{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:33:46Z","timestamp":1782603226784,"version":"3.54.5"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Gastroenterol"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s12664-018-0829-x","type":"journal-article","created":{"date-parts":[[2018,2,18]],"date-time":"2018-02-18T20:32:27Z","timestamp":1518985947000},"page":"31-38","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Maintenance zinc therapy after initial penicillamine chelation to treat symptomatic hepatic Wilson\u2019s disease in resource constrained setting"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3670-2800","authenticated-orcid":false,"given":"Piyush","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehul","family":"Choksi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Goel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday","family":"Zachariah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kattiparambil Gangadharan","family":"Sajith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeyamani","family":"Ramachandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Chandy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kurian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Rebekah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chundamannil Eapen","family":"Eapen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,19]]},"reference":[{"key":"829_CR1","doi-asserted-by":"crossref","unstructured":"Roberts EA, Schilsky ML. Diagnosis and treatment of Wilson\u2019s disease: an update. Hepatology. 2008;47:2089\u2013111.","DOI":"10.1002\/hep.22261"},{"key":"829_CR2","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.jhep.2011.11.007","volume":"56","author":"European Association for Study of Liver","year":"2012","unstructured":"European Association for Study of Liver. EASL clinical practice guidelines: Wilson\u2019s disease. J Hepatol. 2012;56:671\u201385.","journal-title":"J Hepatol"},{"key":"829_CR3","doi-asserted-by":"crossref","unstructured":"Ala A, Walker AP, Ashkan K, Dooley JS, Schilsky ML. Wilson\u2019s disease. Lancet. 2007;369:397\u2013408.","DOI":"10.1016\/S0140-6736(07)60196-2"},{"key":"829_CR4","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1046\/j.1365-2036.2003.01813.x","volume":"19","author":"P Ferenci","year":"2004","unstructured":"Ferenci P. Review article: Diagnosis and current therapy of Wilson\u2019s disease. Aliment Pharmacol Ther. 2004;19:157\u201365.","journal-title":"Aliment Pharmacol Ther"},{"key":"829_CR5","first-page":"41","volume":"9","author":"G Ranucci","year":"2014","unstructured":"Ranucci G, Di Dato F, Spagnuolo MI, Vajro P, Iorio R. Zinc monotherapy is effective in Wilson\u2019s disease patients with mild liver disease diagnosed in childhood: a retrospective study. J Rare Dis. 2014;9:41.","journal-title":"J Rare Dis"},{"key":"829_CR6","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/MPG.0b013e31821d5abe","volume":"53","author":"T Mizuochi","year":"2011","unstructured":"Mizuochi T, Kimura A, Shimizu N, Nishiura H, Matsushita M, Yoshino M. Zinc monotherapy from time of diagnosis for young pediatric patients with presymptomatic Wilson disease. J Pediatr Gastroenterol Nutr. 2011;53:365\u20137.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"829_CR7","doi-asserted-by":"crossref","unstructured":"Simon EG, Joseph AJ, George B, et al. Aetiology of paediatric portal hypertension - experience of a tertiary care centre in South India. Trop Doct. 2009;39:42\u20134.","DOI":"10.1258\/td.2008.080050"},{"key":"829_CR8","first-page":"922","volume":"137","author":"A Goel","year":"2013","unstructured":"Goel A, Madhu K, Zachariah U, et al. A study of aetiology of portal hypertension in adults (including the elderly) at a tertiary centre in southern India. Indian J Med Res. 2013;137:922\u20137.","journal-title":"Indian J Med Res"},{"key":"829_CR9","doi-asserted-by":"crossref","unstructured":"Ramakrishna B, Date A, Kirubakaran C, Raghupathy P. Atypical copper cirrhosis in Indian children. Ann Trop Paediatr. 1995;15:237\u201342.","DOI":"10.1080\/02724936.1995.11747778"},{"key":"829_CR10","doi-asserted-by":"crossref","unstructured":"Kamath PS, Wiesner RH, Malinchoc M, et al. A model to predict survival in patients with end-stage liver disease. Hepatology. 2001;33:464\u201370.","DOI":"10.1053\/jhep.2001.22172"},{"key":"829_CR11","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1136\/gut.27.11.1377","volume":"27","author":"H Nazer","year":"1986","unstructured":"Nazer H, Ede RJ, Mowat AP, Williams R. Wilson\u2019s disease: clinical presentation and use of prognostic index. Gut. 1986;27:1377\u201381.","journal-title":"Gut"},{"key":"829_CR12","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/lt.20352","volume":"11","author":"A Dhawan","year":"2005","unstructured":"Dhawan A, Taylor RM, Cheeseman P, De Silva P, Katsiyiannakis L, Mieli-Vergani G. Wilson\u2019s disease in children: 37-year experience and revised King\u2019s score for liver transplantation. Liver Transpl. 