{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T02:31:41Z","timestamp":1772937101872,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Gastroenterol"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s12664-020-01032-z","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T16:02:42Z","timestamp":1589040162000},"page":"165-170","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Role of esophageal manometry and 24-h pH testing in\u00a0patients with refractory reflux symptoms"],"prefix":"10.1007","volume":"39","author":[{"given":"Mayank","family":"Jain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinodini","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,9]]},"reference":[{"key":"1032_CR1","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1136\/gutjnl-2012-304269","volume":"63","author":"HB El-Serag","year":"2014","unstructured":"El-Serag HB, Sweet S, Winchester CC, Dent J. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2014;63:871\u201380.","journal-title":"Gut."},{"key":"1032_CR2","doi-asserted-by":"crossref","unstructured":"Eusebi LH, Ratnakumaran R, Yuan Y, Solaymani-Dodaran M,\u00a0Bazzoli F,\u00a0Ford AC.\u00a0Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis. Gut. 2018;67:430\u201340.","DOI":"10.1136\/gutjnl-2016-313589"},{"key":"1032_CR3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1007\/s12664-011-0112-x","volume":"30","author":"SJ Bhatia","year":"2011","unstructured":"Bhatia SJ, Reddy DN, Ghoshal UC, et al. Epidemiology and symptom profile of gastroesophageal reflux in the Indian population: report of the Indian Society of Gastroenterology Task Force. Indian J Gastroenterol. 2011;30:118\u201327.","journal-title":"Indian J Gastroenterol"},{"key":"1032_CR4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s12664-018-00931-6","volume":"38","author":"SD Chowdhury","year":"2019","unstructured":"Chowdhury SD, George G, Ramakrishna K, et al. Prevalence and factors associated with gastroesophageal reflux disease in southern India: a community-based study. Indian J Gastroenterol. 2019;38:77\u201382.","journal-title":"Indian J Gastroenterol"},{"key":"1032_CR5","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12876-016-0452-1","volume":"16","author":"HY Wang","year":"2016","unstructured":"Wang HY, Leena KB, Plymoth A, et al. Prevalence of gastro-esophageal reflux disease and its risk factors in a community-based population in southern India. BMC Gastroenterol. 2016;16:36.","journal-title":"BMC Gastroenterol"},{"key":"1032_CR6","first-page":"14","volume":"17","author":"S Bhatia","year":"2017","unstructured":"Bhatia S, Gupta D, Vennalaganti P. Epidemiology of gastroesophageal reflux in Asia. The rise of acid reflux in Asia. J Neurogastroenterol Motil. 2017;17:14\u201327.","journal-title":"J Neurogastroenterol Motil"},{"key":"1032_CR7","doi-asserted-by":"crossref","unstructured":"Bhatia SJ, Makharia GK, Abraham P, et al. Indian consensus on gastroesophageal reflux disease in adults: a position statement of the Indian Society of Gastroenterology. Indian J Gastroenterol. 2019;38:411\u201340.","DOI":"10.1007\/s12664-019-00979-y"},{"key":"1032_CR8","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.bpg.2013.06.005","volume":"27","author":"PJ Kahrilas","year":"2013","unstructured":"Kahrilas PJ, Boeckxstaens G, Smout AJ. Management of the patient with incomplete response to PPI therapy. Best Pract Res Clin Gastroenterol. 2013;27:401\u201314.","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"1032_CR9","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/nmo.12477","volume":"27","author":"International High Resolution Manometry Working Group","year":"2015","unstructured":"International High Resolution Manometry Working Group. The Chicago Classification of esophageal motility disorders, v3.0. Neurogastroenterol Motil. 