{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T16:42:15Z","timestamp":1740156135909,"version":"3.37.3"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T00:00:00Z","timestamp":1686960000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T00:00:00Z","timestamp":1686960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Gastroenterol"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s12664-023-01370-8","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T06:02:10Z","timestamp":1686981730000},"page":"485-495","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gastrointestinal manifestations in symptomatic Coronavirus disease - 19\u00a0 patients and its relevance in predicting severity and outcome"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9214-4786","authenticated-orcid":false,"given":"K. V.","family":"Padmaprakash","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Thareja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishant","family":"Raman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Muthukrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aman","family":"Miglani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Summi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Naveen","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,17]]},"reference":[{"key":"1370_CR1","unstructured":"Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di Napoli R. Features, Evaluation and treatment coronavirus (COVID-19) [Internet]. StatPearls. StatPearls Publishing; 2020 [cited 2022 May 26]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554776\/.\u00a0Accessed 22 November 2021."},{"key":"1370_CR2","unstructured":"Cipriano M, Ruberti E, Giacalone A. Gastrointestinal infection could be new focus for coronavirus diagnosis. Cureus [Internet]. 2020 Mar 26 [cited 2022 May 26];12(3). Available from: https:\/\/www.cureus.com\/articles\/29616-gastrointestinal-infection-could-be-new-focus-for-coronavirus-diagnosis.\u00a0Accessed 22 November 2021."},{"key":"1370_CR3","doi-asserted-by":"crossref","unstructured":"Jiao L, Li H, Xu J, et al. The gastrointestinal tract is an alternative route for SARS-CoV-2 infection in a nonhuman primate model. Gastroenterology. 2021;160:1647\u201361.","DOI":"10.1053\/j.gastro.2020.12.001"},{"key":"1370_CR4","doi-asserted-by":"crossref","unstructured":"Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004;203:631\u20137.","DOI":"10.1002\/path.1570"},{"key":"1370_CR5","doi-asserted-by":"crossref","unstructured":"Kariyawasam JC, Jayarajah U, Riza R, Abeysuriya V, Seneviratne SL. Gastrointestinal manifestations in COVID-19. Trans R Soc Trop Med Hyg. 2021;115:1362\u201388.","DOI":"10.1093\/trstmh\/trab042"},{"key":"1370_CR6","doi-asserted-by":"crossref","unstructured":"Ramachandran P, Onukogu I, Ghanta S, et al. Gastrointestinal symptoms and outcomes in hospitalized coronavirus disease 2019 patients. Dig Dis. 2020;38:373\u20139.","DOI":"10.1159\/000509774"},{"key":"1370_CR7","doi-asserted-by":"crossref","unstructured":"Wang Y, Li Y, Zhang Y, Liu Y, Liu Y. Are gastrointestinal symptoms associated with higher risk of mortality in COVID-19 patients? A systematic review and meta-analysis. BMC Gastroenterol. 2022;22:1\u201315.\u00a0","DOI":"10.1186\/s12876-022-02132-0"},{"key":"1370_CR8","doi-asserted-by":"crossref","unstructured":"Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497\u2013506.","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"1370_CR9","unstructured":"India, Government of M of H and FW, Services DG of H, Division) (EMR. Clinical management protocol: COVID-19 [Internet]. 2020 [cited 2020 Nov 17]. Available from: https:\/\/www.mohfw.gov.in\/pdf\/ClinicalManagementProtocolforCOVID19.pdf.\u00a0Accessed 22 November 2021."},{"key":"1370_CR10","doi-asserted-by":"crossref","unstructured":"Zhang J, Garrett S, Sun J. Gastrointestinal symptoms, pathophysiology, and treatment in COVID-19. Genes Dis. 2021;8:385\u2013400.","DOI":"10.1016\/j.gendis.2020.08.013"},{"key":"1370_CR11","doi-asserted-by":"crossref","unstructured":"Tian Y, Rong L, Nian W, He Y. Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission. Aliment Pharmacol Ther. 2020;51:843\u201351.","DOI":"10.1111\/apt.15731"},{"key":"1370_CR12","doi-asserted-by":"crossref","unstructured":"Ghoshal UC, Ghoshal U, Mathur A,\u00a0 et al. The spectrum of gastrointestinal symptoms in patients with coronavirus disease-19: predictors, relationship with disease severity, and outcome. Clin Transl Gastroenterol. 2019;11:E00259.","DOI":"10.14309\/ctg.0000000000000259"},{"key":"1370_CR13","unstructured":"Fang D, Ma J, Guan J, et al. Manifestations of digestive system of hospitalized patients with coronavirus disease 2019 in Wuhan, China: a single-center descriptive study. Chinese J Dig. 2020: 151\u20136."},{"key":"1370_CR14","doi-asserted-by":"crossref","unstructured":"Groff A, Kavanaugh M, Ramgobin D, et al. Gastrointestinal manifestations of COVID-19: A review of what we know. Ochsner J. 2021;21:177\u201380.","DOI":"10.31486\/toj.20.0086"},{"key":"1370_CR15","doi-asserted-by":"crossref","unstructured":"Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181:271\u201380.","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"1370_CR16","doi-asserted-by":"crossref","unstructured":"Shehab M, Alrashed F, Shuaibi S, Alajmi D, Barkun A. Gastroenterological and hepatic manifestations of patients with COVID-19, prevalence, mortality by country, and intensive care admission rate: systematic review and meta-analysis. BMJ Open Gastroenterol. 2021;8:e000571.","DOI":"10.1136\/bmjgast-2020-000571"},{"key":"1370_CR17","doi-asserted-by":"crossref","unstructured":"Dong ZY, Xiang BJ, Jiang M, Sun MJ, Dai C. The prevalence of gastrointestinal symptoms, abnormal liver function, digestive system disease and liver disease in COVID-19 infection: a systematic review and meta-analysis. J Clin Gastroenterol. 2021;55:67\u201376.","DOI":"10.1097\/MCG.0000000000001424"},{"key":"1370_CR18","doi-asserted-by":"crossref","unstructured":"Elshazli RM, Kline A, Elgaml A, et al. Gastroenterology manifestations and COVID-19 outcomes: a meta-analysis of 25,252 cohorts among the first and second waves. J Med Virol. 2021;93:2740-68.","DOI":"10.1002\/jmv.26836"},{"key":"1370_CR19","doi-asserted-by":"crossref","unstructured":"Tang L, Yin Z, Hu Y, Mei H. Controlling cytokine storm Is Vital in COVID-19. Front Immunol. 2020;11:570993.","DOI":"10.3389\/fimmu.2020.570993"},{"key":"1370_CR20","unstructured":"Kanra GY, Ozen H, Kara A. Infection and anorexia. Turk J Pediatr. 2006;48:279\u201387."},{"key":"1370_CR21","doi-asserted-by":"crossref","unstructured":"van der Voort PHJ, Moser J, Zandstra DF, et al. Leptin levels in SARS-CoV-2 infection related respiratory failure: A cross-sectional study and a pathophysiological framework on the role of fat tissue. Heliyon. 2020;6:e04696.","DOI":"10.1016\/j.heliyon.2020.e04696"},{"key":"1370_CR22","doi-asserted-by":"publisher","unstructured":"Fulghum DA, Butler A. Calm before the storm. Solomon CG, editor. Aviat Week Sp Technol (New York) [Internet]. 2009 Feb 2 [cited 2022 May 26];170(5):30\u20133. https:\/\/doi.org\/10.1056\/NEJMcps2111163","DOI":"10.1056\/NEJMcps2111163"},{"key":"1370_CR23","doi-asserted-by":"crossref","unstructured":"Guan WJ, Ni ZY, Hu Y, et al.\u00a0Clinical characteristics of coronavirus disease 2019 in China.\u00a0\u00a0N Engl J Med. 2020;382:1708\u201320.","DOI":"10.1056\/NEJMoa2002032"},{"key":"1370_CR24","doi-asserted-by":"crossref","unstructured":"Sultan S, Altayar O, Siddique SM, et al. AGA institute rapid review of the gastrointestinal and liver manifestations of COVID-19, meta-analysis of international data, and recommendations for the consultative management of patients with COVID-19. Gastroenterology. 2020;159:320\u201334.e27.","DOI":"10.1053\/j.gastro.2020.05.001"},{"key":"1370_CR25","doi-asserted-by":"crossref","unstructured":"Rogers HK, Choi WSW, Gowda N,\u00a0 et al. Frequency and outcomes of gastrointestinal symptoms in patients with coronavirus disease-19. Indian J Gastroenterol. 