{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T12:07:18Z","timestamp":1770379638548,"version":"3.49.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Gastroenterol"],"DOI":"10.1007\/s12664-025-01930-0","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T20:47:19Z","timestamp":1770324439000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduced esophagogastric junction contractile integral in patients with ineffective esophageal motility"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5164-8577","authenticated-orcid":false,"given":"Tingting","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boda","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"issue":"3","key":"1930_CR1","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1111\/j.1572-0241.2007.01593.x","volume":"103","author":"W Blonski","year":"2008","unstructured":"Blonski W, Vela M, Safder A, et al. Revised criterion for diagnosis of ineffective esophageal motility is associated with more frequent dysphagia and greater bolus transit abnormalities. Am J Gastroenterol. 2008;103:699\u2013704. https:\/\/doi.org\/10.1111\/j.1572-0241.2007.01593.x.","journal-title":"Am J Gastroenterol"},{"key":"1930_CR2","doi-asserted-by":"publisher","unstructured":"Yadlapati R, Kahrilas PJ, Fox MR, et al. Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0\u00a9. Neurogastroenterol Motil. 2021;33:e14058. https:\/\/doi.org\/10.1111\/nmo.14058.","DOI":"10.1111\/nmo.14058"},{"key":"1930_CR3","doi-asserted-by":"publisher","unstructured":"Boland K, Abdul-Hussein M, Tutuian R,\u00a0Castell DO.\u00a0Characteristics of consecutive esophageal motility diagnoses after a decade of change. J Clin Gastroenterol. 2016;50:301\u20136. https:\/\/doi.org\/10.1097\/MCG.0000000000000402.","DOI":"10.1097\/MCG.0000000000000402"},{"key":"1930_CR4","doi-asserted-by":"publisher","unstructured":"Diener U, Patti MG, Molena D,\u00a0Fisichella PM, Way LW. Esophageal dysmotility and gastroesophageal reflux disease. J Gastrointest Surg. 2001;5:260\u20135. https:\/\/doi.org\/10.1016\/s1091-255x(01)80046-9.","DOI":"10.1016\/s1091-255x(01)80046-9"},{"key":"1930_CR5","doi-asserted-by":"publisher","unstructured":"Ho SC, Chang CS, Wu CY,\u00a0Chen GH. Ineffective esophageal motility is a primary motility disorder in gastroesophageal reflux disease. Dig Dis Sci. 2002;47:652\u20136. https:\/\/doi.org\/10.1023\/a:1017992808762.","DOI":"10.1023\/a:1017992808762"},{"issue":"9","key":"1930_CR6","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/S2468-1253(17)30151-6","volume":"2","author":"M Hollenstein","year":"2017","unstructured":"Hollenstein M, Thwaites P, Butikofer S, et al. Pharyngeal swallowing and oesophageal motility during a solid meal test: a prospective study in healthy volunteers and patients with major motility disorders. Lancet Gastroenterol Hepatol .2017;2:644\u201353. https:\/\/doi.org\/10.1016\/S2468-1253(17)30151-6.","journal-title":"The Lancet Gastroenterology & Hepatology"},{"issue":"8","key":"1930_CR7","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1111\/jgh.13720","volume":"32","author":"H Ham","year":"2017","unstructured":"Ham H, Cho YK, Lee HH, et al. Esophagogastric junction contractile integral and morphology: Two high-resolution manometry metrics of the anti-reflux barrier. J Gastroenterol Hepatol. 2017;32:1443\u20139. https:\/\/doi.org\/10.1111\/jgh.13720.","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"1930_CR8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.5056\/jnm16008","volume":"23","author":"C Xie","year":"2017","unstructured":"Xie C, Wang J, Li Y, et al. Esophagogastric junction contractility integral reflect the anti-reflux barrier dysfunction in patients with gastroesophageal reflux disease. J Neurogastroenterol Motil. 2017;23:27\u201333. https:\/\/doi.org\/10.5056\/jnm16008.","journal-title":"J Neurogastroenterol Motil"},{"key":"1930_CR9","doi-asserted-by":"publisher","unstructured":"Wang D, Patel A, Mello M,\u00a0Shriver A, Gyawali CP. Esophagogastric junction contractile integral (EGJ-CI) quantifies changes in EGJ barrier function with surgical intervention. Neurogastroenterol Motil. 2016;28:639\u201346. https:\/\/doi.org\/10.1111\/nmo.12757.","DOI":"10.1111\/nmo.12757"},{"key":"1930_CR10","doi-asserted-by":"publisher","unstructured":"Zhuang QJ, Tan ND, Zhang MY, Chen SF, Luo Y, Xiao YL. Ineffective esophageal motility in Chicago Classification version 4.0 better predicts abnormal acid exposure. Esophagus. 2022;19:197-203.