2015;27:160\u201374.","journal-title":"Neurogastroenterol Motil"},{"key":"1032_CR10","doi-asserted-by":"crossref","unstructured":"Wang F,\u00a0Li P,\u00a0Ji GZ,\u00a0et al. An analysis of 342 patients with refractory gastroesophageal reflux disease symptoms using questionnaires, high-resolution manometry, and impedance-pH monitoring. Medicine\u00a0(Baltimore).\u00a02017;96:e5906.","DOI":"10.1097\/MD.0000000000005906"},{"key":"1032_CR11","doi-asserted-by":"publisher","first-page":"977","DOI":"10.7326\/0003-4819-117-12-977","volume":"117","author":"S Sloan","year":"1992","unstructured":"Sloan S, Rademaker AW, Kahrilas PJ. Determinants of gastroesophageal junction incompetence: hiatal hernia, lower esophageal sphincter, or both? Ann Intern Med. 1992;117:977\u201382.","journal-title":"Ann Intern Med"},{"key":"1032_CR12","doi-asserted-by":"publisher","first-page":"86","DOI":"10.4292\/wjgpt.v5.i2.86","volume":"5","author":"I Martinucci","year":"2014","unstructured":"Martinucci I, Bortoli ND, Giacchino M, et al. Esophageal motility abnormalities in gastroesophageal reflux disease. World J Gastrointest Pharmacol Ther. 2014;5:86\u201396.","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"1032_CR13","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1136\/gut.45.2.172","volume":"45","author":"LR Lundell","year":"1999","unstructured":"Lundell LR, Dent J, Bennett JR, et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut. 1999;45:172\u201380.","journal-title":"Gut"},{"key":"1032_CR14","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nrgastro.2013.50","volume":"10","author":"E Savarino","year":"2013","unstructured":"Savarino E, Zentilin P, Savarino V. NERD: an umbrella term including heterogeneous subpopulations. Nat Rev Gastroenterol Hepatol. 2013;10:371\u201380.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"1032_CR15","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1136\/gut.2008.175810","volume":"58","author":"E Savarino","year":"2009","unstructured":"Savarino E, Pohl D, Zentilin P, et al. Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease. Gut. 2009;58:1185\u201391.","journal-title":"Gut."},{"key":"1032_CR16","doi-asserted-by":"crossref","unstructured":"Aziz Q, Fass R, Gyawali CP, et al. Esophageal disorders. Gastroenterology. 2016;150:1368\u201379.","DOI":"10.1053\/j.gastro.2016.02.012"},{"key":"1032_CR17","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s12664-017-0789-6","volume":"36","author":"B Baruah","year":"2017","unstructured":"Baruah B, Kumar T, Das P, et al. Prevalence of eosinophilic esophagitis in patients with gastroesophageal reflux symptoms: a cross-sectional study from a tertiary care hospital in North India. Indian J Gastroenterol. 2017;36:353\u201360.","journal-title":"Indian J Gastroenterol"},{"key":"1032_CR18","doi-asserted-by":"crossref","unstructured":"Chial HJ, Camilleri M, Williams DE, Litzinger K,\u00a0Perrault J.\u00a0Rumination syndrome in children and adolescents: diagnosis, treatment and prognosis. Pediatrics. 2003;111:158\u201362.","DOI":"10.1542\/peds.111.1.158"},{"key":"1032_CR19","doi-asserted-by":"crossref","unstructured":"Koukias N, Woodland P, Yazaki E, Sifrim D. Supragastric belching: prevalence and association with gastroesophageal reflux disease and esophageal hypomotility. J Neurogastroenterol Motil. 2015;21:398\u2013403.","DOI":"10.5056\/jnm15002"},{"key":"1032_CR20","doi-asserted-by":"crossref","unstructured":"Herregods TV, Troelstra M, Weijenborg PW, Bredenoord AJ,\u00a0Smout AJ.\u00a0Patients with refractory reflux symptoms often do not have GERD. Neurogastroenterol Motil. 2015;27:1267\u201373.","DOI":"10.1111\/nmo.12620"},{"key":"1032_CR21","doi-asserted-by":"crossref","unstructured":"Hemmink GJ, Bredenoord AJ, Weusten BL, Timmer R,\u00a0Smout AJ.\u00a0Supragastric belching in patients with reflux symptoms. Am J Gastroenterol. 