"9549","DOI":"10.1523\/jneurosci.21-24-09549.2001","volume":"21","author":"L Stefanis","year":"2001","unstructured":"Stefanis L, Larsen KE, Rideout HJ, Sulzer D, Greene LA (2001) Expression of p.A53T mutant but not wild-type \u03b1-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death. J Neurosci 21:9549\u20139560. https:\/\/doi.org\/10.1523\/jneurosci.21-24-09549.2001","journal-title":"J Neurosci"},{"key":"827_CR171","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63412-x","volume":"10","author":"TJ Stevenson","year":"2020","unstructured":"Stevenson TJ, Murray HC, Turner C, Faull RLM, Dieriks BV, Curtis MA (2020) \u03b1-synuclein inclusions are abundant in non-neuronal cells in the anterior olfactory nucleus of the Parkinson\u2019s disease olfactory bulb. Sci Rep 10:6682. https:\/\/doi.org\/10.1038\/s41598-020-63412-x","journal-title":"Sci Rep"},{"key":"827_CR172","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109099","volume":"35","author":"MG Stykel","year":"2021","unstructured":"Stykel MG, Humphries KM, Kamski-Hennekam E, Buchner-Duby B, Porte-Trachsel N, Ryan T, Coackley CL, Bamm VV, Harauz G, Ryan SD (2021) \u03b1-synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of \u03b1-synuclein pathology. Cell Rep 35:109099. https:\/\/doi.org\/10.1016\/j.celrep.2021.109099","journal-title":"Cell Rep"},{"key":"827_CR173","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/s41422-020-0299-4","volume":"30","author":"Y Sun","year":"2020","unstructured":"Sun Y, Hou S, Zhao K, Long H, Liu Z, Gao J, Zhang Y, Su X-D, Li D, Liu C (2020) Cryo-EM structure of full-length \u03b1-synuclein amyloid fibril with Parkinson\u2019s disease familial p.A53T mutation. Cell Res 30:360\u2013362. https:\/\/doi.org\/10.1038\/s41422-020-0299-4","journal-title":"Cell Res"},{"key":"827_CR174","doi-asserted-by":"publisher","first-page":"6252","DOI":"10.1038\/s41467-021-26433-2","volume":"12","author":"Y Sun","year":"2021","unstructured":"Sun Y, Long H, Xia W, Wang K, Zhang X, Sun B, Cao Q, Zhang Y, Dai B, Li D, Liu C (2021) The hereditary mutation p.G51D unlocks a distinct fibril strain transmissible to wild-type \u03b1-synuclein. Nat Commun 12:6252. https:\/\/doi.org\/10.1038\/s41467-021-26433-2","journal-title":"Nat Commun"},{"key":"827_CR175","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jbc.2023.104566","volume":"18","author":"C Sun","year":"2023","unstructured":"Sun C, Zhou K, DePaola PIV, Shin WS, Hillyer T, Sawaya MR, Zhu R, Peng C, Zhou ZH, Jiang L (2023) Cryo-EM structure of amyloid fibril formed by \u03b1-synuclein hereditary p.A53E mutation reveals a distinct protofilament interface. J Biol Chem 18:193\u2013200. https:\/\/doi.org\/10.1016\/j.jbc.2023.104566","journal-title":"J Biol Chem"},{"key":"827_CR176","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0304-3940(02)01258-2","volume":"336","author":"M Takahashi","year":"2003","unstructured":"Takahashi M, Kanuka H, Fujiwara H, Koyama A, Hasegawa M, Miura M, Iwatsubo T (2003) Phosphorylation of \u03b1-synuclein characteristic of synucleinopathy lesions is recapitulated in \u03b1-synuclein transgenic Drosophila. Neurosci Lett 336:155\u2013158. https:\/\/doi.org\/10.1016\/S0304-3940(02)01258-2","journal-title":"Neurosci Lett"},{"key":"827_CR177","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1093\/hmg\/10.9.919","volume":"10","author":"Y Tanaka","year":"2001","unstructured":"Tanaka Y, Engelender S, Igarashi S, Rao RK, Wanner T, Tanzi RE, Sawa A, Dawson L, Dawson V, Ross TM CA (2001) Inducible expression of mutant \u03b1-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Hum Mol Genet 10:919\u2013926. https:\/\/doi.org\/10.1093\/hmg\/10.9.919","journal-title":"Hum