\u00a0https:\/\/doi.org\/10.1007\/s10388-021-00867-5.","DOI":"10.1007\/s10388-021-00867-5"},{"issue":"6","key":"1930_CR11","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1053\/j.gastro.2021.12.289","volume":"162","author":"DA Patel","year":"2022","unstructured":"Patel DA, Yadlapati R, Vaezi MF. Esophageal motility disorders: current approach to diagnostics and therapeutics. Gastroenterology. 2022;162:1617\u201334. https:\/\/doi.org\/10.1053\/j.gastro.2021.12.289.","journal-title":"Gastroenterology"},{"issue":"2","key":"1930_CR12","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1136\/gutjnl-2023-330616","volume":"73","author":"CP Gyawali","year":"2024","unstructured":"Gyawali CP, Yadlapati R, Fass R, et al. Updates to the modern diagnosis of GERD: Lyon consensus 2.0. Gut. 2024;73:361\u201371. https:\/\/doi.org\/10.1136\/gutjnl-2023-330616.","journal-title":"Gut"},{"issue":"8","key":"1930_CR13","doi-asserted-by":"publisher","first-page":"413","DOI":"10.14740\/jocmr4576","volume":"13","author":"R Djinbachian","year":"2021","unstructured":"Djinbachian R, Marchand E, Yan W, et al. Effects of age on esophageal motility: A high-resolution manometry study. J Clin Med Res. 2021;13:413\u20139. https:\/\/doi.org\/10.14740\/jocmr4576.","journal-title":"J Clin Med Res"},{"issue":"6","key":"1930_CR14","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14009","volume":"33","author":"BD Rogers","year":"2021","unstructured":"Rogers BD, Rengarajan A, Abrahao L, et al. Esophagogastric junction morphology and contractile integral on high-resolution manometry in asymptomatic healthy volunteers: An international multicenter study. Neurogastroenterol Motil. 2021;33:e14009. https:\/\/doi.org\/10.1111\/nmo.14009.","journal-title":"Neurogastroenterol Motil"},{"key":"1930_CR15","doi-asserted-by":"publisher","unstructured":"Paris S, Ekeanyanwu R, Jiang Y,\u00a0Davis D, Spechler SJ, Souza RF. Obesity and its effects on the esophageal mucosal barrier. Am J Physiol Gastrointest Liver Physiol. 2021;321:G335\u201343. https:\/\/doi.org\/10.1152\/ajpgi.00199.2021.","DOI":"10.1152\/ajpgi.00199.2021"},{"issue":"1","key":"1930_CR16","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1055\/a-0783-2327","volume":"128","author":"S Gokturk","year":"2020","unstructured":"Gokturk S, Akyuz F, Arici S, et al. Gastroesophageal reflux in asymptomatic patients with diabetes: An impedance study diabetes, obesity and gastroesophageal reflux. Exp Clin Endocrinol Diabetes. 2020;128:52\u20138. https:\/\/doi.org\/10.1055\/a-0783-2327.","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"27","key":"1930_CR17","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004089","volume":"95","author":"CH Chen","year":"2016","unstructured":"Chen CH, Lin CL, Kao CH. Association between gastroesophageal reflux disease and coronary heart disease: A nationwide population-based analysis.\u00a0Medicine (Baltimore). 2016;95:e4089. https:\/\/doi.org\/10.1097\/MD.0000000000004089.","journal-title":"Medicine"},{"key":"1930_CR18","unstructured":"Karamanolis GP, Denaxas K, Panopoulos S, et al. Severe oesophageal disease and its associations with systemic sclerosis. Clin Exp Rheumatol. 2017,35 Suppl 106:82\u20135."},{"key":"1930_CR19","unstructured":"Rosztoczy A, Kovacs L, Wittmann T,\u00a0Lonovics J, Pokorny G. Manometric assessment of impaired esophageal motor function in primary Sjogren\u2019s syndrome. Clin Exp Rheumatol. 2001;19:147\u201352."},{"key":"1930_CR20","doi-asserted-by":"publisher","unstructured":"Kahrilas PJ, Mittal RK, Bor S, et al. Chicago classification update (v4.0): technical review of high\u2010resolution manometry metrics for EGJ barrier function. Neurogastroenterol Motil. 2021;33:e14113. https:\/\/doi.org\/10.1111\/nmo.14113.","DOI":"10.1111\/nmo.14113"},{"key":"1930_CR21","doi-asserted-by":"publisher","unstructured":"Mello MD, Shriver AR, Li Y,\u00a0Patel A, Gyawali CP. Ineffective esophageal motility phenotypes following fundoplication in gastroesophageal reflux disease. Neurogastroenterol Motil. 2016;28:292\u20138. https:\/\/doi.org\/10.1111\/nmo.12728.","DOI":"10.1111\/nmo.12728"},{"key":"1930_CR22","doi-asserted-by":"publisher","unstructured":"Simren M, Silny J, Holloway R,\u00a0Tack J, Janssens J, Sifrim D. Relevance of ineffective oesophageal motility during oesophageal acid clearance. Gut. 2003;52:784\u201390. https:\/\/doi.org\/10.1136\/gut.52.6.784.","DOI":"10.1136\/gut.52.6.784"},{"key":"1930_CR23","doi-asserted-by":"publisher","unstructured":"Dao HV, Matsumura T, Kaneko T, et al. Impact of ineffective esophageal motility on chemical clearance in patients with gastroesophageal reflux symptoms.\u00a0Dis Esophagus. 