{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:34:42Z","timestamp":1772757282170,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Gastroenterol"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1007\/s12664-015-0559-2","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T00:17:21Z","timestamp":1430353041000},"page":"152-157","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The effects of topical application of metronidazole for treatment of chronic anal fissure: A randomized, controlled pilot study"],"prefix":"10.1007","volume":"34","author":[{"given":"Natalia Mihailovna","family":"Grekova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena Anatolyevna","family":"Maleva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuliana","family":"Lebedeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor Nicolaevich","family":"Bordunovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa Fedorovna","family":"Telesheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir Anatolyevich","family":"Bychkovskikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,5,1]]},"reference":[{"key":"559_CR1","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/bjs.1800831006","volume":"83","author":"JN Lund","year":"1996","unstructured":"Lund JN, Scholefield JH. Aetiology and treatment of anal fissure. Br J Surg. 1996;83:1335\u201344.","journal-title":"Br J Surg"},{"key":"559_CR2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10354-004-0038-3","volume":"154","author":"J Kirsch","year":"2004","unstructured":"Kirsch J. Anal fissure. Wien Med Wochenschr. 2004;154:69\u201372.","journal-title":"Wien Med Wochenschr"},{"key":"559_CR3","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/01.sla.0000171036.39886.fa","volume":"242","author":"E Ram","year":"2005","unstructured":"Ram E, Alper D, Stein GY, Bramnik Z, Dreznik Z. Internal anal sphincter function following lateral internal sphincterotomy for anal fissure. A long-term manometric study. Ann Surg. 2005;242:208\u201311.","journal-title":"Ann Surg"},{"key":"559_CR4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10151-007-0355-9","volume":"11","author":"EE Collins","year":"2007","unstructured":"Collins EE, Lund JN. A review of chronic anal fissure management. Tech Coloproctol. 2007;11:209\u201323.","journal-title":"Tech Coloproctol"},{"key":"559_CR5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/00015458.2006.11679942","volume":"106","author":"M Outryve Van","year":"2006","unstructured":"Van Outryve M. Physiopathology of the anal fissure. Acta Chir Belg. 2006;106:517\u20138.","journal-title":"Acta Chir Belg"},{"key":"559_CR6","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00384-005-0757-y","volume":"21","author":"JN Lund","year":"2006","unstructured":"Lund JN. Nitric oxide deficiency in the internal anal sphincter of patients with chronic anal fissure. Int J Colorectal Dis. 2006;21:673\u20135.","journal-title":"Int J Colorectal Dis"},{"key":"559_CR7","first-page":"5","volume":"1","author":"NN Krylov","year":"2008","unstructured":"Krylov NN. Chronic anal fissure. Vestn Khir Gastroenterol. 2008;1:5\u201311.","journal-title":"Vestn Khir Gastroenterol"},{"key":"559_CR8","first-page":"1327","volume":"10","author":"LA Blagodarnij","year":"2002","unstructured":"Blagodarnij LA. Treatment of chronic anal fissure. Rus Med J. 2002;10:1327\u201330.","journal-title":"Rus Med J"},{"key":"559_CR9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10151-006-0276-z","volume":"10","author":"JN Lund","year":"2006","unstructured":"Lund JN, Nystr\u00f6m PO, Coremanset G, et al. An evidence-based treatment algorithm for anal fissure. Tech Coloproctol. 2006;10:177\u201380.","journal-title":"Tech Coloproctol"},{"key":"559_CR10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s101510050050","volume":"4","author":"AP Zbar","year":"2000","unstructured":"Zbar AP, Aslam M, Allgar V. Faecal incontinence after internal sphincterotomy for anal fissure. Tech Coloproctol. 2000;4:25\u20138.","journal-title":"Tech Coloproctol"},{"key":"559_CR11","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/j.1572-0241.2003.07423.x","volume":"98","author":"MJ Utzig","year":"2003","unstructured":"Utzig MJ, Kroesen AJ, Buhr HJ. Concepts in pathogenesis and treatment of chronic anal fissure\u2014a review of the literature. Am J Gastroenterol. 