2021;40:502\u201311.","DOI":"10.1007\/s12664-021-01191-7"},{"key":"1370_CR26","doi-asserted-by":"crossref","unstructured":"Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323:1061\u20139.","DOI":"10.1001\/jama.2020.1585"},{"key":"1370_CR27","doi-asserted-by":"crossref","unstructured":"Silva FAFD, Brito BB, Santos MLC, et al. COVID-19 gastrointestinal manifestations: a systematic review. Rev Soc Bras Med Trop. 2020;53:e20200714.","DOI":"10.1590\/0037-8682-0714-2020"},{"key":"1370_CR28","doi-asserted-by":"crossref","unstructured":"Wang Z, Chen X, Lu Y, Chen F, Zhang W. Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment. Biosci Trends. 2020;14:64\u20138.","DOI":"10.5582\/bst.2020.01030"},{"key":"1370_CR29","doi-asserted-by":"crossref","unstructured":"Pan L, Mu M, Yang P,\u00a0 et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study. Am J Gastroenterol. 2020;115:766\u201373.","DOI":"10.14309\/ajg.0000000000000620"},{"key":"1370_CR30","doi-asserted-by":"crossref","unstructured":"Jin X, Lian JS, Hu JH,\u00a0 et al. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut. 2020;69:1002\u20139.","DOI":"10.1136\/gutjnl-2020-320926"},{"key":"1370_CR31","doi-asserted-by":"crossref","unstructured":"Cheung KS, Hung IFN, Chan PPY, et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from a Hong Kong cohort: Systematic review and meta-analysis. Gastroenterology. 2020;159:81-95.","DOI":"10.1053\/j.gastro.2020.03.065"},{"key":"1370_CR32","doi-asserted-by":"crossref","unstructured":"Montazeri M, Maghbouli N, Jamali R, et al. Clinical characteristics of COVID-19 patients with gastrointestinal symptoms. Arch Iran Med. 2021;24:131\u20138.","DOI":"10.34172\/aim.2021.21"},{"key":"1370_CR33","doi-asserted-by":"crossref","unstructured":"Kumar A, Arora A, Sharma P,\u00a0 et al. Gastrointestinal and hepatic manifestations of coronavirus disease-19 and their relationship to severe clinical course: a systematic review and meta-analysis. Indian J Gastroenterol. 2020;39:268\u201384.","DOI":"10.1007\/s12664-020-01058-3"},{"key":"1370_CR34","doi-asserted-by":"crossref","unstructured":"Menon T, Sharma R, Earthineni G, et al. Association of gastrointestinal system with severity and mortality of COVID-19: a systematic review and meta-analysis. Cureus. 2021;13:e13317.","DOI":"10.7759\/cureus.13317"}],"container-title":["Indian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-023-01370-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12664-023-01370-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-023-01370-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T10:19:33Z","timestamp":1690366773000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12664-023-01370-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,17]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["1370"],"URL":"https:\/\/doi.org\/10.1007\/s12664-023-01370-8","relation":{},"ISSN":["0254-8860","0975-0711"],"issn-type":[{"type":"print","value":"0254-8860"},{"type":"electronic","value":"0975-0711"}],"subject":[],"published":{"date-parts":[[2023,6,17]]},"assertion":[{"value":"12 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"KVP, ST, NR, JM, AM, PS\u00a0and SNR\u00a0declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was performed conforming to the Helsinki Declaration of 1975, as revised in 2000 and\u00a02008 concerning human and animal rights, and the authors followed the policy concerning informed consent as shown on\u00a0.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"The authors are solely responsible for the data and the contents of the paper. In no way, the Honorary Editor-in-Chief, Editorial Board Members, the Indian Society of Gastroenterology\u00a0or the printer\/publishers are responsible for the results\/findings and content of this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}