2009;104:1992\u20137.","DOI":"10.1038\/ajg.2009.203"},{"key":"1032_CR22","doi-asserted-by":"crossref","unstructured":"Ong AM, Chua LT, Khor CJ, \u00a0Asokkumar R,\u00a0S\/O Namasivayam V,\u00a0Wang YT.\u00a0Diaphragmatic breathing reduces belching and proton pump inhibitor refractory gastroesophageal reflux symptoms. Clin Gastreoenterol Hepatol. 2018;16:407\u201316.","DOI":"10.1016\/j.cgh.2017.10.038"},{"key":"1032_CR23","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1111\/j.1572-0241.2006.00801.x","volume":"101","author":"DK Chitkara","year":"2006","unstructured":"Chitkara DK, Van Tilburg M, Whitehead WE, Talley NJ. Teaching diaphragmatic breathing for rumination syndrome. Am J Gastroenterol. 2006;101:2449\u201352.","journal-title":"Am J Gastroenterol"},{"key":"1032_CR24","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.cgh.2011.10.042","volume":"10","author":"K Blondeau","year":"2012","unstructured":"Blondeau K, Boecxstaens V, Rommel N, et al. Baclofen improves symptoms and reduces postprandial flow events in patients with rumination and supragastric belching. Clin Gastroenterol Hepatol. 2012;10:379\u201384.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"1032_CR25","doi-asserted-by":"crossref","unstructured":"Andolfi C, Bonavina L, Kavitt RT, \u00a0Konda VJ,\u00a0Asti E,\u00a0Patti MG.\u00a0Importance of esophageal manometry and pH monitoring in the evaluation of patients with refractory gastroesophageal reflux disease: a multicenter study. J Laparoendosc Adv Surg Tech A. 2016;26:548\u201350.","DOI":"10.1089\/lap.2016.0189"},{"key":"1032_CR26","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s12664-019-00942-x","volume":"38","author":"M Jain","year":"2019","unstructured":"Jain M. Achalasia cardia: a diagnosis often delayed! Indian J Gastroenterol. 2019;38:183\u20134.","journal-title":"Indian J Gastroenterol"},{"key":"1032_CR27","doi-asserted-by":"crossref","unstructured":"Hsing TY, Tsai IJ, Tsu CT, Wu JF. Role of esophageal manometry in children with refractory gastroesophageal reflux symptoms. Pediatr Int. 2019;61:807\u20131.","DOI":"10.1111\/ped.13917"},{"key":"1032_CR28","unstructured":"Yamasaki T, O\u2019Neil J, Fass R. Update on functional heartburn. Gastroenterol Hepatol (NY). 2017;13:725\u201334."},{"key":"1032_CR29","doi-asserted-by":"publisher","first-page":"495","DOI":"10.5056\/jnm17097","volume":"23","author":"T Yamasaki","year":"2017","unstructured":"Yamasaki T, Fass R. Reflux hypersensitivity: a new functional esophageal disorder. J Neurogastroenterol Motil. 2017;23:495\u2013503.","journal-title":"J Neurogastroenterol Motil"}],"container-title":["Indian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-020-01032-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12664-020-01032-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-020-01032-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T00:04:29Z","timestamp":1620518669000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12664-020-01032-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["1032"],"URL":"https:\/\/doi.org\/10.1007\/s12664-020-01032-z","relation":{},"ISSN":["0254-8860","0975-0711"],"issn-type":[{"value":"0254-8860","type":"print"},{"value":"0975-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"27 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"\u00a0MJ and VA declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was performed conforming to the Helsinki declaration of 1975, as revised in 2000 and 2008 concerning human and animal rights, and the authors followed the policy concerning informed consent as shown on .The study was approved by the Institutional Ethics Board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"The authors are solely responsible for the data and the contents of the paper. In no way, the Honorary Editor-in-Chief, Editorial Board Members, or the printer\/publishers are responsible for the results\/findings and content of this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}