{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:00:41Z","timestamp":1792839641672,"version":"4.5.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Gastroenterol"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1007\/s12664-018-0871-8","type":"journal-article","created":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:25:19Z","timestamp":1534811119000},"page":"313-320","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Comparison of continuous versus intermittent infusions of terlipressin for the control of acute variceal bleeding in patients with portal hypertension: An open-label randomized controlled trial"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6851-7722","authenticated-orcid":false,"given":"Sanjeev Kumar","family":"Jha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwa Mohan","family":"Dayal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,21]]},"reference":[{"key":"871_CR1","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1002\/hep.20339","volume":"40","author":"N Carbonell","year":"2004","unstructured":"Carbonell N, Pauwels A, Serfaty L, Fourdan O, L\u00e9vy VG, Poupon R. Improved survival after variceal bleeding in patients with cirrhosis over the past two decades. Hepatology. 2004;40:652\u20139.","journal-title":"Hepatology"},{"key":"871_CR2","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","volume":"63","author":"R Franchis de","year":"2015","unstructured":"de Franchis R, Baveno VI. Faculty. Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension. J Hepatol. 2015;63:743\u201352.","journal-title":"J Hepatol"},{"key":"871_CR3","doi-asserted-by":"publisher","first-page":"312","DOI":"10.4253\/wjge.v4.i7.312","volume":"4","author":"J Poza Cordon","year":"2012","unstructured":"Poza Cordon J, Froilan Torres C, Burgos Garc\u00eda A, Gea Rodriguez F, Su\u00e1rez de Parga JM. Endoscopic management of esophageal varices. World J Gastrointest Endosc. 2012;4:312\u201322.","journal-title":"World J Gastrointest Endosc"},{"key":"871_CR4","unstructured":"Ioannou G, Doust J, Rockey DC. Terlipressin for acute esophageal variceal hemorrhage. Cochrane Database Syst Rev. 2001;CD002147."},{"key":"871_CR5","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1111\/j.1478-3231.2010.02322.x","volume":"30","author":"G Kalambokis","year":"2010","unstructured":"Kalambokis G, Tsiouris S, Tsianos EV, Baltayiannis G, Pakou B, Fotopoulos A. Effects of terlipressin and somatostatin on liver and thorax blood volumes in patients with cirrhosis. Liver Int. 2010;30:1371\u20138.","journal-title":"Liver Int"},{"key":"871_CR6","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1111\/j.1572-0241.2005.41381.x","volume":"100","author":"SK Baik","year":"2005","unstructured":"Baik SK, Jeong PH, Ji SW, et al. Acute hemodynamic effects of octreotide and terlipressin in patients with cirrhosis: a randomized comparison. Am J Gastroenterol. 2005;100:631\u20135.","journal-title":"Am J Gastroenterol"},{"key":"871_CR7","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1136\/gutjnl-2015-309262","volume":"64","author":"D Tripathi","year":"2015","unstructured":"Tripathi D, Stanley AJ, Hayes PC, et al. U.K. guidelines on the management of variceal haemorrhage in cirrhotic patients. Gut. 2015;64:1680\u2013704.","journal-title":"Gut"},{"key":"871_CR8","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1111\/jgh.12195","volume":"28","author":"C Ding","year":"2013","unstructured":"Ding C, Wu X, Fan X, He C, Li J. Hemodynamic effects of continuous versus bolus infusion of terlipressin for portal hypertension: a randomized comparison. J Gastroenterol Hepatol. 2013;28:1242\u20136.","journal-title":"J Gastroenterol Hepatol"},{"key":"871_CR9","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.jhep.2010.06.004","volume":"53","author":"R Franchis de","year":"2010","unstructured":"de Franchis R, Baveno V. Faculty. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2010;53:762\u20138.","journal-title":"J Hepatol"},{"key":"871_CR10","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1002\/hep.27080","volume":"60","author":"BE Fortune","year":"2014","unstructured":"Fortune BE, Groszmann RJ. Combination of splanchnic vasoconstrictors and endoscopic band ligation is an effective treatment strategy for acute variceal hemorrhage; but how do we get those drugs approved by the FDA? Hepatology. 2014;60:789\u201391.","journal-title":"Hepatology"},{"key":"871_CR11","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1136\/gut.38.1.129","volume":"38","author":"F Nevens","year":"1996","unstructured":"Nevens F, Van Steenbergen W, Yap SH, Fevery J. Assessment of variceal pressure by continuous non-invasive endoscopic registration: a placebo controlled evaluation of the effect of terlipressin and octreotide. Gut. 1996;38:129\u201334.","journal-title":"Gut"},{"key":"871_CR12","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/S1499-3872(12)60204-5","volume":"11","author":"GN Kalambokis","year":"2012","unstructured":"Kalambokis GN, Pappas K, Tsianos EV. Terlipressin improves pulmonary pressures in cirrhotic patients with pulmonary hypertension and variceal bleeding or hepatorenal syndrome. Hepatobiliary Pancreat Dis Int. 2012;11:434\u20137.","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"871_CR13","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1111\/j.1440-1746.2005.03902.x","volume":"20","author":"G Kalambokis","year":"2005","unstructured":"Kalambokis G, Economou M, Paraskevi K, et al. Effects of somatostatin, terlipressin and somatostatin plus terlipressin on portal and systemic hemodynamics and renal sodium excretion in patients with cirrhosis. J Gastroenterol Hepatol. 