2003;98:968\u201374.","journal-title":"Am J Gastroenterol"},{"key":"559_CR12","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s11605-010-1154-6","volume":"14","author":"P Sileri","year":"2010","unstructured":"Sileri P, Stolfi VM, Franceschilliet L, et al. Conservative and surgical treatment of chronic anal fissure: prospective longer term results. J Gastrointest Surg. 2010;14:773\u201380.","journal-title":"J Gastrointest Surg"},{"key":"559_CR13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0140-6736(97)09003-X","volume":"351","author":"EA Carapeti","year":"1998","unstructured":"Carapeti EA, Kamm MA, McDonald PJ, Phillips RK. Double-blind randomised controlled trial of effect of metronidazole on pain after day-case haemorrhoidectomy. Lancet. 1998;351:169\u201372.","journal-title":"Lancet"},{"key":"559_CR14","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10350-003-0129-z","volume":"47","author":"TJ Nicholson","year":"2004","unstructured":"Nicholson TJ, Armstrong D. Topical metronidazole (10%) decreases posthemorrhoidectomy pain and improves healing. Dis Colon Rectum. 2004;47:711\u20136.","journal-title":"Dis Colon Rectum"},{"key":"559_CR15","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1007\/s10350-007-9022-5","volume":"50","author":"AE Pelta","year":"2007","unstructured":"Pelta AE, Davis KG, Armstrong DN. Subcutaneous fissurotomy: a novel procedure for chronic fissure-in-ano. a review of 109 cases. Dis Colon Rectum. 2007;50:1662\u20137.","journal-title":"Dis Colon Rectum"},{"key":"559_CR16","first-page":"550","volume":"11","author":"SV Hosseini","year":"2008","unstructured":"Hosseini SV, Sabet B, Nouri Amirkolaee M, Bolandparvaz S. A randomized clinical trial on the effect of oral metronidazole on wound healing and pain after analsphincterotomy and fissurectomy. Arch Iran Med. 2008;11:550\u20132.","journal-title":"Arch Iran Med"},{"key":"559_CR17","unstructured":"Holt JG, Krieg NR, Sneath PNA, et al. Bergey's Manual of Systematic Bacteriology. Mir, Moscow. 1997. (In Russian)"},{"key":"559_CR18","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/BF02564159","volume":"25","author":"H Abcarian","year":"1982","unstructured":"Abcarian H, Lakshmahan S, Read DR, Roccaforte P. The role of internal sphincter in chronic anal fissures. Dis Colon Rectum. 1982;25:525\u20138.","journal-title":"Dis Colon Rectum"},{"key":"559_CR19","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0733-8627(05)70278-9","volume":"14","author":"DM Janicke","year":"1996","unstructured":"Janicke DM, Pundt MR. Anorectal disorders. Emerg Med Clin North Am. 1996;14:757\u201388.","journal-title":"Emerg Med Clin North Am"},{"key":"559_CR20","first-page":"76","volume":"1","author":"NM Grekova","year":"2012","unstructured":"Grekova NM, Telesheva LF, Maleva \u0415\u0410, Gritzenko VA, Bahareva LI, Kandalova EN. Analysis of antibiotic sensitivity of microflora of chronic anal fissure in the therapy optimization. Kurskiy Nauch-Pract Vestn. 2012;1:76\u201381.","journal-title":"Kurskiy Nauch-Pract Vestn"},{"key":"559_CR21","first-page":"83","volume":"1","author":"NM Grekova","year":"2013","unstructured":"Grekova NM, Lebedeva YV, Maleva \u0415\u0410. Clinical, endoscopic and microbiological features of chronic anal fissure without spasm of anal sphincter. Sovr Probl Nauk Obraz. 2013;1:83\u201391.","journal-title":"Sovr Probl Nauk Obraz"},{"key":"559_CR22","first-page":"154","volume":"1","author":"\u0415\u0410 Maleva","year":"2012","unstructured":"Maleva \u0415\u0410, Grekova NM, Telesheva LF, Kandalova EN. Outpatient treatment of patients with chronic anal fissure on the background of proctitis and colon dysbiosis. Izv Visch Uch Zaved Ural Reg. 2012;1:154\u201361.","journal-title":"Izv Visch Uch Zaved Ural Reg"},{"key":"559_CR23","first-page":"67","volume":"170","author":"NM Grekova","year":"2011","unstructured":"Grekova NM, Maleva \u0415\u0410, Bordunovskij VN, Lebedeva YV. Role of selective decontamination in combined treatment of chronic anal fissure. Vestn Khir Im I I Grek. 2011;170:67\u201371.","journal-title":"Vestn Khir Im I I Grek"}],"container-title":["Indian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-015-0559-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12664-015-0559-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-015-0559-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T16:29:39Z","timestamp":1651854579000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12664-015-0559-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["559"],"URL":"https:\/\/doi.org\/10.1007\/s12664-015-0559-2","relation":{},"ISSN":["0254-8860","0975-0711"],"issn-type":[{"value":"0254-8860","type":"print"},{"value":"0975-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}