Mol Genet"},{"key":"827_CR178","doi-asserted-by":"publisher","first-page":"9754","DOI":"10.1523\/jneurosci.0344-18.2018","volume":"38","author":"PJ Teravskis","year":"2018","unstructured":"Teravskis PJ, Covelo A, Miller EC, Singh B, Martell-Mart\u00ednez HA, Benneyworth MA, Gallardo C, Oxnard BR, Araque A, Lee MK, Liao D (2018) p.A53T Mutant Alpha-Synuclein Induces Tau-Dependent Postsynaptic Impairment Independently of Neurodegenerative Changes. J Neurosci 38:9754\u20139767. https:\/\/doi.org\/10.1523\/jneurosci.0344-18.2018","journal-title":"J Neurosci"},{"key":"827_CR179","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1091\/mbc.e09-09-0801","volume":"21","author":"N Thayanidhi","year":"2010","unstructured":"Thayanidhi N, Helm JR, Nycz DC, Bentley M, Liang Y, Hay JC (2010) \u03b1-synuclein delays endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER\/Golgi SNAREs. Mol Biol Cell 21:1850\u20131863. https:\/\/doi.org\/10.1091\/mbc.e09-09-0801","journal-title":"Mol Biol Cell"},{"key":"827_CR180","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1212\/WNL.0b013e3181fd613b","volume":"75","author":"T Tokuda","year":"2010","unstructured":"Tokuda T, Qureshi MM, Ardah MT, Varghese S, Shehab SAS, Kasai T, Ishigami N, Tamaoka A, Nakagawa M, El-Agnaf OMA (2010) Detection of elevated levels of \u03b1-synuclein oligomers in CSF from patients with Parkinson disease. Neurology 75:1766\u20131770. https:\/\/doi.org\/10.1212\/WNL.0b013e3181fd613b","journal-title":"Neurology"},{"key":"827_CR181","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.parkreldis.2013.11.008","volume":"20","author":"T Tokutake","year":"2014","unstructured":"Tokutake T, Ishikawa A, Yoshimura N, Miyashita A, Kuwano R, Nishizawa M, Ikeuchi T (2014) Clinical and neuroimaging features of patient with early-onset Parkinson\u2019s disease with dementia carrying SNCA p.p.G51D mutation. Parkinsonism Relat Disord 20:262\u2013264. https:\/\/doi.org\/10.1016\/j.parkreldis.2013.11.008","journal-title":"Parkinsonism Relat Disord"},{"key":"827_CR182","doi-asserted-by":"publisher","first-page":"3409","DOI":"10.1523\/JNEUROSCI.4977-09.2010","volume":"30","author":"E Tsika","year":"2010","unstructured":"Tsika E, Moysidou M, Guo J, Cushman M, Gannon P, Sandaltzopoulos R, Giasson BI, Krainc D, Ischiropoulos H, Mazzulli JR (2010) Distinct Region-Specific \u03b1-synuclein Oligomers in p.A53T Transgenic Mice: Implications for Neurodegeneration. J Neurosci 30:3409\u20133418. https:\/\/doi.org\/10.1523\/JNEUROSCI.4977-09.2010","journal-title":"J Neurosci"},{"key":"827_CR183","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1080\/07391102.2003.10506918","volume":"21","author":"VN Uversky","year":"2003","unstructured":"Uversky VN (2003) A Protein-Chameleon: Conformational Plasticity of \u03b1-synuclein, a Disordered Protein Involved in Neurodegenerative Disorders. J Biomol Struct Dynamics 21:211\u2013234. https:\/\/doi.org\/10.1080\/07391102.2003.10506918","journal-title":"J Biomol Struct Dynamics"},{"key":"827_CR184","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1021\/cn3002027","volume":"4","author":"O Wise-Scira","year":"2013","unstructured":"Wise-Scira O, Dunn A, Aloglu AK, Sakallioglu IT, Coskuner O (2013) Structures of the p.E46K Mutant-Type \u03b1-synuclein Protein and Impact of p.E46K Mutation on the Structures of the Wild-Type \u03b1-synuclein Protein. ACS Chem Neurosci 4:498\u2013508. https:\/\/doi.org\/10.1021\/cn3002027","journal-title":"ACS Chem Neurosci"},{"key":"827_CR185","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1007\/s12035-012-8325-2","volume":"47","author":"SN Witt","year":"2013","unstructured":"Witt SN (2013) Molecular