{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:48:33Z","timestamp":1789192113852,"version":"build-2803163510"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Gastroenterol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s12664-025-01773-9","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T02:45:23Z","timestamp":1747363523000},"page":"60-66","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Stool multiplex PCR assay versus conventional stool tests for detecting gastrointestinal infection as a cause for flare of inflammatory bowel disease"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9756-2493","authenticated-orcid":false,"given":"Manek","family":"Kutar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9741-5549","authenticated-orcid":false,"given":"Devendra","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0604-3306","authenticated-orcid":false,"given":"Philip","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2278-207X","authenticated-orcid":false,"given":"Tarun","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8618-7061","authenticated-orcid":false,"given":"Pavan","family":"Dhoble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"1773_CR1","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1038\/s41395-018-0211-8","volume":"113","author":"JE Axelrad","year":"2018","unstructured":"Axelrad JE, Joelson A, Green PHR, et al. Enteric infections are common in patients with flares of inflammatory bowel disease. Am J Gastroenterol. 2018;113:1530\u20139.","journal-title":"Am J Gastroenterol"},{"key":"1773_CR2","doi-asserted-by":"publisher","first-page":"3064","DOI":"10.1007\/s10620-020-06210-9","volume":"65","author":"JE Axelrad","year":"2020","unstructured":"Axelrad JE, Sauk JS. Gastrointestinal infections in IBD flares: can PCR-based stool tests differentiate the smoke from the fire? Dig Dis Sci. 2020;65:3064\u20135.","journal-title":"Dig Dis Sci"},{"key":"1773_CR3","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1128\/JCM.02674-14","volume":"53","author":"SN Buss","year":"2015","unstructured":"Buss SN, Leber A, Chapin K, et al. Multicenter evaluation of the BioFire FilmArray gastrointestinal panel for etiologic diagnosis of infectious gastroenteritis. J Clin Microbiol. 2015;53:915\u201325.","journal-title":"J Clin Microbiol"},{"key":"1773_CR4","doi-asserted-by":"publisher","first-page":"3287","DOI":"10.1007\/s10620-020-06071-2","volume":"65","author":"J Limsrivilai","year":"2020","unstructured":"Limsrivilai J, Saleh ZM, Johnson LA, et al. Prevalence and effect of intestinal infections detected by a PCR - Based stool test in patients with inflammatory bowel disease. Dig Dis Sci. 2020;65:3287\u201396.","journal-title":"Dig Dis Sci"},{"key":"1773_CR5","first-page":"e01457","volume":"56","author":"SG Beal","year":"2017","unstructured":"Beal SG, Tremblay EE, Toffel S, Velez L, Rand KH. A gastrointestinal PCR panel improves clinical management and lowers health care costs. J Clin Microbiol. 2017;56:e01457-17.","journal-title":"J Clin Microbiol"},{"key":"1773_CR6","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.jinf.2014.11.009","volume":"70","author":"SD Goldenberg","year":"2015","unstructured":"Goldenberg SD, Bacelar M, Brazier P, Bisnauthsing K, Edgeworth JD. A cost benefit analysis of the Luminex xTAG Gastrointestinal Pathogen Panel for detection of infectious gastroenteritis in hospitalised patients. J Infect. 2015;70:504\u201311.","journal-title":"J Infect"},{"issue":"10","key":"1773_CR7","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1093\/ibd\/izaa336","volume":"27","author":"S Hong","year":"2021","unstructured":"Hong S, Zaki TA, Main M, et al. Comparative evaluation of conventional stool testing and multiplex molecular panel in outpatients with relapse of inflammatory bowel disease. Inflamm Bowel Dis. 2021;27:1634\u201340.","journal-title":"Inflamm Bowel Dis"},{"key":"1773_CR8","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S0016-5085(82)80190-X","volume":"83","author":"V Binder","year":"1982","unstructured":"Binder V, Both H, Hansen PK, Hendriksen C, Kreiner S, Torp-Pedersen K. Incidence and prevalence of ulcerative colitis and Crohn\u2019s disease in the County of Copenhagen, 1962 to 1978. Gastroenterology. 1982;83:563\u20138.","journal-title":"Gastroenterology"},{"key":"1773_CR9","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1136\/gut.2005.082909","volume":"55","author":"J Satsangi","year":"2006","unstructured":"Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006;55:749\u201353.","journal-title":"Gut"},{"issue":"1","key":"1773_CR10","doi-asserted-by":"publisher","first-page":"S44","DOI":"10.1053\/j.gastro.2017.11.130","volume":"154","author":"J Limsrivilai","year":"2018","unstructured":"Limsrivilai J, Saleh ZM, Johnson LA, et al. Over 30% of symptomatic flares in inflammatory bowel disease patients are associated with detectable gastrointestinal infectious agents by the biofire gi pcr panel stool test. Gastroenterology. 