{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:38:18Z","timestamp":1765233498585,"version":"3.37.3"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e0 degli Studi di Roma La Sapienza"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Maxillofac. Oral Surg."],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Post ablative oral mucosal defect resulting from the removal of tumors can be treated with various techniques.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>In this paper, we are showing what, in our experience, are the advantages and disadvantages given using biosynthetic skin substitutes when dealing with this kind of lesions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Patients included in the sample came to our attention with both neoplastic lesions (11 subjects) and important scar retraction after previous oncologic surgery (1 subject). All patients underwent trans-oral resection surgery following the same surgical protocol and post ablative oral mucosal defect were treated using the dermal regeneration template. The surgical defect location, size, and time of removal of the silicone layer varied from one subject to the other.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Most patients showed good healing with reduced scarring and adequate remucosalisation of the defect. The main complications were shown in a palatal lesion treated with concomitant osteal resection, which developed an oroantral fistula at follow up, and tongue lesions which showed some scarring.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Given our experience, we would advise using dermal substitutes when reconstructing oral defects only after a cautious evaluation of the area of the lesion, the gap size, the possible adherence of the membrane to the gap, and the presence of tissue supporting the overlying membrane.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12663-023-01889-5","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T18:02:59Z","timestamp":1679421779000},"page":"151-156","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dermal Regeneration Template: Reconstruction in Oral Cancer Defects"],"prefix":"10.1007","volume":"22","author":[{"given":"Nicol\u00f2","family":"Mangini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4829-9895","authenticated-orcid":false,"given":"Francesca","family":"Galvano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Resi","family":"Pucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Battisti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Cassoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentino","family":"Valentini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"issue":"1","key":"1889_CR1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/ccr3.3501","volume":"9","author":"A Srivastava","year":"2020","unstructured":"Srivastava A, Maniakas A, Myers J, Chambers MS, Cardoso R (2020) Reconstruction of intraoral oncologic surgical defects with Integra(\u00ae) bilayer wound matrix. 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Oral Oncol 48(4):379\u2013382. https:\/\/doi.org\/10.1016\/j.oraloncology.2011.10.016","journal-title":"Oral Oncol"},{"issue":"2","key":"1889_CR4","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.anl.2016.07.004","volume":"44","author":"N Jowett","year":"2017","unstructured":"Jowett N, Hadlock TA, Sela E, Toth M, Knecht R, L\u00f6rincz BB (2017) Facial mimetic, cosmetic, and functional standardized assessment of the facial artery musculomucosal (FAMM) flap. Auris Nasus Larynx 44(2):220\u2013226. https:\/\/doi.org\/10.1016\/j.anl.2016.07.004","journal-title":"Auris Nasus Larynx"},{"issue":"2","key":"1889_CR5","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.coms.2020.12.005","volume":"33","author":"F Chouikh","year":"2021","unstructured":"Chouikh F, Dierks EJ (2021) The Buccal fat pad flap. Oral Maxillofac Surg Clin North Am 33(2):177\u2013184. https:\/\/doi.org\/10.1016\/j.coms.2020.12.005","journal-title":"Oral Maxillofac Surg Clin North Am"},{"issue":"8","key":"1889_CR6","doi-asserted-by":"publisher","first-page":"300060520945508","DOI":"10.1177\/0300060520945508","volume":"48","author":"F De Francesco","year":"2020","unstructured":"De Francesco F, Busato A, Mannucci S et al (2020) Artificial dermal substitutes for tissue regeneration: comparison of the clinical outcomes and histological findings of two templates. J Int Med Res 48(8):300060520945508\u2013300060520945508. https:\/\/doi.org\/10.1177\/0300060520945508","journal-title":"J Int Med Res"},{"issue":"3","key":"1889_CR7","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1055\/s-0039-1693401","volume":"33","author":"DK Chang","year":"2019","unstructured":"Chang DK, Louis MR, Gimenez A, Reece EM (2019) The basics of integra dermal regeneration template and its expanding clinical applications. 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No funds, grants, or other support were received.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}