chaperones, alpha-synuclein, and neurodegeneration. Mol Neurobiol 47:552\u2013560. https:\/\/doi.org\/10.1007\/s12035-012-8325-2","journal-title":"Mol Neurobiol"},{"issue":"1","key":"827_CR186","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13024-015-0004-0","volume":"10","author":"W Xiang","year":"2015","unstructured":"Xiang W, Menges S, Schlachetzki JCM, Meixner H, Hoffmann A-C, Schl\u00f6tzer-Schrehardt U, Becker C-M, Winkler J, Klucken J (2015) Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity. Mol Neurodegener 10:8. https:\/\/doi.org\/10.1186\/s13024-015-0004-0","journal-title":"Mol Neurodegener"},{"key":"827_CR187","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1111\/j.1471-4159.2012.07769.x","volume":"122","author":"W Xie","year":"2012","unstructured":"Xie W, Chung KKK (2012) Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson\u2019s disease. J Neurochem 122:404\u2013414. https:\/\/doi.org\/10.1111\/j.1471-4159.2012.07769.x","journal-title":"J Neurochem"},{"key":"827_CR188","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1007\/s00415-016-8213-1","volume":"263","author":"W-X Xiong","year":"2016","unstructured":"Xiong W-X, Sun Y-M, Guan R-Y, Luo S-S, Chen C, An Y, Wang J, Wu J-J (2016) The heterozygous p.A53T mutation in the alpha-synuclein gene in a Chinese Han patient with Parkinson disease: case report and literature review. J Neurol 263:1984\u20131992. https:\/\/doi.org\/10.1007\/s00415-016-8213-1","journal-title":"J Neurol"},{"key":"827_CR189","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/acn3.38","volume":"1","author":"E Yakunin","year":"2014","unstructured":"Yakunin E, Kisos H, Kulik W, Grigoletto J, Wanders RJA, Sharon R (2014) The regulation of catalase activity by PPAR \u03b3 is affected by \u03b1-synuclein. Ann Clin Transl Neurol 1:145\u2013159. https:\/\/doi.org\/10.1002\/acn3.38","journal-title":"Ann Clin Transl Neurol"},{"key":"827_CR190","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s12035-014-8738-1","volume":"50","author":"J-Q Yan","year":"2014","unstructured":"Yan J-Q, Yuan Y-H, Gao Y-N, Huang J-Y, Ma K-L, Gao Y, Zhang W-Q, Guo X-F, Chen N-H (2014) Overexpression of Human p.E46K Mutant \u03b1-synuclein Impairs Macroautophagy via Inactivation of JNK1-Bcl-2 Pathway. Mol Neurobiol 50:685\u2013701. https:\/\/doi.org\/10.1007\/s12035-014-8738-1","journal-title":"Mol Neurobiol"},{"key":"827_CR191","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.nbd.2005.03.010","volume":"20","author":"L Yavich","year":"2005","unstructured":"Yavich L, Oksman M, Tanila H, Kerokoski P, Hiltunen M, van Groen T, Puoliv\u00e4li J, M\u00e4nnist\u00f6 PT, Garc\u00eda-Horsman A, MacDonald E, Beyreuther K, Hartmann T, J\u00e4k\u00e4l\u00e4 P (2005) Locomotor activity and evoked dopamine release are reduced in mice overexpressing p.A30P-mutated human \u03b1-synuclein. Neurobiol Dis 20:303\u2013313. https:\/\/doi.org\/10.1016\/j.nbd.2005.03.010","journal-title":"Neurobiol Dis"},{"key":"827_CR192","doi-asserted-by":"publisher","first-page":"248e247","DOI":"10.1016\/j.neurobiolaging.2017.05.022","volume":"57","author":"H Yoshino","year":"2017","unstructured":"Yoshino H, Hirano M, Stoessl AJ, Imamichi Y, Ikeda A, Li Y, Funayama M, Yamada I, Nakamura Y, Sossi V, Farrer MJ, Nishioka K, Hattori N (2017) Homozygous alpha-synuclein p.p.A53V in familial Parkinson\u2019s disease. Neurobiol Aging 57:248e247\u2013248e248. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.05.022. .e212 doi","journal-title":"Neurobiol Aging"},{"key":"827_CR193","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1002\/ana.10795","volume":"55","author":"JJ Zarranz","year":"2004","unstructured":"Zarranz JJ, Alegre J, G\u00f3mez-Esteban JC, Lezcano E, Ros R, Ampuero I, Vidal L, Hoenicka J, Rodriguez O, Atar\u00e9s B, Llorens V, Gomez Tortosa E, del Ser T, Mu\u00f1oz DG, de Yebenes JG (2004) The new mutation, p.E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 55:164\u2013173. https:\/\/doi.org\/10.1002\/ana.10795","journal-title":"Ann Neurol"},{"key":"827_CR198","doi-asserted-by":"publisher","first-page":"8135","DOI":"10.1021\/bi052584t","volume":"45","author":"M Zhu","year":"2006","unstructured":"Zhu M, Qin Z-J, Hu D, Munishkina LA, Fink AL (2006) \u03b1-synuclein Can Function as an Antioxidant Preventing Oxidation of Unsaturated Lipid in Vesicles. Biochemistry 45:8135\u20138142. https:\/\/doi.org\/10.1021\/bi052584t","journal-title":"Biochemistry"},{"key":"827_CR194","doi-asserted-by":"publisher","unstructured":"Zhan T (2024) p.H50Q Mutation promoting a-synuclein binding to vesicle. Appl Ecol Environ Res 22. https:\/\/doi.org\/10.15666\/aeer\/2206_58635874","DOI":"10.15666\/aeer\/2206_58635874"},{"key":"827_CR196","doi-asserted-by":"publisher","DOI":"10.1101\/2025.10.22.682553","author":"T Zhang","year":"2025","unstructured":"Zhang T, Goya ME, Herron-Bedoya A, van der Weerd JC, Tsagkari D, Couzijn S, G\u00fcng\u00f6rd\u00fc L, Seinstra RI, Fokkema MRH, Chang M, Tavernarakis N, Kuipers F, Nollen EAA (2025) Condensate-Driven Triglyceride Depletion Links \u03b1-synuclein to Mitochondrial Dysfunction. bioRxiv. https:\/\/doi.org\/10.1101\/2025.10.22.682553","journal-title":"bioRxiv"},{"key":"827_CR195","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1093\/hmg\/ddz057","volume":"28","author":"X-M Zhang","year":"2019","unstructured":"Zhang X-M, Anwar S, Kim Y, Brown J, Comte I, Cai H, Cai N-N, Wade-Martins R, Szele FG (2019) The p.A30P \u03b1-synuclein mutation decreases subventricular zone proliferation. Hum Mol Genet 28:2283\u20132294. https:\/\/doi.org\/10.1093\/hmg\/ddz057","journal-title":"Hum Mol Genet"},{"key":"827_CR197","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1093\/brain\/awaa167","volume":"143","author":"Y Zhao","year":"2020","unstructured":"Zhao Y, Qin L, Pan H, Liu Z, Jiang L, He Y, Zeng Q, Zhou X, Zhou X, Zhou Y, Fang Z, Wang Z, Xiang Y, Yang H, Wang Y, Zhang K, Zhang R, He R, Zhou X, Zhou Z, Yang N, Liang D, Chen J, Zhang X, Zhou Y, Liu H, Deng P, Xu K, Xu K, Zhou C, Zhong J, Xu Q, Sun Q, Li B, Zhao G, Wang T, Chen L, Shang H, Liu W, Chan P, Xue Z, Wang Q, Guo L, Wang X, Xu C, Zhang Z, Chen T, Lei L, Zhang H, Wang C, Tan J, Yan X, Shen L, Jiang H, Zhang Z, Hu Z, Xia K, Yue Z, Li J, Guo J, Tang B (2020) The role of genetics in Parkinson\u2019s disease: a large cohort study in Chinese mainland population. Brain 143:2220\u20132234. https:\/\/doi.org\/10.1093\/brain\/awaa167","journal-title":"Brain"}],"container-title":["Neurotoxicity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-026-00827-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-026-00827-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12640-026-00827-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:02:38Z","timestamp":1793300558000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12640-026-00827-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,12]]},"references-count":197,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["827"],"URL":"https:\/\/doi.org\/10.1007\/s12640-026-00827-w","relation":{},"ISSN":["1029-8428","1476-3524"],"issn-type":[{"value":"1029-8428","type":"print"},{"value":"1476-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,12]]},"assertion":[{"value":"22 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":1,"name":"Ethics","label":"Ethical statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"53"}}