2018;154:S44\u20135.","journal-title":"Gastroenterology"},{"key":"1773_CR11","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.cgh.2006.12.027","volume":"5","author":"JF Rodemann","year":"2007","unstructured":"Rodemann JF, Dubberke ER, Reske KA, Seo DH, Stone CD. Incidence of Clostridium difficile infection in inflammatory bowel disease. Clin Gastroenterol Hepatol. 2007;5:339\u201344.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"1773_CR12","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.crohns.2011.07.012","volume":"6","author":"E Antonelli","year":"2012","unstructured":"Antonelli E, Baldoni M, Giovenali P, Villanacci V, Essatari M, Bassotti G. Intestinal superinfections in patients with inflammatory bowel diseases. J Crohns Colitis. 2012;6:154\u20139.","journal-title":"J Crohns Colitis"},{"issue":"6","key":"1773_CR13","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1097\/MIB.0000000000001097","volume":"23","author":"JE Axelrad","year":"2017","unstructured":"Axelrad JE, Joelson A, Nobel YR, et al. Enteric infection in relapse of inflammatory bowel disease. Inflamm Bowel Dis. 2017;23:1034\u20139.","journal-title":"Inflamm Bowel Dis"},{"key":"1773_CR14","doi-asserted-by":"publisher","first-page":"e0026823","DOI":"10.1128\/spectrum.00268-23","volume":"11","author":"J Xie","year":"2023","unstructured":"Xie J, Kim K, Berenger BM, et al. Comparison of a rapid multiplex gastrointestinal panel with standard laboratory testing in the management of children with hematochezia in a pediatric emergency department\u202f: randomized controlled trial. Microbiol Spectr. 2023;11:e0026823.","journal-title":"Microbiol Spectr"},{"issue":"2","key":"1773_CR15","doi-asserted-by":"publisher","first-page":"e89496","DOI":"10.1371\/journal.pone.0089496","volume":"9","author":"R Enserink","year":"2014","unstructured":"Enserink R, Scholts R, Bruijning-verhagen P, et al. High detection rates of enteropathogens in asymptomatic children attending day care. Plos One. 2014;9:e89496.","journal-title":"Plos one"},{"key":"1773_CR16","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1111\/myc.12753","volume":"61","author":"GA Stamatiades","year":"2018","unstructured":"Stamatiades GA, Ioannou P, Petrikkos G, Tsioutis C. Fungal infections in patients with Inflammatory bowel disease: a systematic review. Mycoses. 2018;61:366\u201376.","journal-title":"Mycoses"},{"key":"1773_CR17","doi-asserted-by":"publisher","first-page":"e155786","DOI":"10.1172\/JCI155786","volume":"132","author":"DM Underhill","year":"2022","unstructured":"Underhill DM, Braun J. Fungal microbiome in inflammatory bowel disease\u202f: a critical assessment. J Clin Invest. 2022;132:e155786.","journal-title":"J Clin Invest"},{"issue":"1","key":"1773_CR18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1159\/000212076","volume":"80","author":"M Navarro-Llavat","year":"2009","unstructured":"Navarro-Llavat M, Dom\u00e8nech E, Bernal I, et al. Prospective, observational, cross-sectional study of intestinal infections among acutely active inflammatory bowel disease patients. Digestion. 2009;80:25\u20139.","journal-title":"Digestion"}],"container-title":["Indian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-025-01773-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12664-025-01773-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-025-01773-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:35:56Z","timestamp":1771482956000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12664-025-01773-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["1773"],"URL":"https:\/\/doi.org\/10.1007\/s12664-025-01773-9","relation":{},"ISSN":["0254-8860","0975-0711"],"issn-type":[{"value":"0254-8860","type":"print"},{"value":"0975-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,16]]},"assertion":[{"value":"19 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"MK, DD, PA, TG and PD declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study\u00a0was performed conforming to the Helsinki Declaration of 1975, as revised in 2000 and 2008 concerning human and animal\u00a0rights, and the authors followed the policy concerning informed consent as shown on Springer.com.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"IRB No:\u00a0IRB\/1442\/AL\/21\/36, Date of IRB Approval:14\/05\/2021.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors are solely responsible for the data and the contents of the paper. In no way, the Honorary Editor-in-Chief, Editorial Board Members, the Indian Society of Gastroenterology\u00a0or the printer\/publishers are responsible for the results\/findings and content of this article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}