2005;20:1075\u201381.","journal-title":"J Gastroenterol Hepatol"},{"key":"871_CR14","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1111\/j.1365-2036.2012.05088.x","volume":"35","author":"M Wells","year":"2012","unstructured":"Wells M, Chande N, Adams P, et al. Meta-analysis: vasoactive medications for the management of acute variceal bleeds. Aliment Pharmacol Ther. 2012;35:1267\u201378.","journal-title":"Aliment Pharmacol Ther"},{"key":"871_CR15","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1002\/hep.27006","volume":"60","author":"YS Seo","year":"2014","unstructured":"Seo YS, Park SY, Kim MY, et al. Lack of difference among terlipressin, somatostatin, and octreotide in the control of acute gastroesophageal variceal hemorrhage. Hepatology. 2014;60:954\u201363.","journal-title":"Hepatology"},{"key":"871_CR16","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jceh.2015.06.001","volume":"5","author":"A Kumar","year":"2015","unstructured":"Kumar A, Jha SK, Mittal VV, Sharma P, Sharma BC, Sarin SK. Addition of somatostatin after successful endoscopic variceal ligation does not prevent early rebleeding in comparison to placebo: a double blind randomized controlled trial. J Clin Exp Hepatol. 2015;5:204\u201312.","journal-title":"J Clin Exp Hepatol"},{"key":"871_CR17","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1053\/gast.1996.v111.pm8898643","volume":"111","author":"F Feu","year":"1996","unstructured":"Feu F, Ruiz del Arbol L, Ba\u00f1ares R, Planas R, Bosch J. Double-blind randomized controlled trial comparing terlipressin and somatostatin for acute variceal hemorrhage Variceal Bleeding Study Group. Gastroenterology. 1996;111:1291\u20139.","journal-title":"Gastroenterology"},{"key":"871_CR18","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1002\/hep.28396","volume":"63","author":"M Cavallin","year":"2016","unstructured":"Cavallin M, Piano S, Romano A, et al. Terlipressin given by continuous intravenous infusion versus intravenous boluses in the treatment of hepatorenal syndrome: a randomized controlled study. Hepatology. 2016;63:983\u201392.","journal-title":"Hepatology"},{"key":"871_CR19","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/S0016-5085(99)70455-5","volume":"117","author":"E Moitinho","year":"1999","unstructured":"Moitinho E, Escorsell A, Bandi JC, et al. Prognostic value of early measurements of portal pressure in acute variceal bleeding. Gastroenterology. 1999;117:626\u201331.","journal-title":"Gastroenterology"},{"key":"871_CR20","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1002\/hep.20386","volume":"40","author":"A Monescillo","year":"2004","unstructured":"Monescillo A, Mart\u00ednez-Lagares F, Ruiz-del-Arbol L, et al. Influence of portal hypertension and its early decompression by TIPS placement on the outcome of variceal bleeding. Hepatology. 2004;40:793\u2013801.","journal-title":"Hepatology"}],"container-title":["Indian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12664-018-0871-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-018-0871-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-018-0871-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T19:20:20Z","timestamp":1566328820000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12664-018-0871-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["871"],"URL":"https:\/\/doi.org\/10.1007\/s12664-018-0871-8","relation":{},"ISSN":["0254-8860","0975-0711"],"issn-type":[{"value":"0254-8860","type":"print"},{"value":"0975-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"11 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"SKJ, MM, AJ, and VMD declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All study participants, or their legal guardian, provided written consent prior to study enrolment.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare that the study was performed in a manner to conform with the Helsinki Declaration of 1975, as revised in 2000 and 2008 concerning human and animal rights, and the authors followed the policy concerning informed consent as shown on ..","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"The authors are solely responsible for the data and the content of the paper. In no way, the Honorary Editor-in-Chief, Editorial Board Members or the printer\/publishers are responsible for the results\/findings and content of this article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}