2005;11:441\u20138.","journal-title":"Liver Transpl"},{"key":"829_CR13","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.cgh.2006.04.007","volume":"4","author":"VD Lee","year":"2006","unstructured":"Lee VD, Northup PG, Berg CL. Resolution of decompensated cirrhosis from Wilson\u2019s disease with zinc monotherapy: a potential therapeutic option? Clin Gastroenterol Hepatol. 2006;4:1069\u201371.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"829_CR14","doi-asserted-by":"crossref","unstructured":"Askari FK, Greenson J, Dick RD, Johnson VD, Brewer GJ. Treatment of Wilson\u2019s disease with zinc. XVIII. Initial treatment of the hepatic decompensation presentation with trientine and zinc. J Lab Clin Med. 2003;142:385\u201390.","DOI":"10.1016\/S0022-2143(03)00157-4"},{"key":"829_CR15","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.lab.2005.01.007","volume":"145","author":"M Marcellini","year":"2005","unstructured":"Marcellini M, Di Ciommo V, Callea F, et al. Treatment of Wilson\u2019s disease with zinc from the time of diagnosis in pediatric patients: a single-hospital, 10-year follow-up study. J Lab Clin Med. 2005;145:139\u201343.","journal-title":"J Lab Clin Med"},{"key":"829_CR16","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0022-510X(87)90116-X","volume":"77","author":"TU Hoogenraad","year":"1987","unstructured":"Hoogenraad TU, van Hattum J, Van den Hamer CJ. Management of Wilson\u2019s disease with zinc sulphate. Experience in a series of 27 patients. J Neurol Sci. 1987;77:137\u201346.","journal-title":"J Neurol Sci"},{"key":"829_CR17","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/BF00868525","volume":"243","author":"A Czlonkowska","year":"1996","unstructured":"Czlonkowska A, Gajda J, Rodo M. Effects of long-term treatment in Wilson\u2019s disease with D-penicillamine and zinc sulphate. J Neurol. 1996;243:269\u201373.","journal-title":"J Neurol"},{"key":"829_CR18","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jns.2007.08.006","volume":"264","author":"S Sinha","year":"2008","unstructured":"Sinha S, Taly AB. Withdrawal of penicillamine from zinc sulphate-penicillamine maintenance therapy in Wilson\u2019s disease: promising, safe and cheap. J Neurol Sci. 2008;264:129\u201332.","journal-title":"J Neurol Sci"},{"key":"829_CR19","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.trsl.2010.08.007","volume":"156","author":"N Shimuzu","year":"2010","unstructured":"Shimuzu N, Fujiwara J, Ohnishi S, et al. Effects of long-term zinc treatment in Japanese patients with Wilson\u2019s disease: efficacy, stability, and copper metabolism. Transl Res. 2010;156:350\u20137.","journal-title":"Transl Res"},{"key":"829_CR20","doi-asserted-by":"crossref","unstructured":"Arnon R, Calderon JF, Schilsky M, Emre S, Shneider BL. Wilson disease in children: serum aminotransferases and urinary copper on triethylene tetramine dihydrochloride (trientine) treatment. J Pediatr Gastroenterol Nutr. 2007;44:596\u2013602.","DOI":"10.1097\/MPG.0b013e3180467715"},{"key":"829_CR21","doi-asserted-by":"crossref","unstructured":"Brewer GJ, Dick RD, Johnson VD, Brunberg JA, Kluin KJ, Fink JK. Treatment of Wilson's disease with zinc: XV long-term follow-up studies. J Lab Clin Med. 1998;132:264\u201378.","DOI":"10.1016\/S0022-2143(98)90039-7"},{"key":"829_CR22","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1002\/hep.23182","volume":"50","author":"FH Linn","year":"2009","unstructured":"Linn FH, Houwen RH, van Hattum J, van der Kleij S, van Erpecum KJ. Longterm exclusive zinc monotherapy in symptomatic Wilson disease: experience in 17 patients. Hepatology. 2009;50:1442\u201352.","journal-title":"Hepatology"},{"key":"829_CR23","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.braindev.2005.08.008","volume":"28","author":"TU Hoogenraad","year":"2006","unstructured":"Hoogenraad TU. Paradigm Shift in treatment of Wilson\u2019s disease: zinc therapy now treatment of choice. Brain and Development. 2006;28:14\u20138.","journal-title":"Brain and Development"}],"container-title":["Indian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12664-018-0829-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-018-0829-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-018-0829-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:17:20Z","timestamp":1570753040000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12664-018-0829-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["829"],"URL":"https:\/\/doi.org\/10.1007\/s12664-018-0829-x","relation":{},"ISSN":["0254-8860","0975-0711"],"issn-type":[{"value":"0254-8860","type":"print"},{"value":"0975-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"13 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"PG, MC, AG, UZ, KGS, JR, GC, GK, GR, and CEE declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors declare that the study was performed in a manner conforming to the Helsinki declaration of 1975, as revised in 2000 and 2008 concerning human and animal rights, and the authors followed the policy concerning informed consent as shown on Springer.com.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}]}}