{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:16:17Z","timestamp":1787919377928,"version":"build-2784847793"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Gastroenterol"],"DOI":"10.1007\/s12664-026-02067-4","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T11:19:55Z","timestamp":1787915995000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The right patient, the right time: Revisiting plasma exchange in HAV-related acute liver failure"],"prefix":"10.1007","author":[{"given":"Jitendra Kumar","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0110-5982","authenticated-orcid":false,"given":"Rakhi","family":"Maiwall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"2067_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jhep.2015.08.018","volume":"64","author":"FS Larsen","year":"2016","unstructured":"Larsen FS, Schmidt LE, Bernsmeier C, et al. High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial. J Hepatol. 2016;64:69\u201378.","journal-title":"J Hepatol"},{"key":"2067_CR2","doi-asserted-by":"publisher","first-page":"e831","DOI":"10.1016\/j.cgh.2021.01.036","volume":"20","author":"R Maiwall","year":"2022","unstructured":"Maiwall R, Bajpai M, Singh A, et al. Standard-volume plasma exchange improves outcomes in patients with acute liver failure: A randomized controlled trial. Clin Gastroenterol Hepatol. 2022;20:e831\u201354. https:\/\/doi.org\/10.1016\/j.cgh.2021.01.036.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2067_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/jca.22043","volume":"38","author":"L Connelly-Smith","year":"2023","unstructured":"Connelly-Smith L, Alquist CR, Aqui NA, et al. Guidelines on the use of therapeutic apheresis in clinical practice: Evidence-based approach from the Writing Committee of the American Society for Apheresis. Ninth Special Issue J Clin Apher. 2023;38:77\u2013278. https:\/\/doi.org\/10.1002\/jca.22043.","journal-title":"Ninth Special Issue J Clin Apher"},{"key":"2067_CR4","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s12664-024-01557-7","volume":"43","author":"K Sithamparapillai","year":"2024","unstructured":"Sithamparapillai K, Zachariah U, Eapen CE, Goel A. Plasma exchange improves survival in acute liver failure: An updated systematic review and meta-analysis focussed on comparing within single etiology. Indian J Gastroenterol. 2024;43:397\u2013406. https:\/\/doi.org\/10.1007\/s12664-024-01557-7.","journal-title":"Indian J Gastroenterol"},{"issue":"8","key":"2067_CR5","doi-asserted-by":"publisher","first-page":"904","DOI":"10.4254\/wjh.v13.i8.904","volume":"13","author":"A Chris-Olaiya","year":"2021","unstructured":"Chris-Olaiya A, Kapoor A, Ricci KS, Lindenmeyer CC. Therapeutic plasma exchange in liver failure. World J Hepatol. 2021;13:904\u201315. https:\/\/doi.org\/10.4254\/wjh.v13.i8.904.","journal-title":"World J Hepatol"},{"key":"2067_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-026-02009-0","author":"AM Janeela","year":"2026","unstructured":"Janeela AM, Duseja A, Valsan A, et al. Exploring role of therapeutic plasma exchange for hepatitis A-related acute liver failure: An Indian multi-center cohort study. Indian J Gastroenterol. 2026;\u00a0https:\/\/doi.org\/10.1007\/s12664-026-02009-0.","journal-title":"Indian J Gastroenterol"},{"issue":"4","key":"2067_CR7","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.jhep.2024.09.034","volume":"82","author":"L Burke","year":"2025","unstructured":"Burke L, Bernal W, Pirani T, et al. Plasma exchange does not improve overall survival in patients with acute liver failure in a real-world cohort. J Hepatol. 2025;82:615\u201321.","journal-title":"J Hepatol"},{"issue":"10454","key":"2067_CR8","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/S0140-6736(24)00693-7","volume":"404","author":"R Maiwall","year":"2024","unstructured":"Maiwall R, Kulkarni AV, Arab JP, Piano S. Acute liver failure. Lancet. 2024;404:789\u2013802. https:\/\/doi.org\/10.1016\/S0140-6736(24)00693-7.","journal-title":"Lancet"},{"key":"2067_CR9","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1002\/hep.26372","volume":"58","author":"GC Hugenholtz","year":"2013","unstructured":"Hugenholtz GC, Adelmeijer J, Meijers JC, Porte RJ, Stravitz RT, Lisman T. An unbalance between von Willebrand factor and ADAMTS13 in acute liver failure: implications for hemostasis and clinical outcome. Hepatology. 2013;58:752\u201361. https:\/\/doi.org\/10.1002\/hep.26372.","journal-title":"Hepatology."},{"key":"2067_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2024.102410","volume":"15","author":"D Agrawal","year":"2025","unstructured":"Agrawal D, Ariga KK, Gupta S, Saigal S. Therapeutic plasma exchange in hepatology: Indications, techniques, and practical application. J Clin Exp Hepatol. 2025;15: 102410. https:\/\/doi.org\/10.1016\/j.jceh.2024.102410.","journal-title":"J Clin Exp Hepatol"},{"key":"2067_CR11","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1111\/liv.14806","volume":"41","author":"R Maiwall","year":"2021","unstructured":"Maiwall R, Bajpai M, Choudhury AK, et al. Therapeutic plasma-exchange improves systemic inflammation and survival in acute-on-chronic liver failure: A propensity-score matched study from AARC. Liver Int. 2021;41:1083\u201396. https:\/\/doi.org\/10.1111\/liv.14806.","journal-title":"Liver Int"},{"key":"2067_CR12","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.jceh.2021.07.010","volume":"12","author":"SE Kumar","year":"2022","unstructured":"Kumar SE, Goel A, Zachariah U, et al. Low volume plasma exchange and low dose steroid improve survival in patients with alcohol-related acute-on-chronic liver failure and severe alcoholic hepatitis: Preliminary experience. J Clin Exp Hepatol. 2022;12:372\u20138.","journal-title":"J Clin Exp Hepatol"},{"issue":"1","key":"2067_CR13","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1136\/flgastro-2025-103236","volume":"17","author":"P Alagammai","year":"2026","unstructured":"Alagammai P, Ubal Dhus J, Domakuntla A, et al. Therapeutic plasma exchange in severe alcohol-associated hepatitis-related acute-on-chronic liver failure. Frontline Gastroenterol. 2026;17:9\u201318. https:\/\/doi.org\/10.1136\/flgastro-2025-103236.","journal-title":"Frontline Gastroenterol"},{"key":"2067_CR14","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000001755","author":"S Swaroop","year":"2026","unstructured":"Swaroop S, Biswas S, Aggarwal A, et al. Therapeutic plasma exchange improves short-term survival in patients with acute-on-chronic liver failure: A randomized controlled trial. Hepatology. 2026. https:\/\/doi.org\/10.1097\/HEP.0000000000001755.","journal-title":"Hepatology"}],"container-title":["Indian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-026-02067-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12664-026-02067-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12664-026-02067-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T11:19:55Z","timestamp":1787915995000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12664-026-02067-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":14,"alternative-id":["2067"],"URL":"https:\/\/doi.org\/10.1007\/s12664-026-02067-4","relation":{},"ISSN":["0254-8860","0975-0711"],"issn-type":[{"value":"0254-8860","type":"print"},{"value":"0975-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]},"assertion":[{"value":"28 August 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.\u00a0","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"JKS and RM declare no competing interests.","order":3,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors are solely responsible for the data and the content of the paper. In no way, the Honorary Editor-in-Chief, Editorial Board Members, the Indian Society of Gastroenterology or the printer\/publishers, are responsible for the results\/findings and content of this article.","order":4,"name":"Ethics","label":"Disclaimer","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}