2020;33:doaa026. https:\/\/doi.org\/10.1093\/dote\/doaa026.","DOI":"10.1093\/dote\/doaa026"},{"key":"1930_CR24","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1111\/nmo.12638","volume":"27","author":"S Tolone","year":"2015","unstructured":"Tolone S, De Bortoli N, Marabotto E, et al. Esophagogastric junction contractility for clinical assessment in patients with GERD: a real added value? Neurogastroenterol Motil. 2015;27:1423\u201331. https:\/\/doi.org\/10.1111\/nmo.12638.","journal-title":"Neurogastroenterol Motil."},{"key":"1930_CR25","doi-asserted-by":"publisher","unstructured":"Lin S, Chen Z, Jiang W,\u00a0Zhu Y. Exploring esophagogastric junction morphology and contractile integral: implications for refractory gastroesophageal reflux disease pathophysiology. Scand J Gastroenterol. 2025;60:130\u20135. https:\/\/doi.org\/10.1080\/00365521.2025.2450042.","DOI":"10.1080\/00365521.2025.2450042"},{"key":"1930_CR26","doi-asserted-by":"publisher","unstructured":"Wang Y, Ding Y, Lin L,\u00a0Jiang LQ. Esophagogastric junction contractile integral abnormalities in patients with proton pump inhibitor-refractory symptoms. J Dig Dis. 2021;22:529\u201335. https:\/\/doi.org\/10.1111\/1751-2980.13038.","DOI":"10.1111\/1751-2980.13038"},{"key":"1930_CR27","doi-asserted-by":"publisher","unstructured":"Nicodeme F, Pipa-Muniz M, Khanna K,\u00a0Kahrilas PJ, Pandolfino JE. Quantifying esophagogastric junction contractility with a novel HRM topographic metric, the EGJ-contractile integral: normative values and preliminary evaluation in PPI non-responders. Neurogastroenterol Motil. 2014;26:353\u201360. https:\/\/doi.org\/10.1111\/nmo.12267.","DOI":"10.1111\/nmo.12267"},{"key":"1930_CR28","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13054","author":"Z Lin","year":"2017","unstructured":"Lin Z, Xiao Y, Li Y, Pandolfino JE, Chen M, Kahrilas PJ. Novel 3D high-resolution manometry metrics for quantifying esophagogastric junction contractility. Neurogastroenterol Motil. 2017;29:10.1111\/nmo.13054. https:\/\/doi.org\/10.1111\/nmo.13054.","journal-title":"Neurogastroenterol Motil"},{"issue":"8","key":"1930_CR29","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14597","volume":"35","author":"H Dervin","year":"2023","unstructured":"Dervin H, Bassett P, Sweis R. Esophagogastric junction contractile integral (EGJ-CI) complements reflux disease severity and provides insight into the pathophysiology of reflux disease. Neurogastroenterol Motil. 2023;35:e14597. https:\/\/doi.org\/10.1111\/nmo.14597.","journal-title":"Neurogastroenterol Motil"},{"key":"1930_CR30","doi-asserted-by":"publisher","unstructured":"Xie C, Li Y, Zhang N,\u00a0Xiong L, Chen M, Xiao Y. Gastroesophageal flap valve reflected EGJ morphology and correlated to acid reflux. BMC Gastroenterol. 2017;17:118. https:\/\/doi.org\/10.1186\/s12876-017-0693-7.","DOI":"10.1186\/s12876-017-0693-7"},{"key":"1930_CR31","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12925","author":"D Jasper","year":"2017","unstructured":"Jasper D, Freitas-Queiroz N, Hollenstein M, et al. Prolonged measurement improves the assessment of the barrier function of the esophago-gastric junction by high-resolution manometry.\u00a0Neurogastroenterol Motil. 2017;29.\u00a0https:\/\/doi.org\/10.1111\/nmo.12925.","journal-title":"Neurogastroenterol Motil"}],"container-title":["Indian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-025-01930-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12664-025-01930-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-025-01930-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T20:47:20Z","timestamp":1770324440000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12664-025-01930-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":31,"alternative-id":["1930"],"URL":"https:\/\/doi.org\/10.1007\/s12664-025-01930-0","relation":{},"ISSN":["0254-8860","0975-0711"],"issn-type":[{"value":"0254-8860","type":"print"},{"value":"0975-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]},"assertion":[{"value":"15 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"TW, BW, JW and LY declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was performed conforming to the Helsinki Declaration of 1975, as revised in 2000 and 2008 concerning human and animal rights, and the authors followed the policy concerning informed consent as shown on Springer.com.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"The authors agree to the publication of the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors are solely responsible for the data and the contents of the paper. In no way, the Honorary Editor-in-Chief, Editorial Board Members, the Indian Society of Gastroenterology\u00a0or the printer\/publishers are responsible for the results